Download or read book The Mathematical Modeling of Metabolic and Endocrine Systems written by Ewart R. Carson and published by . This book was released on with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Mathematical Modeling of Metabolic and Endocrine Systems written by Ewart R. Carson and published by . This book was released on 1983-02-25 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces the concepts, methods and techniques of model formulation, identification, and validation as applicable to metabolic and endocrine processes. Shows how modeling can be used to provide a concise description of complex dynamic processes, to test hypotheses concerning physiological and biochemical structure, and to estimate physiological quantities (parameters) that otherwise would not be directly accessible to measurement. Includes numerous examples and case studies.

Download or read book Mathematical Modeling of Endocrine Systems written by Darko Stefanovski and published by Frontiers Media SA. This book was released on 2022-01-04 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Thyroid Systems Engineering written by Simon Goede and published by River Publishers. This book was released on 2018-02-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a considerable amount of effort has been devoted, both in industry and academia, towards the behavioral modeling, evaluation and prediction of the hypothalamus pituitary thyroid system. Thyroid Systems Engineering targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology. Leveraging on the insights emerging from the unique combination of an electrical engineer working with a clinical thyroidologist, and both being scientists skilled in mathematics, the authors introduce this new discipline and field of scientific investigation aptly designated as Thyroid Systems Engineering. Readers will discover that mathematics can indeed model the behavior of the hypothalamus-pituitary-thyroid (HPT) axis. Focused on modeling, each of the eighteen chapters gives the reader a notion of the application of relevant mathematics to pertinent issues encountered in mainstream thyroidology. Many cellular processes resemble the flux of variables and states in a complex multi-parameter space through time analogous to current flow in electrical networks. It is then logical to apply the principles and physical laws of electrodynamics, electrical network theory, control systems theory and signal theory to many of the biological phenomena encountered in endocrinology. Such an approach is used liberally throughout the book and successfully yields elegant solutions to a number of models presented within. This book can serve as a reference to mathematical modeling in other aspects of endocrine physiology, and as the starting point for a fundamental course in medical modeling. It will appeal to postgraduates in electrical engineering, academic physicians and biomedical researchers. Further, readers equipped with advanced calculus, electrical network theory, control theory and signal theory should be able to follow the mathematical expositions that describe thyrotropic control. They represent a new discipline based on mathematical modeling in physiology applicable to medical diagnostics, measurement and treatment to cooperate in the clinical team and realize an optimized treatment for patients.

Download or read book Impulsive Mathematical Models of Endocrine Regulation written by Alexander Medvedev and published by Academic Press. This book was released on 2020-12-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Impulsive Mathematical Models of Endocrine Regulation demonstrates recently-developed mathematical models portraying pulse-modulated regulation in endocrine systems, taking a pragmatic engineering stance by starting with the necessary theoretical background on analytical tools, progressing through a number of mathematical models of increasing complexity, and illustrating the feasibility and fidelity of the mathematical constructs on actual biological data. Compared to a commonplace, theory-oriented book on dynamical systems and control which typically presents a group of design or analysis techniques, the book originates from a real-life problem of fundamental value and introduces mathematical tools that have specifically been devised to solve it. Presents results on impulsive mathematical models of endocrine regulation in a systematic, comprehensive and accessible manner Introduces researchers and engineers specializing in dynamical systems to a rapidly-growing topic Provides biomedical engineering and biological researchers with mathematical modeling and analysis tools for continuous systems using episodic feedback exemplified by non-basal endocrine regulation

Download or read book The Mathematical Modeling of Metabolic and Endocrine Systems written by Ewart R. Carson and published by . This book was released on 1983-02-25 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces the concepts, methods and techniques of model formulation, identification, and validation as applicable to metabolic and endocrine processes. Shows how modeling can be used to provide a concise description of complex dynamic processes, to test hypotheses concerning physiological and biochemical structure, and to estimate physiological quantities (parameters) that otherwise would not be directly accessible to measurement. Includes numerous examples and case studies.

Download or read book Mathematical Modeling in Nutrition and the Health Sciences written by Janet A. Novotny and published by Springer Science & Business Media. This book was released on 2003-10-31 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the proceedings of the 7th Mathematical Modeling in Experimental Nutrition Conference held at Penn State University July 29 until August 1, 2000. The book addresses the determination of optimal intakes of nutrients and food components to provide lifelong health and reduce incidence of disease. Mathematical modelling provides a means of rigorously defining the functions of a system and using a variety of conditions to stimulate responses. This volume presents the newest advances in modelling and related experimental techniques required to meet the new challenges currently facing nutrition and biological science.

