Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.

Download or read book Transforming America written by Steven E. Schier and published by Rowman & Littlefield. This book was released on 2011-09-16 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presidency of Barack Obama seeks a major transformation of American politics and policy. This new collection, edited by Steven E. Schier, examines the unusual combination of risk and ambition in Obama's presidency concerning popular politics, Washington politics, and economic and foreign policy. It also places the Obama presidency in historical perspective, noting the unusual circumstances of his election and the similarities and differences between presidential politics today and those of previous eras. Transforming America: Barack Obama in the White House provides a guiding focus involving the successes and failures of the administration's transformative aspirations during Obama's initial years in the White House.

Download or read book The Magdalene Lineage written by Reena Kumarasingham and published by John Hunt Publishing. This book was released on 2020-03-27 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: NOW IS THE TIME FOR THE DIVINE FEMININE For two thousand years, Mary Magdalene has been a veiled silhouette, a shadow of her vibrant self. An enigmatic figure, she was shrouded in mystery, a feminine caricature of either the purest of saints or the most repentant of sinners. Two thousand years have buried her, her lineage and her legacy. Through past life regression, backed by academic research and oral tradition, journey with Mary Magdalene from the age of six to sixty. Discover intimate knowledge of her as a daughter, a sister, a wife, a mother and a spiritual teacher. Her daughter Tamar, the product, initiate and bearer of her legacy, continues her sacred teachings. This is their story - the story of the feminine in spirituality.

Download or read book The New Enclosures Critical Perspectives on Corporate Land Deals written by Ben White and published by Routledge. This book was released on 2013-09-13 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection explores the complex dynamics of corporate land deals from a broad agrarian political economy perspective, with a special focus on the implications for property and labour regimes, labour processes and structures of accumulation. This involves looking at ways in which existing patterns of rural social differentiation – in terms of class, gender, ethnicity and generation – are being shaped by changes in land use and property relations, as well as by the re-organization of production and exchange as rural communities and resources are incorporated into global commodity chains. It goes further than the descriptive ‘what’ and ‘who’ questions, in order to understand the ‘how’ and ‘why’ of these patterns. It is empirically solid and theoretically sophisticated, making it a robust and boundary-changing work. Contributors come from various scholarly disciplines. Covering nearly all regions of the world, the collection will be of interest to researchers from various disciplines, policymakers and activists. This book was originally published as a Special Issue of the Journal of Peasant Studies.

Download or read book The Clinical Spectrum of Alzheimer s Disease written by Suzanne De La Monte and published by BoD – Books on Demand. This book was released on 2011-09-06 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Clinical Spectrum of Alzheimer's Disease: The Charge Toward Comprehensive Diagnostic and Therapeutic Strategies is highly informative and current. Acknowledged experts in the field critically review both standard and under-appreciated clinical, behavioral, epidemiological, genetic, and neuroimaging attributes of Alzheimer's disease. The collection covers diverse topics of interest to clinicians and researchers alike. Experienced professionals and newcomers to the field will benefit from the read. The strengths and weaknesses of current clinical, non-invasive, neuro-imaging, and biomarker diagnostic approaches are explained. The perspectives give fresh insights into the process of neurodegeneration. Readers will be enlightened by the evidence that the neural circuits damaged by neurodegeneration are much broader than conventionally taught, suggesting that Alzheimer's could be detected at earlier stages of disease by utilizing multi-pronged diagnostic approaches. This book inspires renewed hope that more effective treatments could be developed based upon the expanding list of potential therapeutic targets.

Download or read book The Brain as a Drug Target written by Shafiqur Rahman and published by Academic Press. This book was released on 2011-01-12 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Download or read book Clinical Neuropsychology and Cognitive Neurology of Parkinson s Disease and Other Movement Disorders written by Alexander I. Troster and published by Oxford University Press. This book was released on 2014-10-09 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an up-to-date account of the neuropsychological, cognitive-neurological, and neuropsychiatric aspects of movement disorders. The past ten years have seen an explosion of research covering non-motor aspects of Parkinson's disease and, more recently, movement disorders such as essential tremor, dystonia, corticobasal syndrome, progressive supranuclear palsy, and multiple system atrophy. It is often these neurobehavioral features that become troubling to the patient: they are sometimes difficult to recognize and treat, are associated with diminished patient and caregiver quality of life, and may hasten disease progression, loss of independence, and institutionalization. This book discusses the most recent diagnostic and treatment guidelines for such cognitive and psychiatric conditions in Parkinson's disease and other movement disorders, while providing practical tips and strategies for general assessment. The rapid accumulation of research in this field makes it increasingly difficult for one or two people to author a comprehensive text in an expert manner. The world-class team assembled for this volume succeeds in covering widely diverse areas such as the pathology, neuroimaging, assessment, and treatment of an ever-growing set of neurobehavioral features of movement disorders -- cognitive impairment and dementia, depression, apathy, anxiety, psychosis, and impulse control disorders. The text also surveys fundamental knowledge about basal ganglia function and dysfunction, assessment and evaluation techniques applicable to a range of movement disorders, and quality of life issues more broadly.

Download or read book A Concise Treatise on Natural Remedies written by Antoine Al-Achi and published by Cambridge Scholars Publishing. This book was released on 2020-05-28 with total page 751 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines the use of natural remedies in health and disease, blending scientific findings known to operate in the alternative and complementary medicine modalities with those utilized in folklore medicine. It points toward a unified theory that links the development of chronic degenerative diseases with inflammation, and considers how natural health modalities can alter or halt the progression of chronic diseases through their beneficial actions on inflammation. The book will serve as a venue for educating those who desire concise yet thorough insights into this area of alternative health practices. Students in the healthcare field, as well as medical practitioners, will find the information provided here particularly helpful and educational.

Download or read book Tau Protein Mechanisms from Health to Degeneration written by Isabel Lastres-Becker and published by Frontiers Media SA. This book was released on 2022-01-03 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genes Environment and Alzheimer s Disease written by Orly Lazarov and published by Academic Press. This book was released on 2016-02-25 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer's disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. - Provides the first volume to link genetic and environmental risk factors for Alzheimer's disease and dementia - Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer's disease and cognitive decline - Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities - Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Download or read book Ko Tautoro Te pito o Toku Ao written by Hone Sadler and published by Auckland University Press. This book was released on 2015-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ngapuhi is the largest iwi in New Zealand and its people have occupied the northern North Island, from Tamaki in the south to Te Rerenga Wairua in the north, from the time of their arrival from Hawaiki. Ko Tautoro, Te Pito o Toku Ao is Ngapuhi elder Hone Sadler’s powerful account of the origins, history and culture of the Ngapuhi people – a profound introduction to the Sacred House of Puhi. Sadler illustrates the unbroken chain of Ngapuhi sovereignty by looking in-depth at his own hapu of Ngati Moerewa, Ngati Rangi and Ngai Tawake ki te Waoku of Tautoro and Mataraua. The narrative is told through weaving together karakia and whakapapa, histories and korero that have been part of the oral traditions of Ngapuhi’s whanau, hapu and iwi and handed down through the generations on marae and other gathering places. Presented first to open the Ngapuhi’s claim before the Waitangi Tribunal, Sadler’s narrative is a powerful Maori oral account, presented here in te reo and English on facing pages, of the story of New Zealand’s largest iwi.

