Download or read book The developmental assembly of sensory axon arrays in the central nervous system of Drosophila melanogaster written by Nicholas Robert John Glossop and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Developmental Assembly of Sensory Axon Arrays in the Nervous System of Drosophila Melanogaster written by Nicholas Robert John Glossop and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Development in Drosophila melanogaster written by Gerhard Martin Technau and published by Springer Science & Business Media. This book was released on 2009-01-08 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.
Download or read book Analysis of Axon Guidance in the Embryonic Central Nervous System of Drosophila Melanogaster written by Vicki L. McGovern and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The goal of developmental neurobiology is to understand how a complex nervous system is wired. During development of the central nervous system (CNS) neural connections are assembled in a highly stereotyped fashion. How do axons find their targets with such accuracy? We know that axon migration is direct by attractive and repulsive guidance cues located in the extracellular environment. While many guidance molecules have been identified, we are only just beginning to understand the mechanisms of axon guidance. In order to identify additional genes involved in axon guidance and CNS development we performed a misexpression screen. Using P-elements and the UAS/GAL4 system, transcription of endogenous genes was induced in the embryonic CNS. Misexpression phenotypes were then identified immunohistochemically with two monoclonal antibodies: BP102, a general axon marker, and 1D4, which labels a subset of axon pathways. Over 4100 individual P-element insertion lines were screened. Twenty-five insertions corresponding to 18 genes resulted in misexpression phenotypes. Genes involved in axon guidance, embryonic patterning, and cell cycle regulation were identified. Several transcription factors that have not been previously implicated in CNS development were isolated and characterized as well. The identification of these transcription factors is intriguing since little is known about the transcriptional regulation of axon guidance genes. Additionally, we have studied the regulation of the previously identified guidance molecule Commissureless (Comm). Comm is necessary for proper axon guidance at the CNS midline of the Drosophila embryo. In the absence of Comm, commissural axons fail to cross the midline and instead make ispilateral projections on their respective sides of the midline. Using mosaic analysis, we have identified a cell autonomous neuronal requirement for Comm. Clones containing mutant alleles of comm formed commissural projections at a statistically significant reduced frequency when compared to wild type clones. This result suggests that regulation of Comm expression in neurons is critical for Comm's function in axon guidance at the CNS midline. These studies have both advanced the understanding of the regulation of Comm, and have identified new potential regulators of guidance molecules.
Download or read book Analysis of the Role of the Roundabout Receptors in Axon Guidance in the Embryonic Central Nervous System of Drosophila Melanogaster written by Julie Hayner Simpson and published by . This book was released on 2001 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Central Nervous System of Vertebrates written by Rudolf Nieuwenhuys and published by Springer Science & Business Media. This book was released on 1998 with total page 2270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference is clearly destined to become the definitive anatomical basis for all molecular neuroscience research. The three volumes provide a complete overview and comparison of the structural organisation of all vertebrate groups, ranging from amphioxus and lamprey through fishes, amphibians and birds to mammals. This thus allows a systematic treatment of the concepts and methodology found in modern comparative neuroscience. Neuroscientists, comparative morphologists and anatomists will all benefit from: * 1,200 detailed and standardised neuroanatomical drawings * the illustrations were painstakingly hand-drawn by a team of graphic designers, specially commissioned by the authors, over a period of 25 years * functional correlations of vertebrate brains * concepts and methodology of modern comparative neuroscience * five full-colour posters giving an overview of the central nervous system of the vertebrates, ideal for mounting and display This monumental work is, and will remain, unique; the only source of such brilliant illustrations at both the macroscopic and microscopic levels.
Download or read book Neural Regeneration written by Kwok Fai So and published by Academic Press. This book was released on 2015-02-03 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including: - Neural regeneration in lower vertebrates - Neural regeneration in the peripheral nervous system - Neural regeneration in the central nervous system - Transplantation-mediated neural regeneration - Clinical and translational research on neural regeneration The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China. Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries. This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research. - Provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration - Highly translational and clinically-relevance - International authors who are leaders in their respective fields - Vivid art work making the chapters easily understood
Download or read book Brain Development in Drosophila melanogaster written by Gerhard Martin Technau and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.
