Download or read book Studies Towards the Total Synthesis of Herbimycin A written by Guillaume Marcel Olivier Favier and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbimycin A (1) belongs to the ansamycin family and is a 19-membered lactam with seven stereogenic centres, making it a synthetic challenge, which was first isolated in 1979 by Omura et al. Herbimycin A (1) exhibits a broad spectrum of biological activities: herbicidal, inhibitor of angiogenesis and of the maturation of growth factor receptor tyrosine kinases. Figure 1 - Herbimycin A (for figure see pdf) Since its discovery, only three total syntheses of Herbimycin A (1) have been described in the literature, along with the syntheses of advanced fragments. This thesis describes a new route to Herbimycin A (1), using a wide range of chemical reactions than those used in the previous routes from the literature. The main idea is to split Herbimycin A (1) into an aromatic fragment and an aliphatic fragment as shown below in Scheme 1. Scheme 1 - Retrosynthesis highlighting both aromatic and aliphatic fragments (for figure see pdf) The synthesis of aliphatic fragment (4) follows up the work of Ansell and Pietsch, past members of the Parsons group. Interesting results could be obtained and a wide range of Organic Chemistry reactions could be investigated.

Download or read book The Total Synthesis of Herbimycin A and Studies Directed Toward the Synthesis of Geldanamycin written by Kendra D. Carter and published by . This book was released on 2005 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of the Ansamycin Benzoquinone Antibiotic Herbimycin A written by Inga-Marlene Pietsch and published by . This book was released on 2009 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Anthracimycin written by Laksamee Jeanmard and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Tetrodecamycin written by Jing He and published by . This book was released on 2007 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Merrilactone A written by Karsten Meyer and published by . This book was released on 2009 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of retronecine and Anthracimycin written by Joshua C. Smith and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of the Biologically Active Natural Product Aigialomycin D and Development of Two Novel Methodologies written by Naval Bajwa and published by . This book was released on 2008 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part A Studies Directed Towards the Total Synthesis of A 23187 Part B Formal Total Synthesis of A 23187 written by Eric L. Williams and published by . This book was released on 1980 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Merrilactone A written by Jone Iriondo-Alberdi and published by . This book was released on 2007 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Ficellomycin written by and published by . This book was released on 2008 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Concanamycin A written by M.D. McLeod and published by . This book was released on 1997 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards a Total Synthesis of Neooxazolomycin written by Michael Robert Webb and published by . This book was released on 2006 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards a Total Synthesis of Neooxazolomycin written by Reyhan Bastin and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of the Milbemycins and Avermectins written by Danute M. Bankaitis-Davis and published by . This book was released on 1986 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards Herbimycin A written by Graham Keith Ansell and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Colchicine written by and published by . This book was released on 1995 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: