Download or read book The Carcinoembryonic Antigen Gene Family written by Akira Yachi and published by Elsevier Publishing Company. This book was released on 1989 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Carcinoembryonic Antigen CEA Gene Family in Primates written by Guang-Qian Zhou and published by . This book was released on 2000 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure evolution and regulation of expression of the carcinoembryonic antigen CEA gene family written by John Thompson and published by . This book was released on 1993 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Study on the Expression of the Carcinoembryonic Antigen Gene Family written by Danny Boucher and published by . This book was released on 1992 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A library prepared from CML cells was used to isolate a cDNA clone of CGM6. The predicted product of this novel CEA family member displays 85% sequence similarity to CEA and NCA and its expression is limited to CML and normal human bone marrow cells." --
Download or read book Studies on the Control of Carcinoembryonic Antigen CEA Gene Family Expression in a Differentiating Colon Carcinoma Cell Line written by Wendy Hauck and published by . This book was released on 1993 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Carcinoembryonic antigen (CEA), a widely used clinical tumor marker, functions in vitro as an adhesion molecule and is the prototype for a family of glycoproteins, which includes nonspecific crossreacting antigen (NCA) and biliary glycoprotein (BGP). This study examines the control processes responsible for the overproduction of the CEA family in carcinomas and identifies the trans-acting factors which mediate CEA and BGP gene transcription. During differentiation and $ gamma$-interferon treatment, CEA and NCA are regulated at both transcriptional and post-transcriptional levels and transcriptional control is markedly different between these two corresponding genes. Characterization of the CEA gene promoter revealed both negative and positive regulatory elements and tissue-specific, differentiation-dependent interactions with USF, Sp1, Sp1-like, AP-2-like and novel silencer transcription factors. Characterization of the BGP promoter identified one positively-acting element binding both USF and HNF-4/LF-A1, thereby contributing to distinct BGP gene expression. The Sp1, Sp1-like and silencer factors are specific to CEA gene transcription." --
Download or read book Cell Adhesion and Communication Mediated by the CEA Family written by Clifford P Stanners and published by CRC Press. This book was released on 2003-09-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986. Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered. Reviews, recent results, hypotheses, and clinical applications regarding a gene family that, from its widespread changes in expression in tumors at many sites, should be regarded as a "major player" in human cancer are also discussed. The normal functions such as epithelial and hematopoietic adhesion and signalling molecules are explored, and the possibly unique role of this family in evolution is introduced. This volume will be of interest to researchers in the fields of intercellular adhesion, evolution, and molecular recognition, as well as clinicians interested in the recent knowledge regarding a tumor marker commonly utilised in the clinic, and companies wishing to exploit this cancer-related family for novel commercial applications in the biomedical sphere.
Download or read book The Carcinoembryonic Antigen Gene Family written by Wasif Noor Khan and published by . This book was released on 1990 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Human Carcinoembryonic Antigen Family written by Stephan Teglund and published by . This book was released on 1994 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Download or read book Transcriptional Regulation of Human Nonspecific Cross reacting Antigen a Carcinoembryonic Antigen Gene Family Member Up regulated in Colorectal Carcinomas written by Marten Derek Koops and published by . This book was released on 1997 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Human nonspecific cross-reacting antigen (NCA), a close relative of the tumour marker human carcinoembryonic antigen (CEA), is also an in vitro homotypic intercellular adhesion molecule capable of inhibiting differentiation when expressed ectopically in myoblasts. Moreover, NCA appears to be overexpressed at the transcriptional level to a greater extent and more frequently in colorectal carcinomas than CEA. This study examines the transcriptional control mechanisms responsible for orchestrating NCA expression. The region within 283 bp upstream of the translational start site of the NCA gene was found to be capable of directing high levels of expression in functional promoter assays. Footprinting experiments identified three cis-acting elements and mobility-shift assays revealed that the first of these elements is bound by USF1 and USF2, and the second two are bound by Sp1 and Sp3. No cis-acting elements corresponding to CEA FP4 or the silencer CEA FP5 of the CEA promoter were detected in the NCA promoter, which may contribute to the differential expression of NCA versus CEA in tumourigenesis." --
