Download or read book Early Osteoarthritis written by Christian Lattermann and published by Springer Nature. This book was released on 2021-10-09 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.

Download or read book Early Osteoarthritis written by Christian Lattermann and published by Springer. This book was released on 2022-10-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.

Download or read book Early Osteoarthritis written by Christian Lattermann and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.

Download or read book T Cells in Arthritis written by P. Miossec and published by Birkhäuser. This book was released on 2013-03-11 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.

Download or read book Gene Therapy of Autoimmune Disease written by Gerald J. Prud'homme and published by Springer. This book was released on 2005-07-13 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Download or read book Early Rheumatoid Arthritis written by Paul Emery and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.

Download or read book New Developments in the Pathogenesis of Rheumatoid Arthritis written by Lazaros Sakkas and published by BoD – Books on Demand. This book was released on 2017-02-22 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF-?, IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

Download or read book Rheumatoid Arthritis written by J. J. Goronzy and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the third volume of the new series 'Current Directions in Autoimmunity', is the first one to exclusively focus on one disease. Written by experts in genetics and immunobiology, the articles reflect the complexity and multiple facets of the disease process but also show their convergence to a better understanding of pathogenetic mechanisms and the evolving clinical applications. The models and concepts described in this volume have implications for studies of other inflammatory diseases and are of interest not only for clinical and basic scientists devoted to the study of rheumatoid arthritis but for investigators of autoimmune diseases in general.

Download or read book Vaccinia Vaccination Vaccinology written by Stanley A. Plotkin and published by Elsevier Science Limited. This book was released on 1996 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Rheumatoid Arthritis written by Josef S. Smolen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All these are dealt with in depth in the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between microbes, dysregulated immune responses and oncogenes are also examined. Since autoimmunity is the key aspect of the immunological response in rheumatoid arthritis, the role of antigens is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become important in monitoring disease activity. A chapter reviewing possible future novel therapies is included.

Download or read book Periprosthetic Joint Infection Practical Management Guide written by Parvizi Javad and published by JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD.. This book was released on 2013-12-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book Periprosthetic Joint Infection is a portable guide to the practical management of surgical site infections following orthopedic procedures. It designed to help answer clinician's questions regarding the prevention and treatment of periprosthetic infections. It organized for rapid review, featuring evidence reviews, pitfalls, Rothman Institute Current Practices and Controversies. The guide is being included in the course materials for the 29th Annual Current Concepts in Joint Replacement® (CCJR) meeting thanks to a generous educational grant from 3M Health Care.

Download or read book Immunopathogenetic Mechanisms of Arthritis written by J.A. Goodacre and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental problem facing scientists and clinicians in Rheumatology is that so little is known about the biology of joints. It is our view that a real interface between basic and clinical science offers the best chance of gaining a better understanding of arthritis and in this book we aim to provide a basis for such an interface. Each chapter provides a lucid account of the current literature, reflecting the eminence of each author in their own field. The contributors offer a variety of modern approaches to the study of inflammatory joint disease, illustrating some of the exciting opportunities for research which exist. We hope that those who share our view find these pages informative and stimulating. University of Newcastle upon Tyne, 1987. JOHN A. GOODACRE W. CARSON DICK ix 1 • Polymorphonuclear leukocytes In acute inflammation O. T. G. JONES and A. R. CROSS INTRODUCTION The nonnal function of the professional phagocytes - polymorphonuclear leukocytes (PMN), monocytes, macrophages and eosinophils - is to protect the individual from microbial infection by seeking out and destroying the invading microbes. In order to perform this function effectively the phagocyte must move towards sites of infection, recognize, phagocytose, kill and digest the microbe and, if necessary, recruit other cells to assist. These phagocytic cells possess a membrane-bound enzyme system which can be activated to produce toxic oxygen radicals in response to a wide variety of stimuli.

Download or read book T Cell Clones written by Harald von Boehmer and published by Elsevier Publishing Company. This book was released on 1985 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regulatory T Cells in Inflammation written by Leonie S. Taams and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

Download or read book Inflammation 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.