Download or read book Comprehensive Hypertension E Book written by Gregory Y. H. Lip and published by Elsevier Health Sciences. This book was released on 2007-06-28 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book. Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume. See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations. Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis. Get specific insight into prevention and treatment of hypertension in special populations. Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.

Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Download or read book Endocrinology written by Shlomo Melmed and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, this new edition succinctly summarizes in 450 pages the latest findings on hormone secretion and hormone action, as well as all the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in man and the lower species, and the mechanisms subserving hormone secretion.

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Download or read book The Natriuretic Hormones written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The title follows from the original demonstration by Dr. Hugh de Wardener in 1961 that a humoral agent is produced after extracellular volume expansion which results in a vigorous diuresis and natriuresis. Thus the name of "natriuretic hormone" was coined. In the years that followed several investigators pursued the search for the hormone. What resulted, however, was the discovery of several hormones with different characteristics, all of which were natriuretic. Initially it was found that the hormone was similar in action to ouabain or digoxin, hence the appelation of ouabain-like or digoxin-like. The hormone was found to be an inhibitor of Na-K-ATPase, which would fit with it being a cardiotonic steroid. On the other hand, neither ouabain or digoxin migrated on Sephadex gel filtration in the same locus as the hormone. Other investigators claim to have identified the hormone-initially as a vanadium-diascorbate, later as bufadienolides such as marinobufagenin, yet later as a macrocylic derivative of inorganic carbon suboxide with a molecular weight of 408 Da. Some support for the latter finding was derived from an earlier report that a semi-purified Sephadex-derived compound was found to have a molecular weight of about 12,000 Da but the active compound, when split from its carrier protein, had a molecular weight of exactly 408 Da. This compound had not been further identified. As further development was the demonstration by Bricker and colleagues that a natriuretic substance could be purified from uremic urine. This turned out to be a xathurenic acid derivative. Meanwhile the focus began to turn to natriuretic peptides derived from heart (ANF and BNP). These peptides have a shorter duration of action than the cardiotonic steroid-like hormone and ANF has proved to be most useful as a measure of heart failure. It should also be stressed that marinobufagenin, like ANF, is elevated in congestive heart failure, whereas the steroid-like hormone is depressed or absent in this state. This review will attempt to describe and contrast the properties of each of the proposed natriuretic hormones, including their locus on Sephadex separation, potency, duration of action, chemical structure (if known), behavior in hypertension, renal failure, heart failure, and brain disease. As most recent work has focussed on marinobufagenin, this hormone will be brought up to date by investigators in the field.

Download or read book Cellular Peptide Hormone Synthesis and Secretory Pathways written by Jens F. Rehfeld and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of hormonal regulation using intercellular peptide messengers dates back to the discovery of secretin in 1902. The concept was simple: A peptide is released from specific hormone producing cells, endocrine cells, into circulation upon stimulation of the cells. The peptide hormone travels via blood to its target, the cells of which are equipped with specific receptors for high-affinity binding of the particular peptide hormone. Receptor binding subsequently elicits action of the target cells. This concept has been seriously challenged by modern biochemistry and cell biology. Thus, it is now well established that the gene of a specific peptide hormone may be expressed in different types of endocrine cells, in neurons, and in some instances also in adipocytes, myocytes, osteoblasts, and immune cells. Today, only a few hormones – including the old master hormone insulin – represent the original endocrine paradigm. Instead, the widespread cellular synthesis now raises the qu- tion of how the body maintains the regulation of its functions by peptide hormones when a hormone may originate from a variety of cells.

Download or read book cGMP Generators Effectors and Therapeutic Implications written by Harald H. H. W. Schmidt and published by Springer Science & Business Media. This book was released on 2008-12-17 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Download or read book Oxford Textbook of Endocrinology and Diabetes written by John A.H. Wass and published by Oxford University Press, USA. This book was released on 2011-07-28 with total page 2158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its second edition, the Oxford Textbook of Endocrinology and Diabetes is a fully comprehensive, evidence-based, and highly-valued reference work combining basic science with clinical guidance, and providing first rate advice on diagnosis and treatment.

Download or read book Growth Hormone And The Heart written by Andrea Giustina and published by Springer Science & Business Media. This book was released on 2000-11-30 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth Hormone and the Heart endeavors to bring together knowledge that has been accumulated in the area of GH and the heart, from basic to clinical studies, by research groups working on this topic throughout the world. Lessons from different experimental models and from several human diseases (acromegaly, adult GH deficiency, heart failure) suggest to endocrinologists and cardiologists that GH may not only have a role in the physiology and pathophysiology of heart function, but that GH itself may have a place in the treatment of primary heart diseases (such as dilated cardiomyopathy) or of cardiac complications of hypopituitarism. Growth Hormone and the Heart will be a useful update of the research produced in the field of cardiovascular endocrinology. The Editors also hope that this book will serve as the primary step in the recognition of the wide physiological and clinical significance of GH and heart interactions.

