Download or read book Studies Towards the Total Synthesis of Migrastatin and Investigation Into Novel Polyketide Libraries written by Davina Elizabeth Stevenson and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards Total Synthesis of Polyketide Natural Products and Alkaloids written by Anastasia Hager and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 2006 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Investigations Towards the Total Synthesis of Scyphostatin written by Neil G. Stevenson and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Development of A Synthesis Toward Novel Macrocyclic Polyketides for Use as A Platform in Antibiotic Discovery and Fundamental Studies in Aminoborane Reactivity and Their Applications to Synthesis written by Alexander Achilles Braddock and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products have long been looked to as sources for novel therapeutics. Perhaps the most notable example of a therapeutic natural product is the venerated Penicillin, which for decades was the gold standard for the treatment of bacterial infection. As bacterial infection has proliferated, Scientists have had to develop novel antimicrobial compounds, rather than isolating them from natural sources as they had done initially. An efficacious strategy for developing new drugs is through the diverted total synthesis of natural products, wherein analogs of natural products are synthesized to increase their potency while still maintaining the original biological profile imbued by their structural archetype. Taking inspiration from this strategy, we identified four natural products of related biological activity and conserved structural features. We resolved to substitute the shared structural motifs through total synthetic chemistry to generate new compounds in the hopes of developing a novel platform for antibiotic discovery. The first chapter of this thesis covers the synthetic studies toward this end. Our strategy demonstrates the ability to target different intramolecular Diels-Alder reaction pathways to selectively direct toward endo-axial or endo[negation]-equatorial decalins. It then covers our successful manipulation of this key intermediate to remove all protecting groups and chiral auxiliaries while avoiding undesirable side reactions. We then demonstrate our ability to install the requisite E-Z diene and tricarbonyl motifs to show the feasibility of our strategy to make the final natural product analogs.The second part of this thesis details a study into the fundamental reactivity modes of aminoboranes. Over the course of my studies on macrocyclic polyketides I experienced firsthand the intrinsic inefficiencies of synthetic chemistry. The compounding loss of material through each transformation can make the preparation of large quantities of final product challenging, even for longest-linear-sequences of twenty steps. The easiest way to avoid material loss is to shorten synthetic sequences by avoiding unnecessary steps and manipulations. Difunctionalization reactions, where two functional groups are installed in one synthetic transformation are a powerful way to shorten synthetic sequences. We identified aminoboranes as useful reagents for difunctionalization reactions because they are amphiphilic, giving us multiple activation modes from which to work; furthermore, amination and borylation reactions are of immense interest to the synthetic community and there is a dearth of difunctionalization reactions that use aminoboranes. We set out by examining the nature of coordination between aminoboranes and neutral Lewis bases in solution, using NMR spectroscopy to quantify coordination and chemical shift. We then determined the redox potential of aminoboranes using cyclic voltammetry. From these data we screened a library of commercially available photocatalysts and identified two that were competently quenched by aminoboranes. Finally, we derived Stern-Volmer quenching constants for these photocatalysts and our library of aminoboranes. Using these data we attempted to develop a difunctionalization reaction employing photoactivated aminoborane species, however these pursuits were unfruitful. Ultimately, we were able to discover and develop a ground-state carbene-insertion reaction of aminoboranes.

Download or read book Studies Towards a Total Synthesis of Scyphostatin written by Karen A. Runcie and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards a Total Synthesis of Morphine written by Mark David Charles and published by . This book was released on 2003 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards a Total Synthesis of Morphine written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards a Total Synthesis of Colchicine written by and published by . This book was released on 2003 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Salvinorin A written by Ylva Elisabet Bergman and published by . This book was released on 2008 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Total Synthesis of Bioactive Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2019-04-27 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Download or read book Metal Enhanced Fluorescence written by Chris D. Geddes and published by John Wiley & Sons. This book was released on 2010-06-22 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how metal-enhanced fluorescence is changing traditional concepts of fluorescence This book collects and analyzes all the current trends, opinions, and emerging hot topics in the field of metal-enhanced fluorescence (MEF). Readers learn how this emerging technology enhances the utility of current fluorescence-based approaches. For example, MEF can be used to better detect and track specific molecules that may be present in very low quantities in either clinical samples or biological systems. Author Chris Geddes, a noted pioneer in the field, not only explains the fundamentals of metal-enhanced fluorescence, but also the significance of all the most recent findings and models in the field. Metal-enhanced fluorescence refers to the use of metal colloids and nanoscale metallic particles in fluorescence systems. It offers researchers the opportunity to modify the basic properties of fluorophores in both near- and far-field fluorescence formats. Benefits of metal-enhanced fluorescence compared to traditional fluorescence include: Increased efficiency of fluorescence emission Increased detection sensitivity Protect against fluorophore photobleaching Applicability to almost any molecule, including both intrinsic and extrinsic chromophores Following a discussion of the principles and fundamentals, the author examines the process and applications of metal-enhanced fluorescence. Throughout the book, references lead to the primary literature, facilitating in-depth investigations into particular topics. Guiding readers from the basics to state-of-the-technology applications, this book is recommended for all chemists, physicists, and biomedical engineers working in the field of fluorescence.

