Download or read book Synthesis of Fluorescent Molecules for the Detection of Nerve Agents and Systhesis of Novel Pyrazolo and Isoxazolo Quinoline Derivatives as Potential Drugs written by Rakesh Kumar Sit and published by . This book was released on 2009 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main focus of chapters I and II of this dissertation is the synthesis and characterization of novel materials that will have high specificity and sensitivity for the detection of highly toxic organophosphate and organophosphonate nerve agents. The study was divided into two main sections, synthesis of quinolinone and 4-aminonaphthalimide derivatives, and binding studies of synthesized target molecules with nerve agent mimics, DCP and DFP. Nine quinolinone target molecules (TR-1, TR-2, TR-3, TR-4, TR-5, 8, 32, 9, and 10) were synthesized, and binding studies of these molecules with nerve agent mimic were also carried out. All the molecules containing the Schiff base moiety (e.g. TR-1, TR-2, TR-3 and TR4) undergo protonation upon attempted reaction with DCP. On the other hand, 7-dimethylamino-4-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde oxime (8) react with nerve agent mimic DCP during reaction studies. Three molecules containing functionalized tethers (TR-4S, TR-5S, and TR-1C) were synthesized so that they can bind to anodic aluminum oxide (AAO) with the help of covalent bonds in order to fabricate sensors for nerve agents. Two 4-aminonaphthalimide dyes, the lithium salt of lucifer yellow (38) and the potassium salt of lucifer yellow 43, were also synthesized successfully. Reactions of nerve agent mimic DCP with AAO which had been impregnated with 38 were studied by fluorescence spectroscopy. Twenty-seven other novel compounds, beside target molecules, were generated in the process of synthesizing quinolinone and 4-aminonaphthalimide target molecules. Chapter III of this dissertation deals with the synthesis of novel pyrazolo and isoxazolo quinoline derivatives as potential medicinal agents. Four pyrazolo and isoxazolo quinoline derivatives (51, 53, 54 and 55) were synthesized and are yet to be tested for the antiviral activity. Nine novel compounds were generated in the synthetic routes described in this chapter.
Download or read book Synthesis of Fluorescent Molecules for the Detection of Nerve Agents and Synthesis of Novel Pyrazolo and Isoxazolo Quinoline Derivatives as Potential Drugs written by Rakesh Kumar Sit and published by . This book was released on 2009 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main focus of chapters I and II of this dissertation is the synthesis and characterization of novel materials that will have high specificity and sensitivity for the detection of highly toxic organophosphate and organophosphonate nerve agents. The study was divided into two main sections, synthesis of quinolinone and 4-aminonaphthalimide derivatives, and binding studies of synthesized target molecules with nerve agent mimics, DCP and DFP. Nine quinolinone target molecules ( TR-1, TR-2, TR-3, TR-4, TR-5, 8, 32, 9, and 10 ) were synthesized, and binding studies of these molecules with nerve agent mimic were also carried out. All the molecules containing the Schiff base moiety (e.g. TR-1, TR-2, TR-3 and TR4 ) undergo protonation upon attempted reaction with DCP. On the other hand, 7-dimethylamino-4-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde oxime ( 8 ) react with nerve agent mimic DCP during reaction studies. Three molecules containing functionalized tethers ( TR-4S, TR-5S, and TR-1C ) were synthesized so that they can bind to anodic aluminum oxide (AAO) with the help of covalent bonds in order to fabricate sensors for nerve agents. Two 4-aminonaphthalimide dyes, the lithium salt of lucifer yellow ( 38 ) and the potassium salt of lucifer yellow 43, were also synthesized successfully. Reactions of nerve agent mimic DCP with AAO which had been impregnated with 38 were studied by fluorescence spectroscopy. Twenty-seven other novel compounds, beside target molecules, were generated in the process of synthesizing quinolinone and 4-aminonaphthalimide target molecules. Chapter III of this dissertation deals with the synthesis of novel pyrazolo and isoxazolo quinoline derivatives as potential medicinal agents. Four pyrazolo and isoxazolo quinoline derivatives ( 51, 53, 54 and 55 ) were synthesized and are yet to be tested for the antiviral activity. Nine novel compounds were generated in the synthetic routes described in this chapter.
Download or read book Medicinal Chemistry written by Frank D. King and published by . This book was released on 2002 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an valuable introduction to medicinal chemistry for new graduates and PhDs. It will also serve to update more experienced scientists on the newer technologies in the field.
Download or read book Targets in Heterocyclic Systems written by and published by . This book was released on 1997 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book N Heterocyclic Carbenes in Organocatalysis written by Akkattu T. Biju and published by John Wiley & Sons. This book was released on 2019-01-07 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.
Download or read book Heterocyclic Chemistry in Drug Discovery written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2013-04-26 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Download or read book Bioactive Heterocycles written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Photocatalysis written by Burkhard König and published by Walter de Gruyter. This book was released on 2013-04-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Visible light is an abundant source of energy. While the conversion of light energy into electrical energy (photovoltaics) is highly developed and commercialized, the use of visible light in chemical synthesis is far less explored. Chemical photocatalysts that mimic principles of biological photosynthesis utilize visible light to drive endothermic or kinetically hindered reactions. This work summarizes in 16 chapters the state of the art and the challenges of this emerging future technology.
Download or read book Challenges in Synthetic Organic Chemistry written by Teruaki Mukaiyama and published by Oxford University Press, USA. This book was released on 1994 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the life's work of Professor Teruaki Mukaiyama, one of Japan's most important and respected synthetic organic chemists. It includes information on his early research into a wide range of reactions, including dehydration reactions, the use of organosulfur compounds, and oxidation-reduction condensations in peptide and nucleotide synthesis reagents, as well as an account of Mukaiyama's important work on the applications of titanium compounds in organic synthesis. Three final chapters review Mukaiyama's work in synthetic control, stereoselective synthesis of carbohydrates, the stereoselective aldol, and Michael reactions. This unique book makes accessible much research that has only been available in Japanese, and provides a rare account of the contributions of one of the world's leading chemists.
Download or read book N Heterocycles written by Keshav Lalit Ameta and published by Springer Nature. This book was released on 2022-04-23 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the recent advancements for the synthesis of small- and medium-sized azaheterocycles, including pyrroles, indoles, pyrimidines, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, and 1,2,3-triazoles, which are significant scaffolds for compounds with pharmaceutical uses. The book also discusses various properties and performance attributes of azaheterocycles including their bioactivity and synthetic strategies. Given the contents, the book will be a valuable reference for students, researchers, and professionals interested in organic synthesis and medicinal chemistry.
