Download or read book Symposium on Continuous Cell Lines as Substrates for Biologicals written by and published by . This book was released on 1989 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Cell Culture Engineering written by Wei-Shu Hu and published by Springer. This book was released on 2006-08-16 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1990 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book International Symposium on Continuous Cell Lines written by F. Brown and published by . This book was released on 1991 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recombinant DNA Technical Bulletin written by and published by . This book was released on 1988 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Substrates written by J. C. Petricciani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume stems from a symposium sponsored by the W. Alton Jones Cell Science Center, Lake Placid New York. The Second Annual W. Alton Jones Cell Science Center Symposium: Cell Substrates and Their Use in the Production of Vaccines and Other Biologicals was held October 23-26, 1978. The Center is an operational unit of the Tissue Culture Association and offers, in collaboration with the Association's Education Committee, a wide range of educational and research activities. During the past 20 years there have been numerous national and international conferences on the topic of cell cultures used to produce biological products. Those largely dealt with the technology and associated issues that were current at the time of the meetings. For example, as human diploid cells were developed and proposed for use in vaccine production, a number of meetings were held to examine the pros and cons of human diploid cells. A large amount of data was provided at those conferences which formed the basis for the eventual acceptance of that cell system. Each meeting added to the general base of knowledge in the area of cell cultures and their application to the current and novel set of problems encountered. In general, the participants reaffirmed the basic premises that were formulated in the early days of polio virus vaccine production regarding the criteria for acceptability of cells when used in the manufacture of biologics intended for humans.
Download or read book 18 Congress Joint IABS WHO Symposium on Standardization and Control of Biologicals Produced by Recombinant DNA Technology written by and published by . This book was released on 1985 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book International Symposium on Standardization of the Immunopharmacology of Natural and Synthetic Immunomodulators written by and published by . This book was released on 1992 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Large Scale Mammalian Cell Culture Technology written by Lubiniecki and published by Routledge. This book was released on 2018-05-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator
Download or read book Insect Cell Culture Engineering written by Mattheus F. A. Goosen and published by CRC Press. This book was released on 2020-07-24 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consolidating and expanding current, fundamental notions of virology and animal cell cultivation, this practical reference examines the development of insect cell culture techniques for the production of recombinant proteins and insect pathogenic viruses.;Resolving on-the-job problems such as sparging cell damage and reduced infectivity cells, Insect Cell Culture Engineering: includes special introductory material as well as background information on insect pathogenic viruses, the molecular biology of baculoviruses and bioreactor design; offers advice on how to save time when deciding which insect cell line, bioreactor and medium to exploit; discusses the preparation of mathematical modelling in animal cell culture; addresses the concerns associated with insect cell immobilization and the use of serum-free culture media; provides insights into the protective effects of polymer additives and insect cell gene expression in pharmaceutical research; and analyzes process scale-up and reactor design.;Bridging the gap between laboratory research and pilot plant scale insect culture/baculovirus technology, Insect Cell Culture Engineering is designed as a reference for biochemical and bioprocess engineers, bioprocess technologists, biochemists, molecular and cell biologists, microbiologists, and upper-level undergraduate and graduate students in these disciplines.
Download or read book Summary of Activities written by National Veterinary Services Laboratories (U.S.) and published by . This book was released on 1989 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Automated Microbial Identification and Quantitation written by Wayne P. Olson and published by CRC Press. This book was released on 1996-01-31 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on practical, proven applications to automate the microbial identification process economically and with greater levels of safety and quality for patients. A diverse group of recognized experts survey the topic and present the latest techniques and technologies for microbial detection. They cover bacteria and yeasts, the technology of automation, equipment, methods, and the validation issues involved in "going automated." They also explore the challenges of detection and quantititation of contaminants in the increasing number of biologic injectable drugs and identify current trends in the industry. Features
Download or read book Human Cell Culture written by Manfred R. Koller and published by Springer Science & Business Media. This book was released on 1999-07-31 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes research technology for the growth and differentiation of all 12 types of the primary hematopoietic cells that develop into the various types of blood cells. Also provides background information, discusses current and future clinical applications of large-scale culture methods, and considers regulatory and ethical implications associated with using human and fetal tissues. The 13 studies include treatments of hematopoietic stem and progenitor cells, monocytes and macrophages, isolating and culturing human dendritic cells, purifying and culturing erythroid progenitor cells, the in vitro development of megakaryocytes and platelets, the mature polyclonal and antigen- specific cell expansion of T-lymphocytes, and in vitro T- lymphopoiesis. They are not indexed. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Human Cell Culture written by F. Koller and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The daily production of hundreds of billions of blood cells through the process of hematopoiesis is a remarkable feat of human physiology. Transport of oxygen to tissues, blood clotting, antibody- and cellular-mediated immunity, bone remodeling, and a host of other functions in the body are dependent on a properly functioning hematopoietic system. As a consequence, many pathological conditions are attributable to blood cell abnormalities, and a fair number of these are now clinically treatable as a direct result of hematopoietic research. Proliferation of hematopoietic stem cells, and their differentiation into the many different lineages of functional mature cells, is highly regulated and responsive to many environmental and physiological challenges. Our relatively advanced understanding of this stem cell system provides potentially important insights into the regulation of development in other tissues, many of which are now being acknowledged as stem ce- based, perhaps even into adulthood. The recent public and scientific fanfare following announcement of human embryonic stem cell studies suggests that stem cell research will continue to be a relevant and exciting topic.
Download or read book Continuous Manufacturing for the Modernization of Pharmaceutical Production written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-04-05 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: On July 30-31, 2018, the National Academies of Sciences, Engineering, and Medicine held a workshop titled Continuous Manufacturing for the Modernization of Pharmaceutical Production. This workshop discussed the business and regulatory concerns associated with adopting continuous manufacturing techniques to produce biologics such as enzymes, monoclonal antibodies, and vaccines. The participants also discussed specific challenges for integration across the manufacturing system, including upstream and downstream processes, analytical techniques, and drug product development. The workshop addressed these challenges broadly across the biologics domain but focused particularly on drug categories of greatest FDA and industrial interest such as monoclonal antibodies and vaccines. This publication summarizes the presentations and discussions from the workshop.
Download or read book WHO Expert Committee on Biological Standardization written by WHO Expert Committee on Biological Standardization. Meeting and published by World Health Organization. This book was released on 2007-12-15 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents the recommendations of a WHO Expert Committee commissioned to coordinate activities leading to the adoption of international recommendations to assure the quality safety and efficacy of vaccines blood products and other biological medicines and the establishment of international biological reference standards for these products and related diagnostic devices. The report of particular relevance to manufacturers and national regulatory authorities starts with a discussion of general issues brought to the Committee's attention. The second part of the report contains written specifications that establish international regulatory expectations for the following products; DNA vaccines pertussis (whole cell) vaccine plasma (human) for fractionation rabies vaccine and rotavirus vaccine. The report also provides a risk assessment and defines conditions for the safe production of pandemic strain influenza vaccines. The third part of the report provides information on the status and development of international reference materials for various antibodies antigens blood products and related substances and in vitro diagnostic devices.
