Download or read book Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances II written by and published by . This book was released on 2021-12-13 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances written by Emiliano Manzo and published by . This book was released on 2021-11-04 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, which can complicate both the structural characterization and possible future developments. For these reasons, the study of bioactive marine metabolites should rely on the development of chemical synthesis and synthetic strategies aimed at the preparation of pure compounds and analogs both for structural confirmation and/or for the large-scale preparation necessary for future applications. Moreover, natural products can be a crucial starting point for the preparation of molecules structurally inspired by the latter, opening the path to new classes of biologically active compounds with pharmacological potential. This book collects original research articles regarding synthetic strategies for secondary marine metabolites and/or analogs that favor applications of these molecules and/or solve structural challenges common in the field of natural substances.
Download or read book Synthesis of Marine Natural Products 2 written by K.F. Albizati and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volumes five and six of Bioorganic Marine Chemistry differ from their predecessors in two respects - they deal exclusively with laboratory synthesis of marine natural products and they represent the effort of a single author and his associates. The rationale for these departures is readily perceived. For several decades organic synthesis has without doubt been the most spectacular branch of organic chemistry. While the late R.B. Woodward's dictum - organic compounds can undergo only four basic reactions: they can gain electrons; they can lose electrons; they can be transformed with acid or with base - is still true, the wealth and variety of available reagents which will accomplish chemical transformations has reached staggering proportions. Little wonder then, that synthetic methodology has achieved a high degree of predictability and total synthesis of natural products has been successfully directed toward ever more challenging targets. As for the second point, that of single authorship, multiple authorship would invariably have led to gaps and overlaps, thus making it difficult to assemble and assess recent research in a systematic and comprehens ive fashion.
Download or read book Pharmaceutical and Bioactive Natural Products written by David H. Attaway and published by Springer Science & Business Media. This book was released on 1993-03-31 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology may be defined as the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services (Bullet al. , 1982, p. 21) or as any technique that uses living organisms (or parts of organisms) to make or modify products, to improve plants or animals, or to develop microorganisms for specific use (OTC, 1988). In line with these broad definitions we can consider marine biotechnology as the use of marine organisms or their constituents for useful purposes in a controlled fashion. This series will explore a range of scientific advances in support of marine biotechnology. It will provide information on advances in three categories: (1) basic knowledge, (2) ap plied research and development, and (3) commercial and institutional issues. We hope the presentation of the topics will generate interest and interaction among readers in the academic world, government, and industry. This first volume examines chemical and biological properties of some natural products that are useful or potentially useful in research and in the chemical and pharmaceutical industries. One chapter describes a system for producing such substances on a large scale. Biotechnology incorporates molecular biology in order to go beyond tradi tional biochemical technology such as the production of antibiotic drugs from bacterial cultures in bioreactors. Development of the technology for production of antibiotics in this way resulted from fundamental advances in chemistry, phar macology, microbiology, and biochemical engineering.
Download or read book Marine Natural Products written by Hiromasa Kiyota and published by Springer Nature. This book was released on 2021-09-02 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.
Download or read book Bioactive Marine Natural Products written by Dewan S. Bhakuni and published by Springer Science & Business Media. This book was released on 2006-06-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.
Download or read book Marine Natural Products written by Hiromasa Kiyota and published by Springer. This book was released on 2010-11-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Marine Natural Products 2 written by Kim Albizati and published by Springer. This book was released on 1992-03-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volumes five and six of Bioorganic Marine Chemistry differ from their predecessors in two respects - they deal exclusively with laboratory synthesis of marine natural products and they represent the effort of a single author and his associates. The rationale for these departures is readily perceived. For several decades organic synthesis has without doubt been the most spectacular branch of organic chemistry. While the late R.B. Woodward's dictum - organic compounds can undergo only four basic reactions: they can gain electrons; they can lose electrons; they can be transformed with acid or with base - is still true, the wealth and variety of available reagents which will accomplish chemical transformations has reached staggering proportions. Little wonder then, that synthetic methodology has achieved a high degree of predictability and total synthesis of natural products has been successfully directed toward ever more challenging targets. As for the second point, that of single authorship, multiple authorship would invariably have led to gaps and overlaps, thus making it difficult to assemble and assess recent research in a systematic and comprehens ive fashion.
