Download or read book The C I written by Les Roberts and published by Down & Out Books. This book was released on 2023-03-13 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Slovenian-American Jericho Paich finds himself under arrest by snarling Cleveland police cop Keenan Mayo and forced to be a non-paid confidential informant, setting up friends and strangers to be hauled in for illegal drug use. He turns for help to his mother’s live-in lover, ex-marine officer Laird Janiver. The two have never gotten along, but Jerry has nowhere else to turn. Janiver, a studious African American major who recalls how to kill, decides to help. That brings the two men into contact with a cruelly efficient albino drug lord, the suicidal memory of a lovely young college girl at OSU, and a beautiful woman with what might be a very dangerous past.
Download or read book The Big CI Book written by Ben Slavic and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Democracy in China written by Jiwei Ci and published by . This book was released on 2019-11-19 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Four decades of reform fostered a democratic mentality in China. Now citizens are waiting for the government to catch up. Jiwei Ci argues that the tensions between a largely democratic society and an undemocratic political system will trigger a crisis of legitimacy, compelling the Communist Party to become agents of democratic change--or collapse.
Download or read book Decisions and Orders written by United States. Bituminous Coal Division and published by . This book was released on 1943 with total page 1374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biobetters written by Amy Rosenberg and published by Springer. This book was released on 2015-08-21 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.
Download or read book United States of America V Jachimko written by and published by . This book was released on 1993 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book CI Team Red written by David DeBatto and published by Grand Central Publishing. This book was released on 2007-09-03 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a story so explosive that he can only tell it as fiction, former counterintelligence special agent David DeBatto takes us onto a new kind of battlefield, beyond the reach of reporters, and into the covert ops of elite tactical intelligence teams. Their number one job: to pierce the secrets of an enemy -- before the enemy reaches us . . . Staff Sgt. David DeLuca had a love/hate relationship with the Armed Forces. Then came 9/11. After a career as a street cop, he went to war-and put his skills to work in a secret army within an army. Part detective, con man, spy, and soldier, DeLuca is now hunting a Saddam loyalist Centcom thought was dead. To catch his prey, he'll have to outmaneuver him using microscopic forensic evidence, high-tech espionage tools, and gut instincts. But as he follows a deadly trail out of the Sunni Triangle into Iran, a horrifying picture is coming clear to DeLuca and his elite "red" team: a terrorist group already has its fangs in the USA -- and needs to be hunted down and eliminated right now . . .
Download or read book Vocational Education written by and published by . This book was released on 1912 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sonography written by Reva Arnez Curry and published by Elsevier Health Sciences. This book was released on 2015-10-30 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Without a thorough knowledge of the appearance of normal anatomy, you may have a tough time recognizing abnormalities in ultrasound images. Get a firm grounding in normal anatomy and physiology from an ultrasound perspective with Sonography: Introduction to Normal Structure and Function, 4th Edition. The new edition of this highly visual introductory text presents a wealth of ultrasound images, accompanied by labeled drawings with detailed legends, to increase your comfort with normal anatomy as it appears during scanning. Its consistent chapter format makes the content easy to navigate and reinforces the discipline of following a standard protocol to scan each area of the body. Detailed line drawings accompany most sonograms to explain what you should notice on each scan. If you do not see the structure, or are uncertain of it on the image, you can look at the diagram for confirmation. Over 1,500 images provide a thorough, visual understanding of sonography. Consistent organization with a standardized heading scheme helps you when searching for information. Content on quality control protocols in the clinical setting shows you how to recreate the most optimal scanning settings and techniques. Evolve resources provide you with additional learning tools. NEW! Full 4-color design incorporates color images within the appropriate chapter to help you understand the concepts without having to flip to the front of the book - and highlights the important points within each chapter. NEW! Three all-new chapters bring you the most up-to-date information on fetal echocardiography, laboratory values, and ergonomics. NEW! Updated sonograms demonstrate the latest and best images from the newest equipment, including 3D and 4D images. NEW! Expanded Test Bank, with new questions for each chapter, provides 1,000 questions on the material.
Download or read book The World as Imagination series I written by Edward Douglas Fawcett and published by . This book was released on 1916 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Official Journal written by League of Nations and published by . This book was released on 1925 with total page 1010 pages. Available in PDF, EPUB and Kindle. Book excerpt: Included are the Minutes (or Procès-verbal) of the Council from its first meeting, Paris, January 16, 1920, to the session, ; the budget for the 3d- financial period (1921- ) in 1920, no. 7, 1921, no. 9, 1923- no. 1 of each year; statements of the "Present situations as regards international engagements registered with the Secretariat"; Saar Basin, periodical and other reports and papers; reports on the financial reconstruction of Austria, and of Hungary; and many other reports and papers.
Download or read book Catalogue of Catholic and Other Select Authors in the Enoch Pratt Free Library Baltimore Md written by Enoch Pratt Free Library and published by . This book was released on 1913 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroplasticity and Neurorehabilitation written by Edward Taub and published by Frontiers E-books. This book was released on 2015-01-22 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nothing provided
Download or read book Keresan Texts written by Franz Boas and published by . This book was released on 1928 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Southern Reporter written by and published by . This book was released on 1983 with total page 1662 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book z OS V1 13 DFSMS Technical Update written by Mike Ebbers and published by IBM Redbooks. This book was released on 2012-09-23 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each release of IBM® Data Facility Storage Management Subsystem (DFSMS) builds on the previous version. The latest release, IBM z/OS® V1.13 DFSMS, provides enhancements in these areas for the z/OS platform in a system-managed storage environment: Storage management Data access Device support Program management Distributed data access This IBM Redbooks® publication provides a summary of the functions and enhancements in z/OS V1.13 DFSMS. It provides information that you need to understand and evaluate the content of this DFSMS release, along with practical implementation hints and tips. This book also includes enhancements that are available by enabling PTFs that have been integrated into z/OS DFSMS V1.13. This book was written for storage professionals and system programmers who have experience with the components of DFSMS. It provides sufficient information so that you can start prioritizing the implementation of new functions and evaluating their applicability in your DFSMS environment.
Download or read book Railway Age written by and published by . This book was released on 1926 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