Download or read book Thyroid and Heart Failure written by Giorgio Iervasi and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both thyroid dysfunction and heart failure show a high prevalence in the adult population. Frequently, in clinical practice, a multidisciplinary approach is useful to optimize the management of patients with these conditions. Although there is no doubt regarding the close link between cardiovascular pathophysiology and thyroid homeostasis, our understanding of this association is far from being exhaustive. Thyroid hormone regulates the expression of cardiac-specific functional contractile and structural proteins and plays a pivotal role in modulating both diastolic and systolic function as well as peripheral vascular resistance. The close relationship between thyroid and heart dysfunction is strongly supported by recent evidence demonstrating that an altered thyroid profile is a negative prognostic predictor in patients with heart failure. The treatment of chronic heart failure, especially in advanced stages of the disease, continues to be an open and challenging field. The potential of novel thyroid hormone therapies that address the molecular biology of thyroid dysfunction and heart failure thus represents an attractive area of multidisciplinary scientific interest. This book is a readable, integrated, and highly up to date presentation of the clinical, pathophysiological, and basic science aspects of thyroid–heart failure interactions. It addresses a complex subject in an approach that targets a large audience of readers.

Download or read book Cardiovascular Physiology Concepts written by Richard E. Klabunde and published by Lippincott Williams & Wilkins. This book was released on 2020-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice.

Download or read book Textbook of Nephro Endocrinology written by Ajay K. Singh and published by Academic Press. This book was released on 2009-01-12 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. - Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems - Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work - Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Download or read book An Introduction to Neuroendocrinology written by Richard E. Brown and published by Cambridge University Press. This book was released on 1994-01-27 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.

Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fish Endocrinology 2 Vols written by Manfred Reinecke and published by CRC Press. This book was released on 2020-03-05 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past two decades, fish endocrinology has witnessed exciting developments due to our increased knowledge at all levels of biological organizations, including molecular biology, cell biology, physiology and behavior. New insights into development, neurobiology, immunology and molecular genetics closely correlated with classical aspects of endocrinology and represent important contributions to our knowledge on regulatory processes of vertebrates, including fish. The purpose of this book is to overview major advances in numerous research areas of fish endocrinology. Most of the chapters not only review and discuss the state-of-the-art in the respective field, but also show perspectives of future research. The book will be of interest to scientists involved in basic fish research, comparative endocrinology, fisheries and aquaculture as well as for students of fish biology.

Download or read book The Natriuretic Hormones written by Harvey Craig Gonick and published by Frontiers Media SA. This book was released on 2015-11-24 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: The title follows from the original demonstration by Dr. Hugh de Wardener in 1961 that a humoral agent is produced after extracellular volume expansion which results in a vigorous diuresis and natriuresis. Thus the name of "natriuretic hormone" was coined. In the years that followed several investigators pursued the search for the hormone. What resulted, however, was the discovery of several hormones with different characteristics, all of which were natriuretic. Initially it was found that the hormone was similar in action to ouabain or digoxin, hence the appelation of ouabain-like or digoxin-like. The hormone was found to be an inhibitor of Na-K-ATPase, which would fit with it being a cardiotonic steroid. On the other hand, neither ouabain or digoxin migrated on Sephadex gel filtration in the same locus as the hormone. Other investigators claim to have identified the hormone-initially as a vanadium-diascorbate, later as bufadienolides such as marinobufagenin, yet later as a macrocylic derivative of inorganic carbon suboxide with a molecular weight of 408 Da. Some support for the latter finding was derived from an earlier report that a semi-purified Sephadex-derived compound was found to have a molecular weight of about 12,000 Da but the active compound, when split from its carrier protein, had a molecular weight of exactly 408 Da. This compound had not been further identified. As further development was the demonstration by Bricker and colleagues that a natriuretic substance could be purified from uremic urine. This turned out to be a xathurenic acid derivative. Meanwhile the focus began to turn to natriuretic peptides derived from heart (ANF and BNP). These peptides have a shorter duration of action than the cardiotonic steroid-like hormone and ANF has proved to be most useful as a measure of heart failure. It should also be stressed that marinobufagenin, like ANF, is elevated in congestive heart failure, whereas the steroid-like hormone is depressed or absent in this state. This review will attempt to describe and contrast the properties of each of the proposed natriuretic hormones, including their locus on Sephadex separation, potency, duration of action, chemical structure (if known), behavior in hypertension, renal failure, heart failure, and brain disease. As most recent work has focussed on marinobufagenin, this hormone will be brought up to date by investigators in the field.

Download or read book Greenspan s Basic and Clinical Endocrinology Tenth Edition written by David G. Gardner and published by McGraw Hill Professional. This book was released on 2017-10-13 with total page 941 pages. Available in PDF, EPUB and Kindle. Book excerpt: A full-color guide to the entire field of clinical endocrinology and its scientific underpinnings – updated with the latest breakthroughs and developments A Doody’s Core Title for 2021! Greenspan’s Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan’s is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management. Greenspan’s provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges across the lifespan. Here’s why Greenspan’s is an essential tool for learning how to manage endocrine patients: • The Tenth Edition is enhanced by updated content throughout each chapter • NEW CHAPTERS on Transgender Endocrinology and Disorders of Sexual Determination and Differentiation • Important chapter on Evidence-Based Endocrinology and Clinical Epidemiology • Concise, balanced coverage of both scientific and clinical principles that guide patient management • The best source for current concepts in endocrine pathophysiology to aid clinical decision making • The most practical, current insights into diagnostic testing • More than 270 full-color illustrations and clinical photographs If you are in need of a well-illustrated, completely up-to-date guide to the entire field of clinical endocrinology, this trusted classic belongs on your desk or computer.