Download or read book Synthesis of Lactones and Lactams Updates written by Michael A. Ogliaruso and published by . This book was released on 1993-06-22 with total page 1116 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single source for general and newer synthetic methods of lactones and lactams preparation from 1967 to the present. Contains sufficient detail, tables and examples of typical preparations allowing readers to choose from among several alternative techniques.
Download or read book Synthesis of Lactones and Lactams Updates written by Michael A. Ogliaruso and published by Wiley. This book was released on 1993-06-22 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single source for general and newer synthetic methods of lactones and lactams preparation from 1967 to the present. Contains sufficient detail, tables and examples of typical preparations allowing readers to choose from among several alternative techniques.
Download or read book Natural Lactones and Lactams written by Tomasz Janecki and published by John Wiley & Sons. This book was released on 2013-09-03 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there are numerous books on heterocycles and natural products, this text fills the need for an up-to-date summary focusing on recently developed and improved synthetic methods for the preparation of the most important classes of lactones and lactams - all in one volume. Comprehensive in its coverage, this book also provides readers with a brief description of the occurrence and biological or pharmaceutical activity of the compounds, and each chapter deals with a certain class of lactones or lactames to enable quick access to the information needed. A valuable resource for organic chemists, biochemists and medicinal chemists in academia and industry wanting to learn about successful synthetic routes leading to important natural products and use this as inspiration for their own work in the lab.
Download or read book Synthesis of Lactones and Lactams written by Michael A. Ogliaruso and published by . This book was released on with total page 1099 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Strategies for Efficient Synthesis of Medium sized Lactones and Lactams written by Wanxiang Zhao and published by . This book was released on 2014 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enantioselective Synthesis of Lactams and Lactones written by Anna Dite Cuiper and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Synthesis of Fused Gamma Lactam Beta Lactone Natural Products written by Srinivas Tekkam and published by . This book was released on 2009 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Photochemical Synthesis of beta lactones and beta lactams written by William Raymond Adams and published by . This book was released on 1967 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric Synthesis of Lactones and Lactams written by Hasan Khan and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Lactones and Lactams Updates written by Michael A. Ogliaruso and published by Wiley. This book was released on 1993-06-22 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single source for general and newer synthetic methods of lactones and lactams preparation from 1967 to the present. Contains sufficient detail, tables and examples of typical preparations allowing readers to choose from among several alternative techniques.
Download or read book New Biocatalytic Approaches for Lactonization and Lactamization written by Lei Huang and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Lactones and lactams are cyclic esters and amides, respectively. They are the monomers of polyesters and polyamides, such as polycaprolactone and polycaprolactam, which are the commonly used polymer materials in our daily life and in industry. Apart from that, lactones and lactams are also widely used as raw materials in the pharmaceutical industry and as flavors and fragrances or laundry detergents for bleaching. Up to date, the industrial synthesis of most of the lactones and lactams applies chemical synthesis methods established decades ago that need expensive metal catalysts, aggressive chemicals, high temperature, and depend on non-renewable resources. Thus, there is a necessity to develop more sustainable methods for the synthesis of lactones and lactams. In general, enzymatic reactions show high selectivity and can be conducted in mild conditions leading to environmentally benign approaches compared to chemical methods. In the first part of the PhD study, a nicotinamide adenine dinucleotide (NADH)-dependent redox-neutral convergent cascade for lactonizations was developed. The redox-neutral convergent cascade is composed of a recently discovered type II flavin-containing monooxygenase from Rhodococcus jostii RHA1 (FMO-E) and the well-known horse liver alcohol dehydrogenase (HLADH). Two molar equivalents of ketone substrate converted by FMO-E and one molar equivalent of diol substrate converted by HLADH were converted into three molar equivalents of the single lactone product with high atom efficiency and self-sufficient cofactor regeneration. Two model cascade reactions were demonstrated for the synthesis of [gamma]-butyrolactone and chiral bicyclic lactones. Biochemical characterization of FMO-E and HLADH was firstly done using the individual substrates of the enzymes in the evaluated cascades in order to find the optimal reaction conditions. Having identified the optimized conditions for the enzymatic cascade, achiral and chiral lactone products could be synthesized in high analytical yields (87%) and moderate to high enantioselectivities (up to 99%). In the second part of the PhD study, a direct synthesis of lactams (5-, 6- and 7-membered) starting from amino alcohols in a parallel cascade was developed. HLADH together with the H2O forming NADH oxidase variant from Streptococcus mutans (SmNOX) made up the parallel cascade. First, crucial reaction parameters for the efficiency of this novel cascade reaction were elucidated. pH of the buffer, concentrations of HLADH and NAD+ were identified as the key parameters for the lactamization reaction. Under the optimized conditions, up to 95% analytical yields could be achieved in this newly developed cascade reaction in the case of [gamma]-butyrolactam, whereby the yield decreased with increasing ring-size, as also known from the literature for ring-closure reactions. Overall this PhD study dealt with new biocatalytic approaches for the synthesis of lactones and lactams. For lactone synthesis, NADH-dependent redox-neutral convergent cascade consisting of FMO-E and HLADH was developed for the synthesis of [gamma]-butyrolactone and chiral bicyclic lactones with high atom efficiency in a self-sufficient cofactor regeneration fashion. For lactam synthesis, it was the first report on the direct synthesis of lactams from amino alcohols catalyzed by an alcohol dehydrogenase. The NAD+ regeneration was also achieved by coupling the SmNOX forming H2O as the sole by-product.
Download or read book Synthesis of Macrocyclic Lactams and Lactones Via Intermolecular Schmidt Reactions with Hydroxy Azides and the Formal Total Synthesis of stenine Using a Combined Intramolecular Diels Alder intramolecular Schmidt Reaction Process written by Jennifer E. Golden and published by . This book was released on 2002 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Beta lactams via tricarbonyliron lactone complexes written by E. M. Hebblethwaite and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of lactams Via Tricarbonyliron Lactone Complexes written by E. M. Hebblethwaite and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic and Chromatographic Study of the Spiro lactams and Spiro lactones Based on a 9 10 dihydro 9 10 thermolysis Towards Synthesis of Exo methylene Lactones and Lactams written by James Vincent Gruber and published by . This book was released on 1989 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organochromium Mediated Cyclisation Reactions written by Sharon Mckendry and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Science of Synthesis Knowledge Updates 2014 Vol 2 written by Mogens Brøndsted Nielsen and published by Thieme. This book was released on 2014-05-14 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Science of Synthesis Editorial Board, together with the volume editors and authors, is constantly reviewing the whole field of synthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Four annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology.
