Download or read book Targeted Delivery of Alpha Particle Emitting Radionuclides and Their Alpha Emitting Progeny Breast Cancer Therapy Using Lipsome Encapsulated Alpha Emitters written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concept award was extended by a year over the initial one-year period at no additional cost. The primary objective is to investigate liposomal encapsulation of chelated Ac-225 in order to reduce loss of progeny from the targeting vehicle and, therefore, the tumor site. Results have shown that the extent of daughter retention is dependent upon liposomal vesicle diameter with larger vesicles retaining the alpha- particle emitting daughters to a greater extent. The dependence of retention on the diameter of the liposomal vesicle is thought to arise because of recoil of the daughter nuclei. The recoil distance of daughter nuclei after alpha-particle emission is approximately 100 nm. Depending upon the site of decay, therefore, the recoil distance is sufficient to eject the daughter outside of the liposome. Assuming that ejection by recoil is the only mechanism by which daughters escape from the vesicles, a theoretical model relating vesicular diameter with daughter retention has been developed. Measured retention values do not fall within model predictions. Upcoming studies will focus on understanding the observed divergence between model-predicted and observed retention and also on carrying out animal studies evaluating loco-regional therapy with larger vesicles.
Download or read book Targeted Alpha Therapy Using Components of the Plasminogen Activation System for the Control of Micrometastatic Breast Cancer written by Barry J. Allen and published by . This book was released on 2000 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major failure in breast cancer management is the incomplete killing of malignant tumour cells that have spread throughout the body 1. This is despite the many treatments available, such as surgery, radiation therapy, hormone therapy and chemotherapy. The American Cancer Society estimated 182,800 new cases of invasive breast cancer in the year 2000 among women in America, and 40,800 are expected to die from the disease 2. Novel, more effective treatments that overcome this problem in breast cancer management are essential. Targeted therapy, first discussed over 100 years ago, is based on the idea that a drug will attack its target without damaging other tissue 3. Targeted alpha therapy (TAT) uses an alpha emitting radionuclide as a lethal medicament via an effective targeting carrier to kill cancer cells 5. We are investigating a novel TAT approach that exploits the involvement of cell-surface receptor bound urokinase plasminogen activator (uPA) in the metastatic spread of breast cancer cells.
Download or read book Handbook of Radiopharmaceuticals written by Michael J. Welch and published by John Wiley & Sons. This book was released on 2003-01-17 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States
Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
Download or read book Polymer Science and Nanotechnology written by Ravin Narain and published by Elsevier. This book was released on 2020-06-16 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer Science and Nanotechnology: Fundamentals and Applications brings together the latest advances in polymer science and nanoscience. Sections explain the fundamentals of polymer science, including key aspects and methods in terms of molecular structure, synthesis, characterization, microstructure, phase structure and processing and properties before discussing the materials of particular interest and utility for novel applications, such as hydrogels, natural polymers, smart polymers and polymeric biomaterials. The second part of the book examines essential techniques in nanotechnology, with an emphasis on the utilization of advanced polymeric materials in the context of nanoscience. Throughout the book, chapters are prepared so that materials and products can be geared towards specific applications. Two chapters cover, in detail, major application areas, including fuel and solar cells, tissue engineering, drug and gene delivery, membranes, water treatment and oil recovery. - Presents the latest applications of polymers and polymeric nanomaterials, across energy, biomedical, pharmaceutical, and environmental fields - Contains detailed coverage of polymer nanocomposites, polymer nanoparticles, and hybrid polymer-metallic nanoparticles - Supports an interdisciplinary approach, enabling readers from different disciplines to understand polymer science and nanotechnology and the interface between them
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Download or read book An Ion Exchange Study of Possible Hybridized 5f Bonding in the Actinides written by R. M. Diamond and published by . This book was released on 1953 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: A study has been made of the elution behavior of curium(III), americium(III), plutonium(III), actinium(III), plutonium(IV), neptunium(IV), uraniuM(IV), thorium(IV), neptunium(V), plutonium (VI), uranium (VI), lanthanum(III), cerium(III), europium(III), ytterbium(III), ytterium(III), strontium(II), barium(II), radium(II), cesium(I) with 3.2 M, 6.2 M, 9.3 M, and 12.2 M HCl solutions from Dowex-50 cation exchange resin columns. These elutions show that in high concentrations of hydrochloric acid the actinides form complex ions with chloride ion to a much greater extent than the lanthanides. The strengths of the tripositive actinide complex ions apparently go in the order plutonium > americium> curium, although their ionic radii also decrease in this same order. To explain these results, a partial covalent character may be ascribed to the bonding in the transuranium complex ions. It is shown that a reasonable structure for such covalent bonding involves hybridization of the 5f orbitals in the actinide elements.
