Download or read book Studies Towards Overcoming Current Limitations of Ru alkylidene Catalysed Olefin Metathesis written by Zhen Wang and published by . This book was released on 2013 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic olefin metathesis has significantly enhanced the power of synthetic chemistry. In particular, Ru-alkylidene catalysed olefin metathesis has played a key role in the discovery ofmany new and exciting technologies. However, there are still many challenges which remainunaddressed in this field of chemistry. In this thesis, three independent research projects are presented which collectively extend the scope of olefin metathesis. Towards this end, research exploring i) tandem catalysis (Chapter 2), ii) cross-metathesis of sterically hindered olefins(Chapter 3) and iii) olefin metathesis in aqueous media (Chapter 4) are described. In each case, a brief literature survey is used to contextualise the ensuing research, which is presented in manuscript format with its supporting data.Chapter 1 presents a brief overview of Ru-alkylidene catalysed olefin metathesis. This includes an introduction to the general classes of olefin metathesis reactions, namely ring-closing metathesis, cross metathesis and ring-opening metathesis polymerisation, catalysed by Ru-alkylidene complexes. The mechanism of olefin metathesis is also detailed, as areselected examples which highlight the utility of this class of reaction.Chapter 2 describes the development of a tandem olefin metathesis/hydrogenationprotocol. Also detailed within this chapter are strategies to prevent concomitant alkeneisomerisation during olefin metathesis reactions involving reactive terminal olefins. The methodology developed in this study has been applied to the synthesis of a family of enantiopure lipophilic amino acids. This scalable process delivers lipophilic amino acids with sufficient purity to be directly incorporated into a peptide sequence via solid phase peptidesynthesis.Chapter 3 details studies towards the efficient cross-metathesis of previously unreactive substrates. In particular, this chapter describes the use of a cross-metathesis reaction between allylglycine derivatives and methylenecycloalkanes, followed by an acid-catalysed cyclisation,to access a family of enantiopure 1-azaspiropyrrolidines. Ring-expansion of the1-azaspiropyrrolidine structures conveniently affords 1-azaspiropiperidine motifs. Extension of this strategy was required to access the tricyclic marine alkaloid lepadiformine. This involvedcross-metathesis reactions using allylic substituted methylenecycloalkane derivatives, substrates which were previously unreactive in cross-metathesis reactions due to steric hindrance. Towards this end, this chapter details studies towards the development of a steric reversal strategy for the cross-metathesis of sterically hindered olefins.Chapter 4 describes the development of an ammonium-functionalised second generation Hoveyda Grubbs-type complex for olefin metathesis in water. A simple and scalablepreparation of a strategically functionalised Ru-alkylidene complex is discussed. This Ru-alkylidene complex exhibits high olefin metathesis activity in water, without the need for additives or surfactants. The ring-closing metathesis and cross-metathesis reaction of variousnitrogen- and oxygen-containing substrates is demonstrated.Finally, Chapter 5 contains supporting information for the published manuscripts andexperimental data for any unpublished material presented in this thesis.

