Download or read book Studies on the DNA Polymerase Induced by Vaccinia Virus written by Mark D. Challberg and published by . This book was released on 1979 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on the Vaccinia Virus DNA Polymerase written by William F. McDonald and published by . This book was released on 1993 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Study of DNA Polymerase in Resistant and Susceptible Macrophages Infected with Vaccinia Virus written by Jessie Thomas and published by . This book was released on 1991 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vaccinia Virus and Poxvirology written by Stuart N. Isaacs and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
Download or read book Assessment of Future Scientific Needs for Live Variola Virus written by Institute of Medicine and published by National Academies Press. This book was released on 1999-04-30 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.
Download or read book The Study of DNA Replication in Vaccinia Virus Through the Characterization of the Temperature Sensitive Mutant Ts4149 written by A. Kate Millns and published by . This book was released on 1994 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DNA Polymerase in Vaccinia Virus infected and Uninfected Animal Cells written by Catherine B. Lazier and published by . This book was released on 1967 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Study of DNA Replication in Vaccinia Virus Through the Characterization of the Temperature Sensitive Mutant Ts4149 microform written by A. Kate Millns and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1994 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on Vaccinia Virus DNA Replication Initiation written by Shan Du and published by . This book was released on 1996 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on DNA Precursor Metabolism in Vaccinia Virus infected Mamalian Cells written by Craig Spiro and published by . This book was released on 1987 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccinia virus-infected animal cells have been used to study the interactions between the replication of deoxyribonucleic acid (DNA) and the biosynthesis of its nucleotide precursors. Some antimetabolites that inhibit DNA replication have as their targets enzymes of nucleotide biosynthesis. Furthermore, the disruption of nucleotide metabolism can alter the fidelity of DNA replication. The isolation of viral mutants resistant to the nucleoside analogue arabinosyl cytosine has shown that resistance to certain drugs is associated with altered fidelity of replication of DNA. Furthermore, single mutations can cause altered sensitivity to several compounds. On the other hand, selection of apparent revertants indicates that several sites can be involved in drug resistance and replication fidelity. Vaccinia virus has previously been shown to code for enzymes of DNA precursor metabolism. However, attempts to isolate mutants resistant to drugs that target thymidylate synthase and dihydrofolate reductase were not successful. In fact, stimulation of host cell DNA synthesis makes vaccinia virus extremely sensitive to the effects of the folate analogue methotrexate. Taken together these observations suggest that despite its cytoplasmic site of DNA replication and its large coding capacity, vaccinia virus depends, at least in part, on host cell enzymes to supply deoxynucleoside triphosphates for DNA replication.
Download or read book Genetic and Biochemical Recombination Studies of a Vaccinia DNA Polymerase Mutant written by Melissa Mann and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Actin based Motility written by Marie-France Carlier and published by Springer Science & Business Media. This book was released on 2010-09-23 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of actin by Straub in the 1950’s and the pioneering work of Oosawa on actin self-assembly in helical laments in the 1960’s, many books and conference proceedings have been published. As one of the most essential p- teins in life, essential for movement in organisms rangingfrom bacteria to higher eukaryotes, it is no surprise that actin has fascinated generations of scientists from many different elds. Actin can be considered as a “living treasure” of biology; the kinetics and thermodynamics of self-assembly, the dissipative nature of actin po- merization, the molecular interactions of monomeric and polymerized actin with regulators, the mechanical properties of actin gels, and more recently the force p- ducing motile and morphogenetic processes organized by the actin nanomachine in response to signaling, are all milestones in actin research. Discoveries that directly derive from and provide deeper insight into the fundamental properties of actin are constantly being made, making actin an ever appealing research molecule. At the same time, the explosion in new technologies and techniques in biological sciences has served to attract researchers from an expanding number of disciplines, to study actin. This book presents the latest developments of these new multiscale approaches of force and movement powered by self-assembly processes, with the hope to opening our perspectives on the many areas of actin-based motility research.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book Human Monkeypox written by and published by . This book was released on 1988 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fine Structure Immunocytochemistry written by Gareth Griffiths and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electron microscopy in the biological sciences can be divided into two disciplines. The first, concerned with high resolution detail of particles or periodic structures, is mostly based on sound theoretical principles of physics. The second, by far the larger discipline, is interested in the information obtainable from thin sections. The theoretical back ground to those groups of techniques for preparing and looking at thin sections is often inexact and "loose", for want of a better word. What should be chemistry is often closer to alchemy. This kind of electron microscopy is often enshrined with mystical recipes, handed down from generation to generation. Admittedly, many of the processes involved, such as those required to embed tissue in epoxy resins, involve multiple interconnected steps, which make it difficult to follow the details of anyone of these steps. If all these steps are shrouded in some mystery, however, can one really trust the final image that emerges on the EM screen? When we present the data in some semi quantitative form is there really no better way to do it than to categorize the parameters with ++, +/-, etc? What happens when one labels the sections with antibodies? Does the whole business necess arily need to be more of an "art" than a "science"? Upon reflecting on these problems in 1981, I had the impression that many of the multi-authored textbooks that existed then (and that have appeared since) tended to exacerbate or at least perpetuate this
Download or read book DNA Replication in Eukaryotic Cells written by Melvin L. DePamphilis and published by CSHL Press. This book was released on 1996 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: National Institutes of Health. Cold Spring Harbor Monograph, Volume 31 Extensive text on the replication of DNA, specifically in eukaryotic cells, for researchers. 68 contributors, 54 U.S.
Download or read book Viral Polymerases written by Satya Prakash Gupta and published by Academic Press. This book was released on 2018-10-29 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. - Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition - Analyzes the structure-activity relationships of inhibitors of each viral polymerase - Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets
