Download or read book The Mechanistic Study and Synthetic Use of Carbohydrate modifying Enzymes written by Michael David Burkart and published by . This book was released on 1999 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Carbohydrate Modifying Biocatalysts written by Peter Grunwald and published by CRC Press. This book was released on 2016-11-25 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an actual overview of the structure, function, and application of carbohydrate-modifying biocatalysts. Carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure. Meanwhile, the situation changed with increasing knowledge about the key role carbohydrates play in biological processes such as recognition, signal transduction, immune responses, and others. An outcome of research activities in glycoscience is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases. Furthermore, the employment of carbohydrate-modifying biocatalysts—enzymes as well as microorganisms—will contribute significantly to the development of environmentally friendly processes boosting a shift of the chemical industry from petroleum- to bio-based production of chemicals from renewable resources. The updated content of the second edition of this book has been extended by discussing the current state of the art of using recombinantly expressed carbohydrate-modifying biocatalysts and the synthesis of minicellulosomes in connection with consolidated bioprocessing of lignocellulosic material. Furthermore, a synthetic biology approach for using DAHP-dependent aldolases to catalyze asymmetric aldol reactions is presented.
Download or read book Carbohydrate Active Enzymes written by K-H Park and published by CRC Press. This book was released on 2008-10-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although advances in biochemistry and biotechnology have sparked significant advances in carbohydrate-active enzyme research, the mechanism of catalytic reaction of carbohydrate-active enzymes is still not fully understood. Based on papers presented at the 2008 Agricultural Biotechnology Symposium held in Seoul, this comprehensive collection summarizes some of the most important research in the field of carbohydrate-active enzymes—focusing on the enzymatic reaction mechanism, structure-function relationship and role in the living organism. The text reviews the important results on new types of carbohydrate-active enzymes and their applications reported on at these meetings. Part one focuses on structure-function relationships of carbohydrate-active enzymes. Part two discuss functions and applications of carbohydrate-active enzymes, such as enzymes for grain processing and glycosidases and their mutants as useful tools for glycoside synthesis. With its distinguished editor and international team of contributors, Carbohydrate-Active Enzymes: Structure, Function, and Applications is an essential reference for research scientists, post-graduate students and those in the food industry with an interest in enzymes.
Download or read book Synthetic Strategies in Carbohydrate Chemistry written by Vinod Kumar Tiwari and published by Elsevier. This book was released on 2023-11-01 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry. Presents a practical and detailed overview on glycosylation methodology Covers automated glycosylation strategies in glycan synthesis Includes recent progress in the synthesis and significance of diverse thio-glycosides, C-glycosides, imino sugars and carbasugars Highlights the impact of enzymes in glycan synthesis Discusses the recent approaches for the synthesis of neoglycoconjugates
Download or read book Carbohydrate Modifying Biocatalysts written by Peter Grunwald and published by CRC Press. This book was released on 2011-10-19 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates have long been disregarded by the scientific community due to their complex structure and a lack of suitable experimental methods for structure determination. This book provides an overview of the structure, function, and application of carbohydrate-modifying biocatalysts. It explores glycoconjugates and carbohydrate-modifying enzymes
Download or read book Enzymes in Carbohydrate Synthesis written by Mark D. Bednarski and published by . This book was released on 1991 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only assessing the past, present, and future uses of enzymes to synthesize carbohydrates, this volume also illustrates the significance of carbohydrate chemistry and describes how the combination and use of modern enzyme chemistry can advance exploration in the field. Details research at the interface of chemistry and biology for carbohydrate chemistry by demonstrating how to integrate chemical reactions and biological techniques that can be used to synthesize complex bioactive monosaccharides, oligosaccarides, and glycoconjugates. Of particular interest are chapters by George Whitesides and Chi-Huey Wong covering the use of enzymes in monosaccharide synthesis, and Hindsgaul, Thiem, Nilsson, and Whitesides describing the use of activated sugar nucleosides and glycosyltransferases in the synthesis of oligosaccharides and polysaccharides.