Download or read book Efficient New Routes to Leading Ruthenium Catalysts and Studies of Bimolecular Loss of Alkylidene written by Craig Day and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Olefin metathesis is an exceptionally versatile and general methodology for the catalytic assembly of carbon-carbon bonds. Ruthenium metathesis catalysts have been widely embraced in academia, and are starting to see industrial uptake. However, the challenges of reliability, catalyst productivity, and catalyst cost have limited implementation even in value-added technology areas such as pharmaceutical manufacturing. Key to the broader adoption of metathesis methodologies is improved understanding of catalyst decomposition. Many studies have focused on phenomenological relationships that relate catalyst activity to substrate structure, and on the synthesis of new catalysts that offer improved activity. Until recently, however, relatively little attention was paid to catalyst decomposition. The first part of this thesis explores a largely overlooked decomposition pathway for "second-generation" olefin metathesis catalysts bearing an N-heterocyclic carbenes (NHC) ligand, with a particular focus on identifying the Ru decomposition products. Efforts directed at the deliberate synthesis of these products led to the discovery of a succinct, high-yielding route to the second-generation catalysts. Multiple reports, including a series of detailed mechanistic studies from our group, have documented the negative impact of phosphine ligands in Ru-catalyzed olefin metathesis. Phosphine-free derivatives are now becoming widely adopted, particularly in pharma, as recognition of these limitations has grown. Decomposition of the phosphine-free catalysts, however, was little explored at the outset of this work. The only documented pathway for intrinsic decomposition (i.e. in the absence of an external agent) was -hydride elimination of the metallacyclobutane (MCB) ring as propene. An alternative mechanism, well established for group 3-7 and first-generation ruthenium metathesis catalysts, is bimolecular coupling (BMC) of the four-coordinate methylidene intermediate. However, this pathway was widely viewed as irrelevant to decomposition of second-generation Ru catalysts. This thesis work complements parallel studies from the Fogg group, which set out to examine the relevance and extent of BMC for this important class of catalysts. First, -hydride elimination was quantified, to assess the importance of the accepted pathway. Even at low catalyst concentrations (2 mM Ru), less than 50% decomposition was shown to arise from -hydride elimination. Parallel studies by Gwen Bailey demonstrated ca. 80% BMC for the fast-initiating catalyst RuCl2H2IMes(=CHPh)(py)2 GIII. Second, the ruthenium products of decomposition were isolated and characterized. Importantly, and in contrast to inferences drawn from the serendipitous isolation of crystalline byproducts (which commonly show a cyclometallated NHC ligand), these complexes show an intact H2IMes group. This rules out NHC activation as central to catalyst decomposition, suggesting that catalyst redesign should not focus on NHC cyclometallation as a core problem. Building on historical observations, precautions against bimolecular coupling are proposed to guide catalyst choice, redesign, and experimental setup. The second part of this thesis work focused on the need for more efficient routes to second-generation Ru metathesis catalysts, and indeed a general lack of convenient, well-behaved precursors to RuCl2(H2IMes). This challenge was met by building on early studies in which metathesis catalysts were generated in situ by thermal or photochemical activation of RuCl2(p-cymene)(PCy3) in the presence of diazoesters. Such piano-stool complexes (including the IMes analogue) have also been applied more broadly as catalysts, inorganic drugs, sensors, and supramolecular building blocks. However, RuCl2(p-cymene)(H2IMes), which should in principle offer access to the RuCl2(H2IMes) building block, has been described as too unstable for practical use. The basis of the instability of RuCl2(p-cymene)(H2IMes) toward loss of the p-cymene ring was examined. Key factors included control over reaction stoichiometry (i.e. limiting the proportion of the free NHC), limiting exposure to light, and maintaining low concentrations to inhibit bimolecular displacement of the p-cymene ring. A near-quantitative route to RuCl2(p-cymene)(H2IMes) was achieved using appropriate dilutions and rates of reagent addition, and taking precautions against photodecomposition. This approach was used to develop atom-economical syntheses of the Hoveyda catalyst, RuCl2(H2IMes)(=CHAr) (Ar = 2-isopropoxybenzylidene) and RuCl2(H2IMes)(PPh3)(=CHPh), a fast-initiating analogue of GII. Related p-cymene complexes bearing bulky, inflexible imidazolidene or other donors may likewise be accessible.

Download or read book Longer lived Olefin Metathesis Catalysts Based on Molybdenum and Ruthenium written by Joseph Yoon and published by . This book was released on 2020 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of olefin metathesis has seen considerable growth in the recent past. Some of the earliest milestones in the field include the synthesis of well-defined catalysts based on molybdenum, tungsten, and ruthenium. The efficiencies of these catalysts, however, are limited by their decomposition. Efforts have been made to increase the lifetime of these catalysts by changing the ligand sphere, to stabilize catalytic intermediates. Examples include the employment of the N-heterocyclic carbene (NHC) and the chelating (o-isopropoxy)benzylidene ligand seen in the second-generation Grubbs and Hoveyda catalysts. Processes that utilize the olefin metathesis processes, like those in the petroleum industry and large-scale production of chemicals, are bound by the need for high catalyst loadings which translate to high costs. The work herein presents the pursuit of longer-lived olefin metathesis catalysts based on molybdenum and ruthenium. The first goal of this thesis project was to develop a stable molybdenum-based olefin metathesis catalyst supported by a tridentate PONOP ligand and a chelating (o- x methoxy)benzylidene ligand. Previous attempts in our lab employed nonchelating alkylidene initiators - yielding no success in isolation. The rationale behind this design was that a chelating ether moiety will stabilize the molybdenum-center enough to be isolable. Attempts to isolate the chelating molybdenum-alkylidene species were also unsuccessful. Instead, we probed the in-situ ROMP of norbornene using iPrPONOP MoCl3 as a precatalyst and (2-methoxybenzyl)magnesium chloride as a cocatalyst. This cocatalyst did not lend any improvements to the simpler nonchelating Grignard cocatalysts. The synthesis of a novel dialkyl zirconocene complex is also reported. The second and more heavily pursued endeavor was the development of longer-lived ruthenium olefin metathesis catalysts. Specifically, we aimed at improving the second-generation Hoveyda catalyst with the use of a hemilabile tridentate NHC ligand. Two novel catalysts bearing NHC ligands with a hemilabile ethoxy-pyridyl arm were synthesized along with their unique organic frameworks. The catalyst containing the 2,6-diisopropylphenyl group (C1-Me) was investigated more comprehensively because it was more readily prepared. This complex was characterized by high thermal stability under metathesis conditions and remarkable TONs in the self-metathesis of 1-decene. In our efforts to prepare C1-Me without utilizing a Grubbs I intermediate, a new complex (6) bearing our NHC ligand was isolated and characterized by 1H NMR and single crystal x-ray diffraction spectroscopy. The reaction of C1-Me with ethylene did not produce the desired C1-Me-methylidene variant - however, the same reaction with propylene gave C1-Me-ethylidene with relative ease. Analyzing the active catalytic species under the metathesis of 1-decene revealed that the resting state of the catalyst is not the expected methylidene, but rather the longer chain nonylidene. xi Initiation studies were conducted to compare the rates of initiation for catalyst C1-Me and the nonmethylated C1-H. First, the rate of metathesis was followed in the irreversible reaction with ethyl vinyl ether. Second, ligand exchange equilibrium experiments were carried out to compare the dissociation constants for the pyridyl moieties in both catalysts. The outcome of these studies revealed that catalyst C1-Me, with a methyl group in the phenoxide ring, exhibits a 10-fold increase in initiation versus the nonmethylated C1-H catalyst. The NHC ligand scaffold reported in this work may assist in the development of other inorganic and organometallic catalytic systems, as many rely on the use of ancillary ligands for support. Furthermore, fixing a hemilabile ethoxy-pyridyl arm onto already robust systems, such as ruthenium catalysts bearing a cyclic alkyl amino carbene ligand, may offer even greater catalytic turnover numbers (TONs).

Download or read book Synthetic and Mechanistic Studies in Ruthenium catalyzed Olefin Metathesis written by Amy Reckling and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ruthenium - catalyzed olefin metathesis is now an invaluable tool in organic synthesis. However, routes to the dominant metathesis catalysts, the second - generation Grubbs and Hoveyda catalysts (RuCl 2 (PCy 3 )(H 2 IMes)(=CHPh) and RuCl 2 (H 2 IMes)[= CH( o - O i Pr)C 6 H 4 ], respectively) are plagued with problems. The common reliance on in situ methods to generate the N - heterocyclic carbene H 2 IMes severely limits stoichiometric control, and results in contamination by byproducts, some of which are readily overlooked, and some of which are difficult to remove. Both can affect batch - to - batch reproducibility in catalysis. This thesis work demonstrated that widespread perceptions of the instability of free H 2 IMes are erroneous, and that the free carbene is readily handled under water - free conditions. Clean, convenient, near - quantitative routes were developed to these second - generation catalysts by ligand exchange of their first - gen eration counterparts RuCl 2 (PCy 3 ) 2 (=CHPh), RuCl 2 (PCy 3 )[= CH( o - O i Pr)C 6 H 4 ] with free H 2 IMes, with sequestration of the liberated phosphine by an ion - exchange resin. A second focus was examination of a much - debated hypothesis in olefin metathesis: that is, the extent to which the high productivity of the Hoveyda catalysts reflects re - uptake of the styrenyl ether functionality released in the initial cycle of metathesis. Current evidence for and against this "boomerang" hypothesis is critically examined, and new approaches to examining its operation are described. Specifically, the rate of decomposition, vs. re - uptake, is examined for the active species RuCl 2 (PCy 3 )(=CH 2 ), and background exchange of the parent catalyst with free styrenyl ether is measured by use of a 13 C - labelled styrenyl ether. These studies confirm the relevance of the boomerang mechanism for first - generation Hoveyda catalysts.

