Download or read book The Developmental and Reproductive Effects of Triclocarban on Japanese Medaka Oryzias Latipes written by Ida Janella Flores and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Triclocarban (TCC; 3,4,4'-trichlorocarbanilide) is an antibacterial agent that kills bacteria by disrupting cell membrane permeability. TCC is commonly used in personal products such as soaps, detergents, lotions and wipes. TCC was introduced commercially over fifty years ago in the United States and in Europe, and now it is one of the most frequently and widely detected chemicals in aquatic systems. There is a growing concern that the presence of TCC in the environment may pose unwanted toxic effects to animal health. One key concern is the potential of TCC affecting the endocrine system, which is essential throughout an organism's lifetime. Processes involved in growth, nutrition, reproduction and behavior are all controlled by the endocrine system. In this dissertation, I aimed to identify the developmental and reproductive effects of TCC in fish by investigating endpoints at multiple levels of biological organization. In chapter one, the bioaccumulation, metabolism and elimination of TCC were measured in larval medaka. One-week-old female larvae were exposed to 20 [mu]g/L of TCC for 24 hours and water and fish were sampled throughout the exposure. TCC and metabolites were quantified by online solid phase extraction liquid chromatography-tandem electrospray mass spectrometry (LC-ESI-MS/MS). Results showed that in fish tissue high bioaccumulation of TCC was achieved and a calculated bioconcentration factor (BCF) of log BCF 2.9. Also, oxidative metabolites of TCC were measured in tissue and in water samples demonstrating the first evidence of metabolism and elimination of TCC by fish. From the first study, it was determined that as a result of continuous TCC exposure, a steady concentration of TCC was present in fish tissue thus during prolonged exposures there may be the potential for negative biological effects in fish. Effects on development and reproduction were examined. To investigate developmental effects, medaka embryos were exposed to levels of TCC from 0 to 3,900 ng/L for 14 days. Organogenesis was monitored during specific time-points and heart rate was measured at 144 days post-fertilization. Hatching success, time-to-hatch, and soluble epoxide (sEH) enzyme activity was also measured. TCC had no effect on survival of embryos and had minimal effect on delay in hatching. A dose-dependent increase in heart rate was also observed. Analysis of sEH activity revealed sex-specific effects in alteration. Females exhibited sEH activation at low concentrations and sEH inhibition at higher concentrations while males exhibited a dose-dependent inhibition of the enzyme. The results from this study showed that TCC at environmentally relevant levels has an effect on the health of the developing embryo. The objective of the final chapter was to examine reproductive effects as a result of a full-life chronic exposure to TCC. Medaka embryos were continuously bath-exposed to control (reconstituted water), vehicle control (ethanol), and concentrations of 0.39, 1.36, and 3.71 [mu]g/L of TCC for 3 months until the fish became reproductively active. Health indices, gonad histology, protein and gene expression related to endocrine disruption, fertility, and fecundity were measured. There were no significant differences in condition factor and gonadosomatic index in males and females. A significant increase was observed in hepatosomatic index of females at the 3.71[mu]g/L of TCC treatment group but no significant differences were observed in the males. Adverse effects on fecundity were observed at the 3.71 [mu]g/L level of TCC, as females produced significantly lower number of eggs than control groups. Estrogen responsive genes showed a trend toward down-regulation in liver and gonads though in male testes, expression of ER beta 2 was significantly up-regulated. This full life-cycle assessment revealed that TCC affects the fish endocrine system and can cause adverse outcomes on fish reproduction.
