Download or read book The Brain Without Oxygen written by P.L. Lutz and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well known and researched, that deprivation of oxygen to the brain can quickly result in irreversible damage and death. What is less well known, is that some vertebrate species are exceptionally tolerant of brain hypoxia. The Brain Without Oxygen: Causes of failure - Physiological and molecular mechanisms for survival, Third edition, discusses the mechanisms of brain hypoxia tolerance in these exceptional vertebrates, which include diving marine mammals, high altitude dwellers and the hibernating mammal. Special attention is given to the extraordinary adaptations that allow a few turtle and fish species to tolerate months of brain anoxia. This third, fully updated edition addresses the potential of these animal models as targets for human clinical intervention. Perhaps the most interesting of these, are those involved in the suppression of metabolic activities to new set points well below their normoxic minima or maintenance levels. This volume will be valuable reading for researchers in physiology, medicine and general biological sciences, and of great importance to pharmaceutical companies researching novel models for stroke and brain ischemia.
Download or read book The Brain Without Oxygen written by Peter L. Lutz and published by Landes Bioscience. This book was released on 1997 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research for clinicians and researchers in neurology. New material on the mechanism of brain hypoxia tolerance in some vertebrate species.
Download or read book The Brain Without Oxygen written by Peter L. Lutz and published by . This book was released on 1997-01-01 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the problem of how any interruption in energy supply to the brain of more than a few minutes results in irreversible damage. From a comparative perspective, the book presents the most recent findings concerning the pathological processes occurring in brain hypoxia and discusses in detail the defense mechanisms that allow the brains of a few vertebrate species to survive anoxia for long periods of time. It describes the processes underlying the enhanced hypoxid tolerance shown by the brains of the mammalian neonate, the hibernating mammal and the diving marine mammal. The book identifies the key processes that are protected in anoxia tolerant animals, which allow new insights into the survival hierarchy of the many systems that collapse in the energy-deprived mammalian brain.
Download or read book Oxygen and the Brain The Journey of Our Lifetime written by Philip B. James and published by Best Publishing. This book was released on 2014-06-01 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Man has conquered Everest, been to the bottom of the deepest ocean, and even walked on the Moon by understanding pressure and oxygen. But the one area of life the technology has not influenced is the practice of medicine. Billions have been spent researching drugs to treat the brain and they have failed; drug companies are closing their neuroscience laboratories. This is because there is no substitute for oxygen. As the most astonishing discovery since DNA was unraveled has shown, oxygen, the gas in the air we all breathe, controls our most important genes. If we are sick or seriously injured and in intensive care, the amount of oxygen we can be given is limited by the weather. Without a simple pressure chamber, we are forced to accept a variation of more than 10% when just 2% more oxygen on the summit of Everest can mean the difference between life and death. We have already engineered the solution; the technology used in aircraft that sustains us flying at 40,000 feet can facilitate medical recovery safely on the ground. This book follows the human journey from conception to old age and presents evidence amassed over more than a century that can transform the care of patients with birth injury, head trauma, multiple sclerosis, stroke, and even reverse decline in old age. There is no more necessary and scientific action than to correct a deficiency of oxygen, especially in the brain and it is simple to give more.
Download or read book The Brain Without Oxygen written by Peter L. Lutz and published by . This book was released on 1994 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Brain Without Oxygen written by P. L. Lutz and published by . This book was released on 2014-01-15 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
Download or read book Regulation of Tissue Oxygenation Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Download or read book Cardiopulmonary Critical Care written by David R. Dantzker and published by Philadelphia : Saunders. This book was released on 1991 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores the spectrum of topics important to the treatment of critically ill patients with cardiac and respiratory failure, including in-depth discussions on pathophysiologic principles, approaches to therapy and individual disorders. Ethical and legal aspects are also considered.