Download or read book Ruthenium Catalysts for Olefin Metathesis written by Jennifer M. Bates and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Amines in Olefin Metathesis written by Benjamin John Ireland and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Olefin metathesis is a powerful tool for assembly of carbon-carbon bonds. Amines and related N-donors are problematic functional groups in Ru-catalyzed olefin metathesis - a well- documented, but poorly understood problem. The first part of this thesis focuses on amine-induced deactivation pathways; two of which are described in depth. Alkylidene abstraction, a previously unknown reaction for nitrogen nucleophiles, was observed for smaller and less Bronsted-basic amines. Deprotonation of the metallacyclobutane intermediate formed during catalysis is prominent for highly Bronsted basic or sterically bulky N-donors. Monosubstituted (and, by extension unsubstituted) metallacyclobutanes are particularly vulnerable to deprotonation. For each pathway, the fate of the alkylidene Ru=CHR functional group proved key in determining the nature of deactivation. Both pathways have been detected during catalysis, as evidenced by formation of diagnostic amine (RCH2NR2') or substituted propene products. A combination of quantitative NMR and GC-MS analysis was used to identify these species on loss of the Ru-alkylidene functional group. The second part of this thesis focuses on incorporating amines into catalyst design - an under-utilized strategy in the context of Ru-catalyzed olefin metathesis. A modified Grubbs-type catalyst was developed featuring a bulky, relatively non-basic biaryldiamine ligand. Metathesis activity for this catalyst was comparable, and in some cases superior to the most widely-used homogeneous catalysts currently available. Several new, related Ru-benzylidenes were also prepared and fully characterized in conjunction with the mechanistic studies described above. Progress toward development of N-anion-containing metathesis catalysts is also discussed. Synthesis of Ru-hydride complexes originally intended for this purpose allowed for a fundamental study of the coordination chemistry and reductive elimination chemistry of the NPh2- anion.

Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

Download or read book Handbook of Metathesis 3 Volume Set written by Robert H. Grubbs and published by John Wiley & Sons. This book was released on 2015-05-26 with total page 1639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the complete breadth of the olefin metathesis reaction. The second edition of the ultimate reference in this field is completely updated and features more than 80% new content, with the focus on new developments in the field, especially in industrial applications. No other book covers the topic in such a comprehensive manner and in such high quality, and this new edition retains the three-volume format: Catalyst Development, Applications in Organic Synthesis and Polymer Synthesis. Edited by a Nobel laureate in the field, and with a list of contributors that reads like a "Who's-Who" of metathesis, this is an indispensable one-stop reference for organic, polymer and industrial chemists, as well as chemists working with organometallics. Individual volumes also available separately to purchase Volume 1: Catalyst Development - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339485.html Volume 2: Applications in Organic Synthesis - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339493.html Volume 3: Polymer Synthesis - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339507.html

Download or read book Olefin Metathesis and Metathesis Polymerization written by K. J. Ivin and published by Elsevier. This book was released on 1997-01-07 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a follow-up to Ivins Olefin Metathesis, (Academic Press, 1983). Bringing the standard text in the field up to date, this Second Edition is a result of rapid growth in the field, sparked by the discovery of numerous well-defined metal carbene complexes that can act as very efficient initiators of all types of olefin metathesis reaction, including ring-closing metathesis of acyclic dienes, enynes, and dienynes; ring-opening metathesis polymerizationof cycloalkenes, acyclic diene metathesis polymerization; and polymerization of alkynes, as well as simple olefin metathesis. Olefin Metathesis and Metathesis Polymerization provides a broad, up-to-date account of the subject from its beginnings in 1957 to the latest applications in organic synthesis. The book follows the same format as the original, making it useful toteachers and to researchers, and will be of particular interest to those working in the fields of organic chemistry, polymer chemistry, organometallic chemistry, catalysis, materials science and chemical engineering. Discusses different classes of olefin metathesis and the choice of reaction conditions and catalyst Considers commercial processes with examples from existing and new technologies Provides a complete overview of the subject from its beginning to the present day

Download or read book 9th Congress on Electronic Structure Principles and Applications ESPA 2014 written by Manuel F. Ruiz-Lopez and published by Springer. This book was released on 2016-03-04 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects research findings presented at the 9th Edition of the Electronic Structure: Principles and Applications (ESPA-2014) International Conference, held in Badajoz, Spain, on July 2–4, 2014. The contributions cover research work on theory, methods and foundations, materials science, structure and chemical reactivity as well as environmental effects and modelling. Originally published in the journal Theoretical Chemistry Accounts, these outstanding papers are now available in a hardcover print format, as well as a special electronic edition. This volume provides valuable content for all researchers in theoretical chemistry, and will especially benefit those research groups and libraries with limited access to the journal.

