Download or read book The Functional and Translational Immunology of Regulatory T Cells Tregs the Anti Tumor T Cell Response and Cancer written by Michael A. Alexander and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T cells (Tregs) are a vital component of the T cell immune system by their ability to control T cell responses that would lead to autoimmune disease. Tregs also protect damaged normal cells that are healing from T cells programmed to kill any abnormal cells in the body. Cancer (tumor) develops from normal cells and can express normal self-antigens. Tregs protect precancerous cells as if they were healing damaged cells and inhibit the anti-tumor T cell response by the use of advanced effector mechanisms, which stop the T cell immune system from effectively removing the tumor. The function of cells involved in this process is controlled by the cell membrane activation of intracellular translational pathways interacting with the nucleus that produces transcriptional proteins, which control cellular behavior such as secretion of lymphokines or cell proliferation. This book examines the function and related translational pathways of Tregs, anti-tumor T cells, and cancer cells. It relates that information to the treatment of cancer by examining human clinical trials of new immune cell-based treatments (immunotherapy). The book also proposes ways to improve those treatments by manipulating the translational pathways of immunotherapeutic cells. The hope is that these new treatment proposals stimulate positive thought about the future of cancer immunotherapy.
Download or read book Innate Immune Regulation and Cancer Immunotherapy written by Rong-Fu Wang and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
Download or read book Developments in T Cell Based Cancer Immunotherapies written by Paolo A. Ascierto and published by Humana Press. This book was released on 2015-11-26 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.
Download or read book Regulatory T Cells and Clinical Application written by Shuiping Jiang and published by Springer Science & Business Media. This book was released on 2008-12-14 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering one of the hottest topics in immunology today, this book provides a comprehensive view of all types of regulatory T cells described so far in the literature. The book will have broad appeal to both researchers and clinicians.
Download or read book Natural Killer T cells written by Masaki Terabe and published by Springer Science & Business Media. This book was released on 2011-09-22 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.
Download or read book Control of Regulatory T cell Stability Plasticity and Function in Health and Disease written by Margarita Dominguez-Villar and published by Frontiers Media SA. This book was released on 2021-03-08 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Immunotherapy Principles and Practice written by Lisa H. Butterfield, PhD and published by Springer Publishing Company. This book was released on 2017-06-28 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Drs. Butterfield, Kaufman and Marincola on behalf of the SITC have created a comprehensive must-have resource covering the basic and translational science behind approved and investigational immune therapies, and disease-by-disease clinical application of the therapies, written by leaders in the field. The textbook will be highly valuable reading for those just entering the field and for experienced scientists and clinicians looking to expand their knowledge base.” —Mario Sznol, MD, Professor of Medicine (Medical Oncology), Yale School of Medicine, New Haven, Connecticut “Given the important and exciting advances in cancer immunotherapy, it is not surprising that there is no dearth of books on the subject. Despite the competition, however, this book is a unique masterpiece and a must-have comprehensive resource for anyone interested in this area and for every medical library.” Score: 100, 5 Stars, Doody’s Medical Reviews Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease-Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. KEY FEATURES Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs
Download or read book Immune based Cancer Treatment written by Michael A. Alexander and published by CRC Press. This book was released on 2011-01-21 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies. It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influ
Download or read book Experimental and Applied Immunotherapy written by Jeffrey Medin and published by Springer Science & Business Media. This book was released on 2010-12-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy is now recognized as an essential component of treatment for a wide variety of cancers. It is an interdisciplinary field that is critically dependent upon an improved understanding of a vast network of cross-regulatory cellular populations and a diversity of molecular effectors; it is a leading example of translational medicine with a favorable concept-to-clinical-trial timeframe of just a few years. There are many established immunotherapies already in existence, but there are exciting new cancer immunotherapies just on the horizon, which are likely to be more potent, less toxic and more cost effective than many therapies currently in use. Experimental and Applied Immunotherapy is a state-of-the-art text offering a roadmap leading to the creation of these future cancer-fighting immunotherapies. It includes essays by leading researchers that cover a wide variety of topics including T cell and non-T cell therapy, monoclonal antibody therapy, dendritic cell-based cancer vaccines, mesenchymal stromal cells, negative regulators in cancer immunology and immunotherapy, non-cellular aspects of cancer immunotherapy, the combining of cancer vaccines with conventional therapies, the combining of oncolytic viruses with cancer immunotherapy, transplantation, and more. The field of immunotherapy holds great promise that will soon come to fruition if creative investigators can bridge seemingly disparate disciplines, such as T cell therapy, gene therapy, and transplantation therapy. This text is a vital tool in the building of that bridge.
