Download or read book Systems Biology of Parkinson s Disease written by Peter Wellstead and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.
Download or read book Systems Biology of Parkinson s Disease written by Peter Wellstead and published by Springer. This book was released on 2014-06-11 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Systems Biology of Parkinson’s Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.
Download or read book Systems Biology of Parkinson s Disease Chapter 2 written by Peter Wellstead and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Science and Engineering in High Throughput Biology Including a Theory on Parkinson s Disease written by Andr X. C. N. Valente and published by Lulu.com. This book was released on 2011-08 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology is shifting from its data-poor origins to a quantitative data, high-throughput regime. Accompanying this change is an increasing technical capacity to engineer biological constructs. This book is about theory in this new context for the Life Sciences. Three articles, each preceded by an explanatory introduction, are presented. They propose: * A framework for prediction in this new data-rich regime. * A theory on the systemic nature and hematopoietic origin of Parkinson's Disease. * An approach to engineering design in the biological context, in particular in Synthetic Biology.
Download or read book Parkinson s Disease written by Patrik Verstreken and published by Academic Press. This book was released on 2016-12-19 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson's disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson's. - Written by experts in the field that focus on pathways and mechanisms implicated in Parkinson's pathology - Draws parallels between multidisciplinary discoveries in different model organisms using an array of technologies - Provides a cross-methodology and cross-species approach to understanding the molecular biology of Parkinson's disease - Includes approximately 25 color Illustrations and diagrams to explain concepts and models - Focuses on key pathways and mechanisms (as opposed to model organism or gene) to provide a multidisciplinary approach to Parkinson's disease
Download or read book Parkinson s Disease written by Richard Nass and published by Elsevier. This book was released on 2011-04-28 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. - Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson's disease - Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD - Current overviews of current status of PD research and discovery from bench-to-bedside - Provides novel insights and views on where the future of PD research may lead - Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases
Download or read book Developing Metabolomics for a Systems Biology Approach to Understand Parkinson s Disease written by and published by . This book was released on 2021 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Systems Biology written by Andres Kriete and published by Elsevier Inc. Chapters. This book was released on 2013-11-26 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: What makes the study of aging particularly challenging is the wide spectrum of phenotypical changes that can be observed during its progression. While initial attention was paid to damage accumulation, dysfunction, and failure, it is now realized that aging, and associated diseases including dementias, are influenced by a multitude of interacting factors. Proximal mechanisms beyond passive accumulation of damage include regulatory mechanisms, stress responses, changes in networks, as well as genetic and stochastic effects. The application of computational systems biology in aging, which is in line with other attempts to overcome the study of isolated or compartmentalized mechanisms, has made initial progress allowing us to simulate partial aspects of the aging dynamics and to make new hypotheses about how these aging mechanism shape disease progression. Here we provide examples for analysis of networks, regulatory mechanisms, and spatiotemporal effects in the study of proximal mechanisms of aging and Parkinson’s Disease. In addition, we introduce complexity theories that may contribute to explain the ultimate causes of aging with an evolutionary view.
Download or read book Metabolic Modelling and Integrative Biologic Networks to Understand the Contribution of the Gut Microbiome to the Pathophysiology of Parkinson s Disease written by Dorinês Simões Rosário and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parkinson s Disease From Clinical Aspects to Molecular Basis written by Toshiharu Nagatsu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This b00k reviews the recent advances in the research on Parkinson's disease. It contains review articles from basic to clinical researches including the historical introduction and the molecular biological approach to Parkinson's disease. Parkinson's disease is the most representative, age-related neurodegenerative disease. It is clinically characterized by movement disorders such as muscle rigidity, akinesia and tremor. The elucidation of its biochemical and molecular mechanisms has rapidly been progressing and is expected to contribute to the understanding of normal brain aging in general. This project is supported by a Grant-in-Aid for Scientific Research on Priority Areas, "Molecular Biology of the Motor System", Ministry of Education, Science and Culture, Japan, for 3 years from 1987 to 1989. We are grateful for the support. These reviews are a part of the works which have been supported by this Grant-in-Aid. The characteristics of this research project on Parkinson's disease are interdisciplinary approach from basic, molecular biology to clinical medicine, and the molecular biological approach is expected to be the most promising for the elucidation of the pathogenesis. The collaboration and discussion between basic and clinical researchers in this Priority Area Project has been efficient and productive. We hope that this book can mark another new milestone in the studies on Park,oson's disease and in neuroscience. We are very grateful to Nippon Schering for their generous support for the publication of this book. Last but not least, we thank Springer-Verlag Wien New York for the excellent production of this book and the excellent cooperation.
