Download or read book The Role of Glycosylation in Health and Disease written by Gordan Lauc and published by Springer Nature. This book was released on 2021-09-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book What is Glycosylation The Role Play of Glycosylation in Health Disease An Overview written by Dr.H.K.Saboowala. and published by Dr.Hakim Saboowala. This book was released on 2022-10-20 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is Glycosylation? The Role Play of Glycosylation in Health & Disease. An Overview. Glycosylation is an enzymatic process that attaches carbohydrate or a glycan to proteins, or other organic molecules such as lipids. Glycosylation is a dynamic process that depends on the local milieu of enzymes, sugar precursors and organelle structures as well as the cell types involved and cellular signals. Researchers can now routinely assess how the secreted and cell-surface glycomes reflect overall cellular status in health and disease. In fact, changes in glycosylation can modulate inflammatory responses, enable viral immune escape, promote cancer cell metastasis, or regulate apoptosis; the composition of the glycome also affects kidney function in health and disease. New insights into the structure and function of the glycome can now be applied to therapy development and could improve our ability to fine-tune immunological responses and inflammation, optimize the performance of therapeutic antibodies and boost immune responses to cancer. These examples illustrate the potential of the emerging field of ‘GLYCOMEDICINE’. It is strived in this Booklet to review how glycosylation patterns are altered in multiple human diseases, including Congenital Disorders of Glycosylation (CDGs), Autoimmune, Infectious & Chronic Inflammatory Diseases and Cancer, providing specific examples of how an improved understanding of abnormal glycosylation in various diseases might offer new diagnostic options and/or targets for glycan-mediated therapeutic interventions. Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Download or read book Glycomics based Approach to Understanding the Role of Glycosylation in Health and Disease written by Barbara Adamczyk and published by . This book was released on 2014 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glycobiology and Human Diseases written by Gherman Wiederschain and published by CRC Press. This book was released on 2016-02-22 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal st
Download or read book Translational Glycobiology in Human Health and Disease written by Michelle Kilcoyne and published by Academic Press. This book was released on 2023-11-29 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. - Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology's growing role in human health and disease study - Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health - Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences
Download or read book Role of PrPC Glycosylation in Health and Disease written by Kayleigh Iremonger and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glyco Engineering written by Alexandra Castilho and published by Humana. This book was released on 2015-06-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceived with the intention of providing an array of strategies and technologies currently in use for glyco-engineering distinct living organisms, this book contains a wide range of methods being developed to control the composition of carbohydrates and the properties of proteins through manipulations on the production host rather than in the protein itself. The first five sections deal with host-specific glyco-engineering and contain chapters that provide protocols for modifications of the glycosylation pathway in bacteria, yeast, insect, plants and mammalian cells, while the last two sections explore alternative approaches to host glyco-engineering and selected protocols for the analysis of the N-glycans and glyco-profiling by mass spectrometry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and extensive, Glyco-Engineering: Methods and Protocols offers vast options to help researchers to choose the expression system and approach that best suits their intended protein research or applications.
Download or read book IgE Antibodies Generation and Function written by Juan J. Lafaille and published by Springer. This book was released on 2015-01-02 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.
Download or read book Glycobiology and Medicine written by John S. Axford and published by Springer. This book was released on 2014-11-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Glycosylation: Disease Targets and Therapy, Zitzmann et al.; 2. Long Alkylchain Iminosugars Block the HCV P7 Ion Channel, Pavlovic et al.; 3. The Bovine Viral Diarrhoea Virus: A Model for the Study of Antiviral Molecules Interfering with N-Glycosylation and Folding of Envelope Glycoprotein, Durantel et al.; 4. Antibody Recognition of a Carbohydrate Epitope: A Template for HIV Vaccine Design, Scanlan et al.; 5. Interaction of Schistosome Glycans with the Host Immune System, Van Die et al.; 6. The Mannan-Binding Lectin (MBL) of Complement Activation: Biochemistry, Biology and Clinical Implications, Jensenius et al.; 7. Killer Cell Lectin-like Receptors and the Natural Killer Cell Gene Complex, Nylenna et al.; 8. Glycosylation Influences the Ligand Binding Activities of Mannose Receptor, Roc Su et al.; 9. Human Immunoglobulin Glycosylation and the Lectin Pathway of Complement Activation, Arnold et al.; 10. Gelatinase B Participates in Collagen II Degradation and Releases Glycosylated Remnant Epitopes in Rheumatoid Arthritis, Van den Steen et al.; 11. Hyaluronan in Immune Processes, Alan J. Wright and Anthony J. Day; 12. Glycosylation and the Function of the T Cell Co-receptor CD8, Shore et al.; 13. Immunogenecity of Calreticulin-bound Murine Leukemia Virus Glycoprotein, Mimura et al.; 14. Glycosylation and GPI Anchorage of the Prion Protein, Nigel Hooper; 15. Glycosylation Defects and Muscular Dystrophy, Blake et al.; 16. Roles of Complex and Hybrid N-Glycans and O-Fucose Glycans in Oocyte Development and Function, Shi et al.; 17. Mucin Oligosaccharides and Pigeon Fanciers' Lung, Baldwin et al.; 18. Differential Glycosylation of Gelatinase B from Neutrophils and Breast Cancer Cells, Fry et al.; 19. Detection of Glycosylation Changes in Serum and Tissue Proteins in Cancer by Lectin Blotting, Ferguson et al.; 20. Carbohydrates and Biology of Staphylococcal Infections, Tarkowski et al.; 21. New Developments in Treating Glycosphingolipid StorageDiseases, Platt et al.; 23. New Insights into Rheumatoid Arthritis Associated Glycosylation Changes, Alavi et al.; 24. Production of Complex Human Glycoproteins in Yeast, Tillman Gerngross; 25. Relationship Between the N-glycan Structures and Biological Activitities of Recombinant Human Erythropoietins Produced Using Different Culture Conditions and Purification Procedures, Yuen et al.; 26. Glycosylation of Natural and Recombinant Antibody Molecules, Roy Jefferis.
Download or read book Introduction to Glycobiology written by Maureen E. Taylor and published by Oxford University Press, USA. This book was released on 2011-04-21 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.
Download or read book The Sugar Code written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
Download or read book Glycosaminoglycans and Proteoglycans written by 978-3-03842-836-7 and published by MDPI. This book was released on 2018-07-04 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Glycosaminoglycans and Proteoglycans" that was published in Pharmaceuticals
Download or read book O glycosylation in Health and Disease written by Suzan Wopereis and published by . This book was released on 2006 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NORD Guide to Rare Disorders written by National Organization for Rare Disorders and published by Lippincott Williams & Wilkins. This book was released on 2003 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: NORD Guide to Rare Disorders is a comprehensive, practical, authoritative guide to the diagnosis and management of more than 800 rare diseases. The diseases are discussed in a uniform, easy-to-follow format--a brief description, signs and symptoms, etiology, related disorders, epidemiology, standard treatment, investigational treatment, resources, and references.The book includes a complete directory of orphan drugs, a full-color atlas of visual diagnostic signs, and a Master Resource List of support groups and helpful organizations. An index of symptoms and key words offers physicians valuable assistance in finding the information they need quickly.