Download or read book Regulatory T Cells written by and published by Academic Press. This book was released on 2011-11-21 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on regulatory T-cells. Contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field
Download or read book Regulatory T Cells in Health and Disease written by and published by Academic Press. This book was released on 2015-11-26 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer. Contains contributions from leading authorities in the field of regulatory T cell biology Informs and updates on all the latest developments in the field Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer
Download or read book T Regulatory Cells in Human Health and Diseases written by Song-Guo Zheng and published by Springer Nature. This book was released on 2021-02-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses one of the major challenges of immunology today that is being directed to the translation of the rapidly emerging volume of basic science contributions of immunology to clinical medicine. In so doing, the book systemically introduces and discusses concepts, classifications, phenotypic and functional descriptions of regulatory T (Treg) cells in health and disease. The authors of the 15 chapters were selected from among the most qualified experts in the field of Treg cell research who provide a comprehensive overview of Treg cells and their biology in the ensuing chapters. The beginning chapters provide a useful contemporary classification of Treg cell populations and then progress to chapters that explore basic mechanisms of Treg cell function and epigenetic control. In addition to descriptions of typical CD4+ Foxp3+ cells, other chapters provide detailed presentations of Treg subsets such as CD8+ Tregs and IL-10-producing Tr1 cells. The differences of various Treg subsets, as well as circulating and resident Treg cell populations, are next compared. Importantly, the next chapters provide the clinical correlation of Treg cells with autoimmune diseases, inflammatory diseases, metabolic diseases, cancer and organ transplantation and progress to chapters that highlight emerging innovative technology including nanoparticle-Treg cells and their translational values. In summary, the book will provide a valuable resource not only for graduate students and researchers in the fields of immunology, cell biology and translational medicine but also for all others interested in learning more about Treg cells and their application in human health and disease.
Download or read book Cancer Immunotherapy written by George C. Prendergast and published by Academic Press. This book was released on 2013-06-04 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication Drs. Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research Summarizes the latest insights into how immune escape defines an essential trait of cancer Includes numerous illustrations, including how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy and how reversing immune suppression by the tumor can cause tumor regression
Download or read book Cancer Immunotherapy written by David H. Munn and published by Elsevier Inc. Chapters. This book was released on 2013-06-04 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indoleamine 2,3-dioxygenase (IDO) is a metabolic pathway implicated in a number of settings that lead to acquired peripheral tolerance. IDO may also participate in the functional tolerance of the immune system towards tumors. Foxp3+ Tregs are major contributors to tumor-induced immune suppression, and emerging evidence links the IDO pathway with Treg activation. IDO-expressing dendritic cells (DCs) can drive the differentiation of naive CD4+ T cells into Foxp3+ Tregs. IDO+ DCs can also directly activate mature, preformed Tregs to mediate enhanced suppression. In experimental models, IDO also stabilizes the suppressive Treg phenotype and prevents inflammation-induced reprogramming of Tregs into pro-inflammatory (T-helper-like) cells. IDO may thus represent an important regulatory checkpoint that enhances Treg activity in tumor-bearing hosts. Drugs that target the IDO pathway may assist in reducing Treg-mediated suppression during antitumor immunotherapy.
Download or read book Combinatorial Approaches to Enhance Anti Tumor Immunity Focus on Immune Checkpoint Blockade Therapy written by Patrik Andersson and published by Frontiers Media SA. This book was released on 2019-12-27 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.
Download or read book Cancer Immunology written by Nima Rezaei and published by Springer Nature. This book was released on 2020-09-24 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.
Download or read book Modulation of T cell function and survival by the tumor microenvironment written by Shahrzad Jalali and published by Frontiers Media SA. This book was released on 2023-09-26 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:
