Download or read book The Impact of Nanoparticle Surface Chemistry on Biological Systems written by Angie Sue Morris Thorn and published by . This book was released on 2017 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Moreover, silica nanoparticles are one of the most commonly used nanomaterials because they are easy to synthesize and their properties (such as size, porosity and surface chemistry) can be fine-tuned. Silica nanoparticles can be found in thousands of commercially available products such as toothpastes, cosmetics and detergents and are currently being developed for biomedical applications such as drug delivery and biomedical imaging. Our findings herein indicate that the surface chemistry of silica nanoparticles can have an effect on lung inflammation after exposure. Specifically, amine-modified silica NPs are considered to be less toxic compared to bare silica nanoparticles. Together, these studies provide insight into the role that material properties have on toxicity and allow for a better understanding of their impact on human and environmental health. The final aim of this thesis was to develop surface-modified nanoparticles for drug delivery applications. For this, biodegradable, polymeric NPs were used due to their inert nature and biocompatibility. Furthermore, polymeric NPs are excellent for loading drugs and using them as drug delivery vehicles. In this work, poly (lactic-co-glycolic acid) (PLGA) NPs were loaded with a therapeutic peptide. These NPs were then coated with chitosan (a mucoadhesive polymer) for the treatment of allergic asthma or coated with a small cationic mitochondrial targeting agent for the treatment of ischemia/reperfusion injury. Taken as a whole, this thesis sheds light on the impact of NPs on human health. First by providing useful toxological data for CuO and silica NPs as well as highlighting the potential of surface-modified polymeric NPs to be used in drug delivery-based applications.

Download or read book Microbial Interactions at Nanobiotechnology Interfaces written by R. Navanietha Krishnaraj and published by John Wiley & Sons. This book was released on 2021-11-02 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.

Download or read book Nanomaterial written by David G. Capco and published by Springer Science & Business Media. This book was released on 2014-03-28 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidly developing field of nanomaterials has expanded in many commercial areas. More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, including research into stem cells. Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues. While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function. In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer and an increasing number of new applications. This book investigates these areas and also includes new methods for assessment in cell biology and medicine.

Download or read book Nanoparticle Protein Corona written by Ashutosh Kumar and published by Royal Society of Chemistry. This book was released on 2019-08-02 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles have numerous biomedical applications including drug delivery, bone implants and imaging. A protein corona is formed when proteins existing in a biological system cover the nanoparticle surface. The formation of a nanoparticle–protein corona, changes the behaviour of the nanoparticle, resulting in new biological characteristics and influencing the circulation lifetime, accumulation, toxicity, cellular uptake and agglomeration. This book provides a detailed understanding of nanoparticle–protein corona formation, its biological significance and the factors that govern the formation of coronas. It also explains the impact of nanoparticle–protein interactions on biological assays, ecotoxicity studies and proteomics research. It will be of interest to researchers studying the application of nanoparticles as well as toxicologists and pharmaceutical chemists.

Download or read book Protein Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.

Download or read book Understanding Structure property Relationships at the Nano bio Interface for Delivery Applications written by Krishnendu Saha and published by . This book was released on 2014 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The surface chemistry of the nanomaterials creates an effective interface between two entirely different worlds: nanotechnology and biology. Understanding the interaction between nanomaterial surface chemistry and biological entities can be useful for a wide variety of biomedical applications as well as can provide crucial information for nanotoxicology. In my research, I have used gold nanoparticles as a model platform to synthesize a family of nanoparticles with atomic level control of their surface properties and probe their interaction with biological systems. First part of my research focused on the understanding the uptake mechanisms, toxicity, and hemolytic properties of cationic nanoparticles, an excellent gene delivery vectors, and provide design parameters to avoid toxic consequences. In the second part of my research, a new class of surface engineered antifouling nanomaterials were fabricated that can eschew plasma protein binding, providing opportunity to interrogate nano-biological behavior without any complications arising from the protein binding to nanomaterial surface. Since the surface chemistry of nanoparticles dictates the interaction between nanomaterials and biological entities, the findings in this thesis can be generalized to nanomaterials with a wide of variety of core materials of unique physical properties.

Download or read book Biointeractions of Nanomaterials written by Vijaykumar B. Sutariya and published by CRC Press. This book was released on 2014-07-29 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues. Written by leading scientists, the book focuses on the bio-interaction of nano materials, covering various techniques and tests which have been developed to evaluate the toxicity of materials at the nano level. The book highlights the challenges of bio-interactions of nano materials and possible solutions to those challenges. It addresses the assessment and characterization of nano systems in bio-environments, toxicity and bio-sensing devices for toxicity assessment, carbon nano tubes and pulmonary toxicity, and nano toxicity of solid lipid nanoparticles. It also discusses nano safety concerns and solutions, including the effects of nano particles on different organs and regulatory implications of nano materials. These particles may be used to encapsulate drugs, recognize biological markers, or visualize body tissues among many other possibilities, all enabling their widespread application in biology, medicine, and pharmaceutics. Indeed, these nano materials may have beneficial effects that have not even been imagined. This book gives you an understanding of the safety issues, how to assess for them, and how to mitigate them to move forward in research and development of new applications for nano materials.

