Download or read book Synthesis Modification and Characterization of Ordered Mesoporous Silica Particles for Controlled Drug Release written by Shewaye Yismaw Wubetu and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis Modification and Characterization of Ordered Mesoporous Silica Particles for Controlles Drug Release written by Shewaye Yismaw Wubetu and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis Characterization and Structure Control of Ordered Mesoporous Silica Nanoparticles written by Teeraporn Suteewong and published by . This book was released on 2011 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ordered mesoporous silica materials are characterized by uniform and tunable pore size, high surface area and large pore volume. In particular, nano-sized ordered mesoporous silica particles have drawn interest from several fields, including biorelated areas, because silica is benign, possesses chemical stability and can be integrated with other materials. Structural aspects, such as pore connectivity, geometry and pore size are known to govern materials performance. Extensive efforts have been devoted to synthesize mesoporous silica particles with different structures, functionalities and sizes. In contrast, only a small number of studies so far have concentrated on the formation mechanism of these particles. This is hence the focus of the present dissertation. The first part reports on the synthesis and characterization of ordered mesoporous silica nanoparticles with and without embedded magnetic nanoparticles. The formation mechanism of silica nanocomposites is investigated by capturing particle formation at different time points during the synthesis. A combination of transmission electron microscopy (TEM) and small angle x-ray scattering (SAXS) is used to characterize the structure evolution of resulting materials. Incorporating organic moieties into the silica matrix provides additional functionalities to ordered mesoporous silica nanoparticles. However, it often leads to disordered pore structure or pore blockage. The second part demonstrates the preparation of aminated and ordered mesoporous silica nanoparticles using a cocondensation method. Increasing the amount of aminosilane in the synthesis feed causes a structural transition of organically modified particles from hexagonal to cubic. Pore size of ordered mesoporous silica and aminated ordered mesoporous silica nanoparticles can be tailored by the addition of a swelling agent during the synthesis. The structural transformation from hexagonal to cubic is also observed in the latter case, albeit at different amino silane concentrations. The final part reports on the internalization of nanoparticles into cells. Fluorescent aminated mesoporous silica nanoparticles are first prepared and then coated with poly(ethylene glycol) to improve particle stability and lower protein adsorption. Dye-labeled aminated mesoporous silica nanoparticles are spontaneously internalized by cells.
Download or read book The Chemistry of Silica written by Ralph K. Iler and published by Wiley-Interscience. This book was released on 1979-06-06 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surfactants and Interfacial Phenomena Milton J. Rosen Bridging the gap between purely theoretical aspects of surface chemistry and the purely empirical experience of the industrial technologist, this book applies theoretical surface chemistry to understanding the action of surfactants in modifying interfacial phenomena. It surveys the structural types of commercially available surfactants and discusses interfacial phenomena, the physicochemical principles underlying the action of surfactants in each phenomenon, and the effect of structural changes in the surfactants and environmental changes on their action. Tables of data on various interfacial properties of surfactants, compiled and calculated from the latest scientific literature, are included. 1978 304 pp. An Introduction to Clay Colloid Chemistry, 2nd Ed. H. van Olphen This book provides valuable guidance in research and design efforts by giving a clear understanding of principles and concepts of colloid chemistry as applied to clay systems. Updated and enlarged, this edition includes new information on surface characterization and adsorption mechanisms; recent results in the area of clay-organic interaction--the intercalation and intersalation of kaolinite minerals; and increased attention to the possible role of clays in biological evolution. 1977 318 pp. Physicochemical Processes for Water Quality Control Walter J. Weber, Jr. Focusing on physicochemical rather than biological processes, this book presents a comprehensive treatise on the treatment of municipal and industrial water and wastewater. All of the physicochemical processes important to municipal and industrial water and wastewater treatment--coagulation, filtration, membrane processes, chemical oxidation, and others--are included and each is covered thoroughly from principle through application. To maintain a high level of expertise, contributions have been incorporated from specialists actively involved in research or engineering applications in each area considered. 1972 640 pp.
Download or read book Mesoporous Silica Nanoparticles written by Sachin Namdeo Kothawade and published by . This book was released on 2024-11-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.
Download or read book Update on Silica based Mesoporous Materials for Biomedical Applications written by Luigi Pasqua and published by Smithers Rapra. This book was released on 2011-11-22 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an insightful understanding of the mesoporous silica structure and its special properties. The details of synthesis and modification strategies are discussed by reviewing the open literature. The discussion concerning the potential of mesoporous silica in modern biomedical applications will be related to a critical analysis in the field of material science. This book will help the reader rapidly develop the necessary tools to follow the design of the different mesoporous silica-based devices presented in the various studies. The structure of the different devices is examined in detail and the relationship between the structure and the expected activity are discussed. It will also assist in the ability to design new therapeutic devices in a field where the applications seem to be without limits.
