Download or read book Optimal High Throughput Screening written by Xiaohua Douglas Zhang and published by Cambridge University Press. This book was released on 2011-02-21 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.
Download or read book Combinatorial Materials Science written by Marc D. Porter and published by John Wiley & Sons. This book was released on 2007-08-17 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial Materials Science describes new developments and research results in catalysts, biomaterials, and nanomaterials, together with informatics approaches to the analysis of Combinatorial Science (CombiSci) data. CombiSci has been used extensively in the pharmaceutical industry, but there is enormous potential in its application to materials design and characterization. Addressing advances and applications in both fields, Combinatorial Materials Science: Integrates the scientific fundamentals and interdisciplinary underpinnings required to develop and apply CombiSci concepts Discusses the development and use of CombiSci for the systematic and accelerated investigation of new phenomena and of the complex structure-function interplay in materials Covers the development of new library design strategies for materials processing and for high-throughput tools for rapid sampling Uses a unique, unified approach of applying combinatorial methods to unravel the non-linear structure-function relationships in diverse materials (both hard and soft), together with advances in informatics With chapters written by leading researchers in their specialty areas, this authoritative guide is a must-have resource for scientists and engineers in materials science research, biochemists, chemists, immunologists, cell biologists, polymer scientists, chemical and mechanical engineers, statisticians, and computer scientists. It is also a great text for graduate-level courses in materials science/engineering, polymer science, chemical engineering, and chemistry.
Download or read book Experimentation Matters written by Stefan H. Thomke and published by Harvard Business Press. This book was released on 2003 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every company's ability to innovate depends on a process of experimentation whereby new products and services are created and existing ones improved. But the cost of experimentation often limits innovation. New technologies--including computer modeling and simulation--promise to lift that constraint by changing the economics of experimentation. Never before has it been so economically feasible to ask "what-if" questions and generate preliminary answers. These technologies amplify the impact of learning, paving the way for higher R&D performance and innovation and new ways of creating value for customers.In Experimentation Matters, Stefan Thomke argues that to unlock such potential, companies must not only understand the power of experimentation and new technologies, but also change their processes, organization, and management of innovation. He explains why experimentation is so critical to innovation, underscores the impact of new technologies, and outlines what managers must do to integrate them successfully. Drawing on a decade of research in multiple industries as diverse as automotive, semiconductors, pharmaceuticals, chemicals, and banking, Thomke provides striking illustrations of how companies drive strategy and value creation by accommodating their organizations to new experimentation technologies.As in the outcome of any effective experiment, Thomke also reveals where that has not happened, and explains why. In particular, he shows managers how to: implement "front-loaded" innovation processes that identify potential problems before resources are committed and design decisions locked in; experiment and test frequently without overloading their organizations; integrate new technologies into the current innovation system; organize for rapid experimentation; fail early and often, but avoid wasteful "mistakes"; and manage projects as experiments.Pointing to the custom integrated circuit industry--a multibillion dollar market--Thomke also shows what happens when new experimentation technologies are taken beyond firm boundaries, thereby changing the way companies create new products and services with customers and suppliers. Probing and thoughtful, Experimentation Matters will influence how both executives and academics think about experimentation in general and innovation processes in particular. Experimentation has always been the engine of innovation, and Thomke reveals how it works today.
Download or read book Sample Size Calculations in Clinical Research written by Shein-Chung Chow and published by CRC Press. This book was released on 2017-08-15 with total page 825 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Second Edition: "... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." – Journal of the Royal Statistical Society Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation. Features: Compares the relative merits and disadvantages of statistical methods for sample size calculations Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women’s health Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.
Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
Download or read book New Horizons in Modern Catalysis Five Different Perspectives written by and published by Elsevier. This book was released on 2023-11-24 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Horizons in Modern Catalysis: Six Different Perspectives, Volume 72 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters on Carbanion-functionalized phosphines: New design elements for catalyst development, Molecular Electrocatalysts for Organic Electrosynthesis, Mechanistic aspects of secondary sphere modification in organocatalysis, Earth-Abundant Transition Metal-Catalyzed reactions with Iodine(III) reagents: from catalysis to mechanistic studies, Design of metal nanoparticles for better performance in catalysis, and Computational design of industrially relevant enzymes. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Catalysis series - Acts as a comprehensive platform for experimental and theoretical researchers
Download or read book Enabling Tools and Techniques for Organic Synthesis written by Stephen G. Newman and published by John Wiley & Sons. This book was released on 2023-08-08 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: ENABLING TOOLS AND TECHNIQUES FOR ORGANIC SYNTHESIS Provides the practical knowledge of how new technologies impact organic synthesis, enabling the reader to understand literature, evaluate different techniques, and solve synthetic challenges In recent years, new technologies have impacted organic chemistry to the point that they are no longer the sole domain of dedicated specialists. Computational chemistry, for example, can now be used by organic chemists to help predict outcomes, understand selectivity, and decipher mechanisms. To be prepared to solve various synthetic problems, it is increasingly important for chemists to familiarize themselves with a range of current and emerging tools and techniques. Enabling Tools and Techniques for Organic Synthesis: A Practical Guide to Experimentation, Automation, and Computation provides a broad overview of contemporary research and new technologies applied to organic synthesis. Detailed chapters, written by a team of experts from academia and industry, describe different state-of-the-art techniques such as computer-assisted retrosynthesis, spectroscopy prediction with computational chemistry, high throughput experimentation for reaction screening, and optimization using Design of Experiments (DoE). Emphasizing real-world practicality, the book includes chapters on programming for synthetic chemists, machine learning (ML) in chemical synthesis, concepts and applications of computational chemistry, and more. Highlights the most recent methods in organic synthesis and describes how to employ these techniques in a reader’s own research Familiarizes readers with the application of computational chemistry and automation technology in organic synthesis Introduces synthetic chemists to electrochemistry, photochemistry, and flow chemistry Helps readers comprehend the literature, assess the strengths and limitations of each technique, and apply those tools to solve synthetic challenges Provides case studies and guided examples with graphical illustrations in each chapter Enabling Tools and Techniques for Organic Synthesis: A Practical Guide to Experimentation, Automation, and Computation is an invaluable reference for scientists needing an up-to-date introduction to new tools, graduate students wanting to expand their organic chemistry skills, and instructors teaching courses in advanced techniques for organic synthesis.
Download or read book Advances in Structural Adhesive Bonding written by David A. Dillard and published by Elsevier. This book was released on 2023-06-10 with total page 1190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Structural Adhesive Bonding, Second Edition reviews developments in adhesive bonding for a range of advanced structural engineering applications. This new edition has been fully revised to include the latest advances in materials, testing and modeling methods, lifecycle considerations, and industrial implementation. Sections review advances in commonly used groups of structural adhesives, covering epoxy, acrylic, anaerobic and cyanoacrylate, polyurethane, and silicone adhesives, along with toughening. Other chapters cover various types of adherends and pre-treatment methods for structural materials, including metals, plastics, composites, wood and joint design and testing, including topics such as fracture mechanics, life prediction techniques, and advanced testing methods. This is a valuable guide for all those working with structural adhesives, including those in an industrial setting, adhesive specialists, structural engineers, design engineers, R&D professionals, and scientists, as well as academic researchers and advanced students in adhesives, joining technology, materials science and mechanical engineering. - Provides detailed coverage on the main adhesive groups, including epoxy, acrylic, cyanoacrylate, polyurethane and silicone adhesives - Includes the latest developments across adherends, pre-treatment methods, joint design and testing, durability and lifecycle related issues - Addresses environmental challenges, adhesive specification, quality control, and risk mitigation for specific industrial application areas
Download or read book The Power of High throughput Experimentation written by Marion H. Emmert and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "High-throughput experimentation (HTE) is an emerging and powerful approach to problems in organic chemistry and homogeneous catalysis. This book is targeted at both experts and those new to the field who are seeking general perspectives and design principles for how to build and implement HTE capabilities. Specific examples of high-throughput experimental design and execution in the context of organic synthesis are included. Volume 1 covers general topics, including the history of HTE and its transition from highly specialized groups to more general adoption across industry and academia, along with the current state-of-the-art with respect to high-throughput technologies, including photo- and electrochemistry, nanoscale reactions, and others. Chapters are authored by practitioners in industry and academia, showcasing how a high-throughput mindset enables rapid optimization of existing chemistries and discovery of new reactivity."--
Download or read book Horizons in Bioprocess Engineering written by Ravindra Pogaku and published by Springer Nature. This book was released on 2019-10-12 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is divided into four parts that outline the use of science and technology for applications pertaining to chemical and bioprocess engineering. The book endeavors to help academia, researchers, and practitioners to use the principles and tools of Chemical and Bioprocess Engineering in a pertinent way, while attempting to point out the novel thoughts associated with the brain storming concepts encountered. As an example, the ability to use case studies appropriately is more important, to most practitioners.
