Download or read book The Neurobiology of Multiple Sclerosis written by and published by Academic Press. This book was released on 2007-06-07 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the “cause and the “cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.
Download or read book Multiple Sclerosis As A Neuronal Disease written by Stephen Waxman and published by Elsevier. This book was released on 2005-05-27 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis * Places MS in a new and important perspective that promises to open up new therapeutic avenues * Superbly illustrated and referenced
Download or read book Myelination and Demyelination written by Seung U. Kim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: In June 1987, neurobiologists, immunologists, molecular biologists, virologists and neurologists from several countries met in Vancouver to discuss recent advances of relevance to multiple sclerosis. The symposium was a part of the 22nd Canadian Congress of Neurological Sciences meeting and was sponsored by funds from the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada. The presentations covered five major topics: basic neurobiology, molecular biology, the role of viruses in demyelination, immune function and dysfunction in multiple sclerosis, and clinical magnetic resonance imaging studies. It was heartening to note that scientists from several different disciplines were working towards a common end-point: the understanding and treatment of multiple sclerosis. In this book, speakers at the symposium have each presented a chapter of their findings and discussions. In addition, some non-participants at the symposium have been invited to submit chapters in order to give this volume a more complete scope. It is hoped that the reader will find this book a useful reference for several subjects of interest to multiple sclerosis. In closing, I would like to thank the following for their help and support: the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada for their financial support; the contributors of this book for their manuscripts; Dr. A. Eisen, Mrs. K. Eisen, Mrs. P. Bodnarchuk and Mrs. M. Kim for their efforts in planning and organizing the symposium; and Ms. Catherine Schikowski for her secretarial assistance. Seung U. Kim, M.D. Ph.D.
Download or read book Myelin Repair and Neuroprotection in Multiple Sclerosis written by Ian D. Duncan and published by Springer Science & Business Media. This book was released on 2012-08-31 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myelin Repair and Neuroprotection in Multiple Sclerosis presents an up-date on the translational potential of promoting remyelination in multiple sclerosis (MS). A number of research frontiers still exist in this challenging disease. The cause remains elusive, preventing breakthroughs in its prevention. The move towards oral immunomodulatory therapies has been a major advance, as has the finding of new genes linked to susceptibility that may open the door to new therapeutic approaches. However, a frontier that has been making significant strides in recent years has been that surrounding the neurobiology of myelin regeneration and axon protection: such have been the advances that clinical translation is on the cusp of being achieved. Two broad approaches to therapeutic enhancement of remyelination are envisaged: promoting endogenous remyelination by targeting cells present in the CNS, or, replacing lost myelinating cells from exogenous sources. Current research on oligodendrocyte biology, the pathology of MS, imaging of lesions and the biology of remyelination are paving the way toward opening this new translational frontier. Professor Duncan and Professor Franklin have assembled a broad group of experts in the fields of glial cell biology, neuropathology, radiology and clinical neurology to provide the background toward taking remyelination from experimented models into MS patients.
Download or read book Primer on Multiple Sclerosis written by Barbara S. Giesser and published by Oxford University Press. This book was released on 2016-01-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primer on Multiple Sclerosis, 2nd Edition is an updated reference manual for the practicing clinician. It covers the range of information needed to treat persons with MS, beginning with basic science and immunopathology, thorough differential diagnosis, symptom management and disease modifying therapies. This essential book also includes material covering new and experimental strategies as well as a review of commonly used complementary and alternative modalities that are used by persons with MS.Multiple Sclerosis (MS) is the most common demyelinating disease of the CNS and the third most common cause of disability among young adults. The complex management issues that are often present in the care of individuals with MS may demand the participation of health care professionals from a variety of disciplines, although the team is usually led by a neurologist. It is therefore essential for the neurologist to have a thorough grounding in the basic science and clinical phenomenology of MS. In this second edition of Primer on Multiple Sclerosis, the latest updates on therapeutics are provided, including new medications that have been FDA- approved since the first edition. Includes new diagnostic criteria, as well as any advances made in current diagnostic techniques, e.g. new imaging metrics. Important new information in the basic sciences and pathophysiology of MS is provided as well as newer epidemiologic studies. Treatment algorithms for common symptoms will be expanded, as well as any new guidelines for switching medications for Disease Modifying treatment "failures". The chapter on alternative and complimentary therapies discusses new research on CCSVI. The chapter on legal issues includes information on the putative effect of the Affordable Health Care Act on access to neurologic care and treatments. Finally, there is expanded discussion of progressive forms of MS both from a basic science and treatment perspective.
Download or read book Handbook of Multiple Sclerosis written by Stuart D. Cook and published by CRC Press. This book was released on 2006-03-13 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filled with an abundance of reader-friendly and quick-reference tables and figures, this Fourth Edition spans the etiology, epidemiology, clinical features, diagnosis, pathology, and treatment of multiple sclerosis (MS). Surpassing other texts on the topic, this reference provides recommendations and research updates from renowned authorities in th
Download or read book Multiple Sclerosis written by Moses Rodriguez and published by Oxford University Press. This book was released on 2013-05-17 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest edition to the 'Contemporary Neurology Series' will fill one of the few remaining 'neurologic gaps' within the Series. 'Multiple Sclerosis,' written solely by Moses Rodriguez, Orhun Kantarci and Istvan Pirko of the Mayo Clinic in Rochester, MN will offer proven, effective treatments for specific presentations and symptoms of multiple sclerosis along with a pathophysiological explanation of why they work. It bridges a needed gap between overly simplistic therapy manuals and basic science texts that discuss human disease only insofar as it mimics what is observed in animal models of the disease in the laboratory. Additionally, it seeks to offer an efficient integrative approach to symptomatic treatment to avoid over-medication and side effects. It discusses the heterogeneous causes of the disease and the need to develop individualized treatments that address the basic pathophysiologic processes that characterize each patient's disease with the future goal of individualized medicine. 'Multiple Sclerosis' covers both the basic research aspects of MS: epidemiology, neuropathology, genetics, and immunology as well as the treatment options associated with the MS patient: sleep, steroids, pharma, neuropsychology, and growth factors (to name a few). 'Multiple Sclerosis' will focus on the medical treatment - drug treatment - of MS rather than on physical medicine and rehabilitation (not the author's strength). The authors will also make ample use of flow diagrams, bulleted points, and tables to help the reader better understand MS and its etiology and treatment.
Download or read book Curing MS written by Howard L. Weiner, M.D. and published by Harmony. This book was released on 2007-12-18 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: What causes multiple sclerosis? When will there be a cure? Dr. Howard Weiner has spent nearly three decades trying to find answers to the mysteries of multiple sclerosis, an utterly confounding and debilitating disease that afflicts almost half a million Americans. Curing MS is his moving, personal account of the long-term scientific quest to pinpoint the origins of the disease and to find a breakthrough treatment for its victims. Dr. Weiner has been at the cutting edge of MS research and drug development, and he describes in clear and illuminating detail the science behind the symptoms and how new drugs may hold the key to "taming the monster." From the "Twenty-one Points" of MS--a concise breakdown of the knowns and unknowns of the disease--to stories from the frontlines of laboratories and hospitals, Curing MS offers a message of hope about new treatments and makes a powerful argument that a cure can--and will--be found.
Download or read book Translational Neuroimmunology in Multiple Sclerosis written by Ruth Arnon and published by Academic Press. This book was released on 2016-05-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development. Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and multiple sclerosis Contains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology
Download or read book Navigating Life with Multiple Sclerosis written by Kathleen Costello and published by Brain and Life Books. This book was released on 2015 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Navigating Life with Multiple Sclerosis will serve as a practical guide for meeting the challenges of this life-long disease. MS may cause a myriad of symptoms and varies greatly from person to person. The authors demystify MS and offer practical solutions and guidance based upon their extensive combined clinical and research experience. The book tackles many of the common symptoms experienced by the person with MS and looks into the future to explore where research is headed. If you are newly diagnosed or have been living with MS for years, this book is an invaluable guide.
Download or read book Magnetic Resonance Spectroscopy in Multiple Sclerosis written by Massimo Filippi and published by Springer Science & Business Media. This book was released on 2001 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".
Download or read book Brain and Spinal Cord Atrophy in Multiple Sclerosis written by Robert Zivadinov and published by Nova Publishers. This book was released on 2005 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.
Download or read book From Neuroscience to Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2004-11-05 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field
Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Download or read book Handbook of Multiple Sclerosis written by Stuart D. Cook and published by CRC Press. This book was released on 2001-03-30 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reporting on the latest advances made in treating multiple sclerosis (MS) and continuing the high standards set by earlier editions, the Handbook of Multiple Sclerosis, Third Edition examines a wide range of topics from etiology to treatment options. Analyzes recent developments in the natural history, immunopathology, lesion evolution, and
Download or read book McAlpine s Multiple Sclerosis written by Alastair Compston and published by . This book was released on 1998 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the latest edition of the classic book on the subject of multiple sclerosis. An international group of authors has been involved in updating this edition which features more information on imaging and investigations, and a new chapter on neurobiology and glial development.
Download or read book Multiple Sclerosis written by Alireza Minagar and published by Biota Publishing. This book was released on 2014-09-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis [MS] is one of the most common auto-immune-mediated diseases of the human central nervous system [CNS] which affects young adults and usually causes significant neurological disability. Currently, the causes of MS are still unclear, a cure for MS remains elusive and the effectiveness of treatment varies significantly among individuals. Clinical features and neurological deficits stemming from this progressive neurological disease are diverse since MS potentially affects human CNS at all levels from brain to the end of spinal cord. The triggering event for development of MS remains unknown. Immunopathogenesis of MS involves a number of steps which include activation of peripheral leukocytes against putative CNS antigen(s), interactions of the activated leukocytes with inflamed cerebral endothelial cells, transendothelial migration of activated lymphocytes and macrophages to the CNS milieu, and further propagation of the massive immune response within the CNS. Such massive immune activation leads to loss of myelin-oligodendrocyte complex. Several immune cell types and mediators of the immune-inflammatory response actively contribute to pathogenesis of MS. Genetic factors are also believed to play a central role in the development of most forms of MS. Another important but much unrecognized and under-researched feature of MS immunopathology is “neurodegeneration.” Neuronal loss and axonal degeneration are the core components of irreversible and permanent CNS atrophy and disability in MS. What we call MS in reality is a heterogeneous group of diseases and at least four distinct immunopathological subtypes of MS with dissimilar responses to therapy with immunomodulatory agents exist. MS is a clinical diagnosis, however, its diagnostic process is much facilitated by utilization of laboratory and neuroimaging studies. Present therapies of MS are either immunomodulatory agents or immunosuppressive and mainly target the peripheral immune system with the intention to ameliorate the severity of acute relapses, decrease annual relapse rate, and improve MRI lesions. Currently, much research activity is being conducted to better understand the fundamental disease mechanisms of MS and find more effective and safer treatments for this incurable disease. This book presents an overview of MS as a disease with neuroinflammatory and neurodegenerative features and the authors discuss the most recent findings about MS and its treatment. Table of Contents: Introduction / Clinical Features of Multiple Sclerosis / Pathophysiology of Multiple Sclerosis / Neuroimaging of Multiple Sclerosis / Diagnosis of Multiple Sclerosis / Treatment of Multiple Sclerosis / Prognosis of Multiple Sclerosis / Concluding Remarks . References
