Download or read book The Essential Guide to N of 1 Trials in Health written by Jane Nikles and published by Springer. This book was released on 2015-10-05 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.
Download or read book The Essential Guide to N of 1 Trials in Health written by Jane Nikles and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world's leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.
Download or read book Single Case Experimental Designs for Clinical Research and Neurorehabilitation Settings written by Robyn Tate and published by Routledge. This book was released on 2019-01-15 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical resource designed for clinicians, researchers, and advanced students who wish to learn about single-case research designs. It covers the theoretical and methodological underpinnings of single-case designs, as well as their practical application in the clinical and research neurorehabilitation setting. The book briefly traces the history of single-case experimental designs (SCEDs); outlines important considerations in understanding and planning a scientifically rigorous single-case study, including internal and external validity; describes prototypical single-case designs (withdrawal-reversal designs and the medical N-of-1 trial, multiple-baseline designs, alternating-treatments designs, and changing-criterion designs) and required features to meet evidence standards, threats to internal validity, and strategies to address them; addresses data evaluation, covering visual analysis of graphed data, statistical techniques, and clinical significance; and provides a practical ten-step procedure for implementing single-case methods. Each chapter includes detailed illustrative examples from the neurorehabilitation literature. Novel features include: A focus on the neurorehabilitation setting, which is particularly suitable for single-case designs because of the complex and often unique presentation of many patients/clients. A practical approach to the planning, implementation, data analysis, and reporting of single-case designs. An appendix providing a detailed summary of many recently published SCEDs in representative domains in the neurorehabilitation field, covering basic and instrumental activities of daily living, challenging behaviours, disorders of communication and cognition, mood and emotional functions, and motor-sensory disabilities. It is valuable reading for clinicians and researchers in several disciplines working in rehabilitation, including clinical and neuropsychology, education, language and speech pathology, occupational therapy, and physical therapy. It is also an essential resource for advanced students in these fields who need a textbook for specialised courses on research methodology and use of single-case design in applied clinical and research settings.
Download or read book Grieve s Modern Musculoskeletal Physiotherapy written by Deborah Falla and published by Elsevier Health Sciences. This book was released on 2024-04-02 with total page 1629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally edited by Gregory Grieve, a founder of modern manual therapy, the fifth edition of Grieve's Modern Musculoskeletal Physiotherapy continues to offer contemporary evidence, models of diagnosis and practice that make this one of the most highly respected reference books for physiotherapists. This edition has been fully updated to provide an overview of the latest science in a rapidly evolving field. It includes detailed directions for research-informed patient care for a range of musculoskeletal disorders, as well as up-to-date information on the global burden, research methodologies, measurements, and principles of assessment and management. A new international editorial board, with experience in both research and clinical practice, bring a truly comprehensive perspective to this book, meaning those practising musculoskeletal physiotherapy today will find it highly clinically relevant to their work. Edited by an internationally recognised editorial board – brings expertise in both research and clinical practice Fully updated with the latest published evidence Clear guidance on evidence-based contemporary practice Management of conditions relating to both the vertebral column and peripheral joints Updated reviews on the science and practice of a wide range of treatment modalities Principles of effective communication, screening, clinical reasoning, lifestyle considerations, behavioural change and self-management Summary boxes and clinical tips to support clinical assessment and management More than 300 figures and illustrations Global burden of musculoskeletal disorders – including history, epidemiology and new models of care A range of new research methodologies, including N of 1 research designs, systematic reviews and meta-analyses, population-based cohort studies, consensus research and response analyses in musculoskeletal research How to navigate the endless wave of information and assess different levels of evidence New measures New chapter on cost analyses and value-based care Digital rehabilitation methods
Download or read book The Palgrave Handbook of Paralympic Studies written by Ian Brittain and published by Springer. This book was released on 2018-02-15 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a critical assessment of contemporary issues that define the contours of the Paralympic Movement generally and the Paralympic Games more specifically. It addresses conceptualisations of disability sport, explores the structure of the Paralympic Movement and considers key political strategic and governance issues which have shaped its development. The Palgrave Handbook of Paralympic Studies is written by a range of international authors, a number of whom are senior strategists as well as academics, and explores legacy themes through case studies of recent Paralympic games. Written in the wake of the 2016 Rio Paralympic Games, it provides an assessment of contemporary challenges faced by the International Paralympic Committee and other key stakeholders in the Paralympic Movement. Its critical assessment of approaches to branding, classification, social inclusion and technological advances makes this handbook a valuable resource for undergraduate study across a range of sport and disability related programmes, as well as a point of reference for researchers and policy makers.
