Download or read book The Role of Platelets in Blood Biomaterial Interactions written by E Missirlis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicine and engineering work together towards solutions for biomedical problems. The interactions of blood elements with artificial materials (bags, tubes, artificial organs, etc.) require many disciplines for its understanding. Thus the effort presented in this book is the culmination of a genuine discussion on the problems arising in blood banks, in hospitals, in biomaterials development, in experimental hemocompatibility testing when platelets interact with biomaterials. Hematologists, chemists, biologists and engineers have tried to put their own point of view and to understand the point of view of the other disciplines. The main themes that are presented in the discussion are: Platelet collection, storage and transfusion; Hemostasis and anticoagulation; Platelet and biomaterials, extracorporeal circulation and implanted materials; Hemorheological parameters; Modulation of platelet function; Biological tests for evaluating platelet--biomaterial interactions. £/LIST£

Download or read book Blood Platelet Interactions with Biomaterials written by Hetty Spijker and published by . This book was released on 2002 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book An Introduction to Tissue Biomaterial Interactions written by Kay C. Dee and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.

Download or read book The Roles of Surface Heterogeneity in Protein biomaterial Interactions and Platelet Adhesion written by Jie Liu and published by . This book was released on 1997 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hemocompatibility of Biomaterials for Clinical Applications written by Christopher Siedlecki and published by Woodhead Publishing. This book was released on 2018-03-05 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemocompatibility of Biomaterials for Clinical Applications: Blood-Biomaterials Interactions summarizes the state-of-the-art on this important subject. The first part of the book reviews the latest research on blood composition and response, mechanisms of coagulation, test standards and methods. Next, the book assesses techniques for modifying biomaterial surfaces and developing coatings to improve hemocompatibility. In the final sections, users will find discussions on ways to improve the hemocompatibility of particular classes of biomaterials and a review of methods for improving medical devices. Provides comprehensive information on the fundamentals of hemocompatibility and new technologies Combines research in the biomaterials field in a digestible format for clinical applications Provides a complete overview biomaterials in current use and test methods

Download or read book Manual of Blood Platelets Morphology Physiology and Pharmacology written by Gundu HR Rao and published by Jaypee Brothers Medical Publishers. This book was released on 2018-11-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets are tiny blood cells that help the body form clots to stop bleeding. Antiplatelet medications, such as aspirin and clopidogrel, are commonly used to thin the blood which limits clotting and reduces the risk of heart attack. This book is a comprehensive guide to blood platelets for haematologists. Beginning with discussion on platelet structure, morphology, function and physiology, the next chapters cover the role of calcium in platelet activation and calcium modulation by cyclic nucleotides. The following sections explain the pharmacology of antiplatelet drugs, antiplatelet therapies, aspirin resistance, and the association of diabetes mellitus with major platelet dysfunction. The book concludes with chapters on acute coronary problems, interaction between endothelial cells and platelets, and blood biocompatibility studies. Authored by a Minneapolis-based expert in the field, the text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to blood platelets for haematologists Extensive coverage of antiplatelet drugs and resistance Recognised author from University of Minnesota Highly illustrated with clinical photographs, diagrams and tables

Download or read book Transfusion Medicine and Hemostasis written by Beth H. Shaz and published by Newnes. This book was released on 2013-05-13 with total page 1015 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issues Easy to use, with focused, well-defined chapters in a standardized format throughout Offers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities

Download or read book Blood Platelet Interactions with Biomaterials written by Hendrikje Trijntje Spijker and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Platelets in the Blood polymer Interaction written by Kandice Kottke Marchant and published by . This book was released on 1983 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biomaterials in Blood contacting Devices written by Meng-Jiy Wang and published by Novinka Books. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: All blood-contacting medical devices in use today are subjected to some degree poorer blood compatibility than the native artery. Homeostatic mechanism, arresting bleeding from injured blood vessels, induces platelet adhesion and activation onto artificial biomaterials, which leads to undesirable outcomes such as blood clotting at the site of the implant, continual shedding of thrombi, and depletion of platelets from the blood stream. Such complications have hampered the clinical success of blood contacting devices, limiting the patent of small-diameter vascular grafts and making necessary the use of anticoagulants in patients undergoing extracorporeal bypass or synthetic heart valve implantation. Therefore, development of non-thrombogenic biomaterials is in great need for blood contacting devices. The current approaches mainly focus on surface modifications with biological anticoagulants such as heparin, or anti-fouling molecules like poly(ethylene oxide). In this review, the authors first introduce the blood components involved in hemostasis and thrombosis, followed by the common biomaterials applied in blood-contacting devices. Next, the complications induced by the interactions between blood and biomaterials are briefly addressed. Finally, the commonly used techniques for improving biomaterials' hemocompatibility are expatiated.

Download or read book Biomaterials Interfacial Phenomena and Applications written by American Institute of Chemical Engineers. Annual Meeting and published by . This book was released on 1982 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Blood Protein and Platelet Interactions on Surface Engineered Biomaterials written by Deepika Nandakumar and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Material induced Platelet and Leukocyte Activation written by Tidimogo Gaamangwe and published by . This book was released on 2014 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A systems approach in the study of blood-biomaterial interactions (BBI) is likely to provide better insight into the transient behaviors of complex biological systems. Although some attempts have been made to apply a systems approach in blood-biomaterial studies, a good framework for applying a systems approach has not yet been achieved. In this thesis, the case for a systems approach is presented and a framework is proposed. As a demonstration, the systems approach is applied to the development of an in vitro model for BBI. In vitro models play an important role in the initial investigation of BBI. Therefore, careful consideration of their parameters to mimic physiological parameters is crucial for results that can be translated to physiological conditions. The parameters of the in vitro model used in this thesis were determined using a systems approach method. The fluid dynamics of the model were characterized, to account for the model blood sample always including air, and an improved time-averaged wall shear stress was proposed. Since wall shear stress is an important parameter that determines cell activation and adhesion, in vitro studies were performed to investigate and validate the model with experiments. In line with a systems approach and clinical relevance, whole blood samples were used in the in vitro experiments. Platelet activation was investigated, as characterized by platelet microparticle (PMP) formation and expression of both P-selectin and the integrin glycoprotein receptor GPIIb/IIIa. For whole blood, in the absence of model stents, there was no significant sample volume or shear effect on PMP formation for wall shear stress up to 56 dyn/cm2. However, in the presence of model stents, combined volume and shear-dependent PMP formation was observed. While GPIIb/IIIa expression was reduced, P-selectin, on the other hand, did not generally show significant change after 2 hours of incubation. Leukocyte activation was also investigated, as characterized by the expression of tissue factor (TF), Mac-1, C3aR and toll-like receptor 4 (TLR-4). In the absence of model stents, sample volume had minimal effect on leukocyte activation but in the presence of model stents, a sample volume effect was observed at high shear rates, especially on Mac-1 expression. The other markers, TF, C3aR and TLR-4 did not show sensitivity to the volume effect. However, under combined volume-stent-shear, all markers were down-regulated at high shear. Correspondingly, platelet-leukocyte aggregation was also generally reduced. Leukocytes, as well as platelets, were sensitive to surface-area-to-volume ratio. The use of low surface area-to-volume ratio, below the ISO Standard recommended limit, resulted in reduced platelet and leukocyte sensitivity to shear and/or material. However, sensitivity to shear was still high on platelet-leukocyte aggregation. Also cell surface adhesion was shear-dependent but could not be linked to a sample volume effect. Complement inhibitor FUT-175 reduced PMP formation but had less effect on GPIIb/IIIa expression. Complement inhibition also reduced leukocyte activation, especially under shear conditions. Considerable reduction in leukocyte activation was observed under shear in the presence of model stents. These conditions would normally be expected to produce high complement activation. Furthermore, the conditions with the most reduction in platelet and leukocyte activation corresponded with the most reduction in platelet-leukocyte aggregation in the fluid phase. On the stent surface, FUT-175 inhibited leukocyte adhesion but allowed some platelet adhesion. Thus, complement inhibition with FUT-175 has the potential to reduce thrombosis while possibly retaining platelet function in hemostasis. The effect of surface roughness was investigated with inhomogeneous multiscale roughness surfaces. Although the unetched and acid-etched stent surfaces had similar average surface roughness values, the acid-etched surface resulted in increased platelet activation and platelet-leukocyte aggregation. In addition, platelet-leukocyte aggregates seemed to be more resistant to shear-induced disaggregation. However, when complement inhibitor FUT-175 was introduced, platelet and leukocyte activation and aggregation were reduced to similar levels as for unetched stents. This suggests that complement inhibition with FUT-175 has the potential to reduce material-induced thrombosis in the presence of nano/micro-structured stent surfaces such as those used for drug-eluting stents.

Download or read book Unraveling the Safety Profile of Nanoscale Particles and Materials written by Andreia Ferreira de Castro Gomes and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: As nanomaterials become increasingly present in our daily lives, pertinent questions regarding their safety arise. Nanomaterial risk assessment, as in other areas, directs much of the effort worldwide in defining guidelines that may be translated into national or international directives. Nanomaterials encompass different entities, from nanoparticles to nanostructured materials, with specific effects over cells, tissues, organisms and ecosystems depending on their biophysical characteristics. Such interactions will directly affect the impact of novel nanotechnologies. This book aims to provide the reader with a comprehensive overview of the current state of the art in nanotoxicology, featuring the most important developments and critical issues regarding the use of and exposure to nanoparticles.

Download or read book Atlas of Canine and Feline Peripheral Blood Smears written by Amy C. Valenciano and published by Elsevier Health Sciences. This book was released on 2013-07-01 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: An illustrated guide to the morphology of blood cells, Atlas of Canine and Feline Peripheral Blood Smears covers patient assessment for common hematologic disorders and diseases in dogs and cats. Over 1,000 full-color photomicrographs depict abnormalities within each blood cell line, with multiple pictures of each morphologic abnormality and variations in their appearance. Written by pathology experts Amy Valenciano, Rick Cowell, Theresa Rizzi, and Ronald Tyler, this concise reference will enhance your skills as you interpret blood smears and recognize hematological cellular response to inflammation, infection, and toxicity. "Everything you might encounter looking at dog or cat blood smears is right there, clearly classified and noted (more than 1000 pictures!). Pitfalls and artefacts are clearly explained. The format (spiral binding) makes it the obvious accessory for your microscope. A good investment." Reviewed by: Vet's Today Date: July 2014 Over 1,000 photomicrographs facilitate microscopic analysis and interpretation of the cellular components of the blood. Full-color, high-resolution images facilitate identification of different blood cell types, numbers, anomalies and conditions. Multiple representations of morphologic abnormalities aid in recognition of conditions where variations in appearance commonly occur. Practical information includes an overview of laboratory methods, equipment and supplies, sample collection, staining and handling, and diagnostic interpretation of blood smears. Coverage of 125 topics ranges from the morphology of erythrocytes to chronic myeloid leukemia. Spiral binding allows the book to lay open next to the microscope, making it a quick and easy reference while on the job.

Download or read book Host Response to Biomaterials written by Stephen F. Badylak and published by Academic Press. This book was released on 2015-05-08 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Download or read book Scientific Aspects of Dialysis Therapy written by H. Kawanishi and published by Karger Medical and Scientific Publishers. This book was released on 2016-12-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together papers presented both during the 61st Annual Meeting of the Japanese Society for Dialysis Therapy (JSDT) and the 34th Congress of the International Society of Blood Purification (ISBP), held in Osaka in June and in Hiroshima in September 2016, respectively. They cover a broad spectrum of topics, ranging from hemodialysis, peritoneal dialysis, hemodiafiltration and technical innovations in blood purification to complications of chronic kidney disease and acute kidney injury, including mineral bone disease and anemia.