Download or read book Natural Compounds as Drugs Volume II written by Frank Petersen and published by Springer Science & Business Media. This book was released on 2008-07-29 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.
Download or read book Studies Toward the Synthesis of Marine Natural Products Phormidolides B D written by Alejandro Gil Escolano and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands of years to interact with their biological target and the special and unique conditions present in seas, lakes, oceans and rivers allow the biosynthesis of highly potent compunds. Nowadays, the processes to discover a new drug from MNPs are bio-assay guided, giving more importance to the biological results rather than to the molecular structure. After a molecular entity has shown to be biologically relevant the next step is to determine the structural and stereochemical information of such molecule. It is at this step where the project described in this doctoral thesis started. Phormidolides B, C and D (PM B-D) is a family of complex molecules that were isolated in 2010 by the pharmaceutical company Pharmamar S.A. during an expedition to collect samples in the Pemba Island (Madagascar). The extracts rendered a mixture of PM B-D that, once purified, were tested on an IC50 assay against three tumour cell lines. The results showed activity in the low micromolar range with a still unknown mechanism of action. After extensive HRMS, 1D-NMR and 2D-NMR techniques a possible structure was proposed. Following previous UB doctoral theses (Dr. Adriana Lorente and Dr. Janire Lamariano) this doctoral thesis describes, as a compendium of publications, several synthetic studies with the final objective of achieving a robust total synthesis to confirm the structural information of PM B-D by chemical synthesis. After a general introduction (Chapter 1), Chapter 2 (Org. Lett. 2015, 17, 6246.) describes an optimization for the synthesis of the macrocyclic core present in PM B-D. Chapter 3 (Chem. Eur. J. 2016, 21, 7033.) deals, for the first time, with the synthesis and introduction of the most challenging part of the molecule: the bromo-methoxy-diene (BMD) moiety present at the end of the polyhydroxylated chain. After this finding, Chapter 4 (Org. Lett., 2016, 18, 4485.) illustrates the enantioselective synthesis of the polyol chain present in Oscillariolide and Phormidolides, including the previously mentioned BMD moiety. Chapter 5 reports the preparation of the fatty acids present in PM C and D. Finally, after the previous synthetic optimizations, Chapter 6 describes the first synthetic approach for the construction of this large family of natural products using a highly convergent approach. Finally, as an annex a review article entitled "Role of the Nozaki-Hiayama-Kishi-Takai coupling in the synthesis of natural products" (Chem. Rev., 2017, 117, 8420.) is included to deeply explain the uses of this reaction used, as well, for the synthesis of phormidolide B-D. A section with the general conclusions extracted from this thesis is also included.
Download or read book Synthesis of Biologically Active Marine Natural Product Analogues written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products have long been a source of inspiration for many drugs in human use. The Andersen lab examines compounds from marine sources that can be used as lead structures for drug discovery. Synthetic studies, structure-activity relationships (SAR) and biological findings of two such compounds are described in this thesis. The first is pelorol, a meroterpene isolated from a tropical sponge Dactylospongia elegans. Pelorol is a small molecule activator of SHIP 1, a phosphatase that is a negative regulator of the P13K pathway in hematopoetic cells. Using a synthetic route from a previous co-worker, Lu Yang, a series of SHIP 1 activating compounds based on pelorol were synthesized. These compounds were evaluated for selectivity, potency, and efficacy in a series of biological studies, leading to the discovery of 2.27 as a preclinical lead compound. Water-soluble prodrugs of the SHIP 1-activating compounds were also synthesized and their properties reported. The second compound examined is ceratamine A, an alkaloid isolated from the sponge Pseudoceratina sp. from Papua New Guinea. Ceratamines A and B are microtubule stabilizing antimitotic agents that may be useful in cancer chemotherapy. The core imidazo[4,5,d]azepine heterocycle of the ceratamines has no precedent among known synthetic or natural compounds. The relatively simple structure of the ceratamines and the novel antimitotic phenotype they generate makes them attractive targets. Desbromo ceratamine A (3.44) was synthesized by an efficient and scaleable route, confirming the structure of ceratamine A and validating the biological activity of the core pharmacophore. Synthetic efforts towards ceratamine A were ultimately thwarted by the inability to install the bromine atoms present in the natural product. A significant finding is that the bromine atoms in ceratamine A contribute significantly to the antimitotic potency of the compound necessitating a bioisosteric approach to more potent antimitotic ceratami.
Download or read book Synthesis of Marine Natural Products 1 written by K F Albizati and published by . This book was released on 1992-03-10 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This review is devoted to a compilation of the domain of na- tural product synthesis that involves metabolites from mari- ne organisms. The vast amountof material has been roughly organized along structural-biogenetic lines into two volu- mes: the first covers all terpenoid derived structures, the second nonterpenoid (amino acid, heterocyclic, fatty acid and other miscellaneous derived) metabolites. For each metabolite the source is discussed and some of the properties are described that make the compound attractive to synthesis chemists. These are mainly the substances' bio- logical, e.g. antitumor and antiviral activities.
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Download or read book Total Synthesis of Bioactive Marine Natural Products Inspired by Enolate Chemistry Developments of New Haloalkylations Via Soft Enolizations written by Aaron Thomas Herrmann and published by . This book was released on 2015 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: The final part describes a new procedure for the generation of syn-1,3-diols, which addresses both stereo- and regiocontrol in the rhenium catalyzed transposition of allylic alcohols.
Download or read book Natural Products in Clinical Trials written by Atta-ur- Rahman and published by Bentham Science Publishers. This book was released on 2018-03-03 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.
Download or read book Biomimetic Assembly of Reactive Units for the Total Synthesis of Marine Natural Products from Dual Biosynthetic Origin written by Xinming Zhang and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work described in this PhD dissertation is dedicated to the total synthesis of intriguing natural product structures. Two distinct families of natural substances of marine origin have been targeted in this work: the halichonadins and the araiosamines.- With the halichonadins, we plunge into the marine terpene chemistry. Isolated from sponges of the genus Halichondria, two structures have particularly drawn our attention: halichonadins K and L. Indeed, besides two subunits of terpene origin (namely halichonadin C, a natural isonitrile) with an eudesmane skeleton, a central core of peptidic origin is also original (especially a carboxylic acid disubstituted piperidine ring). A part of the work is dedicated to understanding how, in nature, isonitrile natural products may be formed and may react. The experimental part is organized according to the two following topics:1- Devise an efficient and straightforward total synthesis of halichonadin C. A strategy starting from santonin has been studied and developed. The presence of an isopropyl pending group has attracted many synthetic problems. Anyhow, an advanced intermediate comprising the whole skeleton and the crucial nitrogen atom of the target has been reached and provides good hopes for the access to halichonadin C.2- Conceiving a strategy of the stereocontroled access to the central piperidine ring of halichonadins K and L. Several strategies have been evaluated including the recourse to double Michael additions and reactions inspired by Robinson's tropinone synthesis. The peptidic central core is now accessible in a limited number of steps.Most of the pieces of the puzzle are in our hands at the end of this PhD to secure a rapid access to the complex targets that constitutes halichonadins K and L.- The chapter dedicated to araiosamines (A-D, isolated from sponges of the genus Clathria) is exploratory and allows to propose promising strategies for a bio-inspired synthesis that constitutes true challenges for the organic chemists. One of the challenges to take up is to prepare highly reactive indole aldehyde units that could be foreseen as chemical equivalents of postulated biosynthetic intermediates. A method to generate in situ such units is studied. The first applications have been directed to the synthesis of “Discodermia pyridiniums” and appear to be promising towards the total synthesis of these molecules.The work conducted during this PhD take place in the framework of the “art of total synthesis”. But, in our strategies, the chemical understanding of biosynthetic pathways is never far away.
Download or read book Synthesis of Bioactive Marine Natural Products written by Carmela Della Monica (t.d.-) and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
