Download or read book Heritable Human Genome Editing written by The Royal Society and published by National Academies Press. This book was released on 2021-01-16 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Download or read book Physician s Guide to the Diagnosis Treatment and Follow Up of Inherited Metabolic Diseases written by Nenad Blau and published by Springer. This book was released on 2014-07-08 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, combining and updating two previous editions, is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for both clinicians and laboratory personnel. Reference laboratory data are scattered, and clinical descriptions may be obscure. The Physician’s Guide documents the features of more than five hundred conditions, grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). Relevant clinical findings are provided and pathological values for diagnostic metabolites highlighted. Guidance on appropriate biochemical genetic testing is provided. Established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book will be a valuable desk reference for all who deal with inherited metabolic diseases.
Download or read book Encyclopedia of Systems Biology written by Werner Dubitzky and published by Springer. This book was released on 2013-06-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology refers to the quantitative analysis of the dynamic interactions among several components of a biological system and aims to understand the behavior of the system as a whole. Systems biology involves the development and application of systems theory concepts for the study of complex biological systems through iteration over mathematical modeling, computational simulation and biological experimentation. Systems biology could be viewed as a tool to increase our understanding of biological systems, to develop more directed experiments, and to allow accurate predictions. The Encyclopedia of Systems Biology is conceived as a comprehensive reference work covering all aspects of systems biology, in particular the investigation of living matter involving a tight coupling of biological experimentation, mathematical modeling and computational analysis and simulation. The main goal of the Encyclopedia is to provide a complete reference of established knowledge in systems biology – a ‘one-stop shop’ for someone seeking information on key concepts of systems biology. As a result, the Encyclopedia comprises a broad range of topics relevant in the context of systems biology. The audience targeted by the Encyclopedia includes researchers, developers, teachers, students and practitioners who are interested or working in the field of systems biology. Keeping in mind the varying needs of the potential readership, we have structured and presented the content in a way that is accessible to readers from wide range of backgrounds. In contrast to encyclopedic online resources, which often rely on the general public to author their content, a key consideration in the development of the Encyclopedia of Systems Biology was to have subject matter experts define the concepts and subjects of systems biology.
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Download or read book Clinical Neuro Ophthalmology written by Ulrich Schiefer and published by Springer Science & Business Media. This book was released on 2007-09-11 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all relevant techniques of diagnosis as well as interpretations of clinical signs in Clinical Neuro-Ophthalmology. All information is highly structured, highlighting ‘definition’, ‘note’ and ‘pearl’, so that it can also be used by the physician during the patient encounter. The included flow chart posters remind the physician of the most important information. This unique and practical guide offers invaluable and practical advice for physicians treating patients with neuro-ophthalmic problems.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sequence Evolution Function written by Eugene V. Koonin and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Download or read book Encyclopedia of Bioinformatics and Computational Biology written by and published by Elsevier. This book was released on 2018-08-21 with total page 3421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases
Download or read book Systems Immunology and Infection Microbiology written by Bor-Sen Chen and published by Academic Press. This book was released on 2021-03-16 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells. This book provides new big data-driven and systems-driven systems immunology and infection microbiology to researchers applying systems biology and bioinformatics in their work. It is also invaluable to several members of biomedical field who are interested in learning more about those approaches. Encompasses one applicable example in every chapter to illustrate the solution procedure from big data mining, network modeling, host/pathogen cross-talk detection, drug target identification and systems drug design Presents flowcharts to represent the development procedure of systematic immunology and infection in a very clear format Contains 100 color diagrams to help readers understand the related biological networks, their corresponding mechanisms, and significant network biomarkers for therapeutic drug design
