Download or read book The Radiochemistry of Astatine written by Evan H. Appelman and published by . This book was released on 1960 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Radiochemistry of the Elements written by and published by . This book was released on 1960 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Radiochemistry of Astatine written by Evan H. Appelman and published by . This book was released on 1960 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Radiochemistry of Astatine written by Thomas J. Ruth and published by . This book was released on 1988 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Science Series 3000 written by National Research Council (U.S.). Committee on Nuclear Science. Subcommittee on Radiochemistry and published by . This book was released on 1960 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Properties of Astatine I written by Gordon Lee Johnson and published by . This book was released on 1948 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Procedure for the Radiochemical Analysis of Astatine in Biological Material written by and published by . This book was released on 1950 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ASTATINE 211 RADIOCHEMISTRY written by and published by . This book was released on 2012 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for?-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the?-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At-labeled targeted radiotherapeutics currently is a daunting task. Our central hypothesis is that improvements in 211At radiochemistry are critically dependent on gaining an understanding of and compensating for the effects of radiolysis induced by 211At?-particles. Because of the widespread interest in labeling antibodies, antibody fragments and peptides with 211At, our proposed work plan will initially focus on reagents that we have developed for this purpose. Part of our strategy is the use of synthetic precursors immobilized on polymeric resins or perfluorous and triarylphosphonium supports. Their use could eliminate the need for a purification step to separate unreacted tin precursor from labeled product and hopefully provide a simple kit technology that could be utilized at other institutions. The specific aims of this project are: (1) To optimze methods for 211At production and isolation of 211At from cyclotron targets; (2) To develop convenient and reproducible methodologies for high activity level and high specific activity radiohalogenation of biomolecules with 211At; (3) to develop a procedure for extending the shelf-life of 211At beyond a few hours so that this radionuclide can be utilized at centers remote from its site of production; and (4) to work out high activity level synthesis methods for utilizing support immobilized tin precursors for 211At labeling. If we are successful in achieving our goals, the radiochemical methodologies that are developed could greatly facilitate the use of 211At-labeled targeted cancer therapeutics in patients, even at institutions that are distant from the few sites currently available for 211At production.
Download or read book At Astatine written by Hans K. Kugler and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Astatine is - besides radon and francium - the only natural radioelement which only has short-Lived isotopes, thereby excluding experiments with . . weighable" amounts of the element. This implies that all available data on physics and chemistry of this element are 12 16 based on experiments on the tracer scale with 10- to 10- g - and this will also not change in future because no longer-Lived isotopes as yet known are to be expected. Due to the fact that the only isotope of At occurring in the natural decay series, 219At, results from the 0. 005% a-branching of 223Fr which itself is produced by the only 1. 38% a-branching of 227 Ac - a member of the 235U series - there is no chance to recover substantial amounts of 219At from natural sources for sCientific research of At. All studies, therefore, are being done with the isotopes 209At to 211At having half-lives in the few hours region and being obtained by irradiation of bismuth with a-particles via (a,xn) reactions or by proton irradiation of heavy elements via spallation reactions. The mostly used isotope is 7. 22 h 211At. The fast separation of the obtained At isotopes is no very difficult procedure and is either being done by wet adsorption-precipitation techniques or making use of its high volatility by destilling in air.
Download or read book The Radiochemistry of the Elements written by and published by . This book was released on 1960 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Properties of Astatine written by Evan Hugh Appelman and published by . This book was released on 1960 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Visual Elements Astatine written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Royal Society of Chemistry offers information on the chemical element astatine. Astatine was discovered in 1940 by D.R. Corson and is a dangerously radioactive element made in nuclear reactors. The society highlights chemical data on astatine.
Download or read book Advances in Inorganic Chemistry and Radiochemistry written by and published by Academic Press. This book was released on 1964-01-01 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Inorganic Chemistry and Radiochemistry
Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1976 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book TID written by and published by . This book was released on 1962 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recent Radiochemical Separation Procedures for As At Be Mg Ni Ru and Se written by K. V. Marsh and published by . This book was released on 1974 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
