Download or read book Synthetic and Biosynthetic Studies on Polyketide Natural Products written by Sbu Z. Mbatha and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Biosynthetic Studies on Polyketide Derived Natural Products written by and published by . This book was released on 2012 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Biosynthetic Studies Toward Novel Aromatic Polyketides written by Taek Soon Lee and published by . This book was released on 2006 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Biosynthetic Studies of Natural Products written by Eduardo Alberto Véliz Chanis and published by . This book was released on 1992 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Biosynthetic Studies on Polyketide Intermediates written by and published by . This book was released on 2005 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Applied to Polyketide Natural Products written by Alexander Mandel and published by . This book was released on 2008 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyketide natural products are valuable components of the modern pharmacopea. These secondary metabolites have a diverse range of structures and activities. Studies of their biosynthesis and activity will help to provide access to better medicinal compounds. To this end, directly probing these mechanisms with derivatives of natural products is an important goal. Synthetic organic chemistry allows production of a greater variety of compounds than can be accessed by manipulation of isolated natural products. In some cases, these bioactive molecules are only obtainable in small quantities or at great expense. Herein, a modular synthesis of the Coenzyme A (10) precursors pantethine (35) and phosphopantetheine (14) is described. CoA is a cofactor that interacts with an estimated 4% of all enzymes known in nature, and it is central to the biosynthesis of polyketide antibiotics. Using d-pantolactone (50) to provide the key units, 53 and 63, pantetheine, phosphopantetheine, and derivatives were assembled through peptide couplings. Next, synthetic methods were applied toward the total synthesis of two related macrolide antibiotics, pladienolide B (70b) and FD-895 (71), in an attempt to elucidate their stereochemistries and to get a supply of each molecule for studies into the their stereochemistries and to get a supply of each molecule for studies into the molecule relies on a Stille coupling to connect the sidechain (133) to the 12-membered macrocyclic core (111), and an esterification / ring-closing metathesis sequence to furnish the ring from compounds 115 and 114. The sidechain of pladienolide B was completed and involved in model studies to demonstrate the overall retrosynthetic background. The core structure was proposed to arise from the chiral pool, but the strategy to combine the two units with the necessary stereochemistry met with failure under many different conditions. Due to complications in obtaining an authentic sample of pladienolide B (70b), and subsequent outside publication of a total synthesis incorporating many aspects of the work contained herein, FD-895 (71) was chosen as an alternative target. The same retrosynthetic breakdown was applied to FD-895.

Download or read book Synthetic and Biosynthetic Studies on the Polyketide Metabolites LL D253 Alpha and Averufin written by I. M. Chandler and published by . This book was released on 1987 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Download or read book Synthetic and Biosynthetic Studies on the Polyketide Metabolites LL D253a and Averufin written by Ian Michael Chandler and published by . This book was released on 1987 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Biosynthetic Studies on Polyketides and Diarylheptanoids written by Thomas Ackrill and published by . This book was released on 2015 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemical and Biological Synthesis written by Nick J Westwood and published by Royal Society of Chemistry. This book was released on 2018-08-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology. Covering the synthetic approaches that can be applied across the whole field of chemical biology, this book provides synthetic chemists with the broader context to which their work contributes and the biological questions that can be addressed through it. An ideal guide for postgraduate students and researchers in synthetic organic chemistry and chemical biology, Chemical and Biological Synthesis introduces synthetic techniques and methods to those who wish to incorporate synthesis for the first time in their biology-focused research programmes.

Download or read book Bioorganic Chemistry written by J. Rohr and published by Springer. This book was released on 1997-04-17 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Biosynthesis, chemical synthesis, combinatorial synthesis, enzymatic synthesis, enzymes and genetics are subjects of considerable interest. These themes are dealt with in three areas of current bioorganic research. Deoxysugars and deoxy- oligosaccharides are important structural moieties in bio- active natural products. What is their contribution to the mode of action and how can they be studied? Synthetic strat- egies, biosynthesis and the genetics involved are presented. The second review article, on non-template based multyenzyme systems, addresses the question why polyketides are the most diverse group of natural products. Polyketide syntheses are compared with other non-template multienzyme sytems. The third review article deals with angucycline antibiotics, the largest subgroup of polycyclic aromatic polyketides.

Download or read book Synthesis and Biosynthesis of Polyketide Natural Products written by Atahualpa Pinto and published by . This book was released on 2011 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biosynthetic and Synthetic Studies on Polyketides written by David James Witter and published by . This book was released on 1994 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medicinal Natural Products written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2002-01-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.

Download or read book Biomimetic Organic Synthesis written by Erwan Poupon and published by John Wiley & Sons. This book was released on 2011-05-09 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature. Volume 1 describes the biomimetic synthesis of alkaloids. Volume 2 covers terpenes, polyketides, and polyphenols. A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook. Key features: Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field. Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.

Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-03-17 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field