Download or read book Precision Personalized Pediatric Oncology and Immune Therapies Rather Customize Than Randomize written by Irene Slavc and published by Frontiers Media SA. This book was released on 2020-06-04 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Designing Clinical Research written by Stephen B. Hulley and published by Lippincott Williams & Wilkins. This book was released on 2011-11-30 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop. Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.
Download or read book Practical Data Analytics for Innovation in Medicine written by Gary D. Miner and published by Academic Press. This book was released on 2023-02-08 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Data Analytics for Innovation in Medicine: Building Real Predictive and Prescriptive Models in Personalized Healthcare and Medical Research Using AI, ML, and Related Technologies, Second Edition discusses the needs of healthcare and medicine in the 21st century, explaining how data analytics play an important and revolutionary role. With healthcare effectiveness and economics facing growing challenges, there is a rapidly emerging movement to fortify medical treatment and administration by tapping the predictive power of big data, such as predictive analytics, which can bolster patient care, reduce costs, and deliver greater efficiencies across a wide range of operational functions. Sections bring a historical perspective, highlight the importance of using predictive analytics to help solve health crisis such as the COVID-19 pandemic, provide access to practical step-by-step tutorials and case studies online, and use exercises based on real-world examples of successful predictive and prescriptive tools and systems. The final part of the book focuses on specific technical operations related to quality, cost-effective medical and nursing care delivery and administration brought by practical predictive analytics. Brings a historical perspective in medical care to discuss both the current status of health care delivery worldwide and the importance of using modern predictive analytics to help solve the health care crisis Provides online tutorials on several predictive analytics systems to help readers apply their knowledge on today’s medical issues and basic research Teaches how to develop effective predictive analytic research and to create decisioning/prescriptive analytic systems to make medical decisions quicker and more accurate
Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.
Download or read book A Concise Guide to Clinical Trials written by Allan Hackshaw and published by John Wiley & Sons. This book was released on 2011-09-07 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials have revolutionized the way disease is prevented, detected and treated, and early death avoided, and they continue to be an expanding area of research. They are central to the work of pharmaceutical companies, and there are many academic and public sector organizations that conduct trials on a wide variety of interventions, including drugs, devices, surgical techniques, and changes in behaviour and lifestyle. A Concise Guide to Clinical Trials provides a comprehensive yet easy-to-read overview of the design, conduct and analysis of trials. It requires no prior knowledge on the subject as the important concepts are introduced throughout. There are chapters that distinguish between the different types of trials, and an introduction to systematic reviews, health-related quality of life and health economic evaluation. The book also covers the ethical and legal requirements in setting up a clinical trial due to an increase in governance responsibilities and regulations. This practical guidebook is ideal for busy clinicians and other health professionals who do not have enough time to attend courses or search through extensive textbooks. It will help anyone involved in undertaking clinical research, or those reading about trials. The book is aimed at: Those wishing to learn about clinical trials for the first time, or as a quick reference guide, for example as part of a taught course on clinical trials Health professionals who wish to conduct their own trials, or participate in other people’s studies People who work in pharmaceutical companies, grant funding organisations, or regulatory agencies
Download or read book Handbook of Intellectual Disabilities written by Johnny L. Matson and published by Springer Nature. This book was released on 2019-09-03 with total page 1115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook offers a comprehensive review of intellectual disabilities (ID). It examines historical perspectives and foundational principles in the field. The handbook addresses philosophy of care for individuals with ID, as well as parent and professional issues and organizations, staffing, and working on multidisciplinary teams. Chapters explore issues of client protection, risk factors of ID, basic research issues, and legal concerns. In addition, chapters include information on evidence-based assessments and innovative treatments to address a variety of behaviors associated with ID. The handbook provides an in-depth analysis of comorbid physical disorders, such as cerebral palsy, epilepsy and seizures, and developmental coordination disorders (DCD), in relation to ID. Topics featured in this handbook include: Informed consent and the enablement of persons with ID. The responsible use of restraint and seclusion as a protective measure. Vocational training and job preparation programs that assist individuals with ID. Psychological and educational approaches to the treatment of aggression and tantrums. Emerging technologies that support learning for students with ID. Key sexuality and relationship issues that are faced by individuals with ID. Effective approaches to weight management for individuals with intellectual and developmental disabilities. The Handbook of Intellectual Disabilities is an essential reference for researchers, graduate students, clinicians and related therapists and professionals in clinical child and school psychology, pediatrics, social work, developmental psychology, behavioral therapy/rehabilitation, child and adolescent psychiatry, and special education.