Download or read book Mathematical Modeling in Experimental Nutrition written by Andrew J. Clifford and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrients have been recognized as essential for maximum growth, successful reproduction, and infection prevention since the 1940s; since that time, the lion's share of nutrient research has focused on defining their role in these processes. Around 1990, however, a major shift began in the way that researchers viewed some nutrients particularly the vitamins. This shift was motivated by the discovery that modest declines in vitamin nutritional status are associated with an increased risk of ill-health and disease (such as neural tube defects, heart disease, and cancer), especially in those populations or individuals who are genetically predisposed. In an effort to expand upon this new understanding of nutrient action, nutritionists are increasingly turning their focus to the mathematical modeling of nutrient kinetic data. The availability of suitably-tagged (isotope) nutrients (such as B-carotene, vitamin A, folate, among others), sensitive analytical methods to trace them in humans (mass spectrometry and accelerator mass spectrometry), and powerful software (capable of solving and manipulating differential equations efficiently and accurately), has allowed researchers to construct mathematical models aimed at characterizing the dynamic and kinetic behavior of key nutrients in vivo in humans at an unparalleled level of detail.

Download or read book Mathematics in Biology and Medicine written by Vincenzo Capasso and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Modeling Ruminant Digestion and Metabolism written by R.L. Baldwin and published by Springer Science & Business Media. This book was released on 1995-05-31 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of mminants in human food production; Whyan animal scientist would choose to model animal systems; Basic organization of this book; Modeling principIes and terminology; Classification of models; Objectives in modeling; The modeling process I objective statements, block diagrams, equation forms and parameterization; Steps in modeling; Setting the modeling objective; Block diagrams; Formulation of mathematical statements; Development of numerical inputs; The modeling process II - solution algorithms, model evaluations and parameter estimation; Model solution algorithms; Evaluation of management and research models; Evaluation and use of analytical models for parameter estimation; Decision support software; Animal energetic models; Thermodynamic concepts in nutrition; Historical development of bases for feeding system models; Energy requirements for maintenance and production; Equations used to estimate maintenance and costs of production; Components of maintenanace; Protein and amino acid models; Current protein and amino acid systems; Analytic models of amino aicd and protein metabolism; Dynamic modeling; Biology and algebraic models of ruminant digestion; The rumen microbes and their metabolism; Balance models of ruminant digestion; An analytical model of rumen digestion; Microbial growth elements; Biology and algebraic models of growth; Classical equations for growth; Nutritional models of growth; Concepts of lhe basic biology of growth used in mechanistic models; Biology of lactation; Decent evolution of feeding systems for lactating dairy cattle; An analytical model of nutrient transactions during lactation; Dynamic models of ruminant digestion; Early dynamic models; Current dynamic models; Dynamic models of ruminant adipose tissue metabolism; Evolution of steady-state balance model; Radioisotope tracer elemets; Dynamic models of ruminant mammary metabolism; Development of model inputs and initial parameters; Descriptions of a model of mammary gland metabolism; Dynamic models of liver and viscera metabolism; Overall structure and notation; Mechanistic, dynamic models of growth; Beef growth models; Sheep growth and metabolism model; Lactation Background on MOLL Y. CSL; The program MOLL Y. CSL; Evaluation and use of a growth and lactation model; Behavioral analyses; Sensitivity analyses; Bioeconomic analyse.

Download or read book Objective Medical Decision making Systems Approach in Acute Disease written by J.E.W. Beneken and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Objective medical decision~making has shown itself to be an emerging discipline which is sufficiently robust to promote its further development. This book identifies many important areas for applications in the field of acute patient care. The different approaches require testing, evaluation and mutual co~parisons to ensure that the right method is used to solve the existing problem. Medical sciences and patient care are increasingly supported by system sciences, resulting in growing multi- and interdisciplinary research and development areas. In this context, system sciences involve the methods, techniques, concepts and approaches obtained f~om disciplines such as mathematics, statistics, stochastic signal theory, fuzzy set theory, systems and control theory, signal analysis, pattern recogni tion, simulation, computer languages, structured programming, data base management and computer sciences. This book contains the papers of a workshop "Objective Medical Decision making f Systems approach in acute disease" which was initia ted and supported by the SWG/COMAC on Biomedical Engineering, Evaluation of Technology, Transfer and Standardization of CRM/CREST of the European Community. In setting up the original programme we have been assisted by a group of experts and for their cooperation we are very gratef.ul to S. Dawids, Copenhagen E. Epple, Tlibingen ; J. Jones, Harrow; L. Lambotte, Brussels C. Marchesi, Pisa and D. Robert, Lyon. The papers have been arranged in four groups, each followed by a brief synopsis. The four groups are : diagnosis, monitoring, therapy and control, and evaluation of criteria and procedures.