Download or read book Handbook of Clinical Psychopharmacology for Psychologists written by Mark Muse and published by John Wiley & Sons. This book was released on 2012-03-22 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Handbook of Clinical Psychopharmacology for Psychologists "Handbook of Clinical Psychopharmacology for Psychologists is a remarkably thorough introductory textbook for integrating psychotropic drug prescribing into psychological practices. It covers basic concepts in physiology, neurology, and pharmacology in easily understood language. Not only is this book a requirement for any psychologist seeking to gain prescriptive authority, but it is also helpful for any mental health clinician who collaborates with prescribers of any discipline. I recommend it highly." Daniel Carlat, MD, Editor in Chief of The Carlat Psychiatry Report "An important resource for any psychologist who is preparing to become a prescribing psychologist or for any psychologist who wants to be informed about the practice of medical psychology." Joseph E. Comaty, PhD, MP, coauthor of A Primer of Drug Action "Handbook of Clinical Psychopharmacology for Psychologists is an excellent treatise written by psychologists for psychologists." From the Foreword by Patrick H. DeLeon, PhD, and Jack G. Wiggins, PhD, former presidents of the American Psychological Association An essential and practical guide to integrating psychopharmacology into clinical practice Edited by medical psychologists with contributions by notable experts in their respective specialties, Handbook of Clinical Psychopharmacology for Psychologists covers key topics including: Ethics, standards of care, laws, and regulations relevant to clinical psychopharmacology Disorders of the nervous system, with particular relevance to psychopharmacology Use of comprehensive diagnostic strategies to establish differential diagnoses among possible medical and psychological symptoms Integration of pharmacotherapy with psychotherapy This essential book also provides an introduction to the qualifying exam for psychologists seeking specialty training in psychopharmacology, the Psychopharmacology Exam for Psychologists (PEP). The PEP-like practice test is available on the companion CD-ROM.

Download or read book Untangling the Role of Tau in Physiology and Pathology written by Jesus Avila and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Methods in Tau Cell Biology written by and published by Academic Press. This book was released on 2017-08-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Tau Cell Biology, Volume 141, the latest release in the Methods in Cell Biology series, looks at methods involved in tau cell biology. Edited by leaders in the field, this volume provides proven, state-of-art techniques and relevant historical background and theory that aids researchers with tactics for efficient design and effective implementation of experimental methodologies. Topics of note in this updated volume include sections on Recombinant tau expression and purification, In vitro MT dynamics and MT ends, Methods related to investigating tau structure and MT bundling, Neurite outgrowth and retraction, and Methods related to studying tau fragmentation. Covers sections on Tau Cell Biology Written by experts in the field of cell biology Includes cutting-edge materials

Download or read book PET and SPECT in Neurology written by Rudi A. J. O. Dierckx and published by Springer Nature. This book was released on 2020-10-20 with total page 1270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.

Download or read book Tau Biology written by Akihiko Takashima and published by Springer Nature. This book was released on 2020-02-24 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Download or read book Evidence Based Psychotherapy written by Daniel David and published by John Wiley & Sons. This book was released on 2018-01-02 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive, Systematic Evaluation of Treatment Effectiveness for Major Psychological Disorders With over 500 types of psychotherapy being practiced in the field today, navigating the maze of possible treatments can be daunting for clinicians and researchers, as well as for consumers who seek help in obtaining psychological services. Evidence-Based Psychotherapy: The State of Science and Practice offers a roadmap to identifying the most appropriate and efficacious interventions, and provides the most comprehensive review to date of treatments for psychological disorders most often encountered in clinical practice. Each chapter applies a rigorous assessment framework to evaluate psychotherapeutic interventions for a specific disorder. The authors include the reader in the evaluation scheme by describing both effective and potentially non-effective treatments. Assessments are based upon the extant research evidence regarding both clinical efficacy and support of underyling theory. Ultimately, the book seeks to inform treatment planning and enhance therapeutic outcomes. Evidence-Based Psychotherapy: The State of Science and Practice: Presents the available scientific research for evidence-based psychotherapies commonly practiced today Systematically evaluates theory and intervention efficacy based on the David and Montgomery nine-category evaluative framework Covers essential modes of treatment for major disorders, including bipolar disorder, generalized anxiety disorder, PTSD, eating disorders, alcohol use disorder, major depressive disorder, phobias, and more Includes insightful discussion of clinical practice written by leading experts Clarifies “evidence-based practice” versus “evidence-based science” and offers historical context for the development of the treatments under discussion Evidence-Based Psychotherapy: The State of Science and Practice is designed to inform treatment choices as well as strengthen critical evaluation. In doing so, it provides an invaluable resource for both researchers and clinicians.