Download or read book The Design Manufacture and Characterisation of Polycaprolactone Scaffolds and a Novel Modular Perfusion Bioreactor Strategy for Bone Tissue Engineering written by Peter John Christopher Felstead and published by . This book was released on 2011 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterisation and Design of Tissue Scaffolds written by Paul Tomlins and published by Elsevier. This book was released on 2015-10-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers. Summarizes concepts and current practice in the characterization and design of tissue scaffolds Discusses design and preparation of scaffolds Details how to prepare tissue scaffolds, discusses techniques in characterization, and presents practical considerations for manufacturers
Download or read book Biodegradable Polymer Based Scaffolds for Bone Tissue Engineering written by naznin sultana and published by Springer Science & Business Media. This book was released on 2012-12-15 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the principles, methods and applications of biodegradable polymer based scaffolds for bone tissue engineering. The general principle of bone tissue engineering is reviewed and the traditional and novel scaffolding materials, their properties and scaffold fabrication techniques are explored. By acting as temporary synthetic extracellular matrices for cell accommodation, proliferation, and differentiation, scaffolds play a pivotal role in tissue engineering. This book does not only provide the comprehensive summary of the current trends in scaffolding design but also presents the new trends and directions for scaffold development for the ever expanding tissue engineering applications.
Download or read book Scaffolds for Tissue Engineering written by Claudio Migliaresi and published by CRC Press. This book was released on 2014-06-10 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scaffolds for tissue engineering are devices that exploit specific and complex physical and biological functions, in vitro or in vivo, and communicate through biochemical and physical signals with cells and, when implanted, with the body environment. Scaffolds are produced mainly with synthetic materials, and their fabrication technologies are derived from already well-established industrial processes, with some new specific technologies having been developed in the last years to address required complexities. Often, a generalist approach is followed for the translation of materials and technologies designed for other applications, without considering the specific role of scaffolds from a physical and biological point of view. The book illustrates scaffold design principles, with particular relevance to the biological requirements needed to control and drive the biological cross talk, and reviews materials and fabrication and validation methods.
Download or read book Novel Fabrication Development for the Application of Polycaprolactone and Composite Polycaprolactone hydroxyapitite Scaffolds for Bone Tissue Engineering written by Lauren Shor and published by . This book was released on 2008 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine written by Naznin Sultana and published by Springer. This book was released on 2014-10-16 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses important biomaterials which are commonly used to fabricate scaffolds and it describes two major protocols employed in scaffold fabrication. Tissue engineering or regenerative medicine aims at restoring ex-novo tissues and organs whose functionality has been compromised as a consequence of diseases or traumatic events. The innovative concept underlying tissue engineering is the use of autologous cells, obtained from a biopsy of the patient. Cells are seeded on a porous scaffold which has the role of supporting and guiding cells towards the development of tissue-like structures as well as providing a platform for the delivery under controlled condition of growth factor release, etc. The successful manufacture of scaffolds for tissue engineering applications is crucial. In this book, these biomaterials are discussed. The book also covers illustrated examples, structure and properties of scaffolds, cellular interactions and drug delivery.
