Download or read book Targeted Selection written by William C. Byham and published by . This book was released on 1989 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Target Selection and Validation written by Marcus T. Scotti and published by Springer Nature. This book was released on 2022-05-17 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.

Download or read book Terrorists Target Selection written by C. Drake and published by Springer. This book was released on 1998-08-26 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author examines the factors which influence terrorists' target selection. In particular he looks at the influence of the ideologies, strategies and tactics of terrorist groups, and describes how these are restricted by the terrorists' resources, by protective and anti-terrorist measures, by the society within which the terrorists operate, and by the nature of the terrorists and their supporters. He concludes that terrorists' target selection is often both explicable and logical.

Download or read book Virtual ADMET Assessment in Target Selection and Maturation written by B. Testa and published by IOS Press. This book was released on 2006-12-19 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods have accelerated the process towards drugability of new chemical structures. Another component of the revolution in drug discovery is the replacement of the disease (indication)-based approach by a target-based approach. A better understanding of pathophysiology of diseases and the underlying biological processes of diseases combined with explosive development of genomics and proteomics have been instrumental in the birth of this new paradigm. This volume summarizes discussions of these three aspects of modern drug discovery, i.e. priority for targets, early ADMET assessment, and in silico screening. We trust that readers from academia as well as from industry will benefit from these studies.

Download or read book Essential Ethnographic Methods written by Stephen L. Schensul and published by Rowman Altamira. This book was released on 1999 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Ethnographic Methods akes a mixed methods approach to introducing the fundamental, face-to-face data collection tools that ethnographers and other qualitative researchers use.

Download or read book Expertise and Participation written by Eva Krick and published by Springer Nature. This book was released on 2021-08-25 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the role of expertise and public participation in modern governance. It explores the relationship, tensions and compatibility of these increasingly important and partly conflicting sources of legitimacy and authority. By zooming in on the coordinated procedures of environmental policy-making in European consensus systems and by interconnecting theories of democracy, knowledge and science, organisation and decision-making, the author develops institutional solutions to the tensions between epistemic and democratic demands on public policy-making.

Download or read book Federal Register written by and published by . This book was released on 2012-11 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Innovative Citizen Participation and New Democratic Institutions Catching the Deliberative Wave written by OECD and published by OECD Publishing. This book was released on 2020-06-10 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public authorities from all levels of government increasingly turn to Citizens' Assemblies, Juries, Panels and other representative deliberative processes to tackle complex policy problems ranging from climate change to infrastructure investment decisions. They convene groups of people representing a wide cross-section of society for at least one full day – and often much longer – to learn, deliberate, and develop collective recommendations that consider the complexities and compromises required for solving multifaceted public issues.

Download or read book Targeted Selection written by and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genomic Applications in Pathology written by George Jabboure Netto and published by Springer. This book was released on 2018-12-10 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists, hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will be discussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

Download or read book Essential Ethnographic Methods written by Jean J. Schensul and published by Rowman Altamira. This book was released on 2012-10-01 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is Book 3 of 7 in the Ethnographer's Toolkit, Second Edition. Essential Ethnographic Methods introduces the fundamental, face-to-face data collection tools that ethnographers and other qualitative researchers use on a regular basis. It provides ethnographers with tools to answer the principal ethnographic questions about setting, participants, activities, behavior, and more. The essential “mixed” methods for collecting data include open-ended and focused listening, questioning strategies, participant and non-participant observation, recording techniques, visual recall, mapping the environments and contexts in which participant behavior occurs, and engaging in ethnographically informed survey research. Because these data collection strategies require ethnographers to become involved in the local cultural setting and to acquire their experience through hands-on experience, the essential tools also allow them to learn about new situations from the perspective of an "insider.” With these detailed instructions, the quality and scope of the data ethnographers collect are sure to be improved. Other books in the set: Book 1: Designing and Conducting Ethnographic Research: An Introduction, Second Edition by Margaret D. LeCompte and Jean J. Schensul 9780759118690 Book 2: Initiating Ethnographic Research: A Mixed Methods Approach by Stephen L. Schensul, Jean J. Schensul, and Margaret D. LeCompte 9780759122017 Book 4: Specialized Ethnographic Methods: A Mixed Methods Approach edited by Jean J. Schensul and Margaret D. LeCompte 9780759122055 Book 5: Analysis and Interpretation of Ethnographic Data: A Mixed Methods Approach, Second Edition by Margaret D. LeCompte and Jean J. Schensul 9780759122079 Book 6: Ethics in Ethnography: A Mixed Methods Approach by Margaret D. LeCompte and Jean J. Schensul 9780759122093 Book 7: Ethnography in Action: A Mixed Methods Approach by Jean J. Schensul and Margaret D. LeCompte 9780759122116

