Download or read book The Gene Trap written by Stephen N Berberich and published by Xlibris Corporation. This book was released on 2018-04-26 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Change is inevitable, and it is coming to the modern world as it had for a thousand centuries. A mysterious force, hidden in the shadows of the cosmos, holds sway over the destiny of all living things, and the final chapter for mankind is about to be written. A superior species, borne of humans, is poised to assume dominion over the earth. Enter The Gene Trap. This manuscript is the second in a series of techno-thrillers by Dr. Stephen Berberich. Similar in story line to a Michael Crichton novel, the books plot depicts the struggle of contemporary man in his effort to avoid the inexorable consequences of evolution. As the story unfolds, John Lynch and his girlfriend, Gigi Thompson, are on their way to Pittsburgh to begin their new careersJohn as a medical intern and Gigi as geneticist at the prestigious Hawthorne Institute. Though they remain perplexed by the mysterious disappearance of their best friends, Peter Gault and Kate Donavon (main characters of Berberichs first novel, No Known Species), John and Gigi find themselves consumed by the rigors of their new positions. The last thing they need is to be caught in a titanic struggle for human survivala struggle that would pit them against Peters clan of mutants. Influenced by unexpected events, the couple is drawn into a sinister plot hatched by a worldwide cabal of intellectual elites who are determined to eliminate the gifted species. It is a move that could solidify mankinds rightful place of primacy. Though the elites scheme seems flawless, unforeseen mistakes begin to occur. A deadly synthetic germ is accidently released into the biosphere, creating a plague the likes of which the world has never known. Worse yet, a deadly trap lurks within secret recesses of the human genome. It is genetic time bomb that will be detonated if scientists attempt to tinker with the essence of mankinds DNA. The Gene Trap details the age-old struggle between the old and the new, with Gigi and John caught somewhere between the two worlds. The final act makes clear the meaning of the genesis cycle.
Download or read book The Gene Trap written by Stephen Berberich and published by . This book was released on 2011-05 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Knockout Protocols written by Ralf Kühn and published by Humana Press. This book was released on 2009-03-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the completion of the mouse and human genome sequences, a major challengeisthefunctionalcharacterizationofeverymammaliangeneandthedeciph- ing of their molecular interaction network. The mouse offers many advantages for the use of genetics to study human biology and disease, unmatched among other m- mals. Its development, body plan, physiology, behavior, and diseases have much in common, based on the fact that 99% of the human genes have a mouse ortholog. The investigation of gene function using mouse models is based on many years of tech- logical development. In the two decades since gene targeting in murine embryonic stem (ES) cells was first described by Mario Capecchi and colleagues, more than 3000 predesigned mouse mutants have been developed. To date, a variety of mouse mutagenesis techniques, either gene- or phenotype-driven, are used as systematic approaches. The availability of the genome sequence supports gene-driven approaches such as gene-trap and targeted mutagenesis in ES cells, allowing efficient and precise gene disruption. In combination with the use of site-specific DNA recombinases, in particular the Cre/loxP system, gene disruptioncan be directed to specific cell types in conditionalmousemutants. Furthermore,chemicalandtransposonmutagenesisofthe mouse genome enables us to perform phenotype-driven screens for the unbiased identification of phenotype–genotype correlations involved in models of human d- ease. Over the next several years, the mouse genome will be systematically altered, and the techniques for achieving predesigned manipulations will be constantly developed further and improved. The second edition of Gene Knockout Protocols brings together distinguished c- tributorswithextensiveexperienceinthegenetargetingandmousegeneticsfields.
Download or read book Gene Trap an Approach to Rapidly Identify Clone and Mutate Genes Important in Mouse Development written by William Carl Skarnes and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nematode Trapping Fungi written by Ke-Qin Zhang and published by Springer Science & Business. This book was released on 2014-04-22 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: These chapters provide up-to-date information on nematophagous fungi, particularly those of the Orbiliaceae in Ascomycota, whose asexual states produce nematode-trapping devices. The authors consider fungal-nematode interactions, fossil fungi, the biodiversity, ecology and geographical distribution of nematode-trapping fungi, and their potential use in biocontrol of nematodes, all in detail. Nematode-trapping fungi with adhesive or mechanical hyphal traps are the main focus of this book which begins with an overview of the data on nematode-trapping fungi, including their taxonomy, phylogeny and evolution. Subsequent chapters expand upon the methods and techniques used to study these fascinating fungi. Keys for genera of Arthrobotrys, Drechslerella and Dactylellina, which include all reported species of predatory orbiliaceous fungi are presented and numerous species from these genera are morphologically described and illustrated. The ecology of nematode-trapping fungi is expertly presented: their occurrence and habitats, their geographical and seasonal distribution and the effects of soil conditions and nematode density on their distribution all feature amongst the relevant themes. Further chapters examine the use of nematode-trapping fungi in biological control and the authors consider nematicidal activities in detail, exploring the many compounds from fungi that feature in nematicidal activities and of course useful paths for further study on this topic. This is a highly informative and carefully presented book, providing scientific insight for scholars with an interest in fungi and in biological control of nematodes.
