Download or read book Synthesis of Tetrasubstituted Olefins and Aryl Ketones Via Carbopalladation of Alkynes and Nitriles written by Chengxiang Zhou and published by . This book was released on 2006 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Palladium-catalyzed reactions are versatile methods for carbon-carbon bond formation due to their generality and ability to tolerate a wide range of important organic functional groups. Developing novel Palladium-catalyzed reactions has therefore been of great interest to synthetic chemists for years. The regio- and stereoselective synthesis of tetrasubstituted olefins is a long-pursuing challenge for synthetic chemists. A multi-component reaction route is ideal to generate various tetrasubstituted olefins in a very concise manner and should be highly desirable for applications in combinatorial chemistry. A highly efficient, regio- and stereoselective route to tetrasubstituted olefins has been developed by the Pd-catalyzed three-component reaction of aryl iodides, internal alkynes, and arylboronic acids as described in Chapter 1. By applying the synthetic protocol we have developed, tamoxifen and its derivatives have been successfully prepared in one step with excellent regio- and stereochemical control, employing readily available starting materials. A novel Pd-catalyzed reaction between arylboronic acids and internal alkynes for the synthesis of tetrasubstituted olefins has been successfully developed as described in Chapter 2. Molecular O2 is used as an oxidant and no base is needed for this reaction. A wide variety of tetrasubstituted olefins have been successfully synthesized under our simple and very mild reaction conditions. The activation of nitrile functionality by organopalladium compounds is rather rare and a challenge in Pd chemistry. Using a highly cationic Pd(II) catalyst, a new route to aryl ketones or ketimines has been successfully developed by a novel reaction between arenes and nitriles as described in Chapter 3. A novel reaction between an arylboronic acid and a nitrile has also been successfully developed as a convenient route to aryl ketones. Chromone is an abundant key structure in many natural products. An efficient route to iodochromones has been successfully developed via ICl-induced cyclization as described in Chapter 4. The chemistry is run under very mild conditions and tolerates a wide variety of functional groups. The iodochromones products can be easily transformed to other substituted chromones or polycyclic compounds using organopalladium chemistry.
Download or read book The Stereoselective Synthesis of Trisubstituted Olefins from B keto Esters Via Enol Phosphate Ester Intermediates and the Nickel 0 Catalyzed Coupling of Aryl Halides written by Michael B. Martin and published by . This book was released on 1985 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbocycle Synthesis Via Novel Organopalladium Addition to Nitriles written by Alexandre A. Pletnev and published by . This book was released on 2002 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rarely observed carbopalladation of the cyano group has been investigated. Synthetic methodology for 2,3-diarylindenones by the palladium-catalyzed annulation of alkynes with 2-iodoarenenitriles has been developed. This methodology has also been adapted to the annulation of bicyclic olefins. The reaction affords 2,3-diarylindenones and polycyclic aromatic ketones in very good to excellent yields and tolerates a number of functional groups, making it an efficient synthetic route to these compounds. The reaction is believed to proceed via (1) oxidative addition of the aryl iodide to Pd(0), (2) arylpalladium addition to the carbon-carbon multiple bond, (3) addition of the resulting vinylic or alkylpalladium species across the triple bond of the cyano group to produce an iminopalladium moiety, and (4) hydrolysis of the imine intermediate. A model accounting for the electronic effects of substituents on the aromatic ring of the nitrile has also been proposed. The palladium-catalyzed annulation of alkynes with iodoarenes containing a cyano group has been extended to the synthesis of 3,4-disubstituted 2-aminonaphthalenes. (2-Iodophenyl)--Acetonitrile reacts with a variety of internal alkynes to afford 2-aminonaphthalenes in high yields. In many cases, the regioselectivity of this reaction is excellent. The scope and limitations of this process, which proceeds via a mechanism similar to the reaction between 2-iodoarenenitriles and alkynes, have been studied. When introduced into the reaction, certain hindered propargylic alcohols have been found to afford 1,3-benzoxazine derivatives rather than the expected 2-aminonaphthalenes. The involvement of trialkylamine bases in the formation of these heterocyclic compounds has been established and a mechanism for this transformation has been proposed. A general and efficient procedure for the synthesis of 2,2-disubstituted indanones by the palladium-catalyzed cyclization of 3-(2-iodoaryl)propanenitriles has been developed. This process is also based on intramolecular carbopalladation of the cyano group. A variety of indanones have been prepared in high yields from readily available starting materials containing various functional groups that are compatible with the reaction conditions. The reaction is not limited to the synthesis of indanones as other benzocyclic ketones, as well as a number of substituted cyclopentenones, have been synthesized by this methodology.
