Download or read book The Effects of Omega 3 Polyunsaturated Fatty Acids on Cardiac Rhythm Antiarrhythmic Proarrhythmic Both or Neither written by George E. Billman and published by Frontiers E-books. This book was released on with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cardiovascular benefits of dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) have been actively investigated for nearly 40 years. Beginning with the pioneering studies of Bang and Dyerberg, epidemiological data provide strong evidence for an inverse relationship between fatty fish consumption and cardiac mortality. In contrast to these observational studies, interventional studies using n-3 PUFAs for the secondary prevention of adverse cardiovascular events in patients with heart disease have yielded conflicting results; some studies have reported reduced sudden cardiac death or mortality, while other more recent studies have reported either no effect or an increase in adverse cardiac events. Nevertheless, the American Heart Association and the American College of Cardiology continue to recommend fish oils for the secondary prevention of coronary artery disease. Based in part upon these recommendations, consumer demand for n-3 PUFA products (both nutritional supplements and foods enriched with these lipids) has exploded. In the United States alone, it has been estimated that in 2004, 5-10% of the adult U.S. population were taking a fish oil supplement, with annual sales growth of 40%. In fact, the sales of these products are projected to exceed 7 billion dollars by the end of 2011 (www.marketresearch.com, product reports). Despite the extensive marketing of fish oil products, a scientific consensus on the effects of n-3 PUFA on cardiac rhythm has yet to be reached. It is the purpose of this Research Topic to stimulate a discussion on the putative benefits of n-3 PUFAs on cardiac rhythm. Authors are invited to submit clinical, translational, or experimental research articles, reviews, and hypotheses that address the actions of n-3 PUFA (positive, negative, or neutral) on cardiac rhythm and cardiac electrophysiology. Studies that evaluate the effects of n-3 PUFA on myocyte electrical properties, atrial fibrillation, ventricular fibrillation, and heart rate variability are particularly welcome.
Download or read book Effects of Omega 3 Fatty Acids on Arrhythmogenic Mechanisms in Animal and Isolated Organ cell Culture Studies written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Koda Kimble and Young s Applied Therapeutics written by Brian K. Alldredge and published by Lippincott Williams & Wilkins. This book was released on 2012-02-01 with total page 2562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rev. ed. of: Applied therapeutics: the clinical use of drugs / edited by Mary Anne Koda-Kimble ... [et al.]. 9th ed. c2009.
Download or read book Update on Essential Hypertension written by Lizbeth Salazar-Sanchez and published by BoD – Books on Demand. This book was released on 2016-09-14 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential hypertension is a quantitative characteristic that is important for correlating with the rate of morbidity and mortality in the developed and developing countries. The etiology of essential hypertension is complex. This work, authored by renowned researchers in the field, gives updated concepts about essential hypertension. Novel advanced topics are presented in a sole document as hypertension in children; the contribution in the psychiatric comorbidities associated with it; mechanisms of omega-3 in protection against hypertension-related organ damage; oxidative stress at different levels; genetics-associated studies; the role of pollution in essential hypertension; personalized healthcare in a hypertensive patient; and hypertension-related disparities between ethnic groups. It can conclude so that essential hypertension is one of the hottest topics in contemporary medicine.
Download or read book Cardiovascular Benefits of Omega 3 Polyunsaturated Fatty Acids written by B. Maisch and published by IOS Press. This book was released on 2007-01-18 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decades progress has been made in the treatment of patients who survived myocardial infarction. Nevertheless, patients who survive an acute myocardial infarction are at high risk, with life expectancy half that of their peers who have not experienced similar events, and with increased risk for subsequent cardiovascular events and death. The risk of sudden death increases with severity of systolic dysfunction after myocardial infarction. In recent years, it has become clear that in addition to risk factors such as overweight, lack of exercise, smoking, hypertension and hypercholesterolemia, psychosocial factors play a key role for prognosis in patients with myocardial infarction. Therefore, there is high medical need for drugs which lower the incidence of sudden death and have an effect on other risk factors such as depression. OMACOR®, a pharmaceutical preparation of highly purified and concentrated Ω-3 polyunsaturated acids, may present such a drug. It lowers the incidence of sudden death in patients with myocardial infarction and decreases depression. This publication focuses on the effect of Ω-3 polyunsaturated fatty acids on different risk factors in patients with cardiovascular disease. In addition, aspects of prevention of cardiovascular disease, risk factors and pharmacokinetics of Ω-3 fatty acids ethyl esters are considered.