Download or read book Dissecting Neuronal Specification in the Drosophila Taste System written by Lisa Marie Dennison and published by . This book was released on 2012 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Establishing a complex brain and nervous system requires a wide array of neurons with diverse forms, functions, and characteristics. Developing nervous systems employ many strategies to create this neuronal diversity, and these strategies remain the subject of ongoing investigations in developmental neuroscience. Neuronal diversity in the taste system of Drosophila melanogaster is important for the appropriate detection of chemosensory signals in the fly's environment. Drosophila can distinguish sweet substances, bitter compounds, pheromones, and pure water using distinct populations of taste neurons. The correct detection of such substances is critical for correct ingestion of nutritive foods, avoidance of toxins, recognition of appropriate mates, and hydration, all of which are essential for the survival and propagation of the fly. The first part of this thesis focuses on the developmental relationship between these classes of neurons and the signaling pathways used to diversify them. Mosaic analysis revealed at least two stereotyped lineages for taste neurons innervating bristles on the proboscis of the fly. Furthermore, mutant mosaic studies showed that Numb inheritance or lack thereof is necessary for correct cell fate decisions. The involvement of Numb strongly indicates that Notch signaling is the key player in establishing taste neuron diversity. The second part of this thesis describes an expression screen for transcription factors with specific expression patterns in subsets of taste neurons. The transcription factors activated in each cell type ultimately establish that cell's unique identity by activating expression of appropriate receptors, axon guidance cues, neurotransmitters, and more. The screen identified two transcription factors, knot and Lim3, with specific expression in bitter-sensing neurons. Results of loss-of-function and gain-of-function studies with each gene indicate that neither one alone is necessary or sufficient to specify the full bitter neuron fate, but it remains possible that each could play a role in subsets of the bitter neuron's identity not observed by these analyses.
Download or read book Topographical Projections of Limb Innervating Motor Neurons in Drosophila Melanogaster Specified by Morphological Transcription Factors and Downstream Cell Surface Proteins written by Lalanti Venkatasubramanian and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Using in vivo live imaging I describe the developmental steps involved in Drosophila leg motor neuron axon targeting during metamorphosis and the spatial expression patterns of a novel hetero-binding Ig domain transmembrane protein family - the DIPs and Dprs (Ozkan et al., 2013) in leg neuro-musculature. I further describe a function between interacting partners DIP-alpha and Dpr10, expressed in subsets of leg motor neurons and muscles respectively, in establishing the final stereotyped terminal axon branching of corresponding motor neurons. The combinations of such interactions throughout development between leg motor neurons, not only with muscles in the periphery, but also among themselves, with leg sensory neurons and other components in the central nervous system may ultimately lead to synaptic specificity and stereotyped morphologies of Drosophila leg motor neurons.
Download or read book The Wiley Handbook of Evolutionary Neuroscience written by Stephen V. Shepherd and published by John Wiley & Sons. This book was released on 2017-01-30 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and authoritative, The Wiley Handbook of Evolutionary Neuroscience unifies the diverse strands of an interdisciplinary field exploring the evolution of brains and cognition. A comprehensive reference that unifies the diverse interests and approaches associated with the neuroscientific study of brain evolution and the emergence of cognition Tackles some of the biggest questions in neuroscience including what brains are for, what factors constrain their biological development, and how they evolve and interact Provides a broad and balanced view of the subject, reviewing both vertebrate and invertebrate anatomy and emphasizing their shared origins and mechanisms Features contributions from highly respected scholars in their fields
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1498 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Development of Drosophila Melanogaster written by Michael Bate and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
Download or read book Agrindex written by and published by . This book was released on 1994 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Neuroembryology written by Hans J. ten Donkelaar and published by Springer Science & Business Media. This book was released on 2006-09-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in developmental neurobiology and advances in (neuro) genetics have been spectacular. The high resolution of modern imaging techniques applicable to developmental disorders of the human brain and spinal cord have created a novel insight into the developmental history of the central nervous system (CNS). This book provides a comprehensive overview of the development of the human CNS in the context of its many developmental disorders. It provides a unique combination of data from human embryology, animal research and developmental neuropathology, and there are more than 400 figures in over a hundred separate illustrations.
Download or read book Invertebrate Vision written by Eric Warrant and published by Cambridge University Press. This book was released on 2006-10-05 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher description
Download or read book Development of Sensory Systems written by C. M. Bate and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This preface is addressed to the reader who wishes to inquire into the prevailing concepts, hypotheses and theories about development of sensory systems and wants to know how they are exemplified in the following chapters. I believe that science is hypothesis and theory and that the growth and evolution of any branch of science can be measured by the degree to which its theories have been reified. By that standard, one must conc1ude that developmental neuro biologie is in its infancy. The rapid accumulation of observations which has occurred in this branch of science in the past century leads to progress only to the extent that the facts validate or falsify hypotheses. The following chapters show that we have a plethora of facts but a dearth of hypotheses. Another index of the maturity of any branch of science is its level of historical self-awareness. Because the history of any branch of science is essentially the history of ideas and of the rise and fall of theories, the level of historical awareness is related to the extent to which reification of its hypothetical constructs has advanced. It is largely because few theories of development of sensory systems, or indeed, of developmental neurobiology, have progressed far in the process of reification that the his tory of developmental neurobiology remains unwritten. The subject of this volume is hardly mentioned in the many books devoted to the history of related disciplines.