Download or read book Pathophysiology of Plasma Protein Metabolism written by Giulian Mariant and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a factual account of the proceedings of an international symposium on the pathophysiology of plasma protein metabolism, which was organised in October 1982 by the Plasmaprotein and Immunology Division of the C.N.R. Institute of Clinical Physiology at the University of Pisa (Italy). Several of the contributors are former members of the International Study Group on Plasma Protein Metabolism, the last meeting of which was held in Turin (Italy) in 1974, under the auspices of the scientific organisation of the same institute. The symposium took the form of a series of lectures, with the main objective of providing a positive contribution to the state of the art of several topics related to the kinetic and pathophysiological factors regulating the synthesis, distribution and degradation of plasma proteins. The first four chapters form a group, each one considering a special aspect of the kinetics of turnover and distribution of plasma proteins in general; particular attention is paid to the recent advances in the field of kinetic modelling, the choice of the best models and the optimisation of the experimental designs. The next seven chapters consider the regulation of synthesis, distribution and catab olism of various classes of plasma proteins including albumin, immunoglobulins, complement fractions and acute-phase proteins. The remaining chapters deal with metabolic studies of various plasma proteins (including tumour markers, coagUlation proteins and lipoproteins) in different disease states, such as malig nancies, coagulative disorders, malnutrition and the extensive group of athero sclerotic cardiovascular diseases.

Download or read book Biomedical Engineering Handbook 2 written by Joseph D. Bronzino and published by Springer Science & Business Media. This book was released on 2000-02-15 with total page 1528 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mathematical Modelling written by Murray S. Klamkin and published by SIAM. This book was released on 1987-01-01 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematics of Computing -- Miscellaneous.

Download or read book Endogenous and Exogenous Regulation and Control of Physiological Systems written by Robert B. Northrop and published by CRC Press. This book was released on 2020-11-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: From a biomedical engineering perspective, this book takes an analytic, quantitative approach to describing the basic components of physiological regulators and control systems (PRCs). In Endogenous and Exogenous Regulation and Control of Physiological Systems, the author provides grounding in the classical methods of designing linear and nonlinear systems. He also offers state-of-the-art material on the potential of PRCs to treat immune system ailments, most notably AIDS and cancer. The book focuses on certain "wet" physiological regulators, such as those using endocrine hormones as parametric control substances. Endogenous and Exogenous Regulation and Control of Physiological Systems includes simulations that illustrate model validations and the putative control of cancer and HIV proliferation. It explores novel, untried immunotherapies on the cutting-edge of PRC treatment and explores the latest technologies.

Download or read book Principles of Perinatal Neonatal Metabolism written by Richard M. Cowett and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, a stellar international group of contributors examines the various aspects of metabolism in the human adult during pregnancy, in the foetus, and in the new-born. This second edition has been completely updated and now has more than 17 new chapters. Divided into five sections, the book contains discussions of methodologies using molecular biology techniques, expanded coverage of central nervous system metabolism, and an entirely new section on organ-specific metabolism organised according to each organ-system. A must for every physician who cares for the pregnant patient and her child.

Download or read book Dynamic Systems Biology Modeling and Simulation written by Joseph DiStefano III and published by Academic Press. This book was released on 2015-01-10 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic Systems Biology Modeling and Simuation consolidates and unifies classical and contemporary multiscale methodologies for mathematical modeling and computer simulation of dynamic biological systems – from molecular/cellular, organ-system, on up to population levels. The book pedagogy is developed as a well-annotated, systematic tutorial – with clearly spelled-out and unified nomenclature – derived from the author’s own modeling efforts, publications and teaching over half a century. Ambiguities in some concepts and tools are clarified and others are rendered more accessible and practical. The latter include novel qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory; and analyzing structural and measurement (data) models for quantification feasibility. The level is basic-to-intermediate, with much emphasis on biomodeling from real biodata, for use in real applications. Introductory coverage of core mathematical concepts such as linear and nonlinear differential and difference equations, Laplace transforms, linear algebra, probability, statistics and stochastics topics; PLUS ....... The pertinent biology, biochemistry, biophysics or pharmacology for modeling are provided, to support understanding the amalgam of “math modeling” with life sciences. Strong emphasis on quantifying as well as building and analyzing biomodels: includes methodology and computational tools for parameter identifiability and sensitivity analysis; parameter estimation from real data; model distinguishability and simplification; and practical bioexperiment design and optimization. Companion website provides solutions and program code for examples and exercises using Matlab, Simulink, VisSim, SimBiology, SAAMII, AMIGO, Copasi and SBML-coded models. A full set of PowerPoint slides are available from the author for teaching from his textbook. He uses them to teach a 10 week quarter upper division course at UCLA, which meets twice a week, so there are 20 lectures. They can easily be augmented or stretched for a 15 week semester course. Importantly, the slides are editable, so they can be readily adapted to a lecturer’s personal style and course content needs. The lectures are based on excerpts from 12 of the first 13 chapters of DSBMS. They are designed to highlight the key course material, as a study guide and structure for students following the full text content. The complete PowerPoint slide package (~25 MB) can be obtained by instructors (or prospective instructors) by emailing the author directly, at: [email protected]