Download or read book Calcium Entry Channels in Non Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Download or read book Gene Trap Studies of the Mouse Genome and Embryonic Development written by Mehran Sam and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Guide to Techniques in Mouse Development Part A written by and published by Academic Press. This book was released on 2010-09-09 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guide to Techniques in Mouse Development, Part A comprehensively covers new technologies and methodologies that have appeared for the study of mouse development. Update of volume 225 of Methods in Enzymology, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993 Covers new technologies and methodologies, including: new techniques for the cryopreservation of gametes and embryos production of transgenic and null (knockout) animals (use of ES cells) generation of conditional/inducible mutant animals use of gene-trap mutagenesis analysis of allele-specific expresion use of new reporter constructs humanizing of transgenic animals transcript profiling of mouse development imaging of mouse development rederivation of animals and use of mouse genomics
Download or read book The Molecular Characterisation of the Gene Trap GT411 written by R. A. Axton and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Genomics in Mice by Microarray coupled Gene Trap Mutagenesis written by Weisheng Victor Chen and published by . This book was released on 2004 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Characterization of Genes Using Gene Trap Mouse Mutants written by Safak Yalcin and published by . This book was released on 2006 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Conditional Mutagenesis An Approach to Disease Models written by Robert Feil and published by Springer. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse and their application to model human physiology and pathophysiology. The book illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. In addition, it considers the development of new drugs to treat human diseases.
Download or read book Mouse Genetics written by Professor of Molecular Biology Lee M Silver, Professor Dr and published by Oxford University Press on Demand. This book was released on 1995 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.
Download or read book Gene Trap Screening for Genes Expressed Preferentially in Low Serum Conditions written by Fatmahan Atalar and published by . This book was released on 1999 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of Gene Trap Mutagenesis in Mice written by Michael James Roshon and published by . This book was released on 1998 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Tolerance Trap written by Suzanna Danuta Walters and published by NYU Press. This book was released on 2014 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Froma Glee ato gay marriage, from lesbian senators to out gay Marines, we have undoubtedly experienced a seismic shift in attitudes about gays in American politics and culture. Our reigning national story is that a new era of rainbow acceptance is at hand. But dig a bit deeper, and this seemingly brave new gay world is disappointing. For all of the undeniable changes, the plea for tolerance has sabotaged the full integration of gays into American life. Same-sex marriage is unrecognized and unpopular in the vast majority of states, hate crimes proliferate, and even in the much vaunted gay friendly world of Hollywood and celebrity culture, precious few stars are openly gay. Ina The Tolerance Trap, Suzanna Walters takes on received wisdom about gay identities and gay rights, arguing that we are not almost there, but on the contrary have settled for a watered-down goal of tolerance and acceptance rather than a robust claim to full civil rights. After all, wea tolerate aunpleasant realities: medicine with strong side effects, a long commute, an annoying relative. Drawing on a vast array of sources and sharing her own personal journey, Walters shows how the low bar of tolerance demeans rather than ennobles both gays and straights alike. Her fascinating examination covers the gains in political inclusion and the persistence of anti-gay laws, the easy-out sexual freedom of queer youth and the suicides and murders of those in decidedly intolerant environments. She challenges both born that way storylines that root civil rights in biology, and god made me that way arguments that similarly situate sexuality as innate and impervious to decisions we make to shape it. A sharp and provocative cultural critique, this book deftly argues that a too-soon declaration of victory short-circuits full equality and deprives us all of the transformative possibilities of full integration.Tolerance is not the end goal, but a dead end. Ina The Tolerance Trap, Walters presents a complicated snapshot of a world-shifting moment in American historyOCoone that is both a wake-up call and a call to arms for anyone seeking true equality."
Download or read book Gene Trapping written by Rolf Kemler and published by . This book was released on 1998 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