Download or read book Nanoparticle Retention in Cells A Study of Biology written by Rekhta Bhatia and published by Self Publisher. This book was released on 2023-10-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In "Cellular Retention of Nanoparticles in Biology," author Ujjwal Rajan explores the role of cellular retention in the design and application of nanoparticles in biological systems. The book provides a comprehensive overview of the mechanisms that govern the retention and clearance of nanoparticles in cells, and how these processes can be harnessed for a wide range of applications, including drug delivery, imaging, and gene therapy. Rajan delves into the unique features of different types of nanoparticles, including their size, shape, surface chemistry, and charge, and how these properties influence their cellular uptake and retention. Throughout the book, Rajan presents a detailed analysis of the latest research and development in the field of nanoparticle-based technologies, including advances in nanoparticle synthesis, functionalization, and characterization. The book also explores the potential applications of cellular retention in a wide range of biomedical fields, including cancer therapy, regenerative medicine, and tissue engineering. With its clear and accessible writing style, "Cellular Retention of Nanoparticles in Biology" is an essential resource for researchers, engineers, and clinicians interested in the cutting-edge field of nanoparticle-based technologies and their potential to revolutionize the diagnosis and treatment of a wide range of diseases.

Download or read book Nanoparticle Toxicity and Compatibility written by Jorddy N. Cruz and published by Materials Research Forum LLC. This book was released on 2024-03-15 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on the interplay between nanoparticles and biological systems. Topics covered include the synthesis, characterization, and application of nanomaterials in tissue engineering; the interaction of nanoparticles with macromolecules; biomedical and food science applications; the cardiovascular toxicity of nanoparticles; colon targeted nano drug delivery systems; the biocompatibility and immunogenicity of nanoparticles; plasmon-enhanced biosensing applications; strategies for enhancing the biocompatibility of nanoparticles; the environmental impact of nanoparticles; as well as the intricate dynamics between nanoparticles and living organisms. Keywords: Tissue Engineering, Cardiovascular Toxicity, Drug Delivery Systems, Plasmon-Enhanced Biosensing, Biocompatibility of Nanoparticles, Ecotoxicology of Nanoparticles, Bioinspired Nanosynthesis, Hepatotoxicity, Nano Drug Delivery, Nanofabrication, Nanorobots, Plasmonics, Probiotics, Protein.

Download or read book Nanotechnology for Chemical and Biological Defense written by Margaret Kosal and published by Springer Science & Business Media. This book was released on 2009-06-11 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and unpredicted technologies are emerging at an unprecedented pace around the world. Communication of those new discoveries is occurring faster than ever, meaning that the unique ownership of a piece of new technology is no longer a sufficient position, if not impossible. In today’s world, recognition of the potential applications of a technology and a sense of purpose in exploiting it are far more important than simply having access to it. Technological surprise has and will continue to take many forms. A plethora of new technologies are under development for peaceful means but may have un- tended security consequences and will certainly require innovative counterme- ures. A relevant example is the tremendous development in biotechnology that has occurred since the advent of recombinant DNA and tissue culture-based processes in the 1970s. If US government agencies and the defense and academic commu- ties had more clearly recognized the potential for biotechnology to affect fun- mental security and warfighting doctrines 20 years ago, the situation today could be very different. Defense against chemical and biological weapons – from both states and nonstate actors – currently presents a threat that is difficult to predict and for which traditional solutions are increasingly less effective. Nanotechnology has emerged as a well-funded discipline that, like biote- nology, carries the potential for groundbreaking applications and the potential for unpredictable harm. The world is likely 20 years away from the full impact of the nanotechnology on defensive capabilities.

Download or read book Nanomaterial Biointeractions at the Cellular Organismal and System Levels written by Nilesh Sharma and published by Springer Nature. This book was released on 2021-03-26 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The range of nanomaterial applications has expanded recently from catalysis, electronics, and filtration to therapeutics, diagnostics, agriculture, and food because of unique properties and potentials of different nanoparticles and nanomaterials. Research shows that these exquisite particles can interact with an organism at the cellular, physiological, biochemical, and molecular levels. However, our knowledge of how they affect these changes, selectively or generally, in diverse organism or ecosystems is very limited and far from satisfactory. Data indicate that the biological function largely depends on the shape, size, and surface characteristics of the nanoparticles used besides life cycle stages of an organism. Therefore, this compilation will focus on the body of work carried out by distinguished investigators using diverse nanomaterials and plant and animal species. This book includes specific case studies as well as general review articles highlighting aspects of multilayered interactions, and targets not only research and academic scholars but also the concerned industry and policy makers as well.

