Download or read book Ligand Design in Medicinal Inorganic Chemistry written by Tim Storr and published by John Wiley & Sons. This book was released on 2014-06-12 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.

Download or read book Metallotherapeutic Drugs and Metal Based Diagnostic Agents written by Marcel Gielen and published by John Wiley & Sons. This book was released on 2005-09-01 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.

Download or read book Medicinal Plant Research in Africa written by Victor Kuete and published by Newnes. This book was released on 2013-06-19 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes. Many African scholars have distinguished themselves in the fields of organic chemistry, pharmacology, and pharmacognosy and other areas related to the study of plant medicinal plants. However, until now, there is no global standard book on the nature and specificity of chemicals isolated in African medicinal plants, as well as a book bringing together and discussing the main bioactive metabolites of these plants. This book explores the essence of natural substances from African medicinal plants and their pharmacological potential. In light of possible academic use, this book also scans the bulk of African medicinal plants extract having promising pharmacological activities. - The book contains data of biologically active plants of Africa, plant occurring compounds and synthesis pathways of secondary metabolites - This book explores the essence of natural substances from African medicinal plants and their pharmacological potential - The authors are world reknowned African Scientists

Download or read book Molecular Diagnostics and Treatment of Pancreatic Cancer written by Asfar Azmi and published by Academic Press. This book was released on 2018-11-13 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas - helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Download or read book Studies on Hepatitis Viruses written by Satya Prakash Gupta and published by Academic Press. This book was released on 2018-06-20 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry. - Provides comprehensive, state-of-the-art coverage of hepatitis virus infections, the virus' lifecycle, and mechanisms of protease inhibition - Analyzes structure-activity relationships of inhibitors of viral hepatitis - Presents an in-depth view of the structure and function of viral hepatitis - Discusses classification, epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis, complications, associated disorders and animal models

Download or read book Carbonic Anhydrases and Metabolism written by Claudiu T. Supuran and published by MDPI. This book was released on 2019-04-08 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many parasites (fungi, protozoa), they are involved in the de novo synthesis of important metabolites (lipids, nucleic acids, etc.). The metabolic effects related to interference with CA activity, however, have been scarcely investigated. The present Special Issue of Metabolites aims to fill this gap by presenting the latest developments in the field of CAs and their role in metabolism.

Download or read book Comprehensive Heterocyclic Chemistry III written by and published by Elsevier Science. This book was released on 2008-03-27 with total page 12500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Heterocyclic Chemistry III (CHEC-III) is a new 15-volume reference work which provides the first point of entry to the literature for all scientists interested in heterocyclic ring systems. Since publishing in 1984, Comprehensive Heterocyclic Chemistry (CHEC) has become the standard work on the subject, indispensable to all serious readers in the interdisciplinary areas where heterocycles are employed. CHEC-III builds on and complements the material in CHEC and CHEC-II and is designed to be used both alone and in conjunction with these two works. Written by leading scientists who have evaluated and summarized the most important data published over the last decade, Comprehensive Heterocyclic Chemistry III will be an invaluable addition to the reference library of those working with heterocyclic ring systems. Reviews advances in the properties, structure, synthesis, reactivity and applications of the most important heterocyclic ring systems Contains over 250 specialist reviews, logically organized by size and heteroatom content of the heterocyclic ring Saves researchers valuable time and effort through carefully structured critical reviews of the literature by experts

Download or read book Handbook of Secondary Fungal Metabolites written by Richard J. Cole and published by Gulf Professional Publishing. This book was released on 2003 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume set is a desirable reference for a wide range of specialists who study secondary fungal metabolites ranging from pharmaceutical house researchers, agricultural researchers, those involved in food and feed control regulation, and veterinary researchers. It discusses in depth the molecular formula of, the molecular weights of, and fungal/plant source indexes of secondary fungal metabolites.

Download or read book Medicinal Plants in Asia and Pacific for Parasitic Infections written by Christophe Wiart and published by Academic Press. This book was released on 2020-11-04 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Plants in Asia and Pacific for Parasitic Infections: Botany, Ethnopharmacology, Molecular Basis, and Future Prospect offers an in-depth view into antiprotozoal pharmacology of natural products from medicinal plants in Asia with an emphasis on their molecular basis, cellular pathways, and cellular targets. This book provides scientific names, botanical classifications, botanical description, medicinal uses, chemical constituents and antiprotozoal activity of more than 100 Asian medicinal plants, with high quality original botanical plates, chemical structures, and pharmacological diagrams and lists hundreds of carefully selected references. It also examines the pharmacological and medicinal applications of Asian medicinal plants especially in drug development for protozoan prevention and treatment. Medicinal Plants in Asia and Pacific for Parasitic Infections is a research tool and resource for the discovery of leads for the treatment of protozoal diseases based on interrelated botanical, biochemical, ethnopharmacological, phylogenetic, pharmacological, and chemical information. A critical reference for any researcher involved in the discovery of leads for the treatment of antiprotozoal leads From Asian medicinal plants Written by an expert in the field, this truly unique text fills an important niche do to the increasing global interest in botanical drugs Provide scientific names, botanical classification, botanical description, medicinal uses, chemical constituents and pharmacological activity of more than 100 Asian plants

Download or read book Wood Microbiology written by Robert A. Zabel and published by Academic Press. This book was released on 2012-12-02 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: An in-depth examination of deterioration caused by fungi and other microorganisms, Wood Microbiology explores the major damages to wood and wood products during growth, harvesting, storage, and conversion to finished lumber. The characteristics, causes, detection, effects, and control measures for wood damage are stressed. - Reviews characteristics, classification, and metabolism of fungi responsible for wood deterioration and discoloration - Examines the anatomical, structural, and chemical features of decay - Covers effects of decay on physical and structural properties of wood - Presents methods for preventing biodegradation and for preserving wood - Extensively classroom tested--suitable for a two-quarter or one-semester course - Each chapter contains a summary and detailed references