Download or read book Clinical Trials with Missing Data written by Michael O'Kelly and published by John Wiley & Sons. This book was released on 2014-04-07 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.
Download or read book Single case and Small n Experimental Designs written by John B. Todman and published by Psychology Press. This book was released on 2001-03 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical guide to help researchers draw valid causal inferences from small-scale clinical intervention studies. It should be of interest to teachers of, and students in, courses with an experimental clinical component, as well as clinical researchers. Inferential statistics used in the analysis of group data are frequently invalid for use with data from single-case experimental designs. Even non-parametric rank tests provide, at best, approximate solutions for only some single-case (and small-n ) designs. Randomization (Exact) tests, on the other hand, can provide valid statistical analyses for all designs that incorporate a random procedure for assigning treatments to subjects or observation periods, including single-case designs. These Randomization tests require large numbers of data rearrangements and have been seldom used, partly because desktop computers have only recently become powerful enough to complete the analyses in a reasonable time. Now that the necessary computational power is available, they continue to be under-used because they receive scant attention in standard statistical texts for behavioral researchers and because available programs for running the analyses are relatively inaccessible to researchers with limited statistical or computing interest. This book is first and foremost a practical guide, although it also presents the theoretical basis for Randomization tests. Its most important aim is to make these tests accessible to researchers for a wide range of designs. It does this by providing programs on CD-ROM that allow users to run analyses of their data within a standard package (Minitab, Excel, or SPSS) with which they are already familiar. No statistical or computing expertise is required to use these programs. This is the "new stats" for single-case and small-n intervention studies, and anyone interested in this research approach will benefit.
Download or read book Companion and Complementary Diagnostics written by Jan Trøst Jørgensen and published by Academic Press. This book was released on 2019-05-08 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Companion and Complementary Diagnostics: From Biomarker Discovery to Clinical Implementation provides readers with in-depth insights into the individual steps in the development of companion diagnostic assays, from the early biomarker discovery phase straight through to final regulatory approval. Further, the clinical implementation of companion diagnostic testing in the clinic is also discussed. As the development of predictive or selective biomarker assays linked to specific drugs is substantially increasing, this book offers comprehensive information on this quickly-evolving area of biomedicine. It is an essential resource for those in academic institutions, hospitals and pharma, and biotech and diagnostic commercial companies. Covers all aspects, from biomarker discovery, to development and regulatory approval Explains the "how to" aspects of companion diagnostics Incorporates information on the entire process, allowing for easier and deeper understanding of the topic
Download or read book Drug Information A Guide for Pharmacists 7th Edition written by Patrick M. Malone and published by McGraw Hill Professional. This book was released on 2021-11-19 with total page 1630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Everything pharmacists and pharmacy students need to know about drug information management A Doody's Core Title for 2023! Drug Information: A Guide for Pharmacists provides you with the tools you need to to research, interpret, evaluate, collate, and disseminate drug information in the most effective and efficient manner possible. This trusted resource addresses essential topics such as formulating an effective response and recommendations for information, evaluation of drug literature, the application of statistical analysis in the biomedical sciences, medications and patient safety, investigational drugs, and more. This updated seventh edition also addresses other important issues such as the legal and ethical considerations of providing information, how to respond to requests for information, and how to determine what information should be made available.
Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by . This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access title available under the terms of a CC BY-NC 4.0 International licence. It is free to read at Oxford Scholarship Online and offered as a free PDF download from OUP and selected open access locations. Before new interventions are released into disease control programmes, it is essential that they are carefully evaluated in field trials'. These may be complex and expensive undertakings, requiring the follow-up of hundreds, or thousands, of individuals, often for long periods. Descriptions of the detailed procedures and methods used in the trials that have been conducted have rarely been published. A consequence of this, individuals planning such trials have few guidelines available and little access to knowledge accumulated previously, other than their own. In this manual, practical issues in trial design and conduct are discussed fully and in sufficient detail, that Field Trials of Health Interventions may be used as a toolbox' by field investigators. It has been compiled by an international group of over 30 authors with direct experience in the design, conduct, and analysis of field trials in low and middle income countries and is based on their accumulated knowledge and experience. Available as an open access book via Oxford Medicine Online, this new edition is a comprehensive revision, incorporating the new developments that have taken place in recent years with respect to trials, including seven new chapters on subjects ranging from trial governance, and preliminary studies to pilot testing.
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