Download or read book Effects of Omega 3 Fatty Acids on Arrhythmogenic Mechanisms in Animal and Isolated Organ Cell Culture Studies written by U.s. Department of Health and Human Services and published by CreateSpace. This book was released on 2014-06-27 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This evidence report is one of three prepared by the Tufts-New England Medical Center Evidence-based Practice Center (EPC) concerning the health benefits of omega-3 fatty acids on cardiovascular diseases. The aim of these reports is to summarize the current evidence of the health effects of omega-3 fatty acids on: cardiovascular diseases, cancer, child and maternal health, eye health, gastrointestinal/renal diseases, asthma, autoimmune diseases, immune-mediated diseases, transplantation, mental health, and neurological diseases and conditions. The focus of this report is on arrhythmogenic mechanisms in animal and isolated organ and cell culture studies. Arrhythmias are thought to be the cause of “sudden death” in heart disease. Animal studies have suggested that omega-3 long-chain polyunsaturated fatty acids (LC PUFAs), such as eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), engage in multiple cytoprotective activities that may contribute to antiarrhythmic mechanisms. In this report, we examine evidence that omega-3 fatty acids affect cell organelles—such as cardiac ion channels, pumps, or exchange mechanisms—that are involved in cardiac electrophysiology or electrogenesis. The key questions addressed by this report are: 1) What is the evidence from whole animal studies that omega-3 fatty acids affect arrhythmogenic outcomes (and intermediate outcomes)? 2) What is the evidence from cell culture and tissue studies (including animal and human cardiac tissue) that omega-3 fatty acids directly affect cell organelles such as cardiac ion channels, pumps, or exchange mechanisms involved in electrogenesis? In whole animal studies examined for this report, omega-3 fatty acids were fed to whole, intact animals as part of their diet or were infused intravenously. Outcomes examined by these studies include induced arrhythmia, ventricular ectopic beats, and ventricular and atrial fibrillation. In whole animal isolated organ and cell studies, omega-3 fatty acids were fed to whole, intact animals as part of their diet, and organs or cell tissues were subsequently excised from the animal to study outcomes such as arrhythmia, and myocyte contraction and beating rate. In “pure” isolated organ and cell studies, omega-3 fatty acids were applied directly to mammalian tissues or cultured cell lines or incorporated into the membrane of the mammalian tissues or cultured cell lines. Outcomes examined in these studies include induced arrhythmia, myocyte contraction and beating rate, and any other arrhythmogenic outcomes. In examining studies for this report, we focused on several potential arrhythmogenic mechanisms, including contractile parameters, basoelectromechanical parameters, ion pumps, ion channels, and membrane currents.
Download or read book Antiarrhythmic Mechanisms of Omega 3 Polyunsaturated Fatty Acids in Rat Ventricular Cardiomyocytes written by Wayne Richard Leifert and published by . This book was released on 2001 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigates the mechanisms underlying the antiarrhythmic effects of omega-3 polyunsaturated fatty acids using adult rat ventricular cardiac myocytes.
Download or read book Health Effects of omega 3 Polyunsaturated Fatty Acids in Seafoods written by Artemis P. Simopoulos and published by S. Karger AG (Switzerland). This book was released on 1991 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Frontiers in Sports and Active Living Anniversary Edition written by Frontiers Editorial Office and published by Frontiers Media SA. This book was released on 2020-05-15 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: As we celebrate one year since the launch of Frontiers in Sports and Active Living, in this anniversary edition we wish to showcase a collection of selected articles published across both the natural and social science specialty sections. Led by Gregoire Millet (University of Lausanne) and Richard Giulianotti (Loughborough University), Frontiers in Sports in Active Living provides a multidisciplinary platform to examine sports, physical activity, exercise training and active living from all perspectives and, as a journal, we would like to thank all our editors and authors for their contributions and support.
Download or read book Encyclopedia of Molecular Mechanisms of Disease written by Florian Lang and published by Springer Science & Business Media. This book was released on 2009-03-19 with total page 2348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.
Download or read book Cardiac Electrophysiology from Cell to Bedside written by Douglas P. Zipes and published by Elsevier Health Sciences. This book was released on 2013-10-25 with total page 1395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald's Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should online access to the web site be discontinued.
