Download or read book The Investigation of the Structural and Functional Roles of Glycoprotein Oligosaccharides by Fourier transform Mass Spectrometry FTMS written by Ken Tseng and published by . This book was released on 2002 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Analysis of Oligosaccharides and Peptides Using External Source Fourier Transform Mass Spectrometry written by James Alan Carroll and published by . This book was released on 1995 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization and Structural Elucidation of Oligosaccharides by Matrix assisted Laser Desorption ionization Fourier Transform Mass Spectrometry written by Jinhua Zhang and published by . This book was released on 2004 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Glycosylation Advances in Identification Characterization and Biological Function Elucidation using Mass Spectrometry written by Ganglong Yang and published by Frontiers Media SA. This book was released on 2022-03-14 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of Protein bound Oligosaccharides Using Matrix assisted Laser Desorption ionization Fourier Transform Mass Spectrometry written by Hyun Joo An and published by . This book was released on 2004 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mass Spectrometry Based Glycoproteomics and Its Clinic Application written by Haojie Lu and published by CRC Press. This book was released on 2021 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: As one of the most extensive and important protein post-translational modifications, glycosylation plays very important roles in the organism and is associated with different physiological and pathological processes. Therefore, there has been increasing attention and need to characterize protein glycosylation sites, structures and their modification degree, in order to understand well their biological functions or look for potential biomarkers for disease diagnosis and treatment.Mass spectrometry (MS) is one of the most powerful tools to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more and more techniques have appeared and contribute to understanding the structure and function of glycoproteins and glycans. Therefore, this book demonstrates the progress that has been achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment, qualitative analysis, quantitative analysis and data analysis, together with their clinical applications. And some significant examples will be discussed to illustrate the principles, laboratory protocols and key implementation advice to ensure successful results.This book will serve as a valuable resource to appropriate techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine, and so on.

Download or read book Carbohydrate and Glycoconjugate Analysis written by Katherine N. Schumacher and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates and glycoconjugates play key roles in cellular processes, including signaling, immune response, and influencing protein stability and function. Advances in mass spectrometry (MS)-based methods for the investigation of glycosylation and oligosaccharide structure are being made, however due to the level of structural diversity and complexity of these biomolecules detailed characterization remains a challenge. This dissertation can be generally grouped into two sections; N-glycopeptide analysis and carbohydrate analysis.

Download or read book Analysis of Oligosaccharides by Matrix assisted Laser Desorption ionization Fourier Transform Mass Spectrometry written by Mark Thomas Cancilla and published by . This book was released on 1999 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Guide to Techniques in Glycobiology written by William J. Lennarz and published by Academic Press. This book was released on 1994-01-03 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Detailed procedures newly written for this volume * Extensive practical information * Rationale and strategies for carbohydrate chain analysis Among the topics covered: * Release of Oligosaccharides from Glycoproteins by Hydrazinolysis * Mass Spectrometry of Carbohydrate-Containing Biopolymers * High-resolution Polyacrylamide Gel Electrophoresis of Fluorophore-Labeled Reducing Saccharides * Capillary Electrophoresis of Oligosaccharides * Synthesis and Uses of Azido-Substituted Nucleoside Diphosphate Sugar Photoaffinity Analogs * Structural Analysis of Glycosylphosphatidylinositol Anchors * Identification of Polysialic Acids in Glycoconjugates

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2002 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Structure function Analysis of the Role of Glycoprotein linked Oligosaccharides in Aggregation stage Cell Cohesion in Dictyostelium Discoideum written by Sunita Verghese Cooke and published by . This book was released on 1991 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Glycopeptides and Glycoproteins written by Valentin Wittmann and published by Springer Science & Business Media. This book was released on 2007-02-13 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last 50 years molecular biology was dominated by the exploration of proteins and nucleic acids. Beside their role in energy metabolism, oligos- charides,which represent thethirdclass ofbiomacromolecules, have received less attention. Today it is well established that oligosaccharides are involved in many important biologicalregulation and recognition processes fromp- tein folding to cell-cell communication. Glycosylation of proteins is the most complexformofco-andposttranslationalmodi'cation. Thedeterminationof structure-function relationships, however, remains dif'cult due to the mic- heterogeneity of glycoproteins that exist in many different glycoforms. Thus chemical synthesis of glycoproteins and glycopeptides with de'ned glycan structures plays a pivotal role for the detailed determination of the role of protein glycosylation. This topic is covered by the ?rst two chapters of this bookdealingwiththechemicaland enzymatic synthesis ofglycopeptides and glycoproteins. The third chapter describes the construction of glycopeptide andglycoproteinmimetics containingnon-naturalstructuralelements. These so-calledneoglycopeptidesandneoglycoproteins,respectively,canprovide- sight on the importance of distinct structural elements on biological activity andmayhaveimproved propertiessuchasanincreased stability. Theappli- tion of synthetic glycopeptides, in many cases at the clinical level, as vaccines forbothcancerandHIVisthesubjectofthefourthchapter. Glycopeptide antibiotics are glycosylated secondary metabolites of bacteria and fungi that are synthesized by non-ribosomal peptide synthetases. Some of them serve as antibiotics of last resort in the treatment of nosocomial infections with enterococci and methicillin-resistant Staphylococcus aureus (MRSA) strains. Their structure, biosynthesis, and mode of action are summarized in the ?fth chapter. The last chapter covers current methods for the determination of high-resolution structures of glycopeptides and glycoproteins mainly based onNMRspectroscopy, X-raycrystallography,and molecular modeling.

Download or read book Structural and Functional Analysis of Oligosaccharides with a Novel and Versatile Fluorescent Tag written by Derek K. Toomre and published by . This book was released on 1997 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Glycomics written by Nicolle H. Packer and published by Humana Press. This book was released on 2009-07-16 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the significant contributions of carbohydrates to the functional diversity of the cell, the challenging study of the glycome has expanded beyond the research of carbohydrate experts and into the wider scope of the life sciences. To aid all scientists now delving into this vital subject area, Glycomics: Methods and Protocols collects a compendium of detailed laboratory protocols reflecting the increasing availability of sample preparation, chromatographic, electrophoretic, mass spectrometric, and bioinformatic tools specifically designed for the analysis of glycosylation. Leading researchers in the field address subjects such as glycoprotein and proteoglycan analysis, glycosylation structure determination, as well as various approaches to investigate the interaction between glycans and a variety of carbohydrate-recognizing proteins in order to aid exploration into the functional significance of the oligosaccharides. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glycomics: Methods and Protocols serves as a valuable guide for experimenters facing the challenges of glycan analysis in hope of providing further insights into the biology of cell-cell communication and interaction.

Download or read book Mass Spectrometric Studies on Glycoprotein Oligosaccharides written by Kenneth Eden Hogeland and published by . This book was released on 1993 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of the Structures and Distributions of O linked Oligosaccharides by Mass Spectrometry written by Yongming Xie and published by . This book was released on 2003 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Glycoproteins I written by J. Montreuil and published by Elsevier. This book was released on 1995-06-23 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part I covers modern advances in the determination of glycoprotein structure and in the biosynthesis of mammalian, bacterial, yeast, plant and insect glycoproteins. There are also two chapters on functional aspects (glycoprotein hormones and collagens). The content of the volume is very comprehensive in that, most contributors have focussed on discussing, in depth, the wealth of most recent advances in their field, and referring to previous reviews of older work for background information. This method can effectively produce a very wide subject coverage in a smaller number of chapters/volumes. The volume is an important information source for all glycobiologist researchers (senior investigators, post-doctoral fellows and graduate students), and as a good, comprehensive, reference text for scientists working in the life sciences.