Download or read book Commencement written by Iowa State University and published by . This book was released on 2006 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multicomponent Reactions in Organic Synthesis written by Jieping Zhu and published by John Wiley & Sons. This book was released on 2015-02-09 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and up-to-date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene-promoted MCRs and frequently applied metal-catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a "who's who" in multicomponent reaction chemistry, this is definitely a must-have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.
Download or read book Directory of Graduate Research written by American Chemical Society. Committee on Professional Training and published by . This book was released on 2005 with total page 1932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Download or read book Organocopper Reagents written by Richard J. K. Taylor and published by Oxford University Press, USA. This book was released on 1994 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: A laboratory manual detailing the procedures for the preparation and application of a group of highly specific reagents, and how to overcome the many problems associated with their use. Also includes a historical overview of organocopper chemistry; a description of starting material purification; and guidelines to the reaction, which are usually characterized by a high chemo-, regio-, and stereoselectivity. Begins a series providing practical and accessible laboratory guides for new and experienced researchers unfamiliar with the particular area. Annotation copyright by Book News, Inc., Portland, OR
Download or read book Stereoselective Alkene Synthesis written by Jianbo Wang and published by Springer. This book was released on 2012-08-13 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereoselective Synthesis of Tetrasubstituted Alkenes via Torquoselectivity-Controlled Olefination of Carbonyl Compounds with Ynolates, by Mitsuru Shindo and Kenji Matsumoto.- Stereoselective Synthesis of Z-Alkenes, by Woon-Yew Siau, Yao Zhang and Yu Zhao.- Stereoselective Synthesis of Mono-fluoroalkenes, by Shoji Hara.- Recent Advances in Stereoselective Synthesis of 1,3-Dienes, by Michael De Paolis, Isabelle Chataigner and Jacques Maddaluno.- Selective Olefination of Carbonyl Compounds via Metal-Catalyzed Carbene Transfer from Diazo Reagents, by Yang Hu and X. Peter Zhang.- Selective Alkene Metathesis in the Total Synthesis of Complex Natural Product, by Xiaoguang Lei and Houhua Li.- Olefination Reactions of Phosphorus-Stabilized Carbon Nucleophiles, by Yonghong Gu and Shi-Kai Tian.- Alkene Synthesis Through Transition Metal-Catalyzed Cross-Coupling of N-Tosylhydrazones, by Yan Zhang and Jianbo Wang.
Download or read book Applied Cross Coupling Reactions written by Yasushi Nishihara and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.
Download or read book Superelectrophiles and Their Chemistry written by George A. Olah and published by John Wiley & Sons. This book was released on 2008-01-03 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Superelectrophiles and Their Chemistry contains, for the first-time, a discussion of the basics of this emerging field of organic chemistry, alongside tools to help the reader apply the chemistry. Specific tools include an evaluation of the ways to increase the strength of electrophiles, the classification of superelectrophiles, the solvation issues, a review of methods for studying superelectrophilicity, with details of the superelectrophiles that have been identified and studied. Additional information includes substituent effects in activation of superelectrophiles, and solvation in chemical reactions, as well as an insightful look into future applications.
Download or read book Handbook of Organopalladium Chemistry for Organic Synthesis written by Ei-ichi Negishi and published by John Wiley & Sons. This book was released on 2003-11-24 with total page 1657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Download or read book Organic Synthesis written by Belakatte Parameshwarappa Nandeshwarappa and published by BoD – Books on Demand. This book was released on 2020-05-27 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book ‘Organic Synthesis - A Nascent Relook’ is a compendium of the recent progress in all aspects of organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic, green chemistry and medicinal chemistry, polymer chemistry, as well as analytical methods in organic chemistry. The book presents the latest developments in these fields. The chapters are written by chosen experts who are internationally known for their eminent research contributions. Organic synthesis is the complete chemical synthesis of a target molecule. In this book, special emphasis is given to the synthesis of various bioactive heterocycles. Careful selection of various topics in this book will serve the rightful purpose for the chemistry community and the industrial houses at all levels.
Download or read book Energetic Compounds written by Mohammad Hossein Keshavarz and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-05-05 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses methods for the assessment of energetic compounds through heat of detonation, detonation pressure, velocity and temperature, Gurney energy and power. The authors focus on the detonation pressure and detonation velocity of non-ideal aluminized energetic compounds. This 2nd Edition includes an updated and improved presentation of simple, reliable methods for the design, synthesis and development of novel energetic compounds.
Download or read book C C Bond Activation written by Guangbin Dong and published by Springer. This book was released on 2014-09-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students
Download or read book Applications of Transition Metal Catalysis in Drug Discovery and Development written by Matthew L. Crawley and published by John Wiley & Sons. This book was released on 2012-05-14 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
Download or read book Carbon carbon Bond Formation written by Robert L. Augustine and published by CRC Press. This book was released on 1979-04-01 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:
