Download or read book Studies in Heterocyclic Chemistry Part One Investigations Into the Synthesis of the Indole Alkaloid Quadrigemine A written by Paul Kenneth Battey and published by . This book was released on 1973 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies in Heterocyclic Chemistry Part Two Further Investigations Into the Synthesis of the Calycanthaceous Alkaloid Quadrigemine A written by Derek Leslie Crookes and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies in Heterocyclic Chemistry Part Two Further Investigations Into the Synthesis of the Calcycanthaceous Alkaloid Quadrigemine A written by Paul Kenneth Battey and published by . This book was released on 1976 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Indole Alkaloids written by Maliha Uroos and published by Elsevier. This book was released on 2022-01-30 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indole Alkaloids: Spirooxindole details the multistep synthesis of natural products using schematic diagrams, providing a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. As a volume in the Visual Guides to Natural Product Synthesis series, this book presents the schematic total syntheses of natural products containing a “spirooxindole” core structure. It covers spirooxindole molecules through visual diagrams, highlighting key steps involved in total, formal and semi-syntheses. Sections cover Brevianamide A and B, Citrinadin A and B, Coerulescine and Horsfiline, Elacomine and Isoelacomine, Gelsemine, Paraherquamide A and B, Rynchophylline, Isorynchophylline, and more. Visual layouts provide quick-and- easy access to developed synthetic routes towards the targeted spirooxindoles. Outlines synthetic strategies for natural products bearing a spirooxindole core structure Includes schematic diagrams of multistep synthetic routes, highlighting key steps along the way Describes all routes for the formal synthesis, semi-synthesis and total synthesis of spirooxindole alkaloids
Download or read book Total Synthesis of Indole Alkaloids written by Junpei Matsuoka and published by Springer Nature. This book was released on 2020-09-18 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.
Download or read book Alkaloid Synthesis written by Hans-Joachim Knölker and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Download or read book Part I General Approach to the Total Synthesis of 9 methoxy Substituted Indole Alkaloids written by Jun Ma and published by . This book was released on 2006 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Relating to the Synthesis of an Indole Alkaloid Bio precursor written by Brian William Herten and published by . This book was released on 1975 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Part I The First Regio and Atropdiastereoselective Total Synthesis of the Dimeric Indole Alkaloid dispegatrine as Well as the First Total Synthesis of the Sarpagine Alkaloids spegatrine Lochvinerine lochneram and an Improved Total Synthesis of 10 methoxyvellosimine lochnerine and sarpagine written by Chitra R. Edwankar and published by . This book was released on 2011 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Directed Towards the Synthesis of the Indole Alkaloids written by Nancy Lucretia Sear and published by . This book was released on 1985 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies in the Synthesis of Some Indole Alkaloids written by Andrew David Gazard and published by . This book was released on 1965 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies in the Synthesis of the Indole Alkaloids written by Arthur Eugene Oberster and published by . This book was released on 1957 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index to Theses Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 1978 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pt 1 Extension of 1 3 4 oxadiazole Chemistry written by Houchao Tao and published by ProQuest. This book was released on 2007 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tandem Diels-Alder and dipolar cycloaddition reactions of 1,3,4-oxadiazoles have been disclosed and applied in the total synthesis of several vinca alkaloids. The reactions were initiated by an intramolecular Diels-Alder reaction between 1,3,4-oxadiazole and an olefin which upon loss of nitrogen generated a carbonyl ylide that further reacted with a second olefin in a 1,3-diplar cycloaddition. This methodology was attempted to be extended to synthesize aspidosperma alkaloids by loading a leaving group at C5 of 1,3,4-oxadiazole which was also an electron withdrawing group that can initiate the tandem reaction. A series of oxadiazoles were prepared and tested for the cycloaddition, including C5-nitrile, sulfide, sulfoxide, sulfone, methoxy, methyl, hydrogen and phenyl. And a replacement of oxadiazole with oxazole was also tried in the cycloadditions. For NH-free indole precursors, a vincamine scaffold was produced. The study of alkyne oxadiazole cycloaddition showed the reactivity of the substrates was correlated with the conformation preference instead of electronic effects. A permethyl ningalin B amide library was constructed by coupling permethyl ningalin B acid with the corresponding amines. The MDR reversal activity assessments were run simultaneously in a triplicate alongside internal standard. All of the amide derivatives exhibit MDR reversal properties except two dimers. Derivatives with amines that lack an aromatic ring typically exhibit less MDR reversal activity than those incorporate an aryl ring. Several derivatives were found to exhibit the activity comparable as the lead permethyl ningalin B amide while lack the intrinsic, modest cytotoxic activity providing a more than 100-fold therapeutic window. For the synthesis of rebeccamycin, initial strategy based on tetrazine[arrow right]diazine[arrow right]benzene sequence featured by a novel in situ tautomerization and following transannular Diels-Alder reaction failed due to the formidable macrolactamization. The minimum size of the macrolactam was determined. The attempts for the synthesis of oxadiazole macrolactam failed either. The current strategy by using double Diels-Alder reactions and Cadogan cyclization successfully furnished the model indolocarbazole core of rebeccamycin.
Download or read book Total Syntheses of Indole Alkaloids and Determination of the Electrophilicity of Benzyne and Related Intermediates written by Lucas Morrill and published by . This book was released on 2019 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation encompasses several projects pertaining to natural product total synthesis, reaction methodology development, and kinetic studies. The total synthesis of natural products continues to be a fruitful area of research in organic chemistry. The successful completion of a total synthesis endeavor not only affirms ambitious route designs, but can also allow access to significant amounts of biologically-active compounds. Given that natural product structures inspire the development of new agrochemicals and pharmaceuticals, their syntheses are a worthwhile endeavor. Also, the development of new reaction methodologies and the understanding of fundamental reactivities of many intermediates remain important areas of research. Chapter One offers a current perspective on the field of natural product total synthesis. Alhough historically viewed as a highly competitive field, several recent examples show the growing spirit of collaboration in total synthesis. By forming alliances with chemists in other fields, industries, or laboratories, total synthesis chemists have made many breakthroughs that would arguably not be possible if working independently. Chapters Two and Three describe our laboratory's total syntheses of several bioactive akuammiline alkaloids, including strictamine, 2(S)-cathafoline, akuammiline, -akuammigine, and 10-demethoxynorvincorine. Our strategic approach to the natural products focused on the use of a modern variant of a classic reaction, the Fischer indolization reaction, to install several rings and the common quaternary center found in each target. This strategy allowed for the first total syntheses of akuammilines bearing the methanoquinolizidine core and those that also bear vicinal quaternary centers. In addition, rearrangements of the methanoquinolizidine core were developed that allowed us to access pyrrolidinoindoline-containing akuammilines. Chapter Four describes a series of kinetic studies used to determine the electrophilicity parameter of benzyne and related aryne intermediates. Arynes are a family of strained intermediates whose existence has been postulated for over 100 years. Recent advances have confirmed their existence and proven their synthetic utility. An advanced knowledge of their reactivity thus far has remained elusive. Our laboratory employed the diffusion clock method to measure the rates of reaction between several arynes and a variety of different nucleophilic reaction partners. The result allowed for the first quantification of the electrophilicity of these strained intermediates and should influence synthetic planning in the future. Chapter Five includes a study in the development of reaction methodology. Utilizing a variant of the Fischer Indolization reaction, our laboratory discovered a general method for making aza-indoline structures. This methodology was applied in the synthesis of derivatives of akuammiline alkaloids and Alzheimer's therapeutic molecules. In addition, a predictive computational model of reactivity was derived.
Download or read book Studies on the Synthesis and Biosynthesis of Indole Alkaloids written by Norman G. Lewis and published by . This book was released on 1978 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Unified Approach Toward the Total Syntheses of Prenylated Indole Alkaloid Natural Products written by Eduardo Valentin Mercado-Marin and published by . This book was released on 2016 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract A Unified Approach Toward the Total Syntheses of Prenylated Indole Alkaloid Natural Products by Eduardo Valentin Mercado-Marin Doctor of Philosophy in Chemistry University of California, Berkeley Professor Richmond Sarpong, Chair This dissertation describes our approach toward a unifying synthesis of prenylated indole alkaloid natural products. Chapter 1 is an introduction and provides background to this class of natural products, focusing primarily on the isolation, biological activity, biosynthetic, and previous synthetic work of these natural products. This section also includes a discussion of synthetic approaches to the common bicyclo[2.2.2]diazaoctane core embodied in many of these natural products, which sets the stage for our entry into these molecules by a unifying route. Chapter 2 describes our entry into this class of natural products focused primarily on our synthetic and biosynthetic work toward natural products lacking the bicyclo[2.2.2]diazaoctane core. In particular, we discuss the first chemical syntheses of the prenylated indole alkaloids citrinalin B and cyclopiamine B. Along with unambiguously establishing the structures of these natural products, in collaboration with the Berlinck group, we provide evidence for the existence of a common bicyclo[2.2.2]diazaoctane containing precursor as an intermediate to natural products that lack this structural feature. Lastly, Chapter 3 describes our unified strategy for the synthesis of prenylated indole alkaloid natural products, capitalizing on our results described in Chapter 2. This unifying strategy has resulted in the syntheses of stephacidin A and 17-hydroxy-citrinalin B. Key to the success of this approach in accessing congeners containing and lacking the bicyclo[2.2.2]diazaoctane core was a complexity building isocyanate capture to forge the bicyclo[2.2.2]diazaoctane core from a common all fused precursor.
