Download or read book The Regulation of Proliferation and Differentiation in Normal and Neoplastic Cells written by Emil Frei (III) and published by . This book was released on 1989 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Growth in Neoplasia written by Gajanan V. Sherbet and published by S. Karger AG (Switzerland). This book was released on 1981 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Cell Proliferation and Differentiation written by Warren Nichols and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1974 The National Institute on Aging established a somatic cell genetic resource for aging research at the Institute for Medical Research in Camden, New Jersey. Within this program there is a yearly workshop to promote theory and concept develop ment in aging research with the specific purpose of addressing the use of genetically marked cells for aging research and to stimulate interest in aging research by workers in a variety of disciplines. This monograph, The Regulation of Cell Proliferation and Differentiation, is the result of the first workshop held May 15-17, 1975. The concept of the workshop was to consider two main areas: First, a discussion of clinical syndromes expressing as a major manifestation excessive growth, deficient growth or failure to thrive; and second, to present work in cellular and molecular biology on a model system suitable for in vitro study of regulation of cell proliferation and diff2rentiation. The model selected for this was skeletal muscle. It has been widely accepted that normal somatic cells from individual human donors display limited replicative lifespans when cultivated in vitro (1,2). That such "clonal senescence" may be related to in vivo aging is suggested by observations relating the replicative lifespans of cultures to donor age (3-5,13) donor genotype (4-7) and donor's tissue of origin (5,8). A variety of theories have been developed to explain in vitro clonal senescence (9).
Download or read book Normal and Malignant Cell Growth written by R. J. M. Fry and published by Elsevier. This book was released on 2014-05-12 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal and Malignant Cell Growth is a compendium of papers from the "Proceedings of the Third Cancer Training Grant" of the University of Chicago that deals with the processes associated with malignant neoplasia, as well as the cell proliferation kinetics of normal tissues. One paper presents the techniques used in the study on the proliferation kinetics of hemopoietic stem cells, suggesting that the hemopoietic stem cell population is not homogenous but consists of a "primitive pluripotential stem cell." A series of experiments at the Brookhaven National Laboratory investigates the relationship of cell survival, specifically that of stem cells, to the survival of the irradiated test animal. One result of the experiment shows a rapid migration of a number of stem cells from shielded marrow into unshielded marrow at the pressure of a rapid circulating pool. The numbers of stem cells are somewhat dependent on the dose given to the unshielded marrow, and are greater with the greater dose. Another paper also investigates the four methods that are used in the study of cellular kinetics in human tumors. This compendium can prove helpful for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.
Download or read book Cell Proliferation in Cancer written by Lajos Pusztai and published by . This book was released on 1996 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in cellular and molecular biology has reached the point now where it is possible to begin to see how the different fields of cancer genetics/oncogene research and intercellular communication form an integrated molecular model for the regulation of normal and neoplastic cellproliferation. A number of important discoveries in this field during the past few year shave greatly increased our understanding of cancer biology and have offered new diagnostic and prognostic parameters in oncology. This information also holds the promise of novel, more effective therapeuticapproaches to cancer. However, it is becoming increasingly difficult for an individual to maintain a wide and informed knowledge of current concepts in this rapidly moving field, or to form an integrated overview of the myriad factors involved in neoplastic cell proliferation.This book comprises a number of state-of-the-art reviews written by leading scientists. Each chapter gives a concise overview of specific intra-and intercellular events which regulate the proliferation of neoplastic cells, and the established and potential clinical implications of thesedevelopments. The topics have been selected to cover major recent advances in our understanding of the molecular events which govern cell division. It is expected that students, scientists and clinicians working in the fields of oncology, pathology, and molecular/cellular biology would find thisvolume invaluable as a stimulating source of information.
Download or read book Trends in Stem Cell Proliferation and Cancer Research written by Rodrigo R. Resende and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance
Download or read book Differentiation of Normal and Neoplastic Hematopoietic Cells written by Bayard Clarkson and published by . This book was released on 1978 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Growth Regulation and Carcinogenesis written by Walter R. Paukovits and published by CRC Press. This book was released on 2018-01-18 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; and the role of cell production, cell function, and cell elimination in physiological growth control.
Download or read book THE SOCIETY OF CELLS written by Carlos Sonnenschein and published by Springer. This book was released on 1999 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite decades of work and financial support to explore the somatic mutation theory of carcinogenesis, we appear no nearer to explaining how cancer arises. This requires researchers to take stock and consider new hypotheses and alternative approaches to the study of control of cell proliferation, and cancer in particular. The Society of Cells is intended to encourage such a revaluation and proposes the adoption of new premises to explore these important subjects.
Download or read book Biological Regulation of Cell Proliferation written by Renato Baserga and published by Raven Press (ID). This book was released on 1986 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Differentiation and Neoplasia written by Grady F. Saunders and published by . This book was released on 1978 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Neoplasia and Cell Differentiation written by Gajanan V. Sherbet and published by S. Karger AG (Switzerland). This book was released on 1974 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumor Biology written by Asterios S. Tsiftsoglou and published by Springer. This book was released on 2011-09-26 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the aim of providing an international forum for the communication of both the basic and clinical aspects of molecular and cellular biology of cancer, a NATO ASl was held in Porto Carras, Halkidiki, Greece, September 1-12, 1995. The principles as well as recent developments in tumor biology were discussed in depth, with emphasis on the regulation of the cell cycle, differentiation, programmed cell death (apoptosis) and genetics of cancer. This book constitutes the proceedings of that meeting. Specifically, the following areas were addressed: (a) enzymes and proteins (cyclins) that control the cell cycle, as well as the role of m as gene in meiosis and transformation; (b) the structural basis for specificity in protein-tyrosine kinase reactions; (c) the differentiation of normal as well as neoplastic cells with respect to molecular mechanism(s) by which chemical agents or growth factors trigger maturation; (d) phenotypic and genetic aspects of apoptosis; (e) the role of growth factors, like IGF-l, FGF, TN, IL-6, etc. , in cell cycle regulation, apoptosis (cell death) and senescence; (f) molecular mechanisms of transcriptional activation of globin genes and stability of mRNAs related to growth proteins and iron metabolism; (g) the cellular and molecular biology of bone marrow hemopoiesis; and (h) neurotrophic factors and the generation of cellular diversity in the central nervous system. It was obvious from the studies presented that neoplastic cell growth, differentiation and apoptosis in many cell types are regulated at several levels.
Download or read book The Proliferation and Spread of Neoplastic Cells written by and published by . This book was released on 1968 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Perspectives in Cellular Regulation written by Judith Campisi and published by . This book was released on 1991-06-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides excellent overviews highlighting the research results of leading scientists as well as young investigators in the field of cellular and molecular regulatory mechanisms. How each cell grows and develops at the appropriate time and place is thoroughly covered along with such issues as culturing the types of cells which represent excellent model systems for studies on tumor formation, proliferation and differentiation; cell cycle control; molecular control of DNA replication and repair and much more.
Download or read book Issues in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.