Download or read book Smart Nanovesicles for Drug Targeting and Delivery written by Maria Carafa and published by MDPI. This book was released on 2019-05-20 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: We can use the short text on the SI page for the description, or you make slight modifications on it. The description/summary is only for promotion (flyer, distribution channels), and will not be included in the book You can use the short text on the SI page for the description Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action. The drug/contrast agent-containing vesicles need to be directed to precise locations within the body to obtain desired magnitude and duration of the therapeutic or diagnostic effect. This spatial control in the delivery might open new avenues to modulate drug activity while avoiding side-effects and to optimize contrast agent properties while avoiding a broad distribution in the organism. However, delivering and targeting active substances into specific tissues and cells is still a challenge in designing novel therapeutic approaches against untreatable disorders, such as tumors and degenerative diseases.
Download or read book Silica based Nanoparticles written by Yao Sun and published by . This book was released on 2014 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica nanoparticles (MSNs) combine the benefits of nanomaterials and mesoporous silica materials. This class of materials is characterized by ordered pore structures, controllable pore size, and large surface area. Significant research efforts have been devoted to achieve the control over particle size, morphology, pore size, and mesostructure. In this dissertation, I will describe the synthetic approaches, characterization, and structural control of three types of silica-based nanoparticles (NPs). Firstly, the water-based synthesis of ultrasmall (sub-10 nm) PEGylated gold-silica core-shell NPs is described. These core-shell NPs are composed of an ultrasmall gold core, a thin silica shell, and a polyethylene glycol (PEG) outer layer. The core-shell NPs show long-term stability for nearly a year in both water and PBS buffer solution. The NP suspensions further exhibit good contrast in a microscale computed tomography (micro-CT) scanner. Secondly a type of stimuli-responsive aminated MSNs with shapeshifting behavior is introduced. The shape change can be achieved when MSNs are exposed to water vapor in solid-state form for 24 hours, or when MSN suspensions in ethanol are evaporated at high humidity, or when MSNs are vacuum-dried from water-rich solvents. Under these circumstances, the cross-sectional shape of animated MSN's can change from hexagonal to six-angle-star, accompanied by the loss of mesostructural long-range hexagonal order, a decrease in surface area and mesopore volume, an increase in micropore volume, and further condensation of the silica matrix. Finally, the synthesis and detailed characterization of a class of quasicrystalline MSNs is discussed. These MSNs exhibit dodecagonal (12-fold) symmetry with particle sizes below 100 nm.
Download or read book Polymer Modified Mesoporous Silica Nanoparticles for Controlled Drug and Protein Delivery written by Erick Yu and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery by nanoparticles has been an important, emergent field in the past decade with mesoporous silica at the forefront. With a high surface area and wide variety of modifications possible, mesoporous silica nanoparticles (MSNs) are a robust platform to load, transport and deliver molecular species, including tracer compounds, macromolecules, and anti-cancer agents. A wide variety of MSN crystalline structures were first synthesized in the 1990s and early 2000s. In the following years, advances in silane, inorganic, and organic chemistry led to “smart” drug delivery, a revolutionary method wherein contained species could be released at a desired rate. In combination with stimuli or target responsive functional groups, MSNs in recent years have shown particular promise for the therapeutic delivery of peptides, proteins, and small genetic material. To fully realize the potential for these applications, the porous structure of MSNs needs to be enlarged to accommodate larger species without compromising the overall nanoparticle structure. Additionally, due to the sensitive nature of these proteins and genetic matter, stability and prevention of structural deformation is important for their delivery into biological environments. Combining expanded pore MSNs with stimuli-responsive functional groups is currently a major focus for drug delivery. In this dissertation I report on modification of MSNs through inorganic and polymeric constituents. Using a pore-expansion process to synthesize MSNs capable of delivering proteins, specifically lysozyme (ca. 3.9 nm diameter) and bovine hemoglobin (c.a. 5.5 nm diameter), I further modified the MSNs using triblock polyethylene oxide-polypropylene-polyethylene oxide (PEO-PPO-PEO), poly(n-isopropylacrylamide) (PNIPAM), and polyethylene glycol (PEG). I show a well-controlled release of drugs and proteins with these nanoparticles. Triblock PEO-PPO-PEO copolymers function as weak surfactants, which allow them to potentially increase drug permeability through lipid bilayers that coat MSNs. The release behavior of lipid-MSNs can then be linearly fine-tuned with both the composition of the triblock copolymer and its concentration. Among the stimuli-sensitive functional groups used to modify MSNs, PNIPAM in particular has been developed significantly in the past decade as a gating molecule for both nanoparticles and porous membranes. As a thermoresponsive polymer, which changes both its surface hydrophilic/hydrophobic nature in addition to its morphology at 32 °C, PNIPAM can be applied to the MSN surface to provide a triggered release when temperatures are elevated to physiological temperatures. PNIPAM was investigated under in situ liquid atomic force microscopy at sub 80 nm grafting lengths in order to better understand and characterize its collapse behavior around nanostructured surfaces, comparable to the surface of mesoporous silica nanoparticles. Here I demonstrate that the collapse behavior occurs even at grafted lengths of 10-20 nm. However, under these conditions, the gating effect is minimal around nanostructured edges, as of those of nanopores. I further show that when PNIPAM is combined with the step-wise, template functionality of MSNs and further modified with PEG (notable for its ability to minimize non-specific binding and interactions between proteins and glass substrates), improved release delivery of loaded proteins is realized. With therapeutic peptide delivery in mind, these MSNs were tested with lysozyme and bovine hemoglobin to show their potential for delivery of both proteins and genetic material.