Download or read book Pharmaceuticals in Marine and Coastal Environments written by Juan Carlos Duran-Alvarez and published by Elsevier. This book was released on 2021-06-23 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceuticals in Marine and Coastal Environments: Occurrence, Effects, and Challenges in a Changing World is divided into three sections that address a) coastal areas as the main entrance of pharmaceuticals into the ocean, b) the occurrence and distribution of pharmaceuticals in the environmental compartments of the ocean media, and c) the effects that such pollutants may cause to the exposed marine organisms. With its comprehensive discussions, the book provides a wide depiction of the current state-of-the-art on these topics in an effort to open new sources of investigation and find suitable solutions. Includes maps edited by the Water Information Network System of the International Hydrological Program (IHP-WINS) Provides a compilation of information regarding the occurrence and distribution of pharmaceuticals in the marine environment which will help establish new and more efficient monitoring programs and new research lines Depicts the most important results of environmental risk assessments that can be used as a first step for further toxicological studies
Download or read book Index Medicus written by and published by . This book was released on 2001-08 with total page 2156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Monitoring Water Quality written by Satinder Ahuja and published by Newnes. This book was released on 2013-01-02 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monitoring Water Quality is a practical assessment of one of the most pressing growth and sustainability issues in the developed and developing worlds: water quality. Over the last 10 years, improved laboratory techniques have led to the discovery of microbial and viral contaminants, pharmaceuticals, and endocrine disruptors in our fresh water supplies that were not monitored previously. This book offers in-depth coverage of water quality issues (natural and human-related), monitoring of contaminants, and remediation of water contamination. In particular, readers will learn about arsenic removal techniques, real-time monitoring, and risk assessment. Monitoring Water Quality is a vital text for students and professionals in environmental science, civil engineering, chemistry — anyone concerned with issues of water analysis and sustainability assessment. Covers in depth the scope of sustainable water problems on a worldwide scale Provides a rich source of sophisticated methods for analyzing water to assure its safety Describes the monitoring of contaminants, including pharmaceutical and endocrine disruptors Helps to quickly identify the sources and fates of contaminants and sources of pollutants and their loading
Download or read book The Fish Oocyte written by Patrick J. Babin and published by Springer Science & Business Media. This book was released on 2007-08-20 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the growing needs in deciphering the biological processes associated with fish reproduction, in view of the growth of aquaculture and the dwindling natural stocks of commercially important fish. It presents a comprehensive overview on egg production in fish, from the standpoint of the oocyte. With this view in mind, the book includes chapters on oocyte development (oogenesis), hormonal regulation and hormone receptors, formation of the egg envelopes, growth, accumulation of nutrients and maternal transcripts, maturation, hydration, ovulation and fertilization. A special emphasis is placed on using state-of-the-art tools including electron microscopy for discerning the ultra-structure of the follicle and genomic/proteomic tools to fully understand biological basis of fish reproduction. Studies on promoting oocyte maturation, ovulation and spawning in farmed fish and preservation of fish oocytes at low temperatures are also included. The book will appeal to University lecturers, students, research scientists and those associated with culture of fish in freshwater or marine aquaculture.
Download or read book Personal Care Products in the Aquatic Environment written by M. Silvia Díaz‐Cruz and published by Springer. This book was released on 2015-08-10 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers an overview of the occurrence and distribution of personal care products in continental and marine waters, presents analytical methods and degradation technologies and discusses their impact on human health. Experts from different disciplines highlight major issues for each family of compounds related to their occurrence in the water column as well as in solid and biota samples, methodological strategies for their analysis, non-conventional degradation technologies, (eco)toxicity data and their human and environmental risk assessment. The book also includes a general introduction to personal care products, covering their properties, use, behaviour and regulatory framework, and a final chapter identifying knowledge gaps and future research trends. It will appeal to experts from various fields of research, including analytical and environmental chemistry, toxicology and environmental engineering.
Download or read book Environmental Metabolomics written by Diana Alvarez-Munoz and published by Elsevier. This book was released on 2020-06-03 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Metabolomics Applications in Field and Laboratory Studies: From the Exposome to the Metabolome presents an overview of the current state of aquatic environments and problems caused by human pressure and daily life. The presence of contaminants in nature and their effects are evaluated, along with recommendations for preservation. This book not only shows readers how to implement techniques, it also guides them through the process. As metabolomics becomes a more routine technique for environmental studies and future perspectives, a guide for validation and globalization of current approaches is needed. Presents relevant and reliable information on the use of different analytical techniques for establishing the environmental metabolomics of polluted systems Includes a critical review of each central topic in every chapter, together with a bibliography and future trends Provides, for the first time, a global opinion and guide for achieving standardized results
Download or read book Contaminants of Emerging Concern in the Environment written by Rolf Halden and published by OUP USA. This book was released on 2011-09-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book documents the current science of CECs with important new data on the risks associated with a broad range of persistent organic pollutants.