Download or read book Green Chemistry in Drug Discovery written by Paul F. Richardson and published by Humana. This book was released on 2021-10-26 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist for these techniques to be effectively implemented in the drug discovery process in a routine manner.
Download or read book Flow Cytometry written by Alice Longobardi Givan and published by John Wiley & Sons. This book was released on 2013-04-10 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flow cytometry continually amazes scientists with its ever-expanding utility. Advances in flow cytometry have opened new directions in theoretical science, clinical diagnosis, and medical practice. The new edition of Flow Cytometry: First Principles provides a thorough update of this now classic text, reflecting innovations in the field while outlining the fundamental elements of instrumentation, sample preparation, and data analysis. Flow Cytometry: First Principles, Second Edition explains the basic principles of flow cytometry, surveying its primary scientific and clinical applications and highlighting state-of-the-art techniques at the frontiers of research. This edition contains extensive revisions of all chapters, including new discussions on fluorochrome and laser options for multicolor analysis, an additionalsection on apoptosis in the chapter on DNA, and new chapters onintracellular protein staining and cell sorting, including high-speed sorting and alternative sorting methods, as well as traditional technology. This essential resource: Assumes no prior knowledge of flow cytometry Progresses with an informal, engaging lecture style from simpleto more complex concepts Offers a clear introduction to new vocabulary, principles of instrumentation, and strategies for data analysis Emphasizes the theory relevant to all flow cytometry, with examples from a variety of clinical and scientific fields Flow Cytometry: First Principles, Second Edition provides scientists, clinicians, technologists, and students with the knowledge necessary for beginning the practice of flow cytometry and for understanding related literature.
Download or read book Beyond the Molecular Frontier written by National Research Council and published by National Academies Press. This book was released on 2003-03-19 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Download or read book The Power of Functional Resins in Organic Synthesis written by Fernando Albericio and published by John Wiley & Sons. This book was released on 2008-12-17 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many books cover solid phase synthesis and combinatorial synthesis, this one is unique in its exclusive coverage of the other aspects of solid-phase synthesis. As such, it contains everything you need to know -- from supported reagents, to scavengers, resins, and the synthesis of biomolecules and natural products. An invaluable companion for all chemists and biochemists working in university research and industry.
Download or read book Supercomputing Frontiers written by Rio Yokota and published by Springer. This book was released on 2018-03-20 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: It constitutes the refereed proceedings of the 4th Asian Supercomputing Conference, SCFA 2018, held in Singapore in March 2018. Supercomputing Frontiers will be rebranded as Supercomputing Frontiers Asia (SCFA), which serves as the technical programme for SCA18. The technical programme for SCA18 consists of four tracks: Application, Algorithms & Libraries Programming System Software Architecture, Network/Communications & Management Data, Storage & Visualisation The 20 papers presented in this volume were carefully reviewed nd selected from 60 submissions.
Download or read book Materials Informatics and Catalysts Informatics written by Keisuke Takahashi and published by Springer Nature. This book was released on with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Machine Learning in Molecular Sciences written by Chen Qu and published by Springer Nature. This book was released on 2023-11-02 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Machine learning and artificial intelligence have propelled research across various molecular science disciplines thanks to the rapid progress in computing hardware, algorithms, and data accumulation. This book presents recent machine learning applications in the broad research field of molecular sciences. Written by an international group of renowned experts, this edited volume covers both the machine learning methodologies and state-of-the-art machine learning applications in a wide range of topics in molecular sciences, from electronic structure theory to nuclear dynamics of small molecules, to the design and synthesis of large organic and biological molecules. This book is a valuable resource for researchers and students interested in applying machine learning in the research of molecular sciences.