Download or read book Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications written by Wei Chen and published by . This book was released on 2019 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional mesoporous silica nanoparticles (MSNs) have aroused much attention during the past decades for drug delivery and bioimaging applications because of their intrinsic properties including extremely high surface area, large pore volume, tunable pore diameter, easy surface modification, and high biocompatibility. Even though MSNs have these preeminent properties, rendering this unique nanostructure a promising nanocarrier for biomedical applications, several hurdles still challenge the fields of drug delivery and bioimaging when using MSNs as the nanocarries: (i) high loading and high release amounts of water-insoluble drugs delivered to the site of diseases; (ii) precise control of the dosage of drugs delivered to the site of diseases using non-invasive external stimuli; and (iii) construction of MSNs-based shortwave infrared optical imaging contrast agents as an innovative tool for bioimaging and cancer diagnostics. Therefore, this dissertation primarily focuses on the development of innovative strategies that solve these unmet needs and that advance the research in the field of biomedical applications using MSNs as the nanocarriers. In this dissertation, first of all, we review the research work, which mainly focuses on the design and synthesis of multifunctional MSNs and nanomachines for biomedical applications in Accounts of Chemical Research. A wide variety of nanomachines responsive to the different stimuli (pH, redox, enzyme, heat, light, and/or magnetic field) are discussed in this Account. Additionally, we develop a facile strategy for MSNs delivery and release of the water-insoluble drug clofazimine (CFZ), which is used to treat multidrug-resistant tuberculosis. The strategy employs a companion molecule as a chaperone to improve both the loading of CFZ into the pores of MSNs and its subsequent release, thus enabling both high loading and high release of this water-insoluble drug by MSNs. In vitro treatment of macrophages infected with Mycobacterium tuberculosis with the optimized CFZ-loaded MSNs killed the bacteria in the cells in a dose-dependent manner. These studies demonstrate a highly efficient method for loading nanoparticles with water-insoluble drug molecules and the efficacy of the nanoparticles in delivering drugs into eukaryotic cells in aqueous media. Additionally, we used a noninvasive alternating magnetic field (AMF) to stimulate and control the dosage of drug release from MSNs. Noninvasive stimuli-responsive drug delivery using AMF in conjunction with superparamagnetic nanoparticles also offers the potential for the spatial and temporal control of drug release. In vitro studies showed that the death of pancreatic cancer cells treated by drug-loaded nanoparticles was controlled by different lengths of AMF exposure time due to different amounts of drug released from the carriers. Finally, to develop a new shortwave infrared (SWIR) optical imaging contrast agent which has a higher tissue penetration depth, we demonstrate that J-aggregates of near infrared (NIR) fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The use of J-aggregates stabilized in HMSNs as SWIR imaging agents has the potential to overcome the stability, toxicity, and brightness challenges of contrast agents for this compelling region of the electromagnetic spectrum. Collectively, in this dissertation, we explore and develop innovative strategies to load and deliver high amounts of water-insoluble drugs; control the dosage of anticancer drugs released from MSNs triggered by an AMF; and establish a new SWIR optical imaging contrast agent based on the superior carriers - MSNs.
Download or read book FASTtrack Pharmaceutics written by Yvonne Perrie and published by Pharmaceutical Press. This book was released on 2012 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.
Download or read book Characterization of Pharmaceutical Nano and Microsystems written by Leena Peltonen and published by John Wiley & Sons. This book was released on 2020-12-21 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.