Download or read book Behavioral Toxicology written by Bernard Weiss and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioral toxicology is a young discipline in the United States; so young, in fact, that this is one of its first books. Behavioral questions are bound to play a major role in future scientific work and governmental decisions involving the health effects of environmental contaminants and other chemicals. This role springs from two key problems that face scientists and public agencies required to set acceptable exposure standards or to determine criteria for the toxicity of therapeutic chemicals: How do you evaluate effects that may show up only as subtle functional disturbances? And how do you de tect toxic effects early enough so that they may still be reversible, before they produce major damage? The contributions in this book come from a collection of scientists whose interests span a wide variety of problem areas. The focus is largely on me thodological issues because they represent the most immediate concern of the discipline. We expect that this collection of papers will represent a useful source book for behavioral toxicology for some time. For the past few years, the University of Rochester's Department of Radiation Biology and Biophysics has sponsored a series of international conferences on chemical toxicity, partly as a response to concern over the con sequences to health of the rich chemical soup in which we live. This book is based upon presentations made to the fifth of the series. Held in June, 1972, it was the first formal meeting devoted to behavioral toxicology in this country.
Download or read book Understanding Toxicology written by Steven Mercurio and published by Jones & Bartlett Learning. This book was released on 2016-08-30 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system. Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment. Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts. Key Features • Uses lively, engaging examples making the text fun and easy to read and understand • Allows the reader to approach the subject from a research perspective as well as a public policy perspective • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins • Thoroughly covers all organisms including fish, plants, and microbes • Includes outlines and review questions in each chapter
Download or read book In vitro Plant Breeding towards Novel Agronomic Traits written by Manoj Kumar and published by Springer Nature. This book was released on 2019-11-23 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview of plant stresses caused by salt, drought, extreme temperatures, oxygen and toxic compounds, which are responsible for huge losses in crop yields. It discusses the latest research on the impact of salinity and global environment changes, and examines the advances in the identification and characterization of the mechanisms that allow plants to tolerate biotic and abiotic stresses. Further it presents our current understanding of metabolic fluxes and the various transporters that collectively open the possibility of applying in vitro technology and genetic engineering to improve stress tolerance. Exploring advanced methods that augment traditional plant tissue culture and breeding techniques toward the development of new crop varieties that can tolerate biotic and abiotic stresses to achieve sustainable food production, this book is a valuable resource for plant scientists and researchers.
Download or read book Molecular Biology of Eye Disease written by and published by Academic Press. This book was released on 2015-08-13 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of eye disease. Contributions from leading authorities Informs and updates on all the latest developments in the field
Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...
Download or read book Organic Pollutants written by M. Vasanthy and published by Springer Nature. This book was released on 2021-10-23 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment. The chapters present reviews on current applied toxicology research, occupational health hazards and green remedial solutions for pollution control in terrestrial and aquatic environments, with the aim of raising public awareness of these issues and providing chemists, toxicologists and environmental scientists with the knowledge to combat organic pollutants through sustainable means. Readers will learn about the multi-dimensional applications of materials and processes which harvest energy out of environmental remediation technologies, as well as the roles of biotechnology and nanotechnology in addressing high pollutant load. Specific attention is paid to technologies that draw energy through wastewater remediation, as this covers the primary means by which organic pollutants are introduced into the environment from industry and other sources. The book will be of use to pollution control boards, industry regulators, and students and researchers in the fields of biotechnology, biomedical science, hydrology and water chemistry.
Download or read book Health Impacts of Developmental Exposure to Environmental Chemicals written by Reiko Kishi and published by Springer Nature. This book was released on 2019-12-13 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.
Download or read book Soil Components and Human Health written by Rolf Nieder and published by Springer. This book was released on 2018-01-10 with total page 907 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights important links existing between soils and human health which up to now are not fully realized by the public. Soil materials may have deleterious, beneficial or no impacts on human health; therefore, understanding the complex relationships between diverse soil materials and human health will encourage creative cooperation between soil and environmental sciences and medicine. The topics covered in this book will be of immense value to a wide range of readers, including soil scientists, medical scientists and practitioners, nursing scientists and staff, toxicologists, ecologists, agronomists, geologists, geochemists, public health professionals, planners and several others.
Download or read book Green Chemistry and the Ten Commandments of Sustainability written by Stanley E. Manahan and published by . This book was released on 2011 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
