Download or read book The dependence of the electrogenic sodium potassium pump current on intracellular sodium in isolated guinea pig ventricular myocytes written by David Jeffrey Mogul and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Canadian Journal of Physiology and Pharmacology written by and published by . This book was released on 1999 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Sodium Pump written by Society of General Physiologists. Symposium and published by Rockefeller Univ. Press. This book was released on 1991 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1989 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrophysiologic Basis of ECG and Cardiac Arrhythmias written by Borys Surawicz and published by Lippincott Williams & Wilkins. This book was released on 1995 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Excitation Contraction Coupling and Cardiac Contractile Force written by Donald Bers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.
Download or read book P type ATPases in Health and Disease written by Sigrid A. Langhans and published by Frontiers Media SA. This book was released on 2019-01-11 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart Physiology and Pathophysiology written by Yoshihisa Kurachi and published by Elsevier. This book was released on 2000-10-09 with total page 1286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Download or read book Integrative Aspects of Calcium Signalling written by Alexej Verkhratsky and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is the first effort in a single volume to cover all of the integrative functions of calcium signalling - how changes in intracellular calcium coordinate a variety of coherent cellular responses. Written by a team of internationally established researchers, Integrative Aspects of Calcium Signalling provides the latest experimental data and concepts, bringing together a detailed analysis of the events, processes, and functions regulated by calcium signalling. A unique resource for professionals and students of physiology, biophysics, neurobiology, biochemistry, and all related fields.
Download or read book Cardiac Electrophysiology and Arrhythmias written by Douglas P. Zipes and published by Saunders. This book was released on 1985 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cardiovascular System written by Ernest Page and published by . This book was released on 2002 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunopharmacology of Free Radical Species written by and published by Elsevier. This book was released on 1995-05-15 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.
Download or read book Japanese Heart Journal written by and published by . This book was released on 1986 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ion Channels written by T. Narahashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wealth of information has been accumulated about the function of ion channels of excitable cells since the extensive and pioneering voltage clamp studies by Hodgkin, Huxley, and Katz 36 years ago. The study of ion chan nels has now reached a stage at which a quantum jump in progress is antici pated. There are many good reasons for this. Patch clamp techniques origi nally developed by Neher and Sakmann 12 years ago have made it possible to study the function of ion channels in a variety of cells. Membrane ionic currents can now be recorded practically from many types of cells using the whole-cell patch clamp technique. The opening and closing of individual ion channels can be analyzed using the single-channel patch clamp method. Techniques have also been developed to incorporate purified ion channels into lipid bilayers to reconstitute an "excitable membrane. " Advanced tech niques developed in molecular biology, genetics, and immunology, such as gene cloning and the use of monoclonal antibodies, are now being applied to the study of ion channels. A variety of drugs have now been found or are suspected to interact with ion channels to exert therapeutic effects. In addition to the classical exam ples, as represented by local anesthetics, many other drugs, including cal cium antagonists, psychoactive drugs, cardiac drugs, and anticonvulsants, shown to alter ion channel function. For certain pesticides such as have been pyrethroids and DDT, sodium channels are clearly the major target site.
Download or read book Isolated Adult Cardiomyocytes written by Hans Michael Piper and published by CRC Press. This book was released on 2019-07-17 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1989, written with contributions from experts who have critically evaluated the state of the art and the prospects of isolated adults cardiac myocytes in cardiological research, this two-volume publication summarizes the current knowledge of this technology. The methodology, structure, and metabolism of cardiomyocytes are presented, along with metabolism and cation homeostasis and energy metabolism and hypoxic injury. Additionally, cell isolation and culture and the structure and biochemistry of the sarcolemma is explained. Electrophysiology and contractile function with ionic currents and membrane channels is discussed. Also, the electro-physiological effects of transmitters and hormones are presented, with excitation-contraction coupling and the use of cardiomyocytes in drug design and research explained.
Download or read book Handbook of Physiology written by Ernest Page and published by . This book was released on 2002 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume continues the tradition of thoughtful, in-depth examination of critical subjects in the Handbook of Physiology, though the molecular revolution has transformed cardiovascular research from a stable, mature field into one that is exploding with new findings. The 21 chapters were written by outstanding international investigators in the fields of cell structure, muscle contraction and control, and electrophysiology. They cover basic molecular events but highlight the strong relationships to physiological processes that will soon be important in cardiovascular disease. In the discussions of structure, the emphasis is on normal and abnormal growth as well as the dynamic properties of cell communication via gap junctions. Muscle function is explored from actin-myosin molecular interactions to control of intracellular calcium and contraction by its principal transporters. The book shows how cardiac electrophysiology integrates the whole heart from cellular action potentials and conduction to mathematical models. Current concepts of ion channel structure and function and the heterogeneous distribution and expression of these channels are detailed. The heart as a malfunctioning organ is considered in chapters on arrhythmias, ventricular function, and heart failure. The chapters are extensively referenced and focus on the critical questions in basic cardiology for physiologists to address in the future, drawing on the power of molecular studies and the genome map.
