Download or read book The Immunologic Theory of Aging written by Roy L. Walford and published by . This book was released on 1969 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Aging written by L. Robert and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.
Download or read book Encyclopedia of Aging and Public Health written by Sana Loue and published by Springer Science & Business Media. This book was released on 2008-01-16 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Americans are living longer, and the elder population is growing larger. To meet the ongoing need for quality information on elder health, the Encyclopedia of Aging and Public Health combines multiple perspectives to offer readers a more accurate and complete picture of the aging process. The book takes a biopsychosocial approach to the complexities of its subject. In-depth introductory chapters include coverage on a historical and demographic overview of aging in America, a guide to biological changes accompanying aging, an analysis of the diversity of the U.S. elder population, legal issues commonly affecting older adults, and the ethics of using cognitively impaired elders in research. From there, over 425 entries cover the gamut of topics, trends, diseases, and phenomena: -Specific populations, including ethnic minorities, custodial grandparents, and centenarians -Core medical conditions associated with aging, from cardiac and pulmonary diseases to Parkinson’s and Alzheimer’s -Mental and emotional disorders -Drugs/vitamins/alternative medicine -Disorders of the eyes, feet, and skin -Insomnia and sleep disorders; malnutrition and eating disorders -Sexual and gender-related concerns -And a broad array of social and political issues, including access to care, abuse/neglect, veterans’ affairs, and assisted suicide Entries on not-quite-elders’ concerns (e.g., midlife crisis, menopause) are featured as well. And all chapters and entries include references and resource lists. The Encyclopedia has been developed for maximum utility to clinicians, social workers, researchers, and public health professionals working with older adults. Its multidisciplinary coverage and scope of topics make this volume an invaluable reference for academic and public libraries.
Download or read book Immunology and Aging written by Takashi Makinodan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the classic sense, immunity is the ability of an organism to resist disease. On the one hand, we must distinguish between age and disease; on the other hand, the interaction between them is of considerable theoretical and practical interest. To the gerontologic research community, therefore, immunity also becomes the ability of an organism to resist age. Were the immune and other protective systems of the body able to maintain themselves over the course of time, and if there were no degradation related to age, the everyday loss of energy and vitality that occurs in the lives of older people as a consequence of viruses, arthritis, and other debilitating circumstances would be greatly lessened. The objective of gerontologists is not just to extend the life span but rather to improve the vigor, health, and quality oflife. To date, we have not developed a single index to measure immunity that is of use clinically in the evaluation of older people and of their immunologic compe tence. It may not be surprising that just such a clinical index may be available in the not-too-distant future. We can also look forward to the assembling of a greater body of information explaining how and why the immune system fails with age while, paradoxically, the incidence of autoimmune diseases increases with age. It is this latter phenomenon that may playa part in a wide range of chronic diseases from rheumatoid arthritis to senile dementia.
Download or read book Immunology of Aging written by Ahmad Massoud and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidity of scientific progress over the last few years guarantees the utility of this new collection of state-of-the-art reviews on the immunology of aging, which is the result of extensive collaboration of more than sixty of the greatest thinkers and scholars in the field, in cooperation with a number of junior colleagues. The book summarizes current knowledge on the cellular and molecular aspects of the aging immune system and their clinical relevance, providing insights into the effects of the aging process on susceptibilities to those diseases most common among elders. The retrieval strategies used to slow down the decline in the immune system in the elderly are another subject detailed extensively. By providing a broad overview of immunosenescence and its consequences, as well as their potential modulation, this book will fill a gap in a timely manner. It will be of value to all immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.
Download or read book Intrinsic mutagenesis written by Burnet MacFarlane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with the role of the thymus as central theme. It was to be essentially an expansion of a lecture I gave in 1970 and would inevitably have been concerned with much the same material as Walford's book, The Immunologic Theory of Aging, though from a different slant. What changed its character arose from a series of attempts to find logical connection between two findings that most gerontologists regard as axiomatic: that the lifespan of a mammal is genetically determined, and that the actual process of ageing is an accumulation of genetic error, of somatic mutations. It is possible that the connection is so indirect, circuitous and multiform that generations of detailed and unattractive research will be needed to elucidate it, or, more likely, the whole matter discarded as a non-problem. But a more inspiring approach does seem possible. The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.
Download or read book Inflammation Aging and Cancer written by Mahin Khatami and published by Springer. This book was released on 2018-01-17 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.