Download or read book The Red cockaded Woodpecker written by Richard Conner and published by University of Texas Press. This book was released on 2010-06-28 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though small among its woodpecker relatives, the Red-cockaded Woodpecker poses a huge dilemma for its human neighbors. Uniquely adapted to live in the old-growth pine forests of the southeastern United States, the Red-cockaded Woodpecker has nearly disappeared as the forests have been cleared for agricultural, commercial, and residential uses over the last two centuries. Today, it waits at a crossroads. Scientific management practices could restore the woodpecker's habitat and population, but the imperative to convert old-growth forests to other uses remains. In this book, three of the leading experts on the Red-cockaded Woodpecker offer a comprehensive overview of all that is currently known about its biology and natural history and about the ecology of the fire-maintained forests it requires for survival. As the most visible endangered species in the Southeast, and the one whose conservation impacts the largest land area, the Red-cockaded Woodpecker holds a compelling interest not only for ornithologists, but also for wildlife managers, foresters, developers, environmentalists, and government officials. For all of these groups, this book will be the essential resource for learning more about the Red-cockaded Woodpecker and ensuring its survival.

Download or read book Nanobiomaterials in Drug Delivery written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2016-04-26 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials in Drug Delivery: Applications of Nanobiomaterials presents novel approaches regarding nanostructured drug delivery systems, revealing the most investigated materials for the development of particular nanobioshuttles. This book brings the results of current research to reach those who wish to use this knowledge in an applied setting, providing one coherent text, with focused chapters and easily accessible information. At its core, it is a collection of titles, bringing together many of the novel applications these materials have in biology, also discussing the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment, there is no other comparable book series covering all the subjects approached in this set of titles. - Provides up-to-date and well-structured reference material for students, researchers, and practitioners working in the biomedical, biotechnological, and engineering fields - Presents a valuable guide to recent scientific progress, along with most known applications of nanomaterials in the biomedical area - Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine/nanobiology

Download or read book Nanocatalysts written by Indrajit Sinha and published by BoD – Books on Demand. This book was released on 2019-07-31 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanocatalysis is a topical area of research that has huge potential. It attempts to merge the advantages of heterogeneous and homogeneous catalysis. The collection of articles in this book treats the topics of specificity, activity, reusability, and stability of the catalyst and presents a compilation of articles that focuses on different aspects of these issues.

Download or read book Palladacycles written by Anant Kapdi and published by Elsevier. This book was released on 2019-06-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic complexes in catalysis employing azobenzene and hydrazobenzene as coordinating ligands. Its applications in processes such as selective reduction of alkenes, alkynes, or nitroalkanes are also covered. Palladacycles: Catalysis and Beyond reveals the tremendous advances that have taken place in the potential applications of palladacycles as versatile catalysts in academia and industry. It is a valuable resource for synthetic chemists, organometallic chemists, and chemical biologists.

Download or read book Ruthenium Chemistry written by Ajay Kumar Mishra and published by CRC Press. This book was released on 2018-01-17 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.

Download or read book Sorbents Materials for Controlling Environmental Pollution written by Avelino Nunez-Delgado and published by Elsevier. This book was released on 2021-02-16 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sorbents Materials for Controlling Environmental Pollution: Current State and Trends presents data on current use and future trends regarding sorbent materials employed against soil, water, and air pollution. The book is organized first by use and research for a variety of geographic areas. It will then focus on different sorbent materials and their uses, followed by various pollutants and their management. Including updated and extensive data from an assortment of sources, the book is organized to be very accessible, including with an interactive table to help identify the results of appropriate sorbents for each environmental compartment. The growing concern regarding soil, water and air pollution all over the world has implications for climate change and sustainability, making Sorbents Materials for Controlling Environmental Pollution: Current State and Trends an important reference for environmental scientists to identify tools for moving forward in solving these problems. - Includes data and examples from various geographic locations worldwide - Synthesizes data for a variety of sorbent material from different sources - Presents data for various kinds of pollutants across environmental spheres, including soil, water, and air - Utilizes an interactive table for quicker access to data and results

Download or read book Smart Nanoparticles for Biomedicine written by Gianni Ciofani and published by Elsevier. This book was released on 2018-05-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Nanoparticles for Biomedicine explores smart nanoparticles that change their structural or functional properties in response to specific external stimuli (electric or magnetic fields, electromagnetic radiation, ultrasound, etc.). Particular attention is given to multifunctional nanostructured materials that are pharmacologically active and that can be actuated by virtue of their magnetic, dielectric, optically-active, redox-active, or piezoelectric properties. This important reference resource will be of great value to readers who want to learn more on how smart nanoparticles can be used to create more effective treatment solutions. Nanotechnology has enabled unprecedented control of the interactions between materials and biological entities, from the microscale, to the molecular level. Nanosurfaces and nanostructures have been used to mimic or interact with biological microenvironments, to support specific biological functions, such as cell adhesion, mobility and differentiation, and in tissue healing. Recently, a new paradigm has been proposed for nanomedicine to exploit the intrinsic properties of nanomaterials as active devices rather than as passive structural units or carriers for medications. - Discusses the synthesis, characterization and applications of a new generation of smart nanoparticles for nanomedicine applications - Explores the problems relating to the biocompatibility of a range of nanoparticles, outlining potential solutions - Describes techniques for manipulating specific classes of nanoparticles for a variety of treatment types