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Download or read book Hyperbaric oxygen therapy for brain injury cerebral palsy and stroke written by and published by Department of Health and Human Services Public Health Servic. This book was released on 2003-01-01 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Download or read book Breath written by James Nestor and published by Penguin. This book was released on 2020-05-26 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: A New York Times Bestseller A Washington Post Notable Nonfiction Book of 2020 Named a Best Book of 2020 by NPR “A fascinating scientific, cultural, spiritual and evolutionary history of the way humans breathe—and how we’ve all been doing it wrong for a long, long time.” —Elizabeth Gilbert, author of Big Magic and Eat Pray Love No matter what you eat, how much you exercise, how skinny or young or wise you are, none of it matters if you’re not breathing properly. There is nothing more essential to our health and well-being than breathing: take air in, let it out, repeat twenty-five thousand times a day. Yet, as a species, humans have lost the ability to breathe correctly, with grave consequences. Journalist James Nestor travels the world to figure out what went wrong and how to fix it. The answers aren’t found in pulmonology labs, as we might expect, but in the muddy digs of ancient burial sites, secret Soviet facilities, New Jersey choir schools, and the smoggy streets of São Paulo. Nestor tracks down men and women exploring the hidden science behind ancient breathing practices like Pranayama, Sudarshan Kriya, and Tummo and teams up with pulmonary tinkerers to scientifically test long-held beliefs about how we breathe. Modern research is showing us that making even slight adjustments to the way we inhale and exhale can jump-start athletic performance; rejuvenate internal organs; halt snoring, asthma, and autoimmune disease; and even straighten scoliotic spines. None of this should be possible, and yet it is. Drawing on thousands of years of medical texts and recent cutting-edge studies in pulmonology, psychology, biochemistry, and human physiology, Breath turns the conventional wisdom of what we thought we knew about our most basic biological function on its head. You will never breathe the same again.
Download or read book The Comatose Patient written by Eelco F.M. Wijdicks and published by Oxford University Press. This book was released on 2014-04-28 with total page 809 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Comatose Patient, Second Edition, is a critical historical overview of the concepts of consciousness and unconsciousness, covering all aspects of coma within 100 detailed case vignettes. This comprehensive text includes principles of neurologic examination of comatose patients as well as instruction of the FOUR Score coma scale, and also discusses landmark legal cases and ethical problems. As the Chair of Division of Critical Care Neurology at Mayo Clinic, Dr. Wijdicks uses his extensive knowledge to discuss a new practical multistep approach to the diagnosis of the comatose patient. Additionally, this edition includes extensive coverage of the interpretation of neuroimaging and its role in daily practice and decision making, as well as management in the emergency room and ICU. Dr. Wijdicks details long-term supportive care and an appropriate approach to communication with family members about end-of-life decision making. In addition, video clips on neurologic examination and neurologic manifestations seen in comatose patients can be found here: http://oxfordmedicine.com/comatosepatient2e. All video recordings from the first edition have been reformatted and remastered for optimal use, and several more video clips of patients have also been included.
Download or read book Core Topics in Neuroanaesthesia and Neurointensive Care written by Basil F. Matta and published by Cambridge University Press. This book was released on 2011-10-13 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.
Download or read book Mechanisms of Cerebral Hypoxia and Stroke written by G. Somjen and published by Springer. This book was released on 2012-04-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles and short communications in this volume are based on papers pre sented to the Symposium on Cerebral Hypoxia and Stroke held in Budapest in August of 1987. Besides participants at the meeting, three scientists who were invited but could not attend have also contributed chapters to this volume. A synopsis of the general discussion at the conference and a review chapter conclude this volume. To the readers of this book it will not be news that stroke is a worldwide problem. Efforts to cope with this often devastating condition are worldwide also, as attested by the international membership of the conference. It has been said of oxygen deficiency that it not only stops the machine, it also wrecks the machinery. The paramount question in stroke research is this: why can't the brain be restarted after a hypoxic episode in much the same manner as a motor car can when its gas tank is refilled after it stalled because it ran out of fuel? Participants at the Symposium had been requested in advance of the meeting to especially consider a series of specific questions in relation to this general problem. Among these specific questions were: the mechanism of synaptic blockade in hypoxic brain tissue; the transition from reversible to irreversible arrest of function; the nature of postischemic (delayed) cell death; the possible basic differences in the consequences of hypoxia and ischemia; and actual and potential approaches to the prevention and treatment of cell damage in hypoxia and stroke.
Download or read book Acute Ischemic Stroke written by R. Gilberto González and published by Springer Science & Business Media. This book was released on 2010-10-05 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
