Download or read book The Elusive Synthesis written by A. I. Tauber and published by . This book was released on 2014-01-15 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Elusive Synthesis Aesthetics and Science written by A.I. Tauber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tension between art and science may be traced back to the Greeks. What became "natural philosophy" and later "science" has traditionally been posed as a fundamental alternative to poetry and art. It is a theme that has commanded central attention in Western thought, as it captures the ancient conflict of Apollo and Dionysus over what deserves to order our thought and serve as the aspiration of our cultural efforts. The modern schi sm between art and science was again clearly articulated in the Romantic period and seemingly grew to a crescendo fifty years aga as a result of the debate concerning atomic power. The discussion has not abated in the physical sciences, and in fact has dramatically expanded most prominently into the domains of ecology and medicine. Issues concerning the role of science in modern society, although heavily political, must be regarded at heart as deeply embedded in our cultural values. Although each generation addresses them anew, the philosophical problems which lay at the foundation of these fundamental concerns always appear fresh and difficult. This anthology of original essays considers how science might have a greater commonality with art than was perhaps realized in a more positivist era. The contributors are concerned with how the aesthetic participates in science, both as a factor in constructing theory and influencing practice. The collec tion is thus no less than a spectrum of how Beauty and Science might be regarded through the same prism.

Download or read book Getting Started on Your Genealogy Website written by Thornton Gale and published by Lulu.com. This book was released on 2008-02-01 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: BE PART OF THE GOLDEN AGE OF INTERNET GENEALOGY! For a few pennies a day, a genealogy website invites all other genealogists in the world to see and help you with your own research. A genealogy website puts you in contact with those distant cousins. With a genealogy website, you are saying, ""Hey Cuz, are you out there?"" 1. An understandable coverage of a technical subject matter 2. A website development methodology 3. A detailed explanation of how to organize the information of your genealogy website 4. An explanation of what you'll need (and how to use it) to create your genealogy website 5. How to turn your genealogy website into a genealogy book Wholesale - Click Here

Download or read book Total Chemical Synthesis of Proteins written by Ashraf Brik and published by John Wiley & Sons. This book was released on 2021-06-08 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to synthesize native and modified proteins in the test tube With contributions from a panel of experts representing a range of disciplines, Total Chemical Synthesis of Proteins presents a carefully curated collection of synthetic approaches and strategies for the total synthesis of native and modified proteins. Comprehensive in scope, this important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL). It includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization. In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research. The authors also discuss the synthetic challenges that remain to be addressed. This unmatched resource: Contains valuable insights from the pioneers in the field of chemical protein synthesis Presents proven synthetic approaches for a range of protein families Explores key applications of precisely controlled protein synthesis, including novel diagnostics and therapeutics Written for organic chemists, biochemists, biotechnologists, and molecular biologists, Total Chemical Synthesis of Proteins provides key knowledge for everyone venturing into the burgeoning field of protein design and synthetic biology.

Download or read book The Organic Chemistry of Drug Synthesis Volume 5 written by Daniel Lednicer and published by John Wiley & Sons. This book was released on 1994-12-13 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

Download or read book Strategies and Tactics in Organic Synthesis written by Michael Harmata and published by Elsevier. This book was released on 2021-11-11 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies and Tactics in Organic Synthesis, Volume 15, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world. Provides insight and offers new perspective to problem-solving Presents state-of-the-art developments in organic synthesis Written by leading experts in the field Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

Download or read book Synthesis and application of configured 18 19F FDGs written by Mathias Elgland and published by Linköping University Electronic Press. This book was released on 2018-02-21 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.

Download or read book Aziridines and Epoxides in Organic Synthesis written by Andrei K. Yudin and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.

