Download or read book Synthesis of the Dragmacidin E Core Structure written by Derek Haspeslagh and published by . This book was released on 2014 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reaction sequence leading to the core ring system of Dragmacidin E was proposed. The only prior total synthesis occurred in 25 steps. This study investigated a reaction sequence proposed to have fewer overall steps with a lower cost for the formal synthesis. Experimental results elucidated that attempted substitutions at C(3) of the indole did not provide the intended products. However, a Vilsmeier formylation successfully added a formyl group to C(3) of 4-bromoindole. A new scheme leading to a 6-5-7 indole ring system starting with the Vilsmeier formylation of 4-bromoindole was envisioned. A formal synthesis could be initiated with 4-bromotryptophan, leading to a functionalized C(3)-C(4) bridged indole.
Download or read book Studies Directed Toward the Total Synthesis of Dragmacidin E written by Paiboon Ngernmeesri and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Applied Photochemistry written by Rachel C. Evans and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Photochemistry encompasses the major applications of the chemical effects resulting from light absorption by atoms and molecules in chemistry, physics, medicine and engineering, and contains contributions from specialists in these key areas. Particular emphasis is placed both on how photochemistry contributes to these disciplines and on what the current developments are. The book starts with a general description of the interaction between light and matter, which provides the general background to photochemistry for non-specialists. The following chapters develop the general synthetic and mechanistic aspects of photochemistry as applied to both organic and inorganic materials, together with types of materials which are useful as light absorbers, emitters, sensitisers, etc. for a wide variety of applications. A detailed discussion is presented on the photochemical processes occurring in the Earth’s atmosphere, including discussion of important current aspects such as ozone depletion. Two important distinct, but interconnected, applications of photochemistry are in photocatalytic treatment of wastes and in solar energy conversion. Semiconductor photochemistry plays an important role in these and is discussed with reference to both of these areas. Free radicals and reactive oxygen species are of major importance in many chemical, biological and medical applications of photochemistry, and are discussed in depth. The following chapters discuss the relevance of using light in medicine, both with various types of phototherapy and in medical diagnostics. The development of optical sensors and probes is closely related to diagnostics, but is also relevant to many other applications, and is discussed separately. Important aspects of applied photochemistry in electronics and imaging, through processes such as photolithography, are discussed and it is shown how this is allowing the increasing miniaturisation of semiconductor devices for a wide variety of electronics applications and the development of nanometer scale devices. The final two chapters provide the basic ideas necessary to set up a photochemical laboratory and to characterise excited states. This book is aimed at those in science, engineering and medicine who are interested in applying photochemistry in a broad spectrum of areas. Each chapter has the basic theories and methods for its particular applications and directs the reader to the current, important literature in the field, making Applied Photochemistry suitable for both the novice and the experienced photochemist.
Download or read book Advances in Heterocyclic Chemistry written by and published by Academic Press. This book was released on 2015-08-12 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Heterocyclic Chemistry is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists, and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds
Download or read book Journal written by American Chemical Society and published by . This book was released on 2004 with total page 1450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heterocycles in Natural Product Synthesis written by Krishna C. Majumdar and published by John Wiley & Sons. This book was released on 2011-06-15 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.
Download or read book Tin Chemistry written by Marcel Gielen and published by John Wiley & Sons. This book was released on 2008-09-15 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tin chemistry retains a place in contemporary science as an important element owing to its wide range of applications. New and exciting research is being generated on an annual basis from all parts of the world – the study of tin and its compounds attracts considerable interest from a range of perspectives such as organic synthesis, medicine, materials chemistry, catalysis and environment. Tin Chemistry – Fundamentals, Frontiers and Applications collects, in one comprehensive volume, authoritative and concise snapshots of modern tin chemistry in a full range of applications. Over forty of the leading tin chemistry experts have contributed reviews in six themes: fundamentals in tin chemistry materials chemistry and structural chemistry of tin compounds medicinal and biocidal applications of tin compounds tin in the environment tin in organic synthesis tin in catalysis Tin Chemistry – Fundamentals, Frontiers and Applications is an essential overview of modern perspectives on this important element for the specialist and non-specialist alike. It will promote cross-disciplinary interactions and at the same time be an essential teaching resource for advanced university classes.