Download or read book Olefin Metathesis written by Karol Grela and published by . This book was released on 2014 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a complete examination of the theory and methods of modern olefin metathesis, one of the most widely used chemical reactions in research and industry. Provides basic information for non-specialists, while also explaining the latest trends and advancements in the field to experts Discusses the various types of metathesis reactions, including CM, RCM, enyne metathesis, ROMP, and tandem processes, as well as their common applications Outlines the tools of the trade--from the important classes of active metal complexes to optimal reaction conditions--and suggests practical solutions for common reaction problems Includes tables with structures of commercial catalysts, and recommendations for commercial catalyst suppliers

Download or read book Stereoselective Alkene Synthesis written by Jianbo Wang and published by Springer. This book was released on 2012-08-13 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereoselective Synthesis of Tetrasubstituted Alkenes via Torquoselectivity-Controlled Olefination of Carbonyl Compounds with Ynolates, by Mitsuru Shindo and Kenji Matsumoto.- Stereoselective Synthesis of Z-Alkenes, by Woon-Yew Siau, Yao Zhang and Yu Zhao.- Stereoselective Synthesis of Mono-fluoroalkenes, by Shoji Hara.- Recent Advances in Stereoselective Synthesis of 1,3-Dienes, by Michael De Paolis, Isabelle Chataigner and Jacques Maddaluno.- Selective Olefination of Carbonyl Compounds via Metal-Catalyzed Carbene Transfer from Diazo Reagents, by Yang Hu and X. Peter Zhang.- Selective Alkene Metathesis in the Total Synthesis of Complex Natural Product, by Xiaoguang Lei and Houhua Li.- Olefination Reactions of Phosphorus-Stabilized Carbon Nucleophiles, by Yonghong Gu and Shi-Kai Tian.- Alkene Synthesis Through Transition Metal-Catalyzed Cross-Coupling of N-Tosylhydrazones, by Yan Zhang and Jianbo Wang.

Download or read book Comprehensive Coordination Chemistry II written by J. A. McCleverty and published by Newnes. This book was released on 2003-12-03 with total page 11845 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Coordination Chemistry II (CCC II) is the sequel to what has become a classic in the field, Comprehensive Coordination Chemistry, published in 1987. CCC II builds on the first and surveys new developments authoritatively in over 200 newly comissioned chapters, with an emphasis on current trends in biology, materials science and other areas of contemporary scientific interest.

Download or read book Metal Catalyzed Reactions in Water written by Pierre Dixneuf and published by John Wiley & Sons. This book was released on 2013-02-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water is abundant in nature, non-toxic, non-flammable and renewable and could therefore be safer and economical for the chemical industry wherever it is used as a solvent. This book provides a comprehensive overview of developments in the use of water as a solvent for metal catalysis, illustrating the enormous potential of water in developing new catalytic transformations for fi ne chemicals and molecular materials synthesis. A group of international experts cover the most important metalcatalyzed reactions in water and bring together cutting-edge results from recent literature with the first-hand knowledge gained by the chapter authors. This is a must-have book for scientists in academia and industry involved in the fi eld of catalysis, greener organic synthetic methods, water soluble ligands and catalyst design, as well as for teachers and students interested in innovative and sustainable chemistry.

Download or read book Applied Homogeneous Catalysis with Organometallic Compounds written by Boy Cornils and published by John Wiley & Sons. This book was released on 2017-09-05 with total page 1770 pages. Available in PDF, EPUB and Kindle. Book excerpt: The completely revised third edition of this four-volume classic is fully updated and now includes such topics as as CH-activation and multicomponent reactions. It describes the most important reaction types, new methods and recent developments in catalysis. The internationally renowned editors and a plethora of international authors (including Nobel laureate R. Noyori) guarantee high quality content throughout the book. A "must read" for everyone in academia and industry working in this field.

Download or read book Green Metathesis Chemistry written by Valerian Dragutan and published by Springer Science & Business Media. This book was released on 2009-10-26 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: An outstanding international scientific event in the field of metathesis chemistry, the NATO ASI "Green Metathesis Chemistry: Great Challenges in Synthesis, Catalysis and Nanotechnology" has been recently organized in Bucharest, Romania (July 21- August 2, 2008). Numerous renowned scientists, young researchers and students, convened for two weeks to present and debate on the newest trends in alkene metathesis and identify future perspectives in this fascinating area of organic, organometallic, catalysis and polymer chemistry with foreseen important applications in materials science and technology. Following the fruitful practice of NATO Advanced Study Institutes, selected contributions covering plenary lectures, short communications and posters have been compiled in this special volume dedicated to this successful convention on green metathesis chemistry. General interest was primarily focused on relevant "green chemistry" features related to all types of metathesis reactions (RCM, CM, enyne metathesis, ADMET and ROMP). Diverse opportunities for green and sustainable technologies and industrial procedures based on metahesis have been identified. Largely exemplified was the utility of this broadly applicable strategy in organic synthesis, for accessing natural products and pharmaceuticals, and also its ability to fit in the manufacture of smart and nanostructured materials, self-assemblies with nanoscale morphologies, macromolecular engineering.

Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.