Download or read book Drug Delivery written by Monika Schäfer-Korting and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.
Download or read book Biogenic Nano Particles and their Use in Agro ecosystems written by Mansour Ghorbanpour and published by Springer Nature. This book was released on 2020-03-20 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several nano-scale devices have emerged that are capable of analysing plant diseases, nutrient deficiencies and any other ailments that may affect food security in agro-ecosystems. It has been envisioned that smart delivery systems can be developed and utilised for better management of agricultural ecosystems. These systems could exhibit beneficial, multi-functional characteristics, which could be used to assess and also control habitat-imposed stresses to crops. Nanoparticle-mediated smart delivery systems can control the delivery of nutrients or bioactive and/or pesticide molecules in plants. It has been suggested that nano-particles in plants might help determine their nutrient status and could also be used as cures in agro-ecosystems. Further, to enhance soil and crop productivity, nanotechnology has been used to create and deliver nano fertilizers, which can be defined as nano-particles that directly help supply nutrients for plant growth and soil productivity. Nano-particles can be absorbed onto clay networks, leading to improved soil health and more efficient nutrient use by crops. Additionally, fertilizer particles can be coated with nano-particles that facilitate slow and steady release of nutrients, reducing loss of nutrients and enhancing their efficiency in agri-crops. Although the use of nanotechnology in agro-ecosystems is still in its early stages and needs to be developed further, nano-particle-mediated delivery systems are promising solutions for the successful management of agri-ecosystems. In this context, the book offers insights into nanotechnology in agro-ecosystems with reference to biogenic nanoparticles. It highlights the: • occurrence and diversity of Biogenic Nanoparticles • mechanistic approach involved in the synthesis of biogenic nanoparticles • synthesis of nanoparticles using photo-activation, and their fate in the soil ecosystem • potential applications of nanoparticles in agricultural systems • application and biogenic synthesis of gold nanoparticles and their characterization • impact of biogenic nanoparticles on biotic stress to plants • mechanistic approaches involved in the antimicrobial effects and cytotoxicity of biogenic nanoparticles • role of biogenic nanoparticles in plant diseases management • relevance of biological synthesized nanoparticles in the longevity of agricultural crops • design and synthesis of nano-biosensors for monitoring pollutants in water, soil and plant systems • applications of nanotechnology in agriculture with special refer to soil, water and plant sciences A useful resource for postgraduate and research students in the field of plant and agricultural sciences, it is also of interest to researchers working in nano and biotechnology.
Download or read book Bispecific Antibodies written by Roland E. Kontermann and published by Springer Science & Business Media. This book was released on 2011-07-21 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.
Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Download or read book Nanoparticle Enhanced Radiation Therapy written by Erno Sajo and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Improved targeting of abnormal cells and tissue in the radiotherapy of cancer has been a long-standing goal of researchers. The central purpose in Nanoparticle-Enhanced Radiotherapy (NPRT) is to more precisely control where the radiation dose is delivered, desirably with subcellular precision, provided we can find a method to bring the nanoparticles to target and control their concentration and size distribution. The contents within this book will cover the rationale and fundamental principles of NPRT, optimal nanoparticle sizes, concentrations, design and fabrication, effective nanoparticle delivery methods, emerging clinical applications of NRT modalities, treatment planning and quality assurance and the potential of NPRT in global health. This volume will serve as a resource for researchers, educators and industry, and as a practical guide or comprehensive reference for students, research trainees and others working in cancer nanomedicine. Part of IOP Series in Global Health and Radiation Oncology.
Download or read book Microbial Biotechnology Basic Research and Applications written by Joginder Singh and published by Springer Nature. This book was released on 2020-07-07 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial biotechnology is an important area that promotes advanced research into using microbes for value-added products, human nutrition, and the overall wellbeing of society. This book presents the latest information on the use of microbes for sustainable development, and highlights state-of-the-art biotechnological techniques used to harness microbial biotechnological traits on a commercial scale. Gathering contributions from authoritative researchers in the field, it addresses recent advances in microbial biotechnological approaches that offer sustainable options for future generations. Exploring a broad range of microbial products and their uses, the book specifically places emphasis on the application of microorganisms in healthcare, the environment and industry. It also discusses various compound classes derived from microbial metabolites. Pursuing a holistic approach to recent advances in the utilization of various microbes as biotechnological tools, the book also covers traditional uses, and explores emerging strategies to harness their full potential. Accordingly, it offers a valuable resource for researchers and graduate students alike.
Download or read book NanoBioMedicine written by Shailendra K. Saxena and published by Springer Nature. This book was released on 2020-02-03 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.
Download or read book Applications of Nanocomposite Materials in Drug Delivery written by Inamuddin and published by Woodhead Publishing. This book was released on 2018-06-18 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of Nanocomposite in Drug Delivery discusses and explores the applications of nanocomposites in the area of drug delivery. Starting with a scientific understanding of drug delivery fundamentals, the book explores the utility of nanocomposites in the area of controlled, transdermal, osteo-articular tuberculosis and stimulus sensitive drug delivery applications. The book intricately details and discusses a variety of methods for their preparation, while also highlighting specific applications of nanocomposites in targeted drug delivery. - Discusses nanocomposite and nanotechnology for drug delivery - Outlines the mechanisms involved in targeted drug delivery using nanocomposites - Includes synthesis methods for nanocomposites used in controlled drug delivery - Lists various applications of nanocomposites in drug delivery
Download or read book Neural Metabolism In Vivo written by In-Young Choi and published by Springer Science & Business Media. This book was released on 2012-03-08 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter
Download or read book Microbes written by Prakash S. Bisen and published by John Wiley & Sons. This book was released on 2012-06-22 with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible introduction to the world of microbes—from basic microbe biology through industrial applications Microbes affect our lives in a variety of ways—playing an important role in our health, food, agriculture, and environment. While some microbes are beneficial, others are pathogenic or opportunistic. Microbes: Concepts and Applications describes basic microbe biology and identification and shows not only how they operate in the subfields of medicine, biotechnology, environmental science, bioengineering, agriculture, and food science, but how they can be harnessed as a resource. It provides readers with a solid grasp of etiologic agents, pathogenic processes, epidemiology, and the role of microbes as therapeutic agents. Placing a major emphasis on omics technology, the book covers recent developments in the arena of microbes and discusses their role in industry and agriculture, as well as in related fields such as immunology, cell biology, and molecular biology. It offers complete discussions of the major bacterial, viral, fungal, and parasitic pathogens; includes information on emerging infectious diseases, antibiotic resistance, and bioterrorism; and talks about the future challenges in microbiology. The most complete treatment of microbial biology available, Microbes features eye-opening chapters on: Human and Microbial World Gene Technology: Application and Techniques Molecular Diagnostic and Medical Microbiology Identification and Classification of Microbes Diversity of Microorganisms Microbes in Agriculture Microbes as a Tool for Industry and Research Complete with charts and figures, this book is an invaluable textbook for university teachers, students, researchers, and people everywhere who care about microorganisms.