Download or read book Disease Pathways written by Anastasia P. Nesterova and published by Elsevier. This book was released on 2019-10-18 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Download or read book Pathways for Peace written by United Nations;World Bank and published by World Bank Publications. This book was released on 2018-04-13 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Violent conflicts today are complex and increasingly protracted, involving more nonstate groups and regional and international actors. It is estimated that by 2030—the horizon set by the international community for achieving the Sustainable Development Goals—more than half of the world’s poor will be living in countries affected by high levels of violence. Information and communication technology, population movements, and climate change are also creating shared risks that must be managed at both national and international levels. Pathways for Peace is a joint United Nations†“World Bank Group study that originates from the conviction that the international community’s attention must urgently be refocused on prevention. A scaled-up system for preventive action would save between US$5 billion and US$70 billion per year, which could be reinvested in reducing poverty and improving the well-being of populations. The study aims to improve the way in which domestic development processes interact with security, diplomacy, mediation, and other efforts to prevent conflicts from becoming violent. It stresses the importance of grievances related to exclusion—from access to power, natural resources, security and justice, for example—that are at the root of many violent conflicts today. Based on a review of cases in which prevention has been successful, the study makes recommendations for countries facing emerging risks of violent conflict as well as for the international community. Development policies and programs must be a core part of preventive efforts; when risks are high or building up, inclusive solutions through dialogue, adapted macroeconomic policies, institutional reform, and redistributive policies are required. Inclusion is key, and preventive action needs to adopt a more people-centered approach that includes mainstreaming citizen engagement. Enhancing the participation of women and youth in decision making is fundamental to sustaining peace, as well as long-term policies to address the aspirations of women and young people.
Download or read book The Human Pathway written by Jim Larsson and published by Jim Knut Larsson. This book was released on 2010-11-15 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jim Knut Larsson establishes that the foundation for freewill, meaning and purpose is anchored in the latest findings in quantum mechanics and cosmology-empowering us to create the future. The Human Pathway is destined to become the catalyst for a transformation in politics, justice, government, economics and spiritualism. What choices does humanity need to make now, in order to avoid destruction? What goals can we set up to maximize meaning and purpose both for the individual and also for all of humanity? The Human Pathway might be the most important, inspiring and interesting book you will ever read. Our future depends upon your participation! Also included as an addendum: "What to do in case of arrest!" It could save your life or ... someone close to you! A must read! Some more questions ... What is "enlightenment"? Why the earth created humans? What would be the ultimate goals for humanity? How can you unleash your creative powers and create your own future? Why every act, movement and thought is a manifestation of freewill and why it affects the evolution of the universe? Why the living standard in the US declines daily? Why there are more than 3 million people in jail and more than 50 million with a criminal record? People in America always talk about "they". "Back then, 'they' castrated people who were homosexuals. "They" had strict laws against sodomy." They" did radiation experiments on the population. The question is; who are "they"? Revelation: Does it matter if you are resurrected at some point in the future? It is your desire to know the "truth" that drives your desire for resurrection. You will live forever as long as humanity-or if human intelligence lives on forever-because what is living, even if your ego is dead, is you being one with humanity. Individuals only manifest by their "clinging" to their egos. This "clinging" prevents you from becoming creative, happy and blissful. If you get rid of your ego, which should be everybody's goal, you will dedicate yourself to the eternal "now" and to serve humanity. A great quest is to help humanity reach its highest potential and to achieve "absolute" knowledge, "finish" the creation of the universe and acquire the power to recreate everything that existed forever. Then, at that point, you will be resurrected! However there is a final revelation and, if it is revealed to you, it will give you "absolute" knowledge and peace. This final revelation is the logical conclusion of this book. Understand what is written and the truth will be revealed to you. When it is, you will understand that it cannot be directly communicated and understood by others unless they have the same revelation! You will know that you have the final knowledge when you get the revelation and you don't need to seek validation for it! However, you want to share it with others! Study the revelations in this book and hopefully you will get it. You will know it when you do. We need to dismantle many laws and make society free again. We must get the government out of our lives. The benefit you get from reading my book is that you will be able to see through the myths. When you read my book, you will become an enlightened person. Actually after you read this book you will say, "I'm enlightened now". You will have revelations that will make you enjoy life more and become a happier person, but also you will no longer be seduced by propaganda. This, in the end, is a book of cosmic and spiritual enlightenment and enlightenment with regard to politics, economics and justice. What does it mean to be an enlightened person who helps secure the future prosperity and excitement of living for yourself and for humanity as a whole? Another bonus from this book is that you may no longer fear death. You will become a participant in the conversation and the future goals and aspirations of humanity.
