Download or read book Protein Kinase C Protocols written by Alexandra C. Newton and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery that protein kinase C (PKC) transduces the ab- dance of signals that result in phospholipid hydrolysis, this enzyme has been at the forefront of research in signal transduction. Protein Kinase C Protocols covers fundamental methods for studying the structure, function, regulation, subcellular localization, and macromolecular interactions of PKC. Protein Kinase C Protocols is divided into 11 sections representing the major aspects of PKC regulation and function. Part I contains an introduction and a historical perspective on the discovery of PKC by Drs. Yasutomi Nishizuka and Ushio Kikkawa. Part II describes methods to purify PKC. Part III describes the standard methods for measuring PKC activity: its enzymatic activity and its stimulus-dependent translocation from the cytosol to the membrane. Part IV describes methods for measuring the membrane interaction of PKC in vivo and in vitro. Part V provides methodologies and techniques for measuring the ph- phorylation state of PKC, including a protocol for measuring the activity of PKC’s upstream kinase, PDK-1. Novel methods for identifying substrates are described in Part VI. Part VII presents protocols for expressing and analyzing the membrane targeting domains of PKC. Part VIII provides a comprehensive c- pilation of methods used to identify binding partners for PKC. Part IX describes pharmacological probes used to study PKC. The book ends with a presentation of genetic approaches to study PKC (Part X) and a discussion of approaches used to study PKC in disease (Part XI).
Download or read book Phosphorylation of Protein Kinase C by the Phosphoinositide dependent Kinase written by Erica Monique Dutil and published by . This book was released on 2000 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Phosphorylation of Protein Kinase C written by Andrew John Flint and published by . This book was released on 1990 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Kinase C written by Lodewijk V. Dekker and published by Springer Science & Business Media. This book was released on 2004-06-17 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. In this book, the most significant advances in recent basic research on Protein Kinase C are explained by active researchers in the field. The first seven chapters provide a comprehensive account of the fundamental structural and biochemical properties of Protein Kinase C. The remaining chapters contain overviews of the function of Protein Kinase C, both in lower organisms and in mammalian cells, the latter with a focus on immune cells and nerve cells. This book is the only recent publication devoted entirely to Protein Kinase C and forms a major point of reference for those active in the field. In addition it will appeal to those with a general interest in biochemistry, cell biology, immunology and neurobiology.
Download or read book Processing of Protein Kinase C by Phosphorylation written by Jaime A. Marach and published by . This book was released on 2006 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Protein Kinase C Activation and Substrate Phosphorylation written by Phillip S. Leventhal and published by . This book was released on 1993 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Phosphorylation written by Friedrich Marks and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature.
Download or read book Advances in Protein Kinase C Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Kinase C Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protein Kinase C in a concise format. The editors have built Advances in Protein Kinase C Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protein Kinase C in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Protein Kinase C Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Protein Phosphorylation in Cell Growth Regulation written by Michael J. Clemens and published by CRC Press. This book was released on 1996-12-03 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this text is to integrate the processes of protein phosphorylation and dephosphorylation into the complex pathways by which cellular proliferation is driven, bringing together the many different systems of control implicated in the regulation of cell growth. Presents a survey of protein phosphorylation roles in the control of cellular proliferation and differentiation. A large number of protein kinases and phosphatases have been characterised in higher cells, and have been shown to be involved in signal transduction pathways by which growth factors, mitogens, and extracellular agents exert proliferative effects on cells. Important subjects covered include control of gene expression at the transcriptional and translational levels, and roles of the cdk kinases and cyclins in cell cycles regulation. Describes all major families of protein kinases of significance to growth regulation.
Download or read book Characterization of the Phosphorylation of Protein Kinase C by Phosphoinositide dependent Kinase 1 written by Ginette Thibault and published by . This book was released on 2002 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Phosphorylation of protein kinase Cs (PKCs) by phosphoinositide-dependent kinase I (PDK) is critical for PKC activity. In the nervous system of the marine mollusk Aplysia, there are only two major PKC isoforms, the calcium-activated PKC Apl I and the calcium-independent PKC Apl II, and both PKCs are persistently activated during intermediate memory. We monitored the PDK-dependent phosphorylation of PKC Apl I and PKC Apl II using phosphopeptide antibodies. PDK phosphorylation of PKCs was not sensitive to inhibitors of PI-3 kinase, PKC, nor to expression of a kinase-inactive PDK. Phosphorylation of a kinase inactive PKC was reduced, likely due to dephosphorylation. Localization of PDK-phosphorylated PKC Apl II using immunocytochemistry revealed an enrichment of phosphorylated PKC Apl II at the plasma membrane. These data suggest that increased PDK phosphorylation of PKC Apl II is important for persistent kinase activation. PKC phosphorylation at the PDK site is not affected by the presence of a kinase-inactive form of PDK. Using GFP (green fluorescent protein)-tagged PKC, which was microinjected into neurons, we determined that PKC was translocated to the juxta-membrane region by the PKC activator 4beta-phorbol ester 12,13-dibutyrate (PDBu)." --
Download or read book Phosphorylation of Protein Kinase C written by Stephan Gysin and published by . This book was released on 1998 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Kinase mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Phosphorylation of Elongation Factor 1 by Protein Kinase C and Regulation of Elongation and Nucleotide Exchange Activity written by Holme Ingraban Peters and published by . This book was released on 1993 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Reversible Protein Phosphorylation in Cell Regulation written by R.L. Khandelwal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, published in association with the journal MOLECULAR AND CELLULAR BIOCHEMISTRY, is dedicated to Ed Krebs and Eddy Fischer in celebration of their 1992 Nobel Prize in Physiology and Medicine. Reversible protein phosphorylation is a research field pioneered and developed by Krebs and Fischer. This book contains short reviews and original research papers contributed by Krebs and Fischer's coworkers, both former and current. The contents reflect the two-way interaction between protein phosphorylation and other biomedical research fields. The chapters are grouped into four sections. The first two deal with structure/function aspects of protein kinases and protein mechanisms. Unlike many other research fields, which undergo periods of intense activity and productivity followed by relative calm, the protein phosphorylation field enjoyed continued growth both in scope and intensity, and the pace of this growth has increased markedly in recent years. This volume will provide a glimpse of the dynamism and diversity of the research activity representative of the current state of the field.
Download or read book Spatiotemporal Dynamics of Protein Kinase C Signaling written by Jonathan D. Violin and published by . This book was released on 2003 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Kinase C induced Phosphorylation of MARCKS and GAP 43 in SK N SH Human Neuroblastoma Cells written by Adam Marc Goldsmith and published by . This book was released on 1997 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Kinase C mediated Phosphorylated Proteins and Their Relation to Ornithine Decarboxylase Induction in T24 Cells written by Rey-Chen Pong and published by . This book was released on 1988 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