Download or read book The Surface Chemistry of Nanoparticles Towards Biological and Engineering Applications written by Wayne Lin and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nanotoxicology written by Yuliang Zhao and published by . This book was released on 2007 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Modelling the Toxicity of Nanoparticles written by Lang Tran and published by Springer. This book was released on 2017-02-06 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: In today’s nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.

Download or read book Molecular Impacts of Nanoparticles on Plants and Algae written by Huseyin Tombuloglu and published by Elsevier. This book was released on 2024-03-26 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Impacts of Nanoparticles on Plants and Algae covers molecular mechanisms of plants/algae related to cellular uptake and translocation of nanoparticles, and genome, transcriptome, proteome, and metabolome responses against it. The book introduces readers to state-of-the-art developments and trends of nanoparticles and plants/algae including interaction of nanoparticles with biological compounds in vitro. Nanoscience and nanotechnology have rapidly been developed in the last few decades, and they have a wide range of applications in industry, medicine, food, and agriculture. In agriculture, nanoparticles (NPs) have successfully been used for growth regulation, crop protection and improvement. They are also employed to cope with plant nutrient deficiencies. A predicted significant increase in the output of NPs will cause the discharge of a remarkable number of NPs to ecosystems, creating a need to understand how to optimize or mitigate their impact depending on their potential impact. These include serious health concerns for living organisms in aquatic, terrestrial, and atmospheric environments as well as human health through their potential existence in plant-based foods. The impact of NPs on living organisms including plants and algae, and uptake, translocation and molecular response mechanisms should be carefully considered before producing and using nanoparticles in large amounts as NPs, when entered to the body, induce changes in gene expressions related to the photosystem, water transport, cell wall formation, and cell division. Further recent studies have showed that NPs are potential agents or stressors to alter proteome, transcriptome, genome and metabolome responses. Impacts of nanoparticles on molecular mechanisms of plants and algae presents the most recent findings on nanoparticle and plant/algae interaction by focusing to molecular response mechanisms at genome, transcriptome, proteome and metabolome levels. In addition, uptake and translocation mechanism of nanoparticles will be assessed both in plant and algae Throughout this book, the latest developments and discoveries will be highlighted as well as open problems and future challenges in molecular mechanisms of plants/algae as a response of nanoparticles. Presents genome, transcriptome, proteome, and metabolome responses in plants/algae, along with cellular uptake and translocation mechanisms Illustrates nano-particle-plant/algae interactions Covers both simple and higher organisms, addressing both algae and plant

Download or read book Interaction of Nanomaterials With Living Cells written by Faheem Arjamend Sheikh and published by Springer Nature. This book was released on 2023-11-10 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the interactions of nanomaterials with the biological system. The chapters of the book explore the natural and synthetic biomaterials that modulate immune responses for their applications in drug delivery and tissue engineering. Further, the book discusses the implications of the physiochemical properties of nanoparticles and their microenvironment on their interactions with biological systems. The chapters also present the recognitive capabilities of biomaterials for the development of novel strategies for the detection and treatment of autoimmune disorders. The book also introduces nanotechnology platforms for drug delivery and highlights current and emerging nanotechnologies that could enable novel classes of therapeutics. Towards the end, the book reviews the efficiency of drug-loaded nanoparticles in modulating the functioning of the biological milieu for improved disease treatment. Lastly, the book outlines the ethical issues regarding the use of nanoparticles for in vitro and in vivo applications. Given its scope, it is a valuable resource for graduate students and researchers interested in understanding the biomedical applications of nanoparticles and their interactions with the biological milieu.

Download or read book Measuring Biological Impacts of Nanomaterials written by Joachim Wegener and published by Springer. This book was released on 2016-02-02 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews several aspects of the biological response to nanoscale particles on a molecular and cellular level. Nanoscale materials and nanoscale particles in particular have interesting properties and beneficial applications. While they thus have entered our daily lifes on many different levels (from electronics, over textiles, packaging or surface modifications, to biomedical applications), general rules describing their interaction with biological structures and biological matter are still difficult to derive. The existing literature suggests a variety of interaction schemes between nanoparticles and biological objects, not dispelling the public concerns about possible health effects and harmful properties. A systematic approach to the problem is needed and timely. This book specifically emphasizes bioanalytical problems starting from the characterization of the nanomaterials to the pitfalls and potential artifacts of state-of-the-art cytotoxicity assays that are frequently used to study harmful effects on cells. It also highlights the application of label-free bioanalytical techniques that can potentially complement the present approaches and hence provide new perspectives on this highly discussed cutting-edge field of research and public concern.