Download or read book Alternative Splicing and Adhesion Properties of a Mouse Carcinoembryonic Antigen Gene Family Member written by Kimberly McCuaig and published by . This book was released on 1992 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Carcinoembryonic antigen (CEA) is a tumor marker used clinically to assess post-operative recurrences of breast, lung and colon cancers. The CEA gene family, which is part of the immunoglobulin superfamily, is composed of several proteins crossreactive with anti-CEA antibodies. Carcinoembryonic antigen appears to function in the development of the gastro-intestinal tract as well in tumor formation; it is capable of mediating cell-cell adhesion in vitro which is consistent with its putative role of maintaining tissue architecture in vivo. CEA gene family members have also been identified in various tissues of the mouse. Two of the mouse proteins, mmCGMla and mmCGMlb, have been characterized. By sequence homology, mmCGMla and mmCGMlb are the mouse homologues of human biliary glycoprotein and of rat hepatocyte ecto-ATPase. Both of the mouse CEA related proteins function as adhesion molecules when expressed on the cell surface of transfectant cells; however, mmCGMla, unlike mmCGMlb, mediates cellular aggregation irrespective of calcium concentration or temperature. Sequence comparison of mmCGMla, mmCGMlb, and other cDNAs isolated by polymerase chain reaction techniques, demonstrates that there are at least eight possible transcripts encoding CEA-related proteins and that these transcripts are all produced by alternative splicing of one precursor messenger RNA." --
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Leong s Manual of Diagnostic Antibodies for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2016-11-28 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.
Download or read book Tumor Markers written by Eleftherios P. Diamandis and published by Amer. Assoc. for Clinical Chemistry. This book was released on 2002 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Guide to Human Gene Therapy written by Roland W. Herzog and published by World Scientific. This book was released on 2010 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Non-viral gene therapy / Sean M. Sullivan -- 2. Adenoviral vectors / Stuart A. Nicklin and Andrew H. Baker -- 3. Retroviral vectors and integration analysis / Cynthia C. Bartholomae [und weitere] -- 4. Lentiviral vectors / Janka Matrai, Marinee K.L. Chuah and Thierry VandenDriessche -- 5. Herpes simplex virus vectors / William F. Goins [und weitere] -- 6. Adeno-Associated Viral (AAV) vectors / Nicholas Muzyczka -- 7. Regulatory RNA in gene therapy / Alfred. S. Lewin -- 8. DNA integrating vectors (Transposon, Integrase) / Lauren E. Woodard and Michele P. Calos -- 9. Homologous recombination and targeted gene modification for gene therapy / Matthew Porteus -- 10. Gene switches for pre-clinical studies in gene therapy / Caroline Le Guiner [und weitere] -- 11. Gene therapy for central nervous system disorders / Deborah Young and Patricia A. Lawlor -- 12. Gene therapy of hemoglobinopathies / Angela E. Rivers and Arun Srivastava -- 13. Gene therapy for primary immunodeficiencies / Aisha Sauer, Barbara Cassani and Alessandro Aiuti -- 14. Gene therapy for hemophilia / David Markusic, Babak Moghimi and Roland Herzog -- 15. Gene therapy for obesity and diabetes / Sergei Zolotukhin and Clive H. Wasserfall -- 16. Gene therapy for Duchenne muscular dystrophy / Takashi Okada and Shin'ichi Takeda -- 17. Cancer gene therapy / Kirsten A.K. Weigel-Van Aken -- 18. Gene therapy for autoimmune disorders / Daniel F. Gaddy, Melanie A. Ruffner and Paul D. Robbins -- 19. Gene therapy for inherited metabolic storage diseases / Cathryn Mah -- 20. Retinal diseases / Shannon E. Boye, Sanford L. Boye and William W. Hauswirth -- 21. A brief guide to gene therapy treatments for pulmonary diseases / Ashley T. Martino, Christian Mueller and Terence R. Flotte -- 22. Cardiovascular disease / Darin J. Falk, Cathryn S. Mah and Barry J. Byrne
Download or read book Neoplasm Antigens Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neoplasm Antigens: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Neoplasm Antigens in a concise format. The editors have built Neoplasm Antigens: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neoplasm Antigens in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neoplasm Antigens: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