Download or read book Aging and the Immune Response written by Edmond A. Goidl and published by Marcel Dekker. This book was released on 1987 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biochemistry and Cell Biology of Ageing Part II Clinical Science written by J. Robin Harris and published by Springer. This book was released on 2019-03-19 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.
Download or read book Handbook of Theories of Aging Second Edition written by Merril Silverstein, PhD and published by Springer Publishing Company. This book was released on 2008-10-27 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of gerontology has often been criticized for being "data-rich but theory-poor." The editors of this book address this issue by stressing the importance of theory in gerontology. While the previous edition focused on multidisciplinary approaches to aging theory, this new edition provides cross-disciplinary, integrative explanations of aging theory: The contributors of this text have reached beyond traditional disciplinary boundaries to partner with researchers in adjacent fields in studying aging and age-related phenomena. This edition of the Handbook consists of 39 chapters written by 67 internationally recognized experts in the field of aging. It is organized in seven sections, reflecting the major theoretical developments in gerontology over the past 10 years. Special Features: Comprehensive coverage of aging theory, focusing on the biological, psychological, and social aspects of aging A section dedicated to discussing how aging theory informs public policy A concluding chapter summarizing the major themes of aging, and offering predictions about the future of theory development Required reading for graduate students and post doctoral fellows, this textbook represents the current status of theoretical development in the study of aging.
Download or read book Stress Immunity and Aging written by E. L. Cooper and published by CRC Press. This book was released on 2020-07-24 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains two personal reminiscences of historical importance to research on stress and infectious disease. It deals with perspectives on immunity, aging, and disease and the prospects for immunorestoration in the treatment of immunodeficiency arising from aging and stress.
Download or read book Nutrition and Immunity written by Maryam Mahmoudi and published by Springer. This book was released on 2019-07-30 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals.
Download or read book General system theory of aging Special role of the immune system written by V. Dontsov and published by Litres. This book was released on 2019-08-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The monograph examines the general methodological problems of the aging, main mechanisms, as well as consideration of the fundamental possibilities and directions of influence on this process. A special place is occupied by the use of system analysis, consideration of integrative systems, and the special role of the immune system, namely, that part of it, which is not responsible for immune phenomena proper, but regulates the interaction of proliferation of various cell populations in the body.
Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Download or read book Immunology and Ageing written by N. Fabris and published by Springer Science & Business Media. This book was released on 1982-03-31 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Aging Immune System and Health written by Valquiria Bueno and published by Frontiers Media SA. This book was released on 2020-01-15 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contribute to the low-grade inflammatory process observed (inflammaging). Aging is a complex and multifactorial process in which functions of the organism are adjusted (remodelled) in order to deal with damaging events during life. One of the most important changes in aging individuals occurs in the immune system (innate and adaptive responses) with consequences such as poor response to new infections and vaccinations; increased susceptibility to cancer development and autoimmune diseases; frailty, and organ dysfunction. In addition, it has been proposed that immunosenescence not only reflects the aging of the organism but also contributes to this process. Bone marrow presents decreased hematopoiesis, the thymus undergoes involution and lymphoid organs (lymph nodes, spleen) also present reduced functionality. Therefore, cells derived, matured, or residing in these tissues decline in number and function. These changes have been identified in experimental models, in vitro conditions, peripheral blood, and biopsies via biomarkers such as cell phenotype, stimulus-induced proliferation, cytokines and antibodies levels. Telomere length and telomerase activity also decline in bone marrow-derived and peripheral blood cells and have been shown to play a role in immunosenescence. More recently, the investigation of short non-coding RNA molecules (microRNAs; miRNAs) pointed to this system as a possible control of aging-related mechanisms. Data obtained on these markers for aging individuals could lead to the generation of a marker panel for pathology prediction, to indicate interventions, and to evaluate the efficacy of interventions. Interventions such as nutrition supplements, exercise, vaccination (different dose, concentration of antigen, adjuvants) have been proposed to circumvent age-related diseases. Considering the heterogeneity in the aging process, further investigation is vital before the indication of interventions for aging individuals. As the extension of life expectancy is a reality, it is a challenge to understand how the aging population copes with the remodelling of the organism and how interventions could provide longevity in good health.
Download or read book Immunological Surveillance written by Macfarlane Burnet and published by Elsevier. This book was released on 2014-05-17 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Surveillance