Download or read book Studies in Acceptor acceptor donor Cyclopropanes written by Yahaira De Bary Reyes and published by . This book was released on 2014 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isolated from Spongosorites sp., Dragmacidin E is of synthetic interest due to its biological properties and novel molecular structure. A promising therapeutic target, its synthetic challenge is attributed to its heptacyclic core. In this study, we propose the synthesis of a Dragmacidin E heptacyclic core precursor, mediated through a Lewis acid (LA) mediated cyclization of an acceptor-acceptor-donor (AAD) cyclopropane. Utilizing a model study, alkoxy AAD cyclopropanes were investigated to develop a protocol for precursor synthesis. After generating various ethyl-a-diazobenzoyl acetate derivatives, the metal catalyzed cyclopropanation reaction of these compounds was studied. With vinyl acetate and Rh2esp2, acetoxy AAD cyclopropanes were synthesized in yields ranging from 12 % - 53 %. These cyclopropanes were successfully generated and rearrangement into dihydrofuran products was avoided. To complete our model study, LA cyclization of acetoxy AAD cyclopropanes was studied. Using stoichiometric quantities of TiCl4, naphthol derivatives were synthesized in one step.
Download or read book Green Techniques for Organic Synthesis and Medicinal Chemistry written by Wei Zhang and published by John Wiley & Sons. This book was released on 2012-07-23 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.
Download or read book Frontiers in Medicinal Chemistry written by Atta-ur-Rahman, Allen B. Reitz and M. Iqbal Choudhary and published by Bentham Science Publishers. This book was released on 2013-01-01 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Frontiers in Medicinal Chemistry” is an Ebook series devoted to the review of areas of important topical interest to medicinal chemists and others in allied disciplines. “Frontiers in Medicinal Chemistry” covers all the areas of medicinal chemistry, including developments in rational drug design, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, chemoinformatics, and structure-activity relationships. Medicinal chemistry as a discipline is rapidly maturing. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. “Frontiers in Medicinal Chemistry” aims to contribute in a major way to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. This Ebook series is essential for any medicinal chemist who wishes to be kept informed and up-to-date with the latest and the most important advances.
Download or read book Advances in Organic Synthesis written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2013-01-14 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations. Contributions are written by eminent scientists and each volume is edited by an authority in the field. Advances in Organic Synthesis is essential for all organic chemists in the academia and industry who wish to keep abreast of rapid and important developments in the field.
Download or read book Bibliographic notebooks for organometallic chemistry written by and published by . This book was released on 2006 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stereoselective Synthesis of Drugs and Natural Products written by Vasyl Andrushko and published by John Wiley & Sons. This book was released on 2013-08-16 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.
Download or read book Index Medicus written by and published by . This book was released on 2001 with total page 1634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Total Synthesis of Maoecrystal V written by Jianxian Gong and published by Springer. This book was released on 2014-07-08 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Download or read book Progress in Heterocyclic Chemistry written by Gordon Gribble and published by Elsevier. This book was released on 2003-07-23 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the fifteenth annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2002. The volume opens with three reviews on current heterocyclic topics. The highlight chapters in Volume 15 are all written by leading researchers in their field and these chapters constitute a systematic survey of the important original material reported in the literature on heterocyclic chemistry in 2002. As with previous volumes in the series, Volume 15 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way. A critical review of the heterocyclic literature published during 2002 Opens with three specialized reviews on new developing topics of interest to heterocyclic chemists. Subsequent chapters review advances in the formation and reaction of heterocyclic rings Chapters all written by leading researchers in their field
Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 2007 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