Download or read book Strategies and Tactics in Organic Synthesis written by and published by Elsevier. This book was released on 2016-10-04 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world. Presents state-of-the-art developments in organic synthesis Provides insight and offers new perspective to problem-solving Written by leading experts in the field Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

Download or read book Radiosity and Realistic Image Synthesis written by Michael F. Cohen and published by Elsevier. This book was released on 2012-12-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of image synthesis is to create, using the computer, a visual experience that is identical to what a viewer would experience when viewing a real environment. Radiosity and Realistic Image Synthesis offers the first comprehensive look at the radiosity method for image synthesis and the tools required to approach this elusive goal. Basic concepts and mathematical fundamentals underlying image synthesis and radiosity algorithms are covered thoroughly. (A basic knowledge of undergraduate calculus is assumed). The algorithms that have been developed to implement the radiosity method ranging from environment subdivision to final display are discussed. Successes and difficulties in implementing and using these algorithms are highlighted. Extensions to the basic radiosity method to include glossy surfaces, fog or smoke, and realistic light sources are also described. There are 16 pages of full colour images and over 100 illustrations to explain the development and show the results of the radiosity method. Results of applications of this new technology from a variety of fields are also included. Michael Cohen has worked in the area of realistic image synthesis since 1983 and was instrumental in the development of the radiosity method. He is currently an assistant professor of computer science at Princeton University. John Wallace is a software engineer at 3D/EYE, Inc., where he is the project leader for the development of Hewlett-Packard's ATRCore radiosity and ray tracing library. A chapter on the basic concepts of image synthesis is contributed by Patrick Hanrahan. He has worked on the topic of image synthesis at Pixar, where he was instrumental in the development of the Renderman software. He has also led research on the hierarchical methods at Princeton University, where he is an associate professor of computer science. All three authors have written numerous articles on radiosity that have appeared in the SIGGAPH proceedings and elsewhere. They have also taught the SIGGRAPH course on radiosity for 5 years. * The first comprehensive book written about radiosity - Features applications from the fields of computer graphics, architecture, industrial design, and related computer aided design technologies - Offers over 100 illustrations and 16 pages of full-color images demonstrating the results of radiosity methods - Contains a chapter authored by Pat Hanrahan on the basic concepts of image synthesis and a foreword by Donald Greenberg

Download or read book Endless Forms Most Beautiful The New Science of Evo Devo written by Sean B. Carroll and published by W. W. Norton & Company. This book was released on 2006-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A beautiful and very important book.”—Lewis Wolpert, American Scientist For over a century, opening the black box of embryonic development was the holy grail of biology. Evo Devo—Evolutionary Developmental Biology—is the new science that has finally cracked open the box. Within the pages of his rich and riveting book, Sean B. Carroll explains how we are discovering that complex life is ironically much simpler than anyone ever expected.

Download or read book The Triumph of Uncertainty written by Alfred I. Tauber and published by Central European University Press. This book was released on 2022-08-09 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tauber, a leading figure in history and philosophy of science, offers a unique autobiographical overview of how science as a discipline of thought has been characterized by philosophers and historians over the past century. He frames his account through science’s – and his own personal – quest for explanatory certainty. During the 20th century, that goal was displaced by the probabilistic epistemologies required to characterize complex systems, whether in physics, biology, economics, or the social sciences. This “triumph of uncertainty” is the inevitable outcome of irreducible chance and indeterminate causality. And beyond these epistemological limits, the interpretative faculties of the individual scientist (what Michael Polanyi called the “personal” and the “tacit”) invariably affects how data are understood. Whereas positivism had claimed radical objectivity, post-positivists have identified how a web of non-epistemic values and social forces profoundly influence the production of knowledge. Tauber presents a case study of these claims by showing how immunology has incorporated extra-curricular social elements in its theoretical development and how these in turn have influenced interpretive problems swirling around biological identity, individuality, and cognition. The correspondence between contemporary immunology and cultural notions of selfhood are strong and striking. Just as uncertainty haunts science, so too does it hover over current constructions of personal identity, self knowledge, and moral agency. Across the chasm of uncertainty, science and selfhood speak.