Download or read book Computational Systems Biology written by Andres Kriete and published by Elsevier. This book was released on 2005-11-10 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology is concerned with the quantitative study of complex biosystems at the molecular, cellular, tissue, and systems scales. Its focus is on the function of the system as a whole, rather than on individual parts. This exciting new arena applies mathematical modeling and engineering methods to the study of biological systems. This book is the first of its kind to focus on the newly emerging field of systems biology with an emphasis on computational approaches. The work covers new concepts, methods for information storage, mining and knowledge extraction, reverse engineering of gene and metabolic networks, as well as modelling and simulation of multi-cellular systems. Central themes include strategies for predicting biological properties and methods for elucidating structure-function relationships.
Download or read book Letting Go written by David R. Hawkins, M.D., Ph.D. and published by Hay House, Inc. This book was released on 2014-01-15 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking bestseller describes a simple and effective way to let go of challenges from world-renowned author, psychiatrist, clinician, spiritual teacher, and researcher of consciousness, David R. Hawkins, M.D., Ph.D. “Letting Go” is a guide to helping to remove the obstacles we all have that keep us from living a more conscious life, it is truly a life-changing book. Many of us have trouble Letting Go in our lives even though it can have profound impact on our life.” —Wayne Dyer During the many decades of Dr. David Hawkins’, clinical psychiatric practice, the primary aim was to seek the most effective ways to relieve human suffering in all of its many forms. In Letting Go, he shares from his clinical and personal experience that surrender is the surest route to total fulfillment. This motivational book provides a mechanism for letting go of blocks to happiness, love, joy, success, health, and ultimately Enlightenment. The mechanism of surrender that Dr. Hawkins describes can be done in the midst of everyday life. The book is equally useful for all dimensions of human life: physical health, creativity, financial success, emotional healing, vocational fulfillment, relationships, sexuality and spiritual growth. It is an invaluable resource for all professionals who work in the areas of mental health, psychology, medicine, self-help, addiction recovery and spiritual development. "Letting go is one of the most efficacious tools by which to reach spiritual goals." — David Hawkins, M.D., Ph.D. This profound self-development book offers a roadmap to release emotional burdens, unlock inner peace, and embrace a life of fulfillment. It is a classic that will help you break free from limitations and unlock your true potential. Learn how to navigate challenges with grace and emerge as a stronger, more resilient version of yourself. By incorporating the principles of surrender, "Letting Go" provides practical tools for personal growth and transformation. This consciousness-expanding book will help you: · Release past traumas, negative beliefs, and self-imposed limitations. · Experience a newfound sense of freedom, joy, and authenticity. · Recover from addiction · Enhance your personal relationships · Achieve success in your career Join millions who have experienced profound transformations through the principles outlined in "Letting Go." "Letting Go" is a must-read for anyone on a quest for personal growth, spirituality, and self-improvement. Whether you're new to the realm of self-help books or a seasoned seeker, Dr. David Hawkins' insights will inspire you to embrace a life of conscious living, emotional well-being, positive thinking, and unlimited possibilities. Experience the transformative power of letting go and unlock a life of healing, success, and spiritual growth.
Download or read book Communities in Action written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-04-27 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.
Download or read book Chocolate written by Meredith L. Dreiss and published by University of Arizona Press. This book was released on 2008-10-15 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of chocolate, from its discovery as a food source to today's gourmet chocolate recipes and European chocolatiers.
Download or read book The Pathway to Publishing A Guide to Quantitative Writing in the Health Sciences written by Stephen Luby and published by Springer Nature. This book was released on 2022-05-30 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade.
