Download or read book Systems Biology Approaches to Understanding the Cause and Treatment of Heart Lung Blood and Sleep Disorders written by Raimond L Winslow and published by Frontiers E-books. This book was released on 2014-11-21 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated – they have transformed the nature of both biology and medicine. Despite this dramatic progress, one of the greatest challenges that continues to confront modern biology is to understand how behavior at the level of genome, proteome and metabolome determines physiological function at the level of cell, tissue and organ in both health and disease. Because of the inherent complexity of biological systems, the development, analysis, and validation of integrative computational models based directly on experimental data is necessary to achieve this understanding. This approach, known as systems biology, integrates computational and experimental approaches through iterative development of mathematical models and experimental validation and testing. The combination of these approaches allows for a mechanistic understanding of the function of complex biological systems in health and their dysfunction in disease. The National Heart, Lung, and Blood Institute (NHLBI) has recognized the importance of the systems biology approach for understanding normal physiology and perturbations associated with heart, lung, blood, and sleep diseases and disorders. In 2006, NHLBI announced the Exploratory Program in Systems Biology, followed in 2010 by the NHLBI Systems Biology Collaborations. The goal of these programs is to support collaborative teams of investigators in using experimental and computational strategies to integrate the component parts of biological networks and pathways into computational models that are based firmly on and validated using experimental data. These validated models are then applied to gain insights into the mechanisms of altered system function in disease, to generate novel hypotheses regarding these mechanisms that can be tested experimentally, and to then use the results of experiments to refine the models. The purpose of this Research Topic is to present the range of innovative, new approaches being developed by investigators working in areas of systems biology that couple experimental and modeling studies to understand the cause and possible treatment of heart, lung, blood and sleep diseases and disorders. This Research Topic will be of great interest to the cardiovascular research community as well as to the general community of systems biologists.
Download or read book Sleep Disorders and Sleep Deprivation written by Institute of Medicine and published by National Academies Press. This book was released on 2006-10-13 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.
Download or read book Washington Information Directory 2021 2022 written by CQ Press and published by CQ Press. This book was released on 2021-07-15 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Washington Information Directory (WID) is a topically organized reference resource that lists contact information for federal agencies and nongovernmental organizations in the Washington metro area along with a brief paragraph describing what each organization does related to that topic. In addition, The Washington Information Directory pulls together 55 organization charts for federal agencies, congressional resources related to each chapter topic, hotline and contact information for various specific areas of interest (from Food Safety Resources to internships in Washington), and an extensive list of active congressional caucuses and contact details.
Download or read book NIH Almanac written by National Institutes of Health (U.S.). Division of Public Information and published by . This book was released on 2001 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Washington Information Directory 2020 2021 written by CQ Press, and published by CQ Press. This book was released on 2020-06-26 with total page 1126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Washington Information Directory (WID) is a topically organized reference resource that lists contact information for federal agencies and nongovernmental organizations in the Washington metro area along with a brief paragraph describing what each organization does related to that topic. In addition, WID pulls together 55 organization charts for federal agencies, congressional resources related to each chapter topic, hotline and contact information for various specific areas of interest (from Food Safety Resources to internships in Washington), and an extensive list of active congressional caucuses and contact details. WID has two appendices, one with thorough information on congresspersons and committees, and the second with governors and embassies.
Download or read book The Theory of Endobiogeny written by Kamyar M. Hedayat and published by Academic Press. This book was released on 2019-06-18 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Theory of Endobiogeny Volume 1: Global Systems Thinking and Biological Modeling for Clinical Medicine offers researchers and clinicians a detailed introduction to the theory of Endobiogeny. The book presents a new approach to medicine that is at once scientific and humanistic, quantitative, and qualitative. The philosophical and experimental basis of a global complex systems approach to physiology is presented along with a mathematical approach to modeling the dynamism of the terrain. The importance of the history and physical examination are renewed as a source of "big data readily available to clinicians for greater insight into the patient's state. Expansion of the therapeutic compendium is proposed based on a rational, clinical approach correlated to mathematical indicators of the physiologic state. What is proposed in this work is a fundamental shift in scientific thinking with a resulting expansion of the boundaries of clinical medicine for the 21st century and beyond. - Extends systems biology from the cellular to the integrative physiologic level - Moves the functional medicine approach to a higher level of integration and true global systems thinking - Presents mathematical tools and proofs of formulas related to the biology of functions: a biological modeling system based on the theory of endobiogeny. The biology of functions has assisted clinicians in conceptualizing, treating, and objectively monitoring the longitudinal effects of treatment through the evolution of the patient's unique phenotypic expression of terrain
Download or read book Report of the Director National Heart Lung and Blood Institute written by National Heart, Lung, and Blood Institute and published by . This book was released on 1986 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Beyond the Molecular Frontier written by National Research Council and published by National Academies Press. This book was released on 2003-03-19 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Download or read book Report of the Director of the National Heart Lung and Blood Institute written by National Heart, Lung, and Blood Institute and published by . This book was released on 1983 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2003 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 2002 with total page 1776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coronary Primary Prevention Trial written by and published by . This book was released on 1984 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 1997 National Institutes of Health written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 1996 with total page 1116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrative and Functional Medical Nutrition Therapy written by Diana Noland and published by Springer Nature. This book was released on 2020-03-27 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the application of the philosophy and principles of Integrative and Functional Medical Nutrition Therapy (IFMNT) in the practice of medicine, and the key role nutrition plays in restoring and maintaining wellness. The textbook provides an overview of recent reviews and studies of physiological and biochemical contributions to IFMNT and address nutritional influences in human heath overall, including poor nutrition, genomics, environmental toxicant exposures, fractured human interactions, limited physical movement, stress, sleep deprivation, and other lifestyle factors. Ultimately, this textbook serves to help practitioners, healthcare systems, and policy makers better understand this different and novel approach to complex chronic disorders. It provides the reader with real world examples of applications of the underlying principles and practices of integrative/functional nutrition therapies and presents the most up-to-date intervention strategies and clinical tools to help the reader keep abreast of developments in this emerging specialty field. Many chapters include comprehensive coverage of the topic and clinical applications with supplementary learning features such as case studies, take-home messages, patient and practitioner handouts, algorithms, and suggested readings. Integrative and Functional Medical Nutrition Therapy: Principles and Practices will serve as an invaluable guide for healthcare professionals in their clinical application of nutrition, lifestyle assessment, and intervention for each unique, individual patient.
Download or read book 2003 National Sleep Disorders Research Plan written by National Center on Sleep Disorders Research (National Heart, Lung, and Blood Institute) and published by . This book was released on 2003 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalog of Federal Domestic Assistance written by United States. Office of Management and Budget and published by . This book was released on 1969 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identifies and describes specific government assistance opportunities such as loans, grants, counseling, and procurement contracts available under many agencies and programs.
Download or read book Temporomandibular Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-01 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.
