Download or read book The IGF System written by Ron G. Rosenfeld and published by Springer Science & Business Media. This book was released on 1999-06-01 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.
Download or read book The IGF System written by Ron G. Rosenfeld and published by Humana. This book was released on 2010-11-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.
Download or read book IGF and Nutrition in Health and Disease written by M. Sue Houston and published by Springer Science & Business Media. This book was released on 2004-08-04 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.
Download or read book IGF I and IGF Binding Proteins written by Stefano Cianfarani and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: The IGF system pervades the fields of development, linear and cellular growth and metabolism. Not only is the functional integrity of the IGF system crucial for normal linear growth and metabolism, it is also of fundamental importance for normal fetal development. This book consists of a compilation of chapters based on presentations at a symposium entitled 'IGFs and IGFBPs: Assessment and Therapeutic Benefit'. Highly qualified basic scientists and endocrinologists report new advances in the broad field of IGF physiology and pathophysiology, related to clinical medicine. New and topical areas of the IGF field are covered, focussing particularly on clinically relevant topics related to growth, pediatric and adult growth hormone deficiency, metabolic disorders, diabetes mellitus and neurology. Molecular and developmental defects are discussed, as are the contributions to clinical diagnosis and management of measurement of IGFs and IGFBPs. The therapeutic potential of recombinant human IGFs and IGFBPs in a range of disorders is also covered. The present volume of Endocrine Development will be of particular interest to scientists and clinicians working in IGF and IGF-related fields and to clinicians working in both pediatric and adult endocrinology and metabolism.
Download or read book Insulin like Growth Factors and Cancer written by Derek LeRoith and published by Springer Science & Business Media. This book was released on 2011-09-18 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Gigantism and Acromegaly written by Constantine A. Stratakis and published by Academic Press. This book was released on 2021-06-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism
Download or read book Growth Hormone in Adults written by Anders Juul and published by Cambridge University Press. This book was released on 2000-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.
Download or read book Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy written by G V Sherbet and published by Elsevier. This book was released on 2011-07-14 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.
Download or read book International Textbook of Diabetes Mellitus written by R. A. DeFronzo and published by John Wiley & Sons. This book was released on 2015-03-11 with total page 1240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.
Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.
Download or read book The Endocrine System in Sports and Exercise written by William J. Kraemer and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable new addition to the Encyclopaedia of Sports Medicine series provides a comprehensive and logical look at the principles and mechanisms of endocrinology as related to sports and exercise. It looks at growth hormone factors involved in exercise and the endocrinology of sport competition. It considers various factors and stresses on the body that may alter sporting performance. It covers topics from the acute responses and chronic adaptations of the human endocrine system to the muscular activity involved in conditioning exercise, physical labor, and sport activities. This book is an essential reference for helping to plan better programs of physical fitness, to prepare for sports competitions, and to manage the medical care of athletes.
Download or read book The Role of Insulin like Growth Factors in the Nervous System written by Mohan K. Raizada and published by . This book was released on 1993 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses various aspects of the insulin-like growth factors (IGFs), their binding proteins and receptors. The emphasis is on identification of these important growth factors in the nervous system and their potential role in nervous tissue physiology. The IFGs are compared to other growth factors that are important in the nervous system, including nerve growth factor.
Download or read book Current Perspectives on Insulin like Growth Factor Binding Protein IGFBP Research written by Andreas Hoeflich and published by Frontiers Media SA. This book was released on 2019-02-06 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are located both intra- and extracellularly. Distinct IGFBP-fragments can even be found in the perinuclear compartment or within the nucleus, where they can impact on gene expression. Several contributions presented in the current Research Topic particularly stress the relevance of structural aspects in IGFBP research. The current lack of comprehensive structural information is dramatically limiting the biomarker potential of particular IGFBPs. Finally, the Research Topic also provides novel functions of the IGFBP family from model organisms, farm animals and humans. Thereby, the biomarker potential not only relates to normal and malignant growth but also to metabolism and animal welfare. One important aim of the Research Topic is to encourage next generation IGFBP research reflecting subject-individual, conditional, and hormonal parameters but also structural aspects of the IGFBPs.
Download or read book Growth Hormone Deficiency in Adults written by Jens O. L. Jørgensen and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.
Download or read book IGF Code written by International Maritime Organization and published by . This book was released on 2016-11-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: IGF = International code for ships fuelled by gases or other low-flashpoint fuels
Download or read book Aging and Health written by Anatoli I. Yashin and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