Download or read book Sustainable Public Management written by Neil M. Boyd and published by Routledge. This book was released on 2021-09-09 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sustainable Public Management explores key issues in public sector sustainable management that span from Nation/State to local government. It highlights state-of-the art articulations of public-private partnerships, public engagement, inter-organizational networks, sustainability policy, strategy, standard setting, and reporting. Sustainable management is an important topic across organizational forms in the private, not-for-profit, and public sectors because of the its practice is tied to some of the most pressing environmental and social problems that exist in the world. The public sector is especially important due to its scale and scope across the globe, the tangible impacts that public service delivery can make in resource efficiency and effectiveness, and in directly tackling critical sustainable development goals. This book will be of great value to scholars, students, and policymakers interested in Public Administration and Management, Sustainable Management and Development. The chapters in this book were originally published as a special issue of the Public Management Review.

Download or read book Targeted Selection written by William C. Byham and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Assistive Technologies E Book written by Albert M. Cook and published by Elsevier Health Sciences. This book was released on 2014-11-14 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW! Global issues content broadens the focus of application beyond North America to include technology applications and service delivery in developing countries. NEW! Ethical issues and occupational justice content exposes you to vital information as you start interacting with clients. NEW! More case studies added throughout the text foster an understanding of how assistive technologies are used and how they function. NEW! Updated content reflects current technology and helps keep you current. NEW! Explicit applications of the HAAT model in each of the chapters on specific technologies and more emphasis on the interactions among the elements make content even easier to understand.

Download or read book Merger and Acquisition Target Selection Based on Interval Neutrosophic Multigranulation Rough Sets over Two Universes written by Chao Zhang and published by Infinite Study. This book was released on with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a significant business activity, merger and acquisition (M&A) generally means transactions in which the ownership of companies, other business organizations or their operating unitsaretransferredorcombined.

Download or read book Experts and Democratic Legitimacy written by Eva Krick and published by Routledge. This book was released on 2020-05-21 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts and Democratic Legitimacy challenges the technocratic reading of expert bodies, such as central banks, advisory committees and regulatory agencies. Expert contributors ask in what way expert bodies are subject to some of the key pressures in contemporary governance, such as democratisation, politicisation and expertisation. Based on empirical studies, the book traces the multiple social ties of expert bodies and refines the common perception of expert bodies as ‘de-politicised’ institutions that are detached from political interference and societal input. It further theorises the tension and reconcilability between reliable, independent expert knowledge on the one hand and the need for accountability and legitimacy in modern policy-making on the other hand. Refining the detached, de-politicised image of non-majoritarian institutions, Experts and Democratic Legitimacy will be of great interest to scholars of European studies, political and social theory, modern governance and policy-making. This book was originally published as a special issue of European Politics and Society.

Download or read book New Corporate Governance written by Martin Hilb and published by Springer. This book was released on 2016-02-17 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the 5th edition of this successful book Martin Hilb presents an innovative and integrated approach to the theory and practice of corporate governance. Central to this approach is a set of instruments - developed and tested by the author - that can be used by boards to offer effective strategic direction and control to their organizations. The board instruments can be readily applied to the selection, review, remuneration and development of board members, and for conducting board self-evaluations. This new approach to corporate governance is based on four guiding principles: keep it situational, keep it strategic, keep it integrated, and keep it controlled. Together, these principles form the basis of an integrated approach to all key aspects of corporate governance. The main arguments in each section are supported by conceptual models, practical board tools and case studies, making the book ideally suited to board members, senior managers and post-graduate students. This new edition is updated throughout the book and includes a new chapter on mobile integrated board management and documentation information systems.