Download or read book Synthetic and Mechanistic Studies in Carbohydrate Chemistry written by Kerr Carmichael Yule and published by . This book was released on 1964 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic and Mechanistic Studies in Carbohydrate Chemistry written by K. C. Yule and published by . This book was released on 1964 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Carbohydrate Chemistry and Biochemistry written by and published by Academic Press. This book was released on 2014-12-02 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry. Features contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field
Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical and Enzymatic Synthesis of Oligovalent Carbohydrate Glycopeptide and Aminoglycoside Recognition Elements written by Kathryn Marie Koeller and published by . This book was released on 2000 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex carbohydrates and glycoconjugates mediate a host of biologically and medicinally relevant processes. In this respect, multivalency has emerged as a recognition mechanism intimately associated with carbohydrate function. Selectin-ligand interactions provide an ideal system in which to explore this phenomenon, as high affinity and specificity are governed by distinct patterns of oligovalency. Toward this end, the chemoenzymatic synthesis of sialyl-trimeric-Lewis x was accomplished. This decasaccharide is exhibited on selectin glycoprotein ligands, and has been implicated in cell adhesion processes. Following the development of an efficient synthetic protocol, the target structure was assayed as an E-selectin ligand. The significance of the Lewis x repeats was assessed by comparison to the sialyl Lewis x tetrasaccharide. To investigate P-selectin interactions, the chemoenzymatic synthesis of complex sulfo-glycopeptides from the N-terminus of PSGL-1 was undertaken. The target structure represents both segments of a hetero-dimeric recognition element (tyrosine sulfate and a sLe x O -glycan) necessary for high affinity interactions with P-selectin. A synthetic method toward obtaining the sulfo-glycopeptide was first established, and the effect of the sulfate ester on glycosyltransferase-catalyzed construction of the O -glycan was then examined. Finally, multimerization also represents an avenue for the modulation of carbohydrate-RNA interactions. As such, the synthesis of aminoglycoside dimers as novel antibiotics that target the bacterial 16S rRNA A-site was achieved. RNA affinity and antibiotic potency were determined, and the ability of these unnatural bivalent molecules to inhibit aminoglycoside-modifying enzymes was assessed. Multivalency is a recognition mechanism employed in nature, and can be exploited synthetically to enhance ligand affinity for a receptor. Especially applicable to glycobiology, multivalency is emerging as a general characteristic of carbohydrate-ligand interactions. Research of this nature may provide an improved understanding of oligovalency in biological systems, as well as novel strategies for the design of pharmaceutical agents.
Download or read book Carbohydrates The Essential Molecules of Life written by Robert V. Stick and published by Elsevier. This book was released on 2010-08-06 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes.A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place.Therefore the book will provide a taste for the subject of glycobiology.Covering the basics of carbohydrates and then the chemistry and reactions of carbohydrates this book will enable a chemist to gain essential knowledge that will enable them to move smoothly into the worlds of biochemistry, molecular biology and cell biology. Includes perspective from new co-author Spencer Williams, who enhances coverage of the connection between carbohydrates and life Describes the basic chemistry and biology of carbohydrates Reviews the concepts, synthesis, reactions, and biology of carbohydrates
Download or read book Peptidoglycan modifying Enzymes written by Timin Hadi and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbohydrates in Drug Discovery and Development written by Vinod K. Tiwari and published by Elsevier. This book was released on 2020-07-31 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades. This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more. • Presents a practical and detailed overview of a wide range of carbohydrate systems including KDO, sialic acids, inositols, iminosugars, etc relevant for drug discovery and development. • Highlights the use of functionalized carbohydrates as synthons for the construction of various systems. • Covers recent developments in the synthesis of various glycohybrid molecules and vaccines. • Highlights the significance of heparin mimetics as tools for the modulation of biology. • Provides an impact of glycan microarrays and carbohydrate– protein interaction.
Download or read book ACS Directory of Graduate Research 1993 written by American Chemical Society. Committee on Professional Training and published by . This book was released on 1993 with total page 1700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research and Development in Progress written by U.S. Atomic Energy Commission. Division of Biology and Medicine and published by . This book was released on 1968 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
