Download or read book Synthesis and Biological Evaluation of Nucleosides and Nucleotides as Antitumor Agents written by Michela Pasqualini and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nucleosides and Nucleotides as Antitumor and Antiviral Agents written by D.C. Baker and published by Springer. This book was released on 2013-11-11 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease: isolation of HIV only two years after the identification of the disease, plus major strides in the areas of the molecular biology and virology of the retrovirus, etc. More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease. The last six to seven years have particularly been an exciting and productive period for nucleoside chemists. Since the activity of AZI' was established in 1985, nucleoside chemists have had golden opportunities to discover additional anti-HIV nucleosipes, which are hoped to be less toxic and more effective than AZT, and the opportunity continues. As we all are aware, AZT possesses extremely potent anti-HIY activity, and no other nucleoside or non nucleoside has surpassed the potency of AZT in vitro.

Download or read book Chemistry of Nucleosides and Nucleotides written by L.B. Townsend and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume is the first of a projected four-volume treatise. This volume contains the following chapters: "Synthesis and Reaction of Pyrimidine Nucleosides," "Synthesis and Properties of Purine Nucleosides and Nucleotides," and "Synthesis and Properties of Oligonucleotides." These three chapters were selected for inclusion in Volume I because the areas have provided the basis and impetus for the initiation and development of the other areas of research, which will be described in subsequent volumes. Each chapter is rather comprehensive in nature and should provide a ready reference source for not only the novice but also the experienced investigator or researcher. The chapters have been prepared by authors with considerable experience in each particular area of research, and this has resulted in a lucid presentation of each well-defined area. These volumes were designed with medicinal chemists, medicinal organic chemists, organic chemists, carbohydrate chemists, physical chemists, and biological chemists in mind. However, because of the tremendous recent interest in this research area owing to the biological and chemotherapeutic evaluation of nucleosides and nucleotides as anticancer, antiviral, and antiparasitic agents, these volumes should also be valuable additions to the libraries of virologists, biochemical pharmacologists, oncologists, and pharmacologists. We would like to thank the authors for their enthusiasm and help in making these volumes available to the scientific community.

Download or read book Design Synthesis and Biological Evaluation of Novel Nucleosides and Nucleotides as Potential Anti influenza Agents written by Silvia Meneghesso and published by . This book was released on 2012 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemistry and Biology of Nucleosides and Nucleotides written by Robert Harmon and published by Academic Press. This book was released on 2012-12-02 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of Nucleosides and Nucleotides is a collection of papers presented at the symposium on the Chemistry and Biology of Nucleosides and Nucleotides, held on August 30-September 1, 1976, as part of the San Francisco Centennial Meeting of the Carbohydrate Division of the American Chemical Society. Contributors explore the chemistry and biology of nucleosides and nucleotides ans well as the different chemical and instrumental techniques used in their synthesis. This book is comprised of 28 chapters and begins by describing the synthesis of a gene and its introduction into a biological system where it proved to be functional. The synthesis of nucleosides and nucleotides with anticancer and antiviral activity is also discussed, along with the rationale for the design and synthesis of such compounds. Simple models of nucleic acid interactions are described. Subsequent chapters explore the chemistry and biological activity of C-nucleosides related to pseudouridine and of some nucleoside analogs active against tumor cells; the selectivity and stereospecificity of the ribosylation reaction; synthesis of C-glycosyl thiazoles; and C-nucleoside isosteres of some nucleoside antibiotics. This monograph will serve as reference and source material for many workers in biomedical research as teaching material for instructors of advanced science courses.

Download or read book Synthesis and Biological Evaluation of Novel Nucleosides and Nucleotides as Potential Therapeutic Agents written by Valentina Ferrari and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design Synthesis and Biological Evaluation of Nucleotide Pro drugs Centred on Clinically Active Anticancer Nucleosides written by Blanka Gonczy and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Design Synthesis and Biological Evaluation of Novel Nucleotide Prodrugs as Potential Chemotherapeutic Agents written by Alshaimaa Hassan-Abdallah and published by . This book was released on 2002 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies in the Design Synthesis and Biological Evaluation of Some Novel Antiviral Nucleosides and Nucleotides written by Sally Ann Blewett and published by . This book was released on 2001 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design Synthesis and Biological Evaluation of Novel Bioactive Nucleosides and Nucleotides written by Marco Derudas and published by . This book was released on 2009 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Biological Evaluation of Novel Nucleoside and Nucleotide Analogues written by Qingfeng Li (Doctor in pharmaceutical sciences) and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design Synthesis and Biological Evaluation of Some Novel Nucleotide Prodrugs as Potential Anticancer Agents written by Costantino Congiatu and published by . This book was released on 2006 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design Synthesis and Biological Evaluation of Nucleotide Prodrugs as Potential Anticancer Agents written by Rocco Valente and published by . This book was released on 2009 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Design Synthesis and Biological Evaluation of Novel Nucleoside Analogues as Potential Antiviral Agents written by Giovanna Luoni and published by . This book was released on 2004 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Design Synthesis and Biological Evaluation of Novel Nucleoside Analogues as Potential Antiviral Agents written by Olivier Bidet and published by . This book was released on 2003 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Design Synthesis and Biological Evaluation of Novel Nucleoside Analogues as Potential Antiviral Agents written by Antonella Carangio and published by . This book was released on 2002 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book I Synthesis and Biological Evaluation of Bridged Nucleosides and BE 434B Analogues written by Shelby Paige Ellery and published by . This book was released on 2011 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many groups have researched bridged nucleosides for the purpose of determining their binding affinity for antisense applications, we opted to look into the potential for biological activity within these conformationally-locked structures. A small library of 2',4'- and 3',4'-bridged nucleoside analogues was synthesized, including a novel 3',4'-carbocyclic bridged system. The synthesized compounds were tested for antibacterial, antitumor, and antiviral activities. The most potent compound exhibited significant antiviral activity against pseudoviruses SF162 (IC50 = 7.0 [micro]M) and HxB2 (IC50 = 2.4 [micro]M). These findings render bridged nucleosides as credible leads for drug discovery in the anti-HIV area of research.