Download or read book A Systems Biology Roadmap to Understanding Late onset Neurodegenerative Disease written by Anthony Patrick Milani and published by . This book was released on 2017 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endolysosomal system has recently come under heavy scrutiny as a potentially major contributor to the progression of late-onset neurodegenerative diseases. In this review, I highlight our current understanding of the endolysosomal system, and the Rab GTPase cascade regulating significant portions of its normal progression. Dysfunction in this cascade potentially accounts for many well-documented cellular phenotypes pertaining to neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease. Despite extensive study, many of the molecular mechanisms underlying the progression of late-onset neurodegenerative diseases remain elusive. The use of systems biology approaches appears to be the most promising route forward for understanding the etiologies of the systemic disorder observed in these diseases, which are likely to be highly variable between individuals.
Download or read book The Neuroscience of Parkinson s Disease written by Colin R Martin and published by Academic Press. This book was released on 2020-12-21 with total page 1548 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Parkinson’s Disease (two volume set) provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The book also fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease
Download or read book Biofrequencies and Parkinson s Disease written by Sharry Edwards and published by Parkinsons Recovery. This book was released on 2014-03-04 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, Edwards and her team at Sound Health are using the human voice and the associated frequencies to help clients with Parkinson's Disease in addition to many other chronic illnesses. Sharry Edwards' work is now included in The Duke University Encyclopedia of New Medicine, by Leonard A. Wisnecki and The Scientific Basis of Integrative Medicine, by Lucy Anderson. The effects of BioAcoustic Biology, now accepted by these prestigious medical encyclopedias, have unlimited health and wellness potential. According to Edwards, "BioAcoustics Voice Spectral Analysis can detect hidden or underlying stresses in the body that are expressed as disease." Vocal prints can identify toxins, pathogens and nutritional supplements that are too low or too high. In addition, vocal prints can be used to match the most compatible treatment remedy to each client. The introduction of the proper low frequency sound to the body, indicated through voice analysis, has been shown to help people who currently experience the symptoms of Parkinsons Disease.
Download or read book Rating Scales in Parkinson s Disease written by Cristina Sampaio and published by Oxford University Press. This book was released on 2012-06-28 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another.
Download or read book Run in the Light written by John Mitrofanis and published by Morgan & Claypool Publishers. This book was released on 2019-08-05 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease is a neurological disorder with cardinal motor signs of resting tremor, bradykinesia and lead-pipe rigidity. In addition, many patients display non-motor symptoms, including a diminished sensation of smell, gastrointestinal problems, various disorders of sleep and some cognitive impairment. These clinical features - particularly the motor signs - manifest after a progressive death of many dopaminergic neurones in the brain. Although currently available, conventional therapies can reduce the signs of the disease, the progression of this neuronal death has proved difficult to slow or stop, and the condition is relentlessly progressive. Hence, there is a real need to develop a treatment that is neuroprotective, one that slows the pathology of the disease effectively. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. They involve the use of exercise and light (i.e. photobiomodulation, the use of red to infrared light therapy (λ=600-1070nm) on body tissues). The two therapies are tied together in several ways. First, in animal models of Parkinson's disease, they each have been shown to offer the key feature of neuroprotection, stimulating a series of built-in protective mechanisms within the neurones, that helps their survival, to self-protect and/or self-repair. There are also some promising indications of neuroprotection and many beneficial outcomes in parkinsonian patients. Further, both exercise and light therapies are similar in that they are non-invasive and safe to use, with no known adverse side-effects, making their combination with the conventional therapies, such as dopamine replacement drug therapy and deep brain stimulation, all the more feasible. Given the heterogeneity of Parkinson's disease in humans, tackling the condition from a range of different angles - with a number of different therapies - would only serve to enhance the positive outcomes. This book considers the use of exercise and light therapies, proposing that they have the potential to make a powerful "dynamic duo", offering a most effective neuroprotective treatment option to patients.
Download or read book Homeostatic Control of Brain Function written by Detlev Boison and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