Download or read book Biology and Biotechnology of Actinobacteria written by Joachim Wink and published by Springer. This book was released on 2017-10-19 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides in-depth insights into the biology, taxonomy, genetics, physiology and biotechnological applications of Actinobacteria. It especially focuses on the latter, reviewing the wide variety of actinobacterial bioactive molecules and their benefits for diverse industrial applications such as agriculture, aquaculture, biofuel production and food technology. Actinobacteria are one of the most promising sources of small bioactive molecules and it is estimated that only a small percentage of actinobacterial bioactive chemicals have been discovered to date. Identifying new diverse gene clusters of biotechnological relevance in the genome of Actinobacteria will be crucial to developing advanced applications for pharmaceutical, industrial and agricultural purposes. The book offers a unique resource for all graduate students, researchers and practitioners in the fields of microbiology, microbial biotechnology, and the genetic engineering of Actinobacteria.

Download or read book Microbial Technology for Health and Environment written by Pankaj Kumar Arora and published by Springer Nature. This book was released on 2020-03-21 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rampant industrialization has caused high levels of contamination by various toxic chemicals in our water bodies, which is a matter of concern in terms of ecosystems, as well as human and animal health. Polluted wastewater can contaminate drinking water and is also is a causal factor for bio-magnification of heavy metals into our food cycle. In the last decade, several methodologies have been adopted to clean the wastewaters, and among these, microbial remediation has emerged as an effective technology. Several variants of microbial technologies have been developed for wastewater treatment and biodegradation specific to the industry, type of waste and toxicity of the chemicals. This book describes the recent advances in microbial degradation and microbial remediation of various xenobiotic compounds in soil and wastewater. It also explains various modern microbial technologies for biodegradation and wastewater treatment. It covers various microbial technologies for wastewater treatment, biodegradation, bioremediation and solid waste management. Gathering contributions from leading international it focuses on the status quo in industrial wastewater treatment and its biodegradation. The book is intended for researchers in the field of industrial wastewater, students of environmental sciences and practitioners in water pollution abatement.

Download or read book Molecular Rearrangements in Organic Synthesis written by Christian M. Rojas and published by John Wiley & Sons. This book was released on 2015-10-26 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for practitioners of organic synthesis, this book helps chemists understand and take advantage of rearrangement reactions to enhance the synthesis of useful chemical compounds. Provides ready access to the genesis, mechanisms, and synthetic utility of rearrangement reactions Emphasizes strategic synthetic planning and implementation Covers 20 different rearrangement reactions Includes applications for synthesizing compounds useful as natural products, medicinal compounds, functional materials, and physical organic chemistry

Download or read book The Double 3 2 Photocycloaddition Reaction written by Jason A. Woolford and published by Springer Science & Business Media. This book was released on 2011-08-30 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jason Woolford's thesis describes for the first time, a double [3+2] photocycloaddition of alkenes onto aromatic rings. Modern synthetic chemistry relies on the ability of researchers to uncover new and more efficient ways of creating highly complex structures. This work describes a novel, environmentally friendly photochemical step that converts in one pot, trivial starting materials into otherwise difficult to construct fenstrane frameworks. The rigid cores of these frameworks have significant potential in drug design. Moreover, the novelty of this work overtakes many other methods for the creation of chiral centres. No less than seven chiral centres are created in the photochemical step together with the formation of four carbon-carbon bonds and multifused rings. Jason's innovative work has been the subject of several publications in peer-reviewed journals.