Download or read book Development and Application of a 3 D Perfusion Bioreactor Cell Culture System for Bone Tissue Engineering written by Blaise Damian Porter and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering strategies that combine porous biomaterial scaffolds with cells capable of osteogenesis or bioactive proteins have shown promise as effective bone graft substitutes. Attempts to culture bone tissue-engineering constructs thicker than 1mm in vitro often result in a shell of viable cells and mineralized matrix surrounding a necrotic core. To address this limitation, we developed a perfusion bioreactor system that improves mass transport throughout large cell-seeded constructs. Additionally, we established and validated 3-D computational methods to model flow and shear stresses within the microporosity of perfused constructs. Micro-CT scanning and analysis techniques were used to non-destructively monitor mineral development over time in culture. CFD modeling of axial perfusion through cylindrical scaffolds with a regular microarchitecture revealed a uniform flow field distributed throughout the scaffold. Perfusion resulted in a 140-fold increase in mineral deposition at the interior of 3 mm thick polymer scaffolds seeded with rat bone marrow stromal cells. The total detected mineral volume tripled as the construct length was increased from 3 to 9 mm. Increasing scaffold length to 9 mm did not affect the mineral volume fraction (MVF) within the full volume of each construct. Mineral volume, spatial distribution, density, particle size and particle number were then quantified on cell-seeded constructs in 5 different culture environments. The effect of time varying flow conditions was compared with continuous perfusion as well as two different control cell culture methods in an attempt to enhance mineralized matrix within the constructs. Intermittent elevated perfusion and dynamic culture in an orbital rocker plate produced the greatest amount of mineral within 9 mm long constructs compared to low continuous flow and high continuous flow cases. Together, these studies indicate that dynamic culture conditions enhance construct development with regards to cell viability, mineralized matrix deposition, growth rate, and distribution. Furthermore, these techniques provide a rational approach to selecting perfusion culture conditions that optimize the amount and distribution of mineralized matrix production. Finally, the established perfusion bioreactor, in combination with micro-CT analysis, provides a foundation for evaluating new scaffolds and cell types that may be useful for the development of effective bone graft substitutes.
Download or read book Bio Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine written by Justin Brown and published by Academic Press. This book was released on 2016-11-03 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations. The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications. In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics. Presents a self-contained work for the field of musculoskeletal tissue engineering and regenerative medicine Focuses on how materials of structures can be designed to be resistant while promoting viable grafts Contains major tissue types that are covered with a strategy for each material and structure
Download or read book Handbook of Tissue Engineering Scaffolds Volume One written by Masoud Mozafari and published by Woodhead Publishing. This book was released on 2019-06-15 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Tissue Engineering Scaffolds: Volume One, provides a comprehensive and authoritative review on recent advancements in the application and use of composite scaffolds in tissue engineering. Chapters focus on specific tissue/organ (mostly on the structure and anatomy), the materials used for treatment, natural composite scaffolds, synthetic composite scaffolds, fabrication techniques, innovative materials and approaches for scaffolds preparation, host response to the scaffolds, challenges and future perspectives, and more. Bringing all the information together in one major reference, the authors systematically review and summarize recent research findings, thus providing an in-depth understanding of scaffold use in different body systems. Dedicated to the specialist topic of composite scaffolds, featuring all human body systems Covers basic fundamentals and advanced clinical applications Includes up-to-date information on preparation methodology and characterization techniques Highlights clinical data and case studies
Download or read book Extrusion Bioprinting of Scaffolds for Tissue Engineering Applications written by Daniel X. B. Chen and published by Springer. This book was released on 2018-12-13 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to the theory and practice of extrusion bio-printing of scaffolds for tissue engineering applications. The author emphasizes the fundamentals and practical applications of extrusion bio-printing to scaffold fabrication, in a manner particularly suitable for those who wish to master the subject matter and apply it to real tissue engineering applications. Readers will learn to design, fabricate, and characterize tissue scaffolds to be created by means of extrusion bio-printing technology.
Download or read book Scaffolds in Tissue EngineeringMaterials Technologies and Clinical Applications written by Francesco Baino and published by BoD – Books on Demand. This book was released on 2017-12-13 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials are often designed to act as scaffolds, i.e., 3D porous templates that support and stimulate the growth of healthy tissue and then safely dissolve once they have performed their functions. This book provides a picture of the current state of the art in the field of scaffolds for tissue engineering, highlighting the potential associated to the latest scientific and technological advancements. The former part of the book focuses on the repair of "hard" tissues (primarily bone) by means of bioceramic/glass scaffolds, and the latter deals with the applications of polymeric scaffolds for regenerating "soft" tissues and structures including the peripheral nerve, heart, gastric mucosa and pancreas. Special emphasis is given to the challenges associated to scaffold manufacturing, biomimetic properties and cell-scaffold interactions.
Download or read book A Manual For Biomaterials scaffold Fabrication Technology written by Gilson Khang and published by World Scientific Publishing Company. This book was released on 2007-07-03 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering has been recognized as offering an alternative technique to whole-organ and tissue transplantation for diseased, failed, or malfunctioned organs. To reconstruct a new tissue via tissue engineering, the following triad components are needed: (1) cells which are harvested and dissociated from the donor tissue; (2) biomaterials as scaffold substrates in which cells are attached and cultured, resulting in implantation at the desired site of the functioning tissue; and (3) growth factors which promote and/or prevent cell adhesion, proliferation, migration, and differentiation. Of these three key components, scaffolds play a critical role in tissue engineering. This timely book focuses on the preparation and characterization of scaffold biomaterials for the application of tissue-engineered scaffolds. More importantly, it serves as an experimental guidebook on the standardization of the fabrication process and characterization of scaffolding technology.
Download or read book Development Fabrication and Characterisation of Novel Bone Tissue Engineering Scaffolds written by and published by . This book was released on 2012 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biofabrication written by Joydip Kundu and published by Elsevier Inc. Chapters. This book was released on 2013-03-18 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have advanced from merely interacting with the body to controlling biological processes toward the goal of tissue regeneration. In order to reconstitute a new tissue or repair a damaged/diseased tissue, three components are critical for regenerative medicine or tissue engineering: cells, biomaterials as scaffold substrates, and growth factors. Thus, the design and selection of materials and the methods used for scaffold fabrication play a very important role in tissue engineering and regenerative medicine. Recent developments in biofabrication strategies have created enormous possibilities for the construction of biomimetic 3D scaffolds, where well-defined architectures can be generated with suitable surface chemistry using appropriate materials. This chapter summarizes the materials used for the fabrication of scaffolds, the different types of scaffold manufacturing processes, and the basics of the various tissue-specific scaffolds used in regenerative medicine.
Download or read book Stem Cell and Tissue Engineering written by Krishna Pramanik and published by CRC Press. This book was released on 2024-03-29 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers conventional clinical treatment methods for handling bone, cartilage, and related disorders along with their limitations and highlights the current state of the art of tissue engineering as an alternative for regenerating such defective tissue. Potential biomimetic scaffolding materials and their development, desired properties, modifications, and optimizations are described. The design and advancement in fabrication, characterization, properties, and biological functions of scaffolds, their integration with stem cells, and various bioreactor systems for tissue regeneration are presented. It further reviews in vitro and in vivo (pre-clinical) assessments of tissue constructs, involved translational challenges, and strategies in various stages of neo-tissue production. Features: Discusses the key aspects of generating engineered bone, cartilage, and associated tissues through tissue engineering approach Describes multiple engineering principles, and processes involved in the various stages of developing biomaterials and scaffolds Covers integration of stem cells with scaffolds, including assessment of tissue grafts, and translational strategy Explores key factors influencing tissue graft generation in bioreactors and challenges involved in various stages Includes several exercises including review questions and numerical problems for better understanding of the subject This book is aimed at researchers, students, and professionals in biomedical engineering, tissue engineering, stem cells, biomaterials, and orthopaedics.
Download or read book Materials for Biomedical Engineering Hydrogels and Polymer based Scaffolds written by Alina-Maria Holban and published by Elsevier. This book was released on 2019-03-20 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials for Biomedical Engineering: Hydrogels and Polymer-Based Scaffolds discusses the use of a wide variety of hydrogels as bioactive scaffolds in regenerative medicine, including updates on innovative materials and their properties. Various types of currently investigated scaffolding materials and hydrogels are discussed, as is their future roles and applications, the main techniques for scaffold fabrication, and their characterization procedures. Readers will be able to use this book as a guide for the selection of the best materials for a specific application. Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of hydrogels as bioactive scaffolds in regenerative medicine Includes novel opportunities and ideas for developing or improving technologies in biomaterials, and in related biomedical industries Features at least 50% of references from the last 2-3 years
Download or read book Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine written by Gilson Khang and published by CRC Press. This book was released on 2017-06-26 with total page 1480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.