Download or read book Dietary 3 and 6 Fatty Acids written by Corraldo Galli and published by Springer. This book was released on 2013-04-15 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: On June 24-26, 1985, a major International Conference on the Hea1th Effects of P01yunsaturated Fatty Acids in Seafoods was held in Washington, D. C. The conference had two objectives: (1) to review the research data on the health effects of polyunsaturated fatty acids in seafoods in terms of the impact of omega-3 fatty acids on eicosanoid formation, thrombosis and inflammation, and the role of docosahexaenoic acid in membrane function and metabolism, and (2) to develop a research agenda to determine the spectrum of the health effects of polyunsaturated fatty acids of seafood origin in the American diet. The 1985 conference established the fact that omega-3 fatty acids of marine origin - eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - play important roles in prostaglandin metabolism, thrombosis and atherosc1erosis, immunology and inflammation, and membrane function. In response to the conference recommendations, the Congress of the United States provided special funding for the establishment of a "test materials 1aboratory" within the US Department of Commerce to produce under documented quality contr01 the types and quanti ties of omega-3 te~3t materials required by biomedica1 researchers. The forms of test materials to be produced include refined fish oil, polyunsaturated fatty acid enhanced triglycerides, concentrates of esters of fatty acids, purified omega-3 fatty acids, and omega-3 mono-, di- and tri~lyceride mixtures.
Download or read book Dietary 3 and 6 Fatty Acids written by Corraldo Galli and published by Springer. This book was released on 1989-08-01 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: On June 24-26, 1985, a major International Conference on the Hea1th Effects of P01yunsaturated Fatty Acids in Seafoods was held in Washington, D. C. The conference had two objectives: (1) to review the research data on the health effects of polyunsaturated fatty acids in seafoods in terms of the impact of omega-3 fatty acids on eicosanoid formation, thrombosis and inflammation, and the role of docosahexaenoic acid in membrane function and metabolism, and (2) to develop a research agenda to determine the spectrum of the health effects of polyunsaturated fatty acids of seafood origin in the American diet. The 1985 conference established the fact that omega-3 fatty acids of marine origin - eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - play important roles in prostaglandin metabolism, thrombosis and atherosc1erosis, immunology and inflammation, and membrane function. In response to the conference recommendations, the Congress of the United States provided special funding for the establishment of a "test materials 1aboratory" within the US Department of Commerce to produce under documented quality contr01 the types and quanti ties of omega-3 te~3t materials required by biomedica1 researchers. The forms of test materials to be produced include refined fish oil, polyunsaturated fatty acid enhanced triglycerides, concentrates of esters of fatty acids, purified omega-3 fatty acids, and omega-3 mono-, di- and tri~lyceride mixtures.
Download or read book Antiarrhythmic Drugs written by Antoni Martínez-Rubio and published by Springer Nature. This book was released on 2020-02-03 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format. Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis.
Download or read book Pathophysiology and Pharmacotherapy of Cardiovascular Disease written by Gowraganahalli Jagadeesh and published by Springer. This book was released on 2015-05-06 with total page 1323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.
Download or read book Management of Cardiac Arrhythmias written by Gan-Xin Yan and published by Springer Nature. This book was released on 2020-07-27 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: A significantly expanded third edition, this book provides a comprehensive and concise overview of cardiac arrhythmias and their ECG/telemetry manifestations, including the principles of cardiac electrophysiology, current concepts of pharmacology, clinical features, diagnoses, and state-of-the-art treatments. Additionally, the book emphasizes decision-making strategies in approaching each individual patient and the application of technical innovations in specific clinical situations. Organized into eight parts, beginning chapters introduce the concepts and principles of cardiac electrophysiology, unique rhythms, and ECG waves/signs. These chapters are designed to integrate emerging knowledge in basic science and clinical medicine. Subsequent chapters focus on the diagnosis of a variety of cardiac arrhythmias using non-invasive methodology. Throughout the book, chapters continue to analyze pharmacological and other approaches to therapy of specific arrhythmias, including supraventricular tachycardias, atrial fibrillation and flutter, ventricular arrhythmias, and bradyarrhythmias. Finally, the book closes with coverage on inherited cardiac arrhythmia syndromes including the long, short QT, and J-wave syndromes, catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. The third edition of Management of Cardiac Arrhythmias, is an essential resource for physicians, residents, fellows, and medical students in cardiology, cardiac surgery, vascular surgery, cardiac electrophysiology, and cardiac radiology.
Download or read book Ventricular Arrhythmias written by John M. Miller and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ventricular arrhythmias cause most cases of sudden cardiac death, which is the leading cause of death in the US. This issue reviews the causes of arrhythmias and the promising new drugs and devices to treat arrhythmias.
