Download or read book The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy written by Y. Rustum and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy written by Y Rustum and published by . This book was released on 1989-01-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1989 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Concepts Mechanisms and New Targets for Chemotherapy written by Franco M. Muggia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts, Mechanisms, and New Targets for Chemotherapy describes new interconnections between rationally designed and empirically discovered compounds. One route that has not been travelled previously is that of protein kinase C inhibition. This pathway may be exploited to give potent inhibitors, such as the bryostatins, now in clinical trial. A summary is given of the current status of topoisomerase, focusing on recent clinical advances with camptothecin analogs based on connecting empiricism with concepts of drug selectivity. Modification of existing therapies based on the pursuit of leads arising from mechanistic studies is also being applied clinically on a wide scale. Greater understanding should follow from the studies of reversal of the multidrug resistant phenotype, on the use of hydroxyurea to reverse resistance mediated by extrachromosomal DNA, and on various aspects of the fluoropyrimidine pathways. Successful applications of chemotherapy to the treatment of specific diseases include the growing applications of systemic therapy using various skin malignancies. In prostate cancer, estramustine phosphate will likely play an expanding role. Taxanes are restructuring treatment regimens in breast cancer, and high-dose strategies are described with peripheral blood progenitor autografting in the treatment of ovarian and breast cancers.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1993 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Drugs Concepts and Results in Cancer Chemotherapy written by Franco M. Muggia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Catalog written by and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy written by Stephen B. Howell and published by Springer Science & Business Media. This book was released on 1991 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Download or read book Novel Approaches to Selective Treatments of Human Solid Tumors written by Youcef M. Rustum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Treatment An Update written by P. Banzet and published by Springer Science & Business Media. This book was released on 2013-12-14 with total page 905 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers the educational lectures and the texts of the main presenta tions given at the 4th International Congress on Anticancer Chemotherapy which took place in February 1993 in Paris and was attended by 5 000 oncologists from all continents, physicians, students and nurses. This book aspires to give update of the most scientific and clinical aspects of modern oncology. It aims also at showing the prospects that are opened by the rapid progress of cancer biology. The editors are grateful to the authors whose scholarship de fines the quality of the book. Educational lectures The pathogenesis of human cancer metastasis I] Fidler Cancer is a collection of malignancies with each cancer of each organ consist ing of numerous subsets. This biologic and clinical heterogeneity is probably due to the different etiologies, origins, and selection pressures. Despite this heterogeneity, all malignant neoplasms have a uniform characteristic : the ability to invade host tissues and produce metastases. Clinical observations of cancer patients and studies with experimental rodent tumors have revealed that cer tain tumors produce metastasis to specific organs independent of vascular anat omy, rate of blood flow, and number of tumor cells delivered to each organ. The distribution and fate of hematogeneously disseminated, radiolabelled tumor cells in experimental rodent systems amply demonstrate that tumor cells reach the microvasculature of many organs.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Nude Mouse in Oncology Research written by Epie Boven and published by CRC Press. This book was released on 2018-01-18 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nude, athymic mouse (nu/nu) has become generally accepted as a valuable tool to study the biology and therapy of human cancers. This volume presents a critical review of the scientific merits of the animal as a recipient of human tumor tissue transplants. Important information is provided regarding biology, immunology, and measures for genetic and microbiological control of the nude mouse. The discussion of transplantation sites and transplantability of human tumor tissue to the animals includes both the description of host factors and the tumor type involved. The characterization and monitoring of xenografts is followed by a review on their possible application for studies in tumor biology, such as hormones, growth factors, drug resistance, tumor markers, and heterogeneity. Experimental therapy is dedicated to cytostatic agents, hormones, monoclonal antibodies, cytokines, differentiation inducers and radiotherapy. The book also provides critical remarks regarding the limitation of the nude-mouse tumor models. The Nude Mouse in Oncology Research will provide essential reference information for oncology researchers, researchers who work with the nude mouse on a regular basis, and pharmaceutical companies.
Download or read book Cancer Treatment Reports written by and published by . This book was released on 1987 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Preclinical and Clinical Modulation of Anticancer Drugs written by Kenneth D. Tew and published by CRC Press. This book was released on 1993-09-15 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preclinical and Clinical Modulation of Anticancer Drugs focuses on the theoretical and practical approaches to designing and enacting modulation principles. Each class of anticancer drug and the different types of modulators used within each drug class are discussed within individual chapters. The molecular and biochemical rationale for the use of specific modulators is discussed in detail, and preclinical and clinical implications of the data are integrated into each chapter. Mechanisms of drug resistance and the reasons behind circumventing the resistant phenotype are covered. The book will interest cancer chemotherapists, pharmacologists, oncologists, biochemists, and experimental therapeutics researchers, in addition to students studying the principles of drug discovery and protocol design.
Download or read book Chemosensitivity written by Rosalyn D. Blumenthal and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients.
Download or read book Innovative Antimetabolites in Solid Tumours written by Matti S. Aapro and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.