Download or read book Chemical Synthesis of Hormones Pheromones and Other Bioregulators written by Kenji Mori and published by John Wiley & Sons. This book was released on 2011-02-25 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many small molecules occur naturally as "messenger" chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory. Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include: what are biofunctional molecules? why must biofunctional molecules be synthesized? how can we synthesize biofunctional molecules? the synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin the synthesis of insect juvenile hormones and antifeedants the synthesis of pheromones and the significance of chirality in pheromone science the synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin the synthesis of marine antifeedants and medicinal candidates a synthetic examination of incorrectly proposed structures of biomolecules reflections on science as a human endeavor Drawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's Chemical Synthesis of Hormones, Pheromones and Other Bioregulators is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.

Download or read book Fullerenes From Synthesis to Optoelectronic Properties written by D.M. Guldi and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fullerenes: From Synthesis to Optoelectronic Properties covers a host of topics in organic synthesis, photo- / radiation-chemistry, electron donor-acceptor interaction, supramolecular chemistry, and photovoltaics. The book reviews the state-of-the-art discoveries in these areas of "Fullerene Research" and presents selected examples to prove the potential of fullerenes as multifunctional moieties in well-ordered multicomponent composites. Fullerenes: From Synthesis to Optoelectronic Properties appeals to upper-level undergraduates, graduates, researchers, and professionals in the fields of condensed matter physicists; materials scientists; electrochemists; biochemists; solid-state, physical, organic, inorganic, and theoretical chemists; chemical, electrical, and optical engineers.

Download or read book The Synthesis of the Elements written by Giora Shaviv and published by Springer Science & Business Media. This book was released on 2012-04-13 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the origins and evolution of the chemical elements we and the cosmos are made of. The story starts with the discovery of the common elements on Earth and their subsequent discovery in space. How do we learn the composition of the distant stars? How did progress in quantum theory, nuclear physics, spectroscopy, stellar structure and evolution, together with observations of stars, converge to provide an incredibly detailed picture of the universe? How does research in the micro-world explain the macro-world? How does progress in one affect the other, or lack of knowledge in one inhibit progress in the other? In short, Shaviv describes how we discovered the various pieces of the jigsaw that form our present picture of the universe; and how we sometimes put these in the wrong place before finding in the right one. En route we meet some fascinating personalities and learn about heated controversies. Shaviv shows how science lurched from one dogma to the next, time and again shattering much of what had been considered solid knowledge, until eventually a stable understanding arose. Beginning with generally accepted science, the book ends in today’s terra incognita of nuclear physics, astrophysics and cosmology. A monumental work that will fascinate scientists, philosophers, historians and lay readers alike.

Download or read book Encyclopedia of Supramolecular Chemistry written by J. L. Atwood and published by CRC Press. This book was released on 2004 with total page 1022 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystallizing a rapidly expanding interdisciplinary field and one of the most popular and newsworthy areas in contemporary chemistry, this two-volume encyclopaedia offers authoritative information with user-friendly and high-quality articles.

Download or read book The Elusive Embrace written by Daniel Mendelsohn and published by Vintage. This book was released on 2012-01-04 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hailed for its searing emotional insights, and for the astonishing originality with which it weaves together personal history, cultural essay, and readings of classical texts by Sophocles, Ovid, Euripides, and Sappho, The Elusive Embrace is a profound exploration of the mysteries of identity. It is also a meditation in which the author uses his own divided life to investigate the "rich conflictedness of things," the double lives all of us lead. Daniel Mendelsohn recalls the deceptively quiet suburb where he grew up, torn between his mathematician father's pursuit of scientific truth and the exquisite lies spun by his Orthodox Jewish grandfather; the streets of manhattan's newest "gay ghetto," where "desire for love" competes with "love of desire;" and the quiet moonlit house where a close friend's small son teaches him the meaning of fatherhood. And, finally, in a neglected Jewish cemetery, the author uncovers a family secret that reveals the universal need for storytelling, for inventing myths of the self. The book that Hilton Als calls "equal to Whitman's 'Song of Myself,'" The Elusive Embrace marks a dazzling literary debut.