Download or read book Synthesis and Characterization of Ordered Mesoporous Silica with Controlled Macroscopic Morphology for Membrane Applications written by Shriya Seshadri and published by . This book was released on 2011 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ordered mesoporous materials have tunable pore sizes between 2 and 50 nm and are characterized by ordered pore structures and high surface areas (~1000 m2/g). This makes them particularly favorable for a number of membrane applications such as protein separation, polymer extrusion, nanowire fabrication and membrane reactors. These membranes can be fabricated as top-layers on macroporous supports or as embedded membranes in a dense matrix. The first part of the work deals with the hydrothermal synthesis and water-vapor/oxygen separation properties of supported MCM-48 and a new Al-MCM-48 type membrane for potential use in air conditioning systems. Knudsen-type permeation is observed in these membranes. The combined effect of capillary condensation and the aluminosilicate matrix resulted in the highest separation factor (142) in Al-MCM-48 membranes, with a water vapor permeance of 610-8mol/m2Pas. The second part focuses on synthesis of embedded mesoporous silica membranes with helically ordered pores by a novel Counter Diffusion Self-Assembly (CDSA) method. This method is an extension of the interfacial synthesis method for fiber synthesis using tetrabutylorthosilicate (TBOS) and cetyltrimethylammonium bromide (CTAB) as the silica source and surfactant respectively. The initial part of this study determined the effect of TBOS height and humidity on fiber formation. From this study, the range of TBOS heights for best microscopic and macroscopic ordering were established. Next, the CDSA method was used to successfully synthesize membranes, which were characterized to have good support plugging and an ordered pore structure. Factors that influence membrane synthesis and plug microstructure were determined. SEM studies revealed the presence of gaps between the plugs and support pores, which occur due to shrinking of the plug on drying. Development of a novel liquid deposition method to seal these defects constituted the last part of this work. Post sealing, excess silica was removed by etching with hydrofluoric acid. Membrane quality was evaluated at each step using SEM and gas permeation measurements. After surfactant removal by liquid extraction, the membranes exhibited an O2 permeance of 1.65x10-6mol/m2. Pa.s and He/O2 selectivity of 3.30. The successful synthesis of this membrane is an exciting new development in the area of ordered mesoporous membrane technology.
Download or read book Oral Lipid Based Formulations written by David J. Hauss and published by CRC Press. This book was released on 2007-06-08 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem
Download or read book Nanoporous Materials Science And Engineering written by G Q Max Lu and published by World Scientific. This book was released on 2004-11-22 with total page 911 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porous materials are of scientific and technological importance because of the presence of voids of controllable dimensions at the atomic, molecular, and nanometer scales, enabling them to discriminate and interact with molecules and clusters. Interestingly the big deal about this class of materials is about the “nothingness” within — the pore space. International Union of Pure and Applied Chemistry (IUPAC) classifies porous materials into three categories — micropores of less than 2 nm in diameter, mesopores between 2 and 50 nm, and macropores of greater than 50 nm. In this book, nanoporous materials are defined as those porous materials with pore diameters less than 100 nm.Over the last decade, there has been an ever increasing interest and research effort in the synthesis, characterization, functionalization, molecular modeling and design of nanoporous materials. The main challenges in research include the fundamental understanding of structure-property relations and tailor-design of nanostructures for specific properties and applications. Research efforts in this field have been driven by the rapid growing emerging applications such as biosensor, drug delivery, gas separation, energy storage and fuel cell technology, nanocatalysis and photonics. These applications offer exciting new opportunities for scientists to develop new strategies and techniques for the synthesis and applications of these materials.This book provides a series of systematic reviews of the recent developments in nanoporous materials. It covers the following topics: (1) synthesis, processing, characterization and property evaluation; (2) functionalization by physical and/or chemical treatments; (3) experimental and computational studies on fundamental properties, such as catalytic effects, transport and adsorption, molecular sieving and biosorption; (4) applications, including photonic devices, catalysis, environmental pollution control, biological molecules separation and isolation, sensors, membranes, hydrogen and energy storage, etc./a
Download or read book Strategies to Modify the Drug Release from Pharmaceutical Systems written by Marcos Luciano Bruschi and published by Woodhead Publishing. This book was released on 2015-06-16 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications
Download or read book Nanoparticles in Medicine written by Ashutosh Kumar Shukla and published by Springer Nature. This book was released on 2019-08-31 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the medical applications of inorganic nanoparticles. Nanomedicine is a relatively advanced field, which enhances the treatment of various diseases, offering new options for overcoming the problems associated with the use of conventional medicines. Discussing the toxicological and safety aspects associated with medical applications of nanoparticles, the book presents the latest research on topics such as emerging nanomaterials for cancer therapy, applications of nanoparticles in dentistry, and fluoride nanoparticles for biomedical applications, and also includes chapters on the use of nanoparticles such as silver and gold. /div
