Download or read book The Oncogene and Tumour Suppressor Gene Factsbook written by Robin Hesketh and published by Elsevier. This book was released on 1997-07-11 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. Includes much new data on this fast-moving field, including newly discovered oncogenes Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes Contains more than 2000 terms for reference and further research Revised to included signaling pathways, apoptosis, and metastasis

Download or read book The Oncogene Factsbook written by Robin Hesketh and published by . This book was released on 1995-01-01 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oncogene FactsBook is a condensed version of the Oncogene Handbook, in the FactsBook Series format. The key information on oncogenes, tumor viruses, and tumor suppressor genes has been selected from the Handbook and arranged in the series style to that the essential information is readily accessible. The introduction summarizes the principal developments in our understanding of oncogenes, the presente position with regard to gene therapy for human cancers, and discusses patterns of oncogene expression in human tumors. Chapter 2 contains tables of the major categories of oncogenes that include a summary of the properties of those oncogenes which do not have individual sections. Chapter 3 covers the individual oncogenes in a constant format for each entry. DNA tumor viruses and tumor suppressor genes are considered separately in two sections. The minimum number of references has been included in order to give the reader rapic access to the literature in the key areas of structure and function of each gene and its product. The emphasis has thus been placed on listing the most up-to-date references, rather than an extensive bibliography. The Oncogene FacsBook contains more that 60 entries on oncogenes including: JUN, MAS, MYC, MAX, and RAS, as well as DNA tomur viruses, tumor suppressor genes, and essential introductory material. * Individual Oncogene Entries include: * Identification * Related genes * Chromosomal Location and Mass * Cellular Location * Tissue Distribution * Protein function * Cancer * Amino acid Sequence * Domain structure * Database accession numbers * Key references

Download or read book Tumor Suppressor Genes written by Katherine R. Polinsky and published by Nova Publishers. This book was released on 2007 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: A tumour suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor. Unlike oncogenes, tumor suppressor genes generally follow the 'two-hit hypothesis', which implies that both alleles that code for a particular gene must be affected before an effect is manifested. This is due to the fact that if only one allele for the gene is damaged, the second can still produce the correct protein. However, there are cases where mutations in only one allele will cause an effect. A notable example is the gene that codes for p53. Tumor suppressor genes, or more precisely, the proteins for which they code, either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both. This book presents new and important research from throughout the world.

Download or read book Tumor Suppressor Genes written by Wafik S. El-Deiry and published by . This book was released on 2003 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics. Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect.

Download or read book Tumor Suppressor Genes in Human Cancer written by David E. Fisher and published by . This book was released on 2014-01-15 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oncogenes and Tumor Suppressor Genes written by F. Macdonald and published by Taylor & Francis. This book was released on 1991 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the last few years has shown that deranged oncogenes or tumour suppressor genes play a major role in the development of many cancers. First discovered in obscure animal viruses and rare cancers, they have emerged over the past decade as key regulators of the growth and metabolism of normal cells. Defining the state of these genes is relevant to the diagnosis and prognosis of tumours. Now, the focus of attention is turning to ways of attacking abnormal oncogenes or replacing defective tumour suppressor genes as a new approach to the treatment of cancer.

Download or read book Oncogenes written by Geoffrey M. Cooper and published by Jones & Bartlett Pub. This book was released on 1990 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this authoritative text details major advances and developments in the field, such as the identification of many new tumor suppressor genes and the striking progress in understanding signal transduction pathways leading to cell proliferation. Oncogenes, Second Edition, addresses the needs of advanced undergraduates, graduate students, medical students, physicians, and scientists by examining the current state of oncogene study and where future research may lead.

Download or read book The Oncogene Handbook written by Robin Hesketh and published by . This book was released on 1994 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been an audible clamour for a comprehensive digest of the vast and exciting literature on the molecular biology of cancer. The Oncogene Handbook fulfills this need, providing a definitive guide to the facts about the genes involved in cancer. This compendium summarizes the clinical association and molecular properties of all known oncogenes and tumour suppressor genes, providing instant access to information on any particular facet of the gene of protein. Data covering gene structure and location, mRNA size and the half-life mass, cellular and tissue location, protein structure and function, sequence, databank file name and accession number is clearly and logically presented. This vital reference work will provide the understanding that will fuel further progress in this field, and will be an invaluable resource for research workers and clinicians as well as senior undergraduates and pre-clinical students with an interest in carcinogenesis. Robin Hesketh is a member if the Department of Biochemistry, University of Cambridge, where his principal research interest is in the control of eukaryotic cell growth. He was previously a staff member of the National Institute for Medical Research, London and has also worked in North America, Australia and at the European Molecular Biology Laboratory at Heidelberg.

Download or read book The Gene Knockout Factsbook Two Volume Set written by and published by Academic Press. This book was released on 1998-10-26 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FactsBooks Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by Molecular Medicine Today, and "essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format and drawing from meticulous research, the Factsbooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. The Gene Knockout FactsBook contains entries, grouped into subject disciplines, covering immunology, neurobiology, development, cancer, and other knockouts. It describes more than 600 gene knockouts described and listed in alphabetical order for easy reference. Key Features * Entries provide information on: * general description of the protein and its function * gene symbol and database accession number * knockout construct * mouse phenotype * key references

Download or read book Introduction to Cancer Biology written by Robin Hesketh and published by Cambridge University Press. This book was released on 2013 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise overview of the fundamental concepts of cancer biology, ideal for those with little or no background in the field. From cancer epidemiology and the underlying mechanisms, through to tumour detection and treatment, the comprehensive picture revealed will enable students to move into the cancer field with confidence.

Download or read book Cancer written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2007-07-31 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an editorial board containing 11 Nobel laureates, this invaluable collection of high-quality articles on cancer biology is taken from the highly acclaimed R.A. Meyer's Encyclopedia. Clearly divided into three main sections, this ready reference covers molecular mechanisms, organ specific cancers, as well as diagnostic and therapeutic approaches. The articles are uniformly structured for ease of use, carefully designed to aid readers of all levels of expertise. To this end, each chapter includes a glossary of the most important keywords, a concise summary of the article and comprehensive literature references.

Download or read book The Leucocyte Antigen Factsbook written by A. Neil Barclay and published by Elsevier. This book was released on 1997-06-22 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: A volume in the popular FactsBook Series, the First Edition of The Leucocyte Antigen FactsBook was hugely successful. The new Second Edition has been completely revised, updated, and expanded by 65% to include new findings and up-to-date key references. The introductory chapters have also been updated, especially in terms of nomenclature, the role of the World Wide Web, and new structural data. The Leucocyte Antigen FactsBook, Second Edition contains more than 200 entries, with approximately 70 new entries, on all the molecules specifically expressed in the surface of cells of the haematopoietic system, including all characterized CD antigens, antigen receptors, MHC antigens, adhesion molecules, and cytokine receptors. This FactsBook will be of enormous value to immunologists, cell biologists, biochemists, and endocrinologists. Key Features* Completely up-to-date* Revised and expanded to include over 70 new entries* More than 200 entries in total, plus additional introductory material* New structural data* New nomenclature for CD and related molecules covered

Download or read book Progress in Haematology Volume 2 written by Christopher J. Pallister and published by Cambridge University Press. This book was released on 2000-01-02 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haematology is a rapidly changing subject, and it is therefore difficult for students to attain the level of knowledge required to get the most from their studies and to interpret scientific papers. This text is intended to bridge the gap between what students know and "cutting edge" advances.

Download or read book The Immunoglobulin FactsBook written by Marie-Paule Lefranc and published by Gulf Professional Publishing. This book was released on 2001-05-29 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field. The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.

Download or read book The Nuclear Receptor FactsBook written by Vincent Laudet and published by Gulf Professional Publishing. This book was released on 2002 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure, Isolation, DNA binding properties, Ligands, Expression, Target genes, Knockouts, Disease association, Gene structure, promoter and isoforms, Chromosomal location, Amino acid sequences, Key references

Download or read book The Complement FactsBook written by Scott R. Barnum and published by Academic Press. This book was released on 1999-10-28 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information including cDNA and gene structure for all proteins Introduces complement function, simply described for each function Data is as up-to-date as possible, including unpublished work from many contributors Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, familiesEach chapter has been written by an expert in the field Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: Alternative nomenclature, Physiochemical properties, Structure and function, Tissue distribution and regulation expression, Protein sequence/modules, Chromosomal location, Genomic structure, Database accession numbers, Deficiency and polymorphic variants, Key references

Download or read book The HLA FactsBook written by Steven G.E. Marsh and published by Elsevier. This book was released on 1999-12-13 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists Up-to-date, complete listing of HLA alleles Invaluable reference resource for immunologists, geneticists, and cell biologists Combines both structural and functional information, which has never been compiled in a single reference book previously Serological specificity of allotypes Identity of material sequenced including ethnic origin Database accession numbers Population distribution Peptide binding specificities T cell epitopes Amino acid